Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis.

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：:In childhood-onset acute myeloid leukaemia (AML) the clinical value of karyotypic aberrations is now acknowledged, although there is still debate concerning the prognostic significance of some events. To add to this knowledge, cytogenetic analysis was performed on a consecutive series of 84 childhood AML patients diag...

journal_title：European journal of haematology

authors： Betts DR,Ammann RA,Hirt A,Hengartner H,Beck-Popovic M,Kuhne T,Nobile L,Caflisch U,Wacker P,Niggli FK

更新日期：2007-06-01 00:00:00

abstract：:Haemoglobin (Hb) Hope [beta136(H14)Gly-->Asp(GGT-->GAT)] is one of the unstable haemoglobin variants of the beta-globin chain, which is demonstrated in people of various ethnic backgrounds. Here we report a Thai female patient with clinical thalassaemia intermedia since childhood. This patient had experienced neither ...

journal_title：European journal of haematology

authors： Sura T,Busabaratana M,Youngcharoen S,Wisedpanichkij R,Viprakasit V,Trachoo O

更新日期：2007-09-01 00:00:00

abstract：INTRODUCTION:Tumor cells of primary cutaneous T-cell lymphomas are able to adopt a regulatory T-cell phenotype in vitro. The significance of this finding in vivo is matter of debate. METHODS:We stained five cases with transformed mycosis fungoides (MF) with an antibody against FOXP3, which is a sensitive and specific ...

journal_title：European journal of haematology

authors： Hallermann C,Niermann C,Schulze HJ

更新日期：2007-03-01 00:00:00

abstract：:Ibrutinib is an oral inhibitor of Bruton tyrosine kinase approved for the treatment of chronic lymphocytic leukaemia, mantle cell lymphoma and refractory Waldenstrom's disease. It increases progression-free survival, overall survival, response rate. The most frequent adverse reactions, are increased risk in of bleedin...

journal_title：European journal of haematology

authors： Bernardeschi P,Pirrotta MT,Del Rosso A,Fontanelli G,Milandri C

更新日期：2019-10-01 00:00:00

abstract：:Serological analyses within epidemiological cohort and case-control studies indicate to an association between HBV infection and risk of multiple myeloma (MM). To verify the relationship with an independent approach, we investigated the correlation between HBV positivity and chromosomal aberrations within 680 patients...

journal_title：European journal of haematology

authors： Becker N,Byl A,Friedrich S,Jauch A,Schnitzler P,Egerer G,Ho AD,Goldschmidt H,Neben K

更新日期：2013-04-01 00:00:00

abstract：:The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). E...

journal_title：European journal of haematology

authors： Joly P,Garnier N,Kebaili K,Renoux C,Dony A,Cheikh N,Renard C,Ceraulo A,Cuzzubbo D,Pondarré C,Martin C,Pialoux V,Francina A,Bertrand Y,Connes P

更新日期：2016-04-01 00:00:00

abstract：:Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. OBJECTIVES:To report outcomes and AEs in a population-b...

journal_title：European journal of haematology

authors： Aarup K,Rotbain EC,Enggaard L,Pedersen RS,Bergmann OJ,Thomsen RH,Frederiksen M,Frederiksen H,Nielsen T,Christiansen I,Andersen MA,Niemann CU

更新日期：2020-11-01 00:00:00

abstract：:Sickle cell disease (SCD) is an inherited disorder secondary to a point mutation at the sixth position of the beta chain of human hemoglobin resulting in the replacement of valine for glutamic acid. This recessive genetic abnormality precipitates the polymerization of the deoxygenated form of hemoglobin S inducing a m...

journal_title：European journal of haematology

authors： Talano JA,Cairo MS

更新日期：2015-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...

journal_title：European journal of haematology

authors： Olsson I,Lantz M,Nilsson E,Peetre C,Thysell H,Grubb A,Adolf G

更新日期：1989-03-01 00:00:00

abstract：:Upshaw-Schulman syndrome (USS) is due to severe congenital deficiency of von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 domains, nr 13) activity resulting in the presence of unusually large forms of VWF in the circulation, causing intravascular plat...

