Polyclonal B-cell activation after intravenous immunoglobulin therapy in idiopathic thrombocytopenic purpura--an anti-idiotype response?

abstract：:We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried...

journal_title：European journal of haematology

authors： Ciaudo M,Doco-Lecompte T,Guettier C,d'Agay MF,David F,Rioual N,Buu-Hoi A,Molina JM,Kazatchkine M,Modai J

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:Current prognostic models for myelodysplastic syndrome (MDS) do not consider the prognostic value of a bone marrow blast level that is <5%. Exploring the prognostic value of the International Prognostic Scoring System (IPSS) and a marrow blast level that is <5% may lead to better risk-adapted therapeutic str...

journal_title：European journal of haematology

authors： Wang H,Wang XQ,Xu XP,Lin GW

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Tumor lysis syndrome (TLS) is a complication that can cause renal failure by precipitation of uric acid (UA) and phosphate crystals in renal tubules. Rasburicase proved to be effective in rapidly reducing UA levels. Costs of rasburicase average up to 4500 euros. To assess if lower doses of rasburicase are ef...

journal_title：European journal of haematology

authors： Hummel M,Reiter S,Adam K,Hehlmann R,Buchheidt D

更新日期：2008-04-01 00:00:00

abstract：:The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...

journal_title：European journal of haematology

authors： Tuthill M,Crook T,Corbet T,King J,Webb A

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Symptomology of AL amyloidosis can be vague, with a broad range of manifestations and potential etiologies. We sought to determine whether time from initial patient-reported symptom onset to diagnosis was associated with survival. METHODS:The Boston University Amyloidosis Patient Database was queried for ...

journal_title：European journal of haematology

authors： Schulman A,Connors LH,Weinberg J,Mendelson LM,Joshi T,Shelton AC,Sanchorawala V

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

journal_title：European journal of haematology

authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

更新日期：2015-10-01 00:00:00

abstract：:While cellular modulation in vitro of committed hematopoietic stem cell (HSC) growth has been known for some time, less is known about the effect of accessory cells (AC) on the growth of more immature HSC. We have examined the effect of peripheral blood (PB) AC on hematopoiesis by coculturing enriched PB CD34+ cells (...

journal_title：European journal of haematology

authors： Olesen G,Tønder H,Palshof T,Hokland P

更新日期：2002-02-01 00:00:00

abstract：:Bcl-2 expression, the number of apoptotic cells and the growth and differentiation of early bone marrow progenitor cells were studied in patients with confirmed diagnosis of acute myeloid leukaemia (AML). Bone marrow cells from normal individuals were used as controls. We observed an increased percentage of bcl-2-mono...

journal_title：European journal of haematology

authors： Bincoletto C,Saad ST,da Silva ES,Queiroz ML

更新日期：1999-01-01 00:00:00

abstract：:We describe a case of Philadelphia-positive chronic myeloid leukaemia occurring simultaneously with B-cell chronic lymphocytic leukaemia in a 69-yr-old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominan...

journal_title：European journal of haematology

authors： Browett PJ,Pattinson J,Pinkney J,Hoffbrand AV,Norton JD

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) play key roles in a wide variety of normal and pathological cellular processes. A number of studies identified hematopoietic-specific miRNAs that are necessary for correct function of blood cells. Out of our microarray data, we chose 13 miRNAs that showed differential expression in periphe...

journal_title：European journal of haematology

authors： Merkerova M,Belickova M,Bruchova H

更新日期：2008-10-01 00:00:00

abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

journal_title：European journal of haematology

authors： Bhandari S,Galanello R

更新日期：2012-09-01 00:00:00

abstract：:Very high-dose chemotherapy with autologous blood stem cell (BSC) rescue becomes more and more widely performed. In order to simplify the technique, a large volume apheresis programme combined with an uncontrolled rate cryopreservation at -80 degrees C was developed. Twenty-six patients suffering from multiple myeloma...

