当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HAEMATOLOGY期刊下所有文献 > FCGR3A-158V/F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation.

FCGR3A-158V/F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation.

Abstract：

OBJECTIVES:Recent studies have indicated that patients who receive stem cell transplantation (SCT) and rituximab demonstrate an increased risk of developing hypogammaglobulinemia. Such hypogammaglobulinemia has been found to be due to delayed recovery of memory B cells with an abnormal cell marker expression and impaired immunoglobulin production in vitro. However, no predictive factors for the levels of immunoglobulin after autologous SCT and rituximab therapy have been reported. The aim of this study is to clarify the relationships between the FCGR3A-158V/F genotype and the levels of serum immunoglobulin after SCT. METHODS:A total of 24 non-Hodgkin's lymphoma (NHL) patients received autologous SCT with an adjuvant rituximab. The FCGR3A-158V/F genotype was determined in these patients. We also included ten NHL patients who received an identical conditioning regimen and autologous SCT but no rituximab as control patients. RESULTS:The levels of IgG were significantly lower in FCGR3A-158F homozygous patients (n = 9) in comparison to those in FCGR3A-158V carriers (n = 15). Moreover, the levels of IgG and IgA of FCGR3A-158F homozygous patients, but not those of FCGR3A-158V carriers, were significantly lower than those of control patients. CONCLUSIONS:The genotype of FCGR3A determines not only the response to rituximab, but also the levels of immunoglobulin after SCT and an adjuvant rituximab.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Nishio M,Endo T,Fujimoto K,Yamamoto S,Obara M,Yamaguchi K,Takeda Y,Goto H,Kasahara I,Sato N,Koike T

doi

10.1111/j.1600-0609.2008.01174.x

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

143-7

issue

2

eissn

0902-4441

issn

1600-0609

pii

EJH1174

journal_volume

82

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF HAEMATOLOGY文献大全
  • Cryopreservation of the bone marrow from patients with acute myeloid leukaemia leads to functional abnormalities.

    abstract：:We compared the performance of the stroma (SL) and haematopoietic progenitors before (group A) or following cryopreservation from patients in complete remission (CR) of acute myeloid leukaemia before autologous transplantation (AML) (group B), to similarly treated normal cells (groups A and B). From each group, fibrob...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1999.tb01726.x

    authors： Novitzky N,Kruger W,Mohamed R

    更新日期：1999-02-01 00:00:00

  • Osteocalcin is not a marker of progress in multiple myeloma. Le Groupe d'Etude et de Recherche sur le Myélome (GERM).

    abstract：:The aim of this study was to evaluate the usefulness of serum osteocalcin (OC) levels in multiple myeloma (MM) in order to assess its significance and activity, and to predict its course. Serum OC was measurement in 117 patients with MM and 116 healthy controls matched for age and sex. Serum OC levels were weakly corr...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：

    authors： Mejjad O,Le Loët X,Basuyau JP,Ménard JF,Jego P,Grisot C,Daragon A,Grosbois B,Euller-Ziegler L,Monconduit M

    更新日期：1996-01-01 00:00:00

  • B cell maturation antigen-specific chimeric antigen receptor T cells for relapsed or refractory multiple myeloma: A meta-analysis.

    abstract：INTRODUCTION:Chimeric antigen receptor (CAR) T cells targeting B cell maturation antigen (BCMA) have shown impressive results in clinical studies for relapsed/refractory multiple myeloma (RRMM). We performed a systematic literature review to summarize the current body of evidence on the role of anti-BCMA CAR T cells fo...

    journal_title：European journal of haematology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/ejh.13380

    authors： Gagelmann N,Ayuk F,Atanackovic D,Kröger N

    更新日期：2020-04-01 00:00:00

  • Predictors of splenic function preservation in children with sickle cell anemia treated with hydroxyurea.