journal_title：European journal of haematology

authors： Rank CU,Kremer Hovinga J,Taleghani MM,Lämmle B,Gøtze JP,Nielsen OJ

更新日期：2014-02-01 00:00:00

abstract：:Several studies have reported data on factors influencing mobilization of peripheral blood stem cells (PBSC) in non-myeloid malignancies. On the contrary, data from patients with acute myeloid leukemia (AML) are very limited, in particular, as the impact of an antecedent diagnosis of refractory anemia with excess blas...

journal_title：European journal of haematology

authors： Viola A,Falco C,D'Elia R,D'Amico MR,Vicari L,Tambaro FP,Correale P,Laudati D,Palmieri S,Ferrara F

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Non-Hodgkin lymphoma patients have a 25% increased risk of secondary primary neoplasms (SPNs). Regarding the controversy about the increased risk of SPN in patients exposed to radioimmunotherapy (RIT), we have analyzed this issue in a cohort of follicular lymphoma (FL) patients treated with/without RIT. PAT...

journal_title：European journal of haematology

authors： Andrade-Campos MM,Liévano P,Espinosa-Lara N,Soro-Alcubierre G,Grasa-Ulrich JM,López-Gómez L,Baringo T,Giraldo P

更新日期：2016-12-01 00:00:00

abstract：:Skin necrosis caused by heparins is a rare complication. We report a case of a 71-yr-old white woman who developed painful diffuse skin lesions, most probably related to enoxaparin treatment. Other causes of skin necrosis, including heparin induced thrombocytopenia, disseminated intravascular coagulation, protein C/pr...

journal_title：European journal of haematology

authors： Nadir Y,Mazor Y,Reuven B,Sarig G,Brenner B,Krivoy N

更新日期：2006-08-01 00:00:00

abstract：:Immune reconstitution may be delayed after CD34-selected compared with unmanipulated autologous peripheral blood stem cell transplantation (PBSCT), resulting in a theoretically increased risk of infections. In a case-control matched study we compared the incidence of infection in 25 recipients of CD34-selected PBSC (C...

journal_title：European journal of haematology

authors： Frère P,Pereira M,Fillet G,Beguin Y

更新日期：2006-02-01 00:00:00

abstract：:Although cladribine has been reported to be an active purine analog against indolent B-cell non-Hodgkin lymphoma (B-NHL), there are few reports of combination use of cladribine and rituximab. This multicenter phase II study evaluated the efficacy and toxicity of cladribine with rituximab (R-2-CdA) therapy in relapsed ...

journal_title：European journal of haematology

authors： Nagai H,Ogura M,Kusumoto S,Takahashi N,Yamaguchi M,Takayama N,Kinoshita T,Motoji T,Ohyashiki K,Kosugi H,Matsuda S,Ohnishi K,Omachi K,Hotta T

更新日期：2011-02-01 00:00:00

abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis. Due to the lack of unique surface markers expressed by neoplastic monocytes and the frequent CD34-negative blast immunophenotype, the diagnostic value of flow cytometric immunophenotyping (...

journal_title：European journal of haematology

authors： Shen Q,Ouyang J,Tang G,Jabbour EJ,Garcia-Manero G,Routbort M,Konoplev S,Bueso-Ramos C,Medeiros LJ,Jorgensen JL,Wang SA

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:In patients with essential thrombocythemia (ET), vascular complications contribute to both morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score of thrombosis for ET (IPSET-thrombosis) was recently developed. We hereby presented an external validati...

journal_title：European journal of haematology

authors： Fu R,Xuan M,Lv C,Zhang L,Li H,Zhang X,Zhang D,Sun T,Xue F,Liu X,Liang H,Zhang L,Yang R

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (CPI) are widely used in modern oncology and have improved the prognosis of lung cancer, malignant melanoma, and other malignancies. Unlike cytotoxic chemotherapy, drugs such as nivolumab, pembrolizumab, and ipilimumab are associated with immune-related adverse effects. We recent...

journal_title：European journal of haematology

authors： Tanios GE,Doley PB,Munker R

更新日期：2019-02-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) characterized by the translocation t(11;14)(q13;q32). This lymphoma exhibits a poor prognosis and remains incurable with standard chemotherapy approaches. Recently, we have shown that a majority of patients with acute-type adult T-cell leuke...

journal_title：European journal of haematology

authors： Liu F,Yoshida N,Suguro M,Kato H,Karube K,Arita K,Yamamoto K,Tsuzuki S,Oshima K,Seto M

