Mononucleosis syndrome and acute monocytic leukemia.

abstract：OBJECTIVES:An aberrant pattern of expression of L-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). METHODS:In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICA...

journal_title：European journal of haematology

authors： Buccisano F,Maurillo L,Tamburini A,Del Poeta G,Del Principe MI,Ammatuna E,Consalvo MI,Campagna S,Ottaviani L,Sarlo C,Renzi D,Faccia S,Fraboni D,Lo Coco F,Amadori S,Venditti A

更新日期：2008-02-01 00:00:00

abstract：:The therapeutic management of patients with idiopathic hemochromatosis (IH) requires an accurate estimate of hepatic iron overload in order to prevent tissue fibrosis and organ failure. Magnetic resonance imaging (MRI) was used to estimate liver iron overload in 5 patients with IH and in 8 normal controls. Signal inte...

journal_title：European journal of haematology

authors： Andersen PB,Birgegård G,Nyman R,Hemmingsson A

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:To compare the gene expression pattern in children and adults with acute lymphoblastic leukaemia (ALL) in order to improve our understanding of the difference in disease biology and prognosis. METHODS:The gene expression profiles in diagnostic samples from 29 children and 15 adults with ALL were analysed us...

journal_title：European journal of haematology

authors： Kuchinskaya E,Heyman M,Grandér D,Linderholm M,Söderhäll S,Zaritskey A,Nordgren A,Porwit-Macdonald A,Zueva E,Pawitan Y,Corcoran M,Nordenskjöld M,Blennow E

更新日期：2005-06-01 00:00:00

abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

journal_title：European journal of haematology

authors： Bhandari S,Galanello R

更新日期：2012-09-01 00:00:00

abstract：:In groups of 26 patients with myeloproliferative disorders (MPD), 8 with chronic myelogenous leukaemia (CML); 8 with polycythaemia vera (PV); 10 with essential thrombocythaemia (ET); and 6 patients with reactive thrombocytosis (RT), we studied the growth characteristics of bone marrow CFU-M in agar culture. The bone m...

journal_title：European journal of haematology

authors： Hamaguchi H,Takano N,Sakamaki H,Enokihara H,Saito K,Furusawa S,Shishido H

更新日期：1988-08-01 00:00:00

abstract：:In a prognostic univariate analysis of a series of 80 patients with idiopathic myelofibrosis the Hb-concentration, the platelet count and osteomyelosclerosis emerged as factors with prognostic significance. A Hb-concentration less than 10 g/dl was associated with a significantly shorter survival than a Hb-concentratio...

journal_title：European journal of haematology

authors： Hasselbalch H,Jensen BA

更新日期：1990-03-01 00:00:00

abstract：:15 cases of acute leukemia (AL) displaying a TdT+, HLA-DR+ phenotype were studied; surface immunoglobulins, T cell markers and the common acute lymphoblastic leukaemia (c-ALL) antigen were negative, as were peroxidase and non-specific esterase cytochemical reactions. All cases were extensively investigated by conventi...

journal_title：European journal of haematology

authors： Basso G,Putti MC,Catoretti G,Consolini R,Galdiolo D,Guglielmi C,Messina C,Milanesi C,Testi AM,Xillo MZ

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVES:Imatinib (Glivec, STI571) has been successfully used in patients with chronic myelogenous leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome (Ph). We used imatinib interim therapy for four consecutive patients with newly diagnosed Ph+ acute myeloid leukemia (AML). We monitored the pat...

journal_title：European journal of haematology

authors： Cho BS,Kim HJ,Lee S,Eom KS,Min WS,Lee JW,Kim CC

更新日期：2007-08-01 00:00:00

abstract：:We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (DLI) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T-cell depletion. We also investigated progno...

journal_title：European journal of haematology

authors： Yan CH,Wang JZ,Liu DH,Xu LP,Chen H,Liu KY,Huang XJ

更新日期：2013-10-01 00:00:00

abstract：:Although cladribine has been reported to be an active purine analog against indolent B-cell non-Hodgkin lymphoma (B-NHL), there are few reports of combination use of cladribine and rituximab. This multicenter phase II study evaluated the efficacy and toxicity of cladribine with rituximab (R-2-CdA) therapy in relapsed ...

journal_title：European journal of haematology

authors： Nagai H,Ogura M,Kusumoto S,Takahashi N,Yamaguchi M,Takayama N,Kinoshita T,Motoji T,Ohyashiki K,Kosugi H,Matsuda S,Ohnishi K,Omachi K,Hotta T