    abstract：BACKGROUND:More than 90% of children with sickle cell anemia (SCA) lose splenic function by the age of 2 yrs. Splenic function may improve with hydroxyurea, but previous studies are conflicting. We prospectively evaluated the effect of hydroxyurea on splenic filtrative function. METHODS:Children with SCA enrolled in t...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/ejh.12361

    authors： Nottage KA,Ware RE,Winter B,Smeltzer M,Wang WC,Hankins JS,Dertinger SD,Shulkin B,Aygun B

    更新日期：2014-11-01 00:00:00

  • Response to pretransplant hypomethylating agents influences the outcome of allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndromes.

    abstract：:This study describes a retrospective analysis on the transplant outcome of 56 consecutive patients with myelodysplastic syndrome (MDS) according to their response to hypomethylating agents (HMA). While 2-yr disease-free survival (DFS) of patients who transformed to acute myeloid leukemia (n = 12) was 25%, that of the ...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/ejh.12038

    authors： Yahng SA,Yoon JH,Shin SH,Lee SE,Cho BS,Lee DG,Eom KS,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Lee JW,Min WS,Kim TG,Park CW,Kim YJ

    更新日期：2013-02-01 00:00:00

  • Diagnosis of meningeal involvement in childhood acute lymphoblastic leukemia: cytomorphology and TdT.

    abstract：:Between December, 1984, and May, 1986, 98 CSF samples were sent to a central laboratory by postal express. The samples could be kept in a medium for up to 24 hours after the lumbar puncture. The quality of the cells proved to be good. Excluded were 5 samples delayed in delivery and 13 samples contaminated with blood, ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00832.x

    authors： van Wering ER,Veerman AJ,van der Linden-Schrever BE

    更新日期：1988-03-01 00:00:00

  • Pathophysiological significance of simultaneous measurement of reticulated platelets, large platelets and serum thrombopoietin in non-neoplastic thrombocytopenic disorders.

    abstract：:An automated reticulocyte counter using flowcytometric analysis, the R-3000 (Sysmex Inc. Kobe, Japan), has recently been modified to determine reticulated platelets (RPs) and large platelets (LPs). We measured frequencies of RPs, LPs in total platelet count and serum thrombopoietin concentration comprehensively in non...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1999.tb01131.x

    authors： Koh KR,Yamane T,Ohta K,Hino M,Takubo T,Tatsumi N

    更新日期：1999-11-01 00:00:00

  • Prognostic value of increased soluble thrombomodulin and increased soluble E-selectin in ischaemic heart disease.

    abstract：:Endothelial cell dysfunction is likely to be important in the pathophysiology of ischaemic heart disease and increased levels of endothelial cell markers soluble E-selectin and soluble thrombomodulin may reflect this damage. To determine whether increased levels of these markers were predictive of disease progression,...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1997.tb00735.x

    authors： Blann AD,Amiral J,McCollum CN

    更新日期：1997-08-01 00:00:00

  • Immunological typing of acute leukemias: immunoenzymatic staining of fixed cells compared with immunofluorescence staining of unfixed cells in suspension.

    abstract：:A panel of 14 monoclonal antibodies (McAb) against hematopoietic cell surface antigens was applied on mononuclear blood or bone marrow cells from 40 cases of acute leukemia in order to compare immunoenzymatic staining (IE) (alkaline phosphatase) of fixed cells with immunofluorescence staining (IF) of unfixed suspended...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00884.x

    authors： Ly B,Beiske K,Larsen N

    更新日期：1988-08-01 00:00:00

  • Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment.

    abstract：OBJECTIVES:Myeloma bone disease is a result of excessive osteoclast activation and impaired osteoblast function. Recent in vitro studies suggested that proteasome inhibitors might increase osteoblast function. METHODS:We analyzed serum markers of osteoblast activity in 25 patients with multiple myeloma receiving borte...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2006.00692.x

    authors： Heider U,Kaiser M,Müller C,Jakob C,Zavrski I,Schulz CO,Fleissner C,Hecht M,Sezer O