更新日期：2013-01-01 00:00:00

abstract：:Between December, 1984, and May, 1986, 98 CSF samples were sent to a central laboratory by postal express. The samples could be kept in a medium for up to 24 hours after the lumbar puncture. The quality of the cells proved to be good. Excluded were 5 samples delayed in delivery and 13 samples contaminated with blood, ...

journal_title：European journal of haematology

authors： van Wering ER,Veerman AJ,van der Linden-Schrever BE

更新日期：1988-03-01 00:00:00

abstract：:The association of infectious mononucleosis and an immunocompromised host such as occurs in acute leukemia is reported. The most common cause of infectious mononucleosis is Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Patients with mononucleosis syndrome caused by other agents are rare. We report a case of acut...

journal_title：European journal of haematology

authors： Tamayose K,Sugimoto K,Ando M,Oshimi K

更新日期：2002-04-01 00:00:00

abstract：:Immunoglobulin gene rearrangements in B-cell lymphoma subtypes may not always be detected by PCR if only one primer set is applied. We therefore analysed a range of low and high grade B-cell lymphoma subtypes for monoclonality using PCR, to determine appropriate primer selection strategies for routine diagnostic use. ...

journal_title：European journal of haematology

authors： Essop MF,Blakolmer K,Close PM,Manuel YE,Cornelius S

更新日期：1997-09-01 00:00:00

abstract：:To determine if mutations of the Wilms' tumor predisposing gene (WT1) are associated with haematological malignancies, we have investigated 65 cases of acute leukaemia, including 39 patients in blast crisis of chronic myeloid leukaemia (CML), by amplification of WT1 exons 7, 8 and 9 followed by single-strand conformat...

journal_title：European journal of haematology

authors： Carapeti M,Goldman JM,Cross NC

更新日期：1997-05-01 00:00:00

abstract：:Splenic volume was measured by visual assessment of planar images of the spleen, and also by single photon emission computerised tomography (SPECT) using 99mtechnetium tin colloid, in a group of 33 patients with primary thrombocythaemia (PT) or reactive thrombocytosis. Volumes greater than 337 cm3 correlated strongly ...

journal_title：European journal of haematology

authors： Messinezy M,Chapman R,Dudley JM,Nunan TO,Pearson TC

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Serum lactate dehydrogenase (LDH) has been an adverse prognostic factor for myeloma but does not feature in the International Staging System (ISS). We examined whether elevated serum LDH at diagnosis remains an adverse risk factor independent of ISS for survivals transplant-eligible myeloma patients receivin...

journal_title：European journal of haematology

authors： Chim CS,Sim J,Tam S,Tse E,Lie AK,Kwong YL

更新日期：2015-04-01 00:00:00

abstract：:Heparin binds to platelets and can cause platelet proaggregating and potentiating effects, possibly causing thrombocytopenia, particularly in patients in intensive care with hyperaggregable platelets. In this study we compared the platelet proaggregating and potentiating effects of unfractionated heparin (UH), 2 low m...

journal_title：European journal of haematology

authors： Burgess JK,Chong BH

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Warfarin represents the most commonly prescribed oral anticoagulants, which functions as an antagonist of vitamin K, an essential factor of blood coagulation cascade. Warfarin has a narrow therapeutic index. An insufficient dose can cause failure of antithrombotic effect, and an overdose increases a risk of b...

journal_title：European journal of haematology

authors： Krajčíová L,Petrovič R,Déžiová L,Chandoga J,Turčáni P

更新日期：2014-10-01 00:00:00

abstract：:It has been recently demonstrated that ecto-5'nucleotidase (5'NT) activity is significantly decreased in the peripheral blood lymphocytes (PBL) of homosexual men. This paper reports a study of PBL 5'NT activity in 38 hemophiliacs at risk for the acquired immunodeficiency syndrome (AIDS). The enzyme activity was correl...

journal_title：European journal of haematology

authors： Massaia M,Pioppo P,Dianzani U,Guerra MG,Peyretti F,Pileri A,Tamponi G

更新日期：1987-04-01 00:00:00

abstract：:We have demonstrated that the intracellular processing of transferrin to effect iron removal involves two pathways, one sensitive to rotenone and the other not. We have also found that the effect of the rotenone is dependent on the transferrin concentration: iron uptake was suppressed with concentrations of transferri...

journal_title：European journal of haematology

authors： Zhan H,Pollack S,Weaver J

更新日期：1990-07-01 00:00:00