journal_title：European journal of haematology

authors： Feremans WW,Bastin G,Moine FL,Ravoet C,Delville JP,Pradier O,Wallef G,Dupont E,Capel P,Lambermont M

更新日期：1996-05-01 00:00:00

abstract：:CD200R is an inhibitory receptor involved in the regulation of myeloid cells. It recruits Dok-1 and Dok-2, which are potent inhibitors of the Ras signalling pathway used by colony-stimulating factor (CSF) receptors. Dok-1/Dok-2 double knockout (DKO) mice develop leukaemia at 10-12 months of age. We investigated whethe...

journal_title：European journal of haematology

authors： Rijkers ES,de Ruiter T,Buitenhuis M,Veninga H,Hoek RM,Meyaard L

更新日期：2007-11-01 00:00:00

abstract：:Targeting of cellular metabolism has emerged as a possible strategy in the treatment of human malignancies, and several experimental studies suggest that this therapeutic approach should also be considered in acute myeloid leukemia (AML). Clinical studies of metabolic intervention in AML patients with isocitrate dehyd...

journal_title：European journal of haematology

authors： Hauge M,Bruserud Ø,Hatfield KJ

更新日期：2016-03-01 00:00:00

abstract：:In an attempt to clarify the significance of hydrocortisone (HC) in human long-term bone marrow cultures, the production of colony-stimulating activity (CSA) and colony-enhancing activity (CEA) by human bone marrow-derived adherent cells (MDAC) and the modulation by HC were examined. The CSA production by MDAC was dem...

journal_title：European journal of haematology

authors： Hirata J,Kaneko S,Nishimura J,Motomura S,Ibayashi H

更新日期：1988-03-01 00:00:00

abstract：INTRODUCTION:Outcome of patients with standard-risk (SR) multiple myeloma (MM) has improved; however, subsets of patients do worse than expected. We sought to identify the factors associated with inferior outcome. METHODS:We evaluated 51 patients with SR MM that received upfront autologous hematopoietic stem cell tran...

journal_title：European journal of haematology

authors： Badar T,Srour S,Bashir Q,Shah N,Al-Atrash G,Hosing C,Popat U,Nieto Y,Orlowski RZ,Champlin R,Qazilbash MH

更新日期：2017-03-01 00:00:00

abstract：:BLyS and APRIL share two receptors - transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) - and BLyS binds to a third receptor, BAFF-R. We previously reported that TACI gene expression is a good indicator of a BLyS-binding receptor in human multipl...

journal_title：European journal of haematology

authors： Moreaux J,Sprynski AC,Dillon SR,Mahtouk K,Jourdan M,Ythier A,Moine P,Robert N,Jourdan E,Rossi JF,Klein B

更新日期：2009-08-01 00:00:00

abstract：:10 patients with CLL and 2 with CML were treated with gradually increasing doses of 1 alpha(OH)D3, up to 4 micrograms daily during 6 wk. 3 patients with preleukemia and 1 with myelofibrosis were treated with 2 micrograms daily of 1 alpha(OH)D3 for a prolonged period up to 17 wk. The treatment with 1 alpha (OH)D3 did n...

journal_title：European journal of haematology

authors： Wieslander SB,Mortensen BT,Binderup L,Nissen NI

更新日期：1987-07-01 00:00:00

abstract：:We describe a case of acute promyelocytic leukemia in a 61-yr-old woman with a cryptic insertion of RARA gene into PML gene. Using a combination of cytogenetic and molecular methods, we confirmed the insertion and presence of the PML-RARA transcript and lack of the reciprocal RARA-PML transcript. Although such cryptic...

journal_title：European journal of haematology

authors： Fan H,Ortega V,Fanasch HM,Wang Y,Holder KN,Higgins RA,Mendiola C,Mohamed G,Vadlamudi K,Velagaleti G

