Lenalidomide as maintenance treatment for patients with multiple myeloma after autologous stem cell transplantation: A pharmaco-economic assessment.

abstract：:Multiple myeloma (MM) is considered to be an essentially incurable haematological malignant disease, probably because of the existence of resistant clonal precursor cell with self-renewal capacity. Recent data have indicated that the myeloma cell hierarchy includes circulating clonal memory B cells, which differ consi...

journal_title：European journal of haematology

authors： Björkstrand B,Rasmussen T,Remes K,Gruber A,Pelliniemi TT,Johnsen HE

更新日期：2003-06-01 00:00:00

abstract：:33 patients with advanced refractory multiple myeloma received a combination of vincristine, cyclophosphamide, carmustine, melphalan and steroids (M-2 protocol). 20 of them had failed prior chemotherapy with alkylating agents and the remaining 13 patients had relapsed after a response to these drugs. An objective tumo...

journal_title：European journal of haematology

authors： Cavo M,Galieni P,Tassi C,Gobbi M,Tura S

更新日期：1988-02-01 00:00:00

abstract：:The purpose of this study was to analyse the influence of the hospital size, measured as the number of annual patient enrolments in the Finnish Leukaemia Group trials in the period 1979-85, on response rate and survival after conventional chemotherapy for multiple myeloma. The 432 myeloma patients for this study were ...

journal_title：European journal of haematology

authors： Oivanen T,Kellokumpu-Lehtinen P,Koivisto AM,Koivunen E

更新日期：1999-10-01 00:00:00

abstract：:Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, CD33, HLA-DR) were studied in 53 cases of acute myeloid leukemia...

journal_title：European journal of haematology

authors： Misery L,Campos L,Dezutter-Dambuyant C,Guyotat D,Treille D,Schmitt D,Thivolet J

更新日期：1992-01-01 00:00:00

abstract：:Heparin binds to platelets and can cause platelet proaggregating and potentiating effects, possibly causing thrombocytopenia, particularly in patients in intensive care with hyperaggregable platelets. In this study we compared the platelet proaggregating and potentiating effects of unfractionated heparin (UH), 2 low m...

journal_title：European journal of haematology

authors： Burgess JK,Chong BH

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:The benefits of combined chelation therapy with daily deferiprone (DFP) and subcutaneous desferrioxamine (DFO) have been widely reported in literature. We retrospectively evaluated the efficacy of different schedules of combined chelation therapy and the incidence of adverse events. METHODS:We evaluated 36 ...

journal_title：European journal of haematology

authors： Ricchi P,Ammirabile M,Spasiano A,Costantini S,Cinque P,Di Matola T,Pagano L,Prossomariti L

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:Recent studies have indicated that patients who receive stem cell transplantation (SCT) and rituximab demonstrate an increased risk of developing hypogammaglobulinemia. Such hypogammaglobulinemia has been found to be due to delayed recovery of memory B cells with an abnormal cell marker expression and impair...

journal_title：European journal of haematology

authors： Nishio M,Endo T,Fujimoto K,Yamamoto S,Obara M,Yamaguchi K,Takeda Y,Goto H,Kasahara I,Sato N,Koike T

更新日期：2009-02-01 00:00:00

abstract：:Recent studies have greatly illuminated the genomic landscape of the myelodysplastic syndromes (MDS), and the pace of discovery is accelerating. The most common mutations found in MDS occur in genes involved in RNA splicing (including SF3B1, SRSF2, U2AF1, and ZRSR2) and epigenetic modification (including TET2, ASXL1, ...

journal_title：European journal of haematology

authors： Pellagatti A,Boultwood J

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:An excessive intramedullar progenitor cell apoptosis, to which elevated expression of tumor necrosis factor-alpha (TNF-alpha) might contribute, is considered the main cause of inefficient hematopoiesis in myelodysplastic syndromes (MDS). Enhanced bone marrow (BM) angiogenesis is regarded as an essential cofa...

journal_title：European journal of haematology

authors： Stifter G,Heiss S,Gastl G,Tzankov A,Stauder R

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:To retrospectively identify characteristics and risk factors of viral encephalitis (VE) in patients who underwent a haplo-identical hematopoietic stem cell transplant (HSCT). METHODS:A nested case-control study was designed. Cases with VE and controls were identified from a cohort composed of 1274 patients w...

