Expression of tartrate-resistant acid phosphatase in B-CLL treated with phorbol ester or phorbol ester plus calcium ionophore.

abstract：INTRODUCTION:PI3K inhibitors are evaluated for relapsed and refractory Diffuse large B-cell lymphoma (DLBCL) patients. OBJECTIVE:As rituximab has shown to influence B-cell receptor (BCR) signaling, we investigated the interaction of anti-CD20 antibody rituximab and the new type II glycoengineered anti-CD20 antibody ob...

journal_title：European journal of haematology

authors： Zoellner AK,Peter N,Zimmermann Y,Hutter G,Hiddemann W,Dreyling M

更新日期：2018-04-04 00:00:00

abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...

journal_title：European journal of haematology

authors： Liliemark J,Knochenhauer E,Gruber A,Pettersson B,Björkholm M,Peterson C

更新日期：1993-01-01 00:00:00

abstract：:The β⁰-thalassemia/Hb-E causes a wide range of severe conditions. A high medical cost is incurred in severe cases. Thus, the prevention of new cases of β⁰-thalassemia/Hb-E is required. The aim of this study is to use the SYTO9 and SYBR GREEN1 high-resolution melting (HRM) analysis for prenatal diagnosis of β⁰-thalasse...

journal_title：European journal of haematology

authors： Pornprasert S,Sukunthamala K

更新日期：2010-11-01 00:00:00

abstract：:Lactoferrin, unlabelled or 125I-labelled by 2 different methods, was given intravenously to rats. Blood, tissue and liver cell radioactivity was measured. Both of the radiolabelled preparations were eliminated by the liver, and some deposited extrahepatically. One preparation formed large aggregates--here 90% of the h...

journal_title：European journal of haematology

authors： Peen E,Johansson A,Engquist M,Skogh T

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA-haploidentical transplantation. Adoptive immunotransfer of virus-specific T cells from the donor is a promising therapeutic approach, although ...

journal_title：European journal of haematology

authors： Pello OM,Innes AJ,Bradshaw A,Finn SA,Uddin S,Bray E,Olavarria E,Apperley JF,Pavlů J

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

journal_title：European journal of haematology

authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

更新日期：2015-10-01 00:00:00

abstract：:We generated a 100-kb map of the region 5' of the PML (promyelocytic leukemia) gene on human chromosome 15q22 and identified a new gene provisionally named STORP for stomatin-related protein. The STORP gene is positioned 2 kb upstream of the PML gene in a head-to-head configuration, and contains 7 exons spanning a gen...

journal_title：European journal of haematology

authors： Gilles F,Glenn M,Goy A,Remache Y,Zelenetz AD

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Autologous stem cell transplantation (ASCT) has improved progression-free survival (PFS) and overall survival in eligible patients with newly diagnosed multiple myeloma (NDMM); however, relapse occurs. Maintenance therapy with lenalidomide (Len-Mt) extends survival and delays relapse and the subsequent initia...

journal_title：European journal of haematology

authors： Uyl-de Groot CA,Ramsden R,Lee D,Boersma J,Zweegman S,Dhanasiri S

更新日期：2020-11-01 00:00:00

abstract：:In this study, Escherichia coli LPS dose-dependently (100-500 microg/ml) and time-dependently (10-60 min) inhibited platelet aggregation in human and rabbit platelets stimulated by agonists. LPS also dose-dependently inhibited the intracellular Ca2+ mobilization in human platelets stimulated by collagen. In addition, ...

journal_title：European journal of haematology

authors： Sheu JR,Hung WC,Su CH,Lin CH,Lee LW,Lee YM,Yen MH

更新日期：1999-05-01 00:00:00

abstract：:We evaluated the serum/plasma levels of cytokines [interleukin (IL)-6, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-beta2] and markers of coagulation, fibrinolysis, endothelial and platelet activation during the first 4 wk of treatment with the thalidomide analogue Actimid (CC-4047) in 1...

journal_title：European journal of haematology

authors： Streetly M,Hunt BJ,Parmar K,Jones R,Zeldis J,Schey S

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The exact fate of polymorphonuclear neutrophilic granulocytes (PMN; neutrophils) after their mobilization from the bone marrow is not known. It is believed that they, after a relatively short lifespan (1-3 d), become apoptotic and phagocytosed by macrophages. We have recently shown that transfused neutrophils...