更新日期：2014-10-01 00:00:00

abstract：:A hairy cell leukaemia (HCL) patient is presented in whom the peripheral blood mononuclear cells (PBMCs) carried suppressor T-cell markers (CD3+, CD2+, CD8+/CD4-, CD38+). Analysis of genomic DNA of PBMNC showed the presence of a monoclonal population of T cells, the T-cell receptor (TCR) beta-chain gene being rearrang...

journal_title：European journal of haematology

authors： Demeter J,Pálóczi K,Földi J,Hokland M,Hokland P,Benczúr M,Lehoczky D

更新日期：1989-10-01 00:00:00

abstract：:A 59-yr-old man developed fevers, shortness of breath, persistent cough and weight loss, shortly after initiation of therapy with interferon-alpha 2a and cytosine arabinoside for treatment of chronic myelogenous leukemia. Radiologic pulmonary infiltrates and lung tissue biopsy were consistent with bronchiolitis oblite...

journal_title：European journal of haematology

authors： Patel M,Ezzat W,Pauw KL,Lowsky R

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Granulocyte colony-stimulating factor-mobilized peripheral blood hematopoietic stem cell transplantation (HSCT) provides a valuable and increasingly used alternative to bone marrow transplantation (BMT). This retrospective study aimed at determining whether the stem cell source is predictive for outcome, rel...

journal_title：European journal of haematology

authors： Auberger J,Clausen J,Kircher B,Kropshofer G,Lindner B,Nachbaur D

更新日期：2011-12-01 00:00:00

abstract：:15 cases of acute leukemia (AL) displaying a TdT+, HLA-DR+ phenotype were studied; surface immunoglobulins, T cell markers and the common acute lymphoblastic leukaemia (c-ALL) antigen were negative, as were peroxidase and non-specific esterase cytochemical reactions. All cases were extensively investigated by conventi...

journal_title：European journal of haematology

authors： Basso G,Putti MC,Catoretti G,Consolini R,Galdiolo D,Guglielmi C,Messina C,Milanesi C,Testi AM,Xillo MZ

更新日期：1987-02-01 00:00:00

abstract：:Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence i...

journal_title：European journal of haematology

authors： Thomas X

更新日期：2015-02-16 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Minimal residual disease (MRD) assessment by PCR in multiple myeloma (MM) has several shortcomings, including the lack of a suitable target. Kappa deleting element (KDE) rearrangements occur in virtually all Ig-lambda B-cell malignancies and in 1/3 of Ig-kappa are not affected by somatic hyper...

journal_title：European journal of haematology

authors： Puig N,Sarasquete ME,Alcoceba M,Balanzategui A,Chillón MC,Sebastián E,Díaz MG,San Miguel JF,García-Sanz R

更新日期：2012-10-01 00:00:00

abstract：:In recent years, several direct-acting oral anticoagulants (DOAC) have become available for use in Europe and other regions in indications related to prophylaxis and treatment of venous and arterial thromboembolism. They include the oral direct thrombin inhibitor dabigatran etexilate (Pradaxa, Boehringer Ingelheim) an...

journal_title：European journal of haematology

authors： Gómez-Outes A,Suárez-Gea ML,Lecumberri R,Terleira-Fernández AI,Vargas-Castrillón E

更新日期：2015-11-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder of the hematopoietic stem cell that makes blood cells more sensitive to the action of complement. Patients experience intravascular hemolysis, smooth muscle dystonia, renal failure, arterial and pulmonary hypertension, recurrent infectious diseases and ...

journal_title：European journal of haematology

authors： Devalet B,Mullier F,Chatelain B,Dogné JM,Chatelain C

更新日期：2015-09-01 00:00:00

abstract：:Immunoglobulin gene rearrangements in B-cell lymphoma subtypes may not always be detected by PCR if only one primer set is applied. We therefore analysed a range of low and high grade B-cell lymphoma subtypes for monoclonality using PCR, to determine appropriate primer selection strategies for