    更新日期：2006-09-01 00:00:00

  • Polyclonal B-cell activation after intravenous immunoglobulin therapy in idiopathic thrombocytopenic purpura--an anti-idiotype response?

    abstract：:Polyclonal B cell activation occurred in 3 patients following treatment with intravenous immunoglobulin (i.v. Ig) for idiopathic thrombocytopenic purpura (ITP). The possibility that this may represent an anti-idiotype response and the hypothesis that prolonged remission of ITP may be induced by this mechanism are disc...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1987.tb00759.x

    authors： Wangel AG,Lorenzetti M,Pettersson T

    更新日期：1987-09-01 00:00:00

  • Characterization of a new human plasma cell leukemia cell line UHKT-944.

    abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12505

    authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

    更新日期：2015-10-01 00:00:00

  • A new exon 12 mutation in the EPAS1 gene possibly associated with erythrocytosis.

    abstract：:In secondary erythrocytosis, the elevated red cell count is powered by factors outside the erythroid compartment, for instance by raised erythropoietin (EPO) synthesis based on congenital defects of the oxygen-sensing pathway. The principal transcriptional regulator of EPO synthesis is endothelial PAS domain-containin...

    journal_title：European journal of haematology

    pub_type：

    doi：10.1111/ejh.13241

    authors： Schelker RC,Herr W,Grassinger J

    更新日期：2019-07-01 00:00:00

  • Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality.

    abstract：OBJECTIVE:Myelodysplastic syndromes (MDS) and aplastic anemia (AA) are the most common anemias that require transfusion therapy in Japan. This retrospective survey investigated relationships between iron overload, chelation practices, and morbidity/mortality in patients with these diseases. METHOD:Medical histories of...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2007.00842.x

    authors： Takatoku M,Uchiyama T,Okamoto S,Kanakura Y,Sawada K,Tomonaga M,Nakao S,Nakahata T,Harada M,Murate T,Ozawa K,Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

    更新日期：2007-06-01 00:00:00

  • Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma.

    abstract：OBJECTIVES:Mantle cell lymphoma (MCL) is an incurable disease with an aggressive course and novel treatment strategies are urgently needed. The purpose of this study was to evaluate the effects of histone deacetylase (HDAC) inhibitors, a new group of antiproliferative agents, on human MCL cells. METHODS:Three MCL cell...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2005.00546.x

    authors： Heider U,Kaiser M,Sterz J,Zavrski I,Jakob C,Fleissner C,Eucker J,Possinger K,Sezer O

    更新日期：2006-01-01 00:00:00

  • Two novel unstable hemoglobin variants due to in-frame deletions of key amino acids in the β-globin chain.

    abstract：:Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. The aim of this work was the molecular and structural characterization of two heterozygous in-...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.13029

    authors： Scheps KG,Hasenahuer MA,Parisi G,Targovnik HM,García E,Veber ES,Crisp R,Elena G,Varela V,Fornasari MS

    更新日期：2018-06-01 00:00:00

  • Clinical results according to age in patients with chronic myeloid leukemia receiving imatinib frontline: The younger, the later, the worse?

    abstract：OBJECTIVES:To evaluate differences in clinical results according to age among patients with chronic myeloid leukemia (CML). METHODS:207 consecutive CML patients treated with imatinib frontline were revised, dividing them in young adults (>20 < 45 years) (YA), middle-aged adults (≥45 < 65 years) (MA) and elderly (≥65 y...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.13110

    authors： Latagliata R,Breccia M,Carmosino I,Cesini L,De Benedittis D,Mohamed S,Vozella F,Molica M,Campanelli M,De Luca ML,Colafigli G,Quattrocchi L,Loglisci MG,Massaro F,Canichella M,Diverio D,Mancini M,Alimena G,Foà R

    更新日期：2018-06-13 00:00:00

  • G6PD deficiency and absence of α-thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia.