journal_title：European journal of haematology

authors： Knudsen E,Benestad HB,Seierstad T,Iversen PO

更新日期：2004-08-01 00:00:00

abstract：:Severe iron overload is frequent in dehydrated hereditary stomatocytosis (DHSt) despite well-compensated hemolysis and no or little transfusion requirement. We investigated 4 patients with proven DHSt, in whom the degree of hemolysis was closely related to iron status. Genetic modifiers increasing iron stores (HFE:pCy...

journal_title：European journal of haematology

authors： Orvain C,Da Costa L,Van Wijk R,Pissard S,Picard V,Mansour-Hendili L,Cunat S,Giansily-Blaizot M,Cartron G,Schved JF,Aguilar-Martinez P

更新日期：2018-10-01 00:00:00

abstract：:Although targeted therapies are used increasingly in hematologic malignancies, we are unaware of any prior studies of radioimmunotherapy (RAIT) in B-acute lymphoblastic leukemia (ALL), even though this radiosensitive tumor expresses CD22, potentially a good target for this approach. Here, we report a patient with Phil...

journal_title：European journal of haematology

authors： Chevallier P,Bodet-Milin C,Robillard N,Eugene T,Menard A,Le Houerou C,Guillaume T,Delaunay J,Escoffre-Barbe M,Wegener WA,Goldenberg DM,Kraeber-Bodéré F

更新日期：2013-12-01 00:00:00

abstract：:The therapeutic management of patients with idiopathic hemochromatosis (IH) requires an accurate estimate of hepatic iron overload in order to prevent tissue fibrosis and organ failure. Magnetic resonance imaging (MRI) was used to estimate liver iron overload in 5 patients with IH and in 8 normal controls. Signal inte...

journal_title：European journal of haematology

authors： Andersen PB,Birgegård G,Nyman R,Hemmingsson A

更新日期：1991-09-01 00:00:00

abstract：:We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (DLI) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T-cell depletion. We also investigated progno...

journal_title：European journal of haematology

authors： Yan CH,Wang JZ,Liu DH,Xu LP,Chen H,Liu KY,Huang XJ

更新日期：2013-10-01 00:00:00

abstract：:A long plateau phase is one of the strongest signs predicting long survival in multiple myeloma. The kinetics of escape from the plateau is, however, poorly known, and so is its influence on subsequent survival. During a 9-yr follow-up of 432 myeloma patients the serum M-protein doubling time at first relapse was meas...

journal_title：European journal of haematology

authors： Oivanen TM

更新日期：1996-09-01 00:00:00

abstract：:Cobalamin levels are frequently low in patients with dementia, but it is unclear if they represent definable deficiency and what the mechanisms are. Therefore, patients being evaluated for dementia who had low cobalamin levels but no obvious evidence of deficiency were studied hematologically, neurologically and with ...

journal_title：European journal of haematology

authors： Carmel R,Gott PS,Waters CH,Cairo K,Green R,Bondareff W,DeGiorgio CM,Cummings JL,Jacobsen DW,Buckwalter G

更新日期：1995-04-01 00:00:00

abstract：:A 32-year-old male presented with isolated neutropenia 6 months after allogeneic bone marrow transplantation for CML from his HLA-matched brother. The presence of granulocyte-specific IgM and IgG antibodies in the patient's serum indicated an immune-mediated basis for the neutropenia. A variety of manoeuvres to suppre...

journal_title：European journal of haematology

authors： Koeppler H,Goldman JM

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:Extracellular vesicles (EVs) are important for intercellular signalling in cancer. Tumour-associated macrophages, expressing the haemoglobin-haptoglobin and mannose receptors CD163 and CD206, are crucial for cancer progression. We recently identified CD163 on EVs in the circulation as a fraction of total sol...

journal_title：European journal of haematology

authors： Kvorning SL,Nielsen MC,Andersen NF,Hokland M,Andersen MN,Møller HJ

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evalua...

journal_title：European journal of haematology

authors： Catherwood MA,Matthews C,Niblock R,Dobbin E,Morris TC,Alexander HD

更新日期：2006-04-01 00:00:00

abstract：:Patients with essential thrombocythemia (ET) often suffer from neurological symptoms (NS) not ever resulting from previous thrombotic cerebral events (TCE). We reported NS occurred in 282 patients, in order to identify the factors influencing ET-related NS in the absence of TCE, and the response to therapy. Overall, 1...