更新日期：2011-02-01 00:00:00

abstract：:Central nervous system (CNS) involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages with lymph node or visceral involvement. We describe a patient with advanced stage MF in large-cell transformation who presented with profound hearing loss after chemotherapy. Despite an initial differenti...

journal_title：European journal of haematology

authors： Chua SL,Seymour JF,Prince HM

更新日期：2000-05-01 00:00:00

abstract：:We investigated the significance of cytokines (soluble interleukin-2 receptor, granulocyte-macrophage colony-stimulating factor, interleukin-6, and interferon-gamma) and CD68-positive microparticles in immune thrombocytopenic purpura. Cytokines were measured by enzyme-linked immunosorbent assay and microparticles were...

journal_title：European journal of haematology

authors： Nomura S,Yanabu M,Kido H,Lan XG,Ichiyoshi H,Katsura K,Miyake T,Miyazaki Y,Kagawa H,Fukuhara S

更新日期：1995-07-01 00:00:00

abstract：:We evaluated the serum/plasma levels of cytokines [interleukin (IL)-6, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-beta2] and markers of coagulation, fibrinolysis, endothelial and platelet activation during the first 4 wk of treatment with the thalidomide analogue Actimid (CC-4047) in 1...

journal_title：European journal of haematology

authors： Streetly M,Hunt BJ,Parmar K,Jones R,Zeldis J,Schey S

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Infections are the major cause of morbidity and mortality in patients with acute myeloid leukaemia (AML). They primarily occur during the first course of induction chemotherapy and may increase the risk of leukaemia relapse, due to a significant delay in consolidation therapy. The intensification of inductio...

journal_title：European journal of haematology

authors： Malagola M,Peli A,Damiani D,Candoni A,Tiribelli M,Martinelli G,Piccaluga PP,Paolini S,De Rosa F,Lauria F,Bocchia M,Gobbi M,Pierri I,Zaccaria A,Zuffa E,Mazza P,Priccolo G,Gugliotta L,Bonini A,Visani G,Skert C,Ber

更新日期：2008-11-01 00:00:00

abstract：:Polyclonal B cell activation occurred in 3 patients following treatment with intravenous immunoglobulin (i.v. Ig) for idiopathic thrombocytopenic purpura (ITP). The possibility that this may represent an anti-idiotype response and the hypothesis that prolonged remission of ITP may be induced by this mechanism are disc...

journal_title：European journal of haematology

authors： Wangel AG,Lorenzetti M,Pettersson T

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVES:Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD. METHODS:We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell trans...

journal_title：European journal of haematology

authors： Gjaerde LK,Ostrowski SR,Minculescu L,Andersen NS,Friis LS,Kornblit B,Petersen SL,Schjødt I,Sengeløv H

更新日期：2020-12-12 00:00:00

abstract：OBJECTIVES:Beta thalassaemia major (β-TM) and sickle-cell disease (SCD) are severe haemogobinopathies requiring life-lasting, advanced medical management. In the Mediterranean region, both conditions occur with high frequency. We assessed the efficacy of the National Program for the Prevention of Haemoglobinopathies in...

journal_title：European journal of haematology

authors： Ladis V,Karagiorga-Lagana M,Tsatra I,Chouliaras G

更新日期：2013-04-01 00:00:00

abstract：:In patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), expression of the hematopoietic stem cell marker CD34 has been associated with a poorer prognosis. CD34 is usually analyzed by flow cytometry (FC), but may also be analyzed using immunohistochemistry (IH). The present study was undertak...

journal_title：European journal of haematology

authors： Kanter-Lewensohn L,Hellström-Lindberg E,Kock Y,Elmhorn-Rosenborg A,Ost A

更新日期：1996-03-01 00:00:00

abstract：:The oncogenes c-myc and c-ras are known to elicit a cooperative tumorigenicity. In this study we investigated their role in the pathogenesis of Hodgkin's disease. The expression of these oncogenes was determined in Hodgkin's disease patients by avidin-biotin peroxidase complex immunohistochemical staining and was comp...

journal_title：European journal of haematology

authors： Benharroch D,Yermiahu T,Geffen DB,Prinsloo I,Gopas J,Segal S,Aboud M

更新日期：1995-09-01 00:00:00

abstract：:Previous studies in our laboratory have shown that patients with chronic idiopathic neutropenia of adults (CINA) have increased serum levels of inflammatory cytokines including IL-1beta. Since IL-1beta may affect bone marrow stromal cell function, a study was designed to investigate the capacity of patients' stromal c...

journal_title：European journal of haematology

authors： Papadaki HA,Giouremou K,Eliopoulos GD

更新日期：1999-09-01 00:00:00

abstract：:In Western countries, the age distribution of Hodgkin lymphoma (HL) follows a characteristic bimodal curve showing an early and a late peak at approximately 35 and 70 yr, respectively. Furthermore, the presence of latent Epstein-Barr virus (EBV) genome in the Hodgkin Reed-Sternberg cells, the tumour cell population of...