    abstract：:The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). E...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12607

    authors： Joly P,Garnier N,Kebaili K,Renoux C,Dony A,Cheikh N,Renard C,Ceraulo A,Cuzzubbo D,Pondarré C,Martin C,Pialoux V,Francina A,Bertrand Y,Connes P

    更新日期：2016-04-01 00:00:00

  • Brazilian guidelines on hematopoietic stem cell transplantation in acute myeloid leukemia.

    abstract：INTRODUCTION/OBJECTIVES:Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74/100 000 men and 1.37/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of...

    journal_title：European journal of haematology

    pub_type： 杂志文章,实务指引

    doi：10.1111/ejh.12808

    authors： Silla L,Dulley F,Saboya R,Kerbauy F,de Moraes Arantes A,Pezzi A,Gross LG,Paton E,Hamerschlak N

    更新日期：2017-02-01 00:00:00

  • Analysis of CD34-positive cells in bone marrow from patients with myelodysplastic syndromes and acute myeloid leukemia and in normal individuals: a comparison between FACS analysis and immunohistochemistry.

    abstract：:In patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), expression of the hematopoietic stem cell marker CD34 has been associated with a poorer prognosis. CD34 is usually analyzed by flow cytometry (FC), but may also be analyzed using immunohistochemistry (IH). The present study was undertak...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1996.tb01330.x

    authors： Kanter-Lewensohn L,Hellström-Lindberg E,Kock Y,Elmhorn-Rosenborg A,Ost A

    更新日期：1996-03-01 00:00:00

  • Effects of interleukin-3 following chemotherapy of non-Hodgkin's lymphoma. A prospective, controlled phase I/II study.

    abstract：:The effect of rhIL-3 was investigated in 32 patients with newly diagnosed non-Hodgkin lymphoma in a phase I/II trial. All patients received 6 cycles of standard CHOP chemotherapy, and each patient was his own control where rhIL-3 was given as a daily s.c. injection for 14 days (day 2-15) in cycle 2 and 4, while cycle ...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1600-0609.1995.tb01772.x

    authors： Hovgaard DJ,Nissen NI

    更新日期：1995-02-01 00:00:00

  • Neonatal isoimmune thrombocytopenia caused by type I CD36 deficiency having novel splicing isoforms of the CD36 gene.

    abstract：:Neonatal alloimmune thrombocytopenia (NAIT) occurs because of transplacentally acquired maternal platelet alloantibodies. Most of the alloantibodies are against human platelet antigens, but the alloantibody against CD36 is rare. A full-term female baby was delivered by a mother who experienced two spontaneous abortion...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2008.01093.x

    authors： Taketani T,Ito K,Mishima S,Kanai R,Uchiyama A,Hirata Y,Kumakura S,Ishikura H,Yamaguchi S

    更新日期：2008-07-01 00:00:00

  • The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG).

    abstract：:In childhood-onset acute myeloid leukaemia (AML) the clinical value of karyotypic aberrations is now acknowledged, although there is still debate concerning the prognostic significance of some events. To add to this knowledge, cytogenetic analysis was performed on a consecutive series of 84 childhood AML patients diag...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2007.00854.x

    authors： Betts DR,Ammann RA,Hirt A,Hengartner H,Beck-Popovic M,Kuhne T,Nobile L,Caflisch U,Wacker P,Niggli FK

    更新日期：2007-06-01 00:00:00

  • Survivin expression, apoptosis and proliferation in chronic myelomonocytic leukemia.

    abstract：:We analyzed the expression of the inhibitor of apoptosis survivin by immunocytochemistry in bone marrow cells from patients with chronic myelomonocytic leukemia (CMML) to evaluate possible abnormalities in comparison with other myelodysplastic (MDS) and myeloproliferative syndromes, and to investigate a possible corre...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.0902-4441.2006.t01-1-EJH2588.x

    authors： Invernizzi R,Travaglino E,Benatti C,Malcovati L,Della Porta M,Cazzola M,Ascari E