journal_title：European journal of haematology

authors： Aroldi A,Cecchetti C,Colombo A,Cattaneo L,Pioltelli PE,Pogliani EM,Elli EM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Internal tandem duplications (ITDs) of the fms-like tyrosine kinase 3 ( FLT3) gene occur in 13-35% of patients with acute myeloid leukemia (AML). FLT3-ITD is associated with poor clinical outcome and is an indication for allogeneic stem cell transplantation (allo-SCT). METHODS:To investigate FLT3-ITD length...

journal_title：European journal of haematology

authors： Schiller J,Praulich I,Krings Rocha C,Kreuzer KA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Limited progress had been made in prognostic stratification of patients with Hodgkin lymphoma (HL) until recent studies suggested that the number of CD68-expressing macrophages is prognostic in classical HL. However, its significance in Asian patients with HL has not been explored yet perhaps because of its ...

journal_title：European journal of haematology

authors： Yoon DH,Koh YW,Kang HJ,Kim S,Park CS,Lee SW,Suh C,Huh J

更新日期：2012-04-01 00:00:00

abstract：:Myeloproliferative neoplasms associated with FIP1L1-PDGFR rearrangements represent a rare subset of myeloid and lymphoid malignancies, characterised by the presence of eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 genes. The fusion product of such genes is a tyrosine kinase oncoprotein sensitive to imatini...

journal_title：European journal of haematology

authors： Barraco D,Carobolante F,Candoni A,Simeone E,Piccaluga P,Tabanelli V,Fanin R

更新日期：2014-06-01 00:00:00

abstract：:Eighteen patients with malignant lymphoma, 10 non-Hodgkin's and 8 Hodgkin's, were treated with high-dose CVB (cyclophosphamide 4 x 1.5 g/m2, etoposide 4 x 250-400 mg/m2, carmustine 4 x 150-200 mg/m2), followed by autologous peripheral blood stem cells (PBSC, 13 patients) or bone marrow (BM, 5 patients) transplantation...

journal_title：European journal of haematology

authors： Patti C,Majolino I,Scimè R,Indovina A,Vasta S,Liberti G,Gentile S,Santoro A,Pisa R,Caronia F

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:Myeloma bone disease is a result of excessive osteoclast activation and impaired osteoblast function. Recent in vitro studies suggested that proteasome inhibitors might increase osteoblast function. METHODS:We analyzed serum markers of osteoblast activity in 25 patients with multiple myeloma receiving borte...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Müller C,Jakob C,Zavrski I,Schulz CO,Fleissner C,Hecht M,Sezer O

更新日期：2006-09-01 00:00:00

abstract：:It is well-documented that iron chelation by desferrioxamine protects/improves the cardiac function in blood transfusion-dependent children suffering from beta-thalassaemia. In patients who do not become dependent upon blood transfusion until adulthood (ANT-patients), iron chelation by desferrioxamine may affect the c...

journal_title：European journal of haematology

authors： Jensen PD,Olsen N,Bagger JP,Jensen FT,Christensen T,Ellegaard J

更新日期：1997-10-01 00:00:00

abstract：:The new World Health Organization (WHO) classification of hematologic malignancies has incorporated t(8;21) myelodysplastic syndromes (MDS) according to the French-American-British classification into the category of acute myeloid leukemia (AML) with t(8;21)(q22;q22), while our knowledge about clinicopathological feat...

journal_title：European journal of haematology

authors： Kaneda K,Kojima K,Takeuchi M,Takimoto H,Takaba S,Shinagawa K,Kobayashi H,Miyata A,Hara M,Tanimoto M

更新日期：2002-09-01 00:00:00

abstract：:Host cells are protected from the lytic effect of the complement system by complement regulatory proteins. This study was designed to investigate the expression of complement regulatory proteins on leukemic blasts which may be susceptible to the lytic effects of the complement system in the circulation. The surface ex...

journal_title：European journal of haematology

authors： Guc D,Canpinar H,Kucukaksu C,Kansu E

更新日期：2000-01-01 00:00:00

abstract：:Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 1...

journal_title：European journal of haematology

authors： Billström R,Johansson B,Fioretos T,Garwicz S,Malm C,Zettervall O,Mitelman F

更新日期：1997-07-01 00:00:00