journal_title：European journal of haematology

authors： Zhang XH,Zhang JM,Han W,Chen H,Chen YH,Wang FR,Wang JZ,Zhang YY,Mo XD,Chen Y,Wang Y,Chang YJ,Xu LP,Liu KY,Huang XJ

更新日期：2017-05-01 00:00:00

abstract：:We generated a 100-kb map of the region 5' of the PML (promyelocytic leukemia) gene on human chromosome 15q22 and identified a new gene provisionally named STORP for stomatin-related protein. The STORP gene is positioned 2 kb upstream of the PML gene in a head-to-head configuration, and contains 7 exons spanning a gen...

journal_title：European journal of haematology

authors： Gilles F,Glenn M,Goy A,Remache Y,Zelenetz AD

更新日期：2000-02-01 00:00:00

abstract：:The small-dose (20 mg) oral iron absorption test (OIAT) was performed in 76 hospitalized elderly patients and 30 healthy adults. Of the elderly patients, 34 were considered as iron deficient (serum ferritin level < 20 micrograms/L) of whom 23 were anaemic and 11 not anaemic, 21 had the anaemia of chronic disorders (AC...

journal_title：European journal of haematology

authors： Joosten E,Vander Elst B,Billen J

更新日期：1997-02-01 00:00:00

abstract：:We demonstrate the in vivo effects of bacterially synthesized, N-methionine-free recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) using a crab-eating monkey model. Monkeys were treated with cyclophosphamide (60 mg/kg) and administered with rh GM-CSF (30 micrograms/kg/d) subcutaneously (s....

journal_title：European journal of haematology

authors： Akashi K,Taniguchi S,Teshima T,Shibuya T,Okamura T,Harada M,Niho Y

更新日期：1990-02-01 00:00:00

abstract：:Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophils. Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products. MPO is synthesized during the promyelocytic stage of myeloid ...

journal_title：European journal of haematology

authors： Nauseef WM,Olsson I,Arnljots K

更新日期：1988-02-01 00:00:00

abstract：INTRODUCTION:Outcome of patients with standard-risk (SR) multiple myeloma (MM) has improved; however, subsets of patients do worse than expected. We sought to identify the factors associated with inferior outcome. METHODS:We evaluated 51 patients with SR MM that received upfront autologous hematopoietic stem cell tran...

journal_title：European journal of haematology

authors： Badar T,Srour S,Bashir Q,Shah N,Al-Atrash G,Hosing C,Popat U,Nieto Y,Orlowski RZ,Champlin R,Qazilbash MH

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To describe a case of venlafaxine-induced ecchymoses. METHODS:A patient with a history of ecchymoses coincident with venlafaxine therapy was rechallenged with the drug. Her platelet function was assessed with aggregation and ATP release studies before the rechallenge and after she developed ecchymoses. In ad...

journal_title：European journal of haematology

authors： Sarma A,Horne MK 3rd

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:Human Disabled-2 (Dab2), a putative tumor suppressor gene, is frequently down-regulated in human tumors. This study aims to explore the association between Dab2 methylation status and expression in newly diagnosed myelodysplastic syndrome (MDS) patients and patients who received 5-aza-2'-deoxycytidine (decit...

journal_title：European journal of haematology

authors： Yang Y,Zhang Q,Xu F,Chang C,Li X

更新日期：2012-12-01 00:00:00

abstract：:We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (DLI) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T-cell depletion. We also investigated progno...

journal_title：European journal of haematology

authors： Yan CH,Wang JZ,Liu DH,Xu LP,Chen H,Liu KY,Huang XJ

更新日期：2013-10-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Most viral infections are known to exert adverse effects on bone marrow function. However, certain viruses have recently been found to be therapeutically beneficial in the treatment of some malignant disorders. METHODS AND MATERIALS:A retrospective study was conducted at the Armed Forces Hospital, Riyadh, S...

journal_title：European journal of haematology

authors： Al-Anazi KA,Al-Jasser AM,Evans DA

更新日期：2005-09-01 00:00:00

abstract：:A transgenic SCID (TG-SCID) mouse expressing the human cytokines interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) has been generated with the aim of making a model system allowing the in vivo proliferation of human hematopoietic cells. Using TG-SCID mice expressing high levels (30-35 ...