journal_title：European journal of haematology

authors： Ludvigsen M,Kamper P,Hamilton-Dutroit SJ,Bendix K,Møller MB,d'Amore FA,Honoré B

更新日期：2015-08-01 00:00:00

abstract：:We previously reported an increased risk of monoclonal gammopathy of undetermined significance (MGUS) in first-degree relatives of MGUS and multiple myeloma patients. Here, we examine whether primary cytogenetic categories of myeloma differ between patients with and without a family history of MGUS or myeloma. We stud...

journal_title：European journal of haematology

authors： Greenberg AJ,Cousin M,Kumar S,Ketterling RP,Knudson RA,Larson D,Colby C,Scott C,Vachon CM,Rajkumar SV

更新日期：2013-09-01 00:00:00

abstract：:Host cells are protected from the lytic effect of the complement system by complement regulatory proteins. This study was designed to investigate the expression of complement regulatory proteins on leukemic blasts which may be susceptible to the lytic effects of the complement system in the circulation. The surface ex...

journal_title：European journal of haematology

authors： Guc D,Canpinar H,Kucukaksu C,Kansu E

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Little prospective data regarding factors determining patient outcomes in myelodysplastic syndromes (MDS) are available. To establish features of early mortality in MDS, we compare characteristics of patients dying within 1 year of diagnosis with those surviving longer. METHODS:We prospectively enrolled adul...

journal_title：European journal of haematology

authors： Jacobsen AM,Poynter JN,Richardson MR,Nguyen PL,Hirsch B,Cioc A,Roesler MA,Warlick ED

更新日期：2019-07-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) characterized by the translocation t(11;14)(q13;q32). This lymphoma exhibits a poor prognosis and remains incurable with standard chemotherapy approaches. Recently, we have shown that a majority of patients with acute-type adult T-cell leuke...

journal_title：European journal of haematology

authors： Liu F,Yoshida N,Suguro M,Kato H,Karube K,Arita K,Yamamoto K,Tsuzuki S,Oshima K,Seto M

更新日期：2013-01-01 00:00:00

abstract：:In an attempt to improve treatment outcome high-dose methylprednisolone (HDMP, 20-30 mg/kg, once a day orally) was used instead of a conventional dose of steroid (2 mg/kg/d, in 3 divided doses) in children with acute lymphoblastic leukemia (ALL) with increased risk factors. HDMP combined with cytotoxic agents (vincris...

journal_title：European journal of haematology

authors： Hiçsönmez G,Gümrük F,Zamani PV,Tuncer MA,Yetgin S,Gürgey A,Atahan L,Ozsoylu S

更新日期：1997-01-01 00:00:00

abstract：:Implantation of Yoshida ascites sarcoma in rats was found to lead to a reduction in the hemoglobin content, the erythrocyte count and the packed cell volume of blood to 30% of normal in 4 d; however, there was no decrease in the mean cell hemoglobin, the mean cell volume and the mean corpuscular hemoglobin concentrati...

journal_title：European journal of haematology

authors： Bhanushali AA,Raghunathan R,Kalraiya RD,Mehta NG

更新日期：2002-01-01 00:00:00

abstract：:Splenic volume was measured by visual assessment of planar images of the spleen, and also by single photon emission computerised tomography (SPECT) using 99mtechnetium tin colloid, in a group of 33 patients with primary thrombocythaemia (PT) or reactive thrombocytosis. Volumes greater than 337 cm3 correlated strongly ...

journal_title：European journal of haematology

authors： Messinezy M,Chapman R,Dudley JM,Nunan TO,Pearson TC

更新日期：1988-04-01 00:00:00

abstract：:Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1-PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophi...

journal_title：European journal of haematology

authors： Capovilla M,Cayuela JM,Bilhou-Nabera C,Gardin C,Letestu R,Baran-Marzak F,Fenaux P,Martin A

更新日期：2008-01-01 00:00:00

abstract：:Cells from 3 patients with B-chronic lymphocytic leukaemia (B-CLL) and 1 with B-prolymphocytic leukaemia (B-PLL) were treated in vitro with the phorbol ester 12-0-tetradecanoylphorbol (TPA), the calcium ionophore A23187, or a combination of TPA and A23187. TPA induced the cells to adhere to the culture flask or to clu...

journal_title：European journal of haematology

authors： Drexler HG,Brenner MK,Gignac SM,Hoffbrand AV

更新日期：1988-09-01 00:00:00