Abstract:
:Neonatal alloimmune thrombocytopenia (NAIT) occurs because of transplacentally acquired maternal platelet alloantibodies. Most of the alloantibodies are against human platelet antigens, but the alloantibody against CD36 is rare. A full-term female baby was delivered by a mother who experienced two spontaneous abortions. The baby had thrombocytopenia with cephalhematoma. The platelet count increased by immunoglobulin therapy (400 mg/kg) for 3 d. Platelet antibody was detected in the postpartum maternal serum. The specificity of the antibody directed against platelets was identified as anti-Nak(a) (CD36). Flow cytometric analysis showed no expression of CD36 in both platelets and monocytes from mother. Mutation analysis revealed two different splicing isoforms of maternal CD36 mRNA. One allele was exon 4 skipping, another was exon 9 skipping, both of which led to a frameshift and produced a truncated CD36 protein. These results indicate that NAIT is caused by maternal CD36 deficiency having CD36 splicing abnormalities.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Taketani T,Ito K,Mishima S,Kanai R,Uchiyama A,Hirata Y,Kumakura S,Ishikura H,Yamaguchi Sdoi
10.1111/j.1600-0609.2008.01093.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
70-4issue
1eissn
0902-4441issn
1600-0609pii
EJH1093journal_volume
81pub_type
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pub_type: 临床试验,杂志文章
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
pub_type: 杂志文章,评审
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更新日期:1988-02-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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doi:10.1111/ejh.12535
更新日期:2015-02-16 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1989.tb01247.x
更新日期:1989-07-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1988.tb00816.x
更新日期:1988-02-01 00:00:00
abstract::Implantation of Yoshida ascites sarcoma in rats was found to lead to a reduction in the hemoglobin content, the erythrocyte count and the packed cell volume of blood to 30% of normal in 4 d; however, there was no decrease in the mean cell hemoglobin, the mean cell volume and the mean corpuscular hemoglobin concentrati...
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pub_type: 杂志文章
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doi:10.1111/j.1600-0609.2007.01013.x
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pub_type: 杂志文章,评审
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journal_title:European journal of haematology
pub_type: 杂志文章,评审
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更新日期:2021-01-16 00:00:00
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pub_type: 杂志文章
doi:10.1111/ejh.12991
更新日期:2018-02-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1988.tb00831.x
更新日期:1988-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/ejh.12508
更新日期:2015-11-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1988.tb00798.x
更新日期:1988-01-01 00:00:00
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journal_title:European journal of haematology
pub_type:
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更新日期:2019-07-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2008.01081.x
更新日期:2008-07-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/ejh.13477
更新日期:2020-11-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00