journal_title：European journal of haematology

authors： Kim DK,Kojima M,Fukushima T,Miyasaka M,Nakauchi H

更新日期：1998-08-01 00:00:00

abstract：:This study shows that the ingestion of ethanol provokes alterations in iron metabolism which may lead to iron overload. Impaired release of reticuloendothelial iron was shown by a decrease of the maximum red blood cell utilization when radioactive iron was supplied as colloidal iron. An impairment in the erythropoieti...

journal_title：European journal of haematology

authors： Sánchez J,Casas M,Rama R

更新日期：1988-10-01 00:00:00

abstract：:Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7-8 May 2015 in Amsterdam, The Netherlands, aimed to prom...

journal_title：European journal of haematology

authors： Berntorp E,Hart D,Mancuso ME,d'Oiron R,Perry D,O'Mahony B,Kaczmarek R,Crato M,Pasi J,Miners A,Carlsson KS,Kitchen S,Boehlen F,Giangrande P,Cebura E,Uitslager N,Osooli M,Janeckova D,Haldon R,Rivolta GF

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evalua...

journal_title：European journal of haematology

authors： Catherwood MA,Matthews C,Niblock R,Dobbin E,Morris TC,Alexander HD

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:We sought to evaluate the effectiveness and safety of rivaroxaban vs apixaban in non-valvular atrial fibrillation (NVAF) patients with end-stage renal disease (ESRD) and/or receiving dialysis in routine practice. METHODS:Using US MarketScan claims data from January 1, 2014, to December 31, 2017, we identifi...

journal_title：European journal of haematology

authors： Miao B,Sood N,Bunz TJ,Coleman CI

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the activation of clotting systems in patients with sickle cell disease (SCD) by measuring the plasma D-dimer level and to determine the effect of low-dose warfarin on D-dimer level during vaso-occlusive crisis. METHODS:Plasma D-dimer level was measured in 65 blood samples of 37 adult patients wi...

journal_title：European journal of haematology

authors： Ahmed S,Siddiqui AK,Iqbal U,Sison CP,Shahid RK,Sheth M,Patel DV,Russo LA

更新日期：2004-03-01 00:00:00

abstract：:Fas (APO-1/CD95) is a 45-kDa membrane protein which regulates apoptosis in many lymphoid cell types. In the present study, FAS expression was examined in primary leukemic cells from infants with acute lymphoblastic leukemia (ALL). The cells were resistant to apoptosis induction by an anti-FAS antibody and expressed ne...

journal_title：European journal of haematology

authors： Wood CM,Goodman PA,Vassilev AO,Uckun FM

更新日期：2003-03-01 00:00:00

abstract：INTRODUCTION:Increased levels of Wilms' tumor (WT1) mRNA have been used to establish risk categories in patients with acute myeloid leukemia (AML). Raised values of WT1 have been associated with progression in myelodysplastic syndrome (MDS). METHODS:We retrospectively analyzed the available bone marrow (BM) samples fr...

journal_title：European journal of haematology

authors： Santaliestra M,Garrido A,Carricondo M,Bussaglia E,Pratcorona M,Blanco ML,Gich I,Hoyos M,Esquirol A,García-Cadenas I,Brunet S,Martino R,Sierra J,Nomdedéu JF

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Primary Hepatic (PHL) and Primary Splenic (PSL) non-Hodgkin's Lymphoma are rare entities. Small series of PHL and PSL have been reported, suggesting a non-fortuitous association with Hepatitis C Virus (HCV) infection. The prognosis is believed to be dismal, with early recurrence and short survival. PATIENTS...

journal_title：European journal of haematology

authors： De Renzo A,Perna F,Persico M,Notaro R,Mainolfi C,de Sio I,Ciancia G,Picardi M,Del Vecchio L,Pane F,Rotoli B

更新日期：2008-07-01 00:00:00

abstract：:Endothelial cell dysfunction is likely to be important in the pathophysiology of ischaemic heart disease and increased levels of endothelial cell markers soluble E-selectin and soluble thrombomodulin may reflect this damage. To determine whether increased levels of these markers were predictive of disease progression,...

journal_title：European journal of haematology

authors： Blann AD,Amiral J,McCollum CN

更新日期：1997-08-01 00:00:00