    更新日期：2006-06-01 00:00:00

  • Pirarubicin nuclear uptake does not correlate with its induced cell death effect during reversal of multidrug resistance by quinine in human K562 and CEM leukemic cells.

    abstract：:A number of small and lipophilic cations are able to reverse in vitro the resistance to anthracyclines and other natural products through their interaction with P-glycoprotein or P-gp. However, some modulators do not interact with P-gp. We have demonstrated in a previous a work, using confocal laser microspectrofluoro...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1998.tb01709.x

    authors： Morjani H,Belhoussine R,Lahlil R,Manfait M

    更新日期：1998-10-01 00:00:00

  • Long-term complication in follicular lymphoma: assessing the risk of secondary neoplasm in 242 patients treated or not with 90-yttrium-ibritumomab-tiuxetan.

    abstract：BACKGROUND:Non-Hodgkin lymphoma patients have a 25% increased risk of secondary primary neoplasms (SPNs). Regarding the controversy about the increased risk of SPN in patients exposed to radioimmunotherapy (RIT), we have analyzed this issue in a cohort of follicular lymphoma (FL) patients treated with/without RIT. PAT...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12775

    authors： Andrade-Campos MM,Liévano P,Espinosa-Lara N,Soro-Alcubierre G,Grasa-Ulrich JM,López-Gómez L,Baringo T,Giraldo P

    更新日期：2016-12-01 00:00:00

  • Gene transduction into murine primitive hematopoietic cells with 2-gene retroviral vectors using a Transwell coculture system.

    abstract：:The present study aims at expressing a reporter gene in hematopoietic cells in vivo by introducing it into primitive hematopoietic cells with a 2-gene retroviral vector. Various constructs of retroviral vectors containing the human IL-2 receptor alpha chain gene (TAC) as the reporter and the neomycin phosphotransferas...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1996.tb01378.x

    authors： Asami N,Germeraad WT,Fujimoto S,Nagai S,Izumi T,Katsura Y

    更新日期：1996-10-01 00:00:00

  • Flow cytometry immunophenotypic findings in chronic myelomonocytic leukemia and its utility in monitoring treatment response.

    abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis. Due to the lack of unique surface markers expressed by neoplastic monocytes and the frequent CD34-negative blast immunophenotype, the diagnostic value of flow cytometric immunophenotyping (...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12477

    authors： Shen Q,Ouyang J,Tang G,Jabbour EJ,Garcia-Manero G,Routbort M,Konoplev S,Bueso-Ramos C,Medeiros LJ,Jorgensen JL,Wang SA

    更新日期：2015-08-01 00:00:00

  • Identification of a new mutation (Gly420Ser), distal to the active site, that leads to factor XIII deficiency.

    abstract：:The molecular defects of the factor XIII A subunit gene were studied in a patient with factor XIII deficiency. Mutation analysis was performed on amplified DNA from each exon of this gene by single-strand conformation polymorphism (SSCP) and DNA sequencing techniques. A substitution of guanine by adenine at nucleotide...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2000.065004279.x

    authors： Kangsadalampai S,Yenchitsomanus P,Chelvanayagam G,Sawasdee N,Laosombat V,Board P

    更新日期：2000-10-01 00:00:00

  • An Arg545----Cys545 substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease.

    abstract：:Type IIB is a special variant of von Willebrand's disease, characterized by an abnormal von Willebrand factor which shows an increased interaction with platelets. This interaction sometimes causes platelet aggregation and thrombocytopenia in vivo. It involves the glycoprotein-Ib (GPIb) receptor on platelets and corres...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1991.tb01858.x

    authors： Donnér M,Andersson AM,Kristoffersson AC,Nilsson IM,Dahlbäck B,Holmberg L

    更新日期：1991-11-01 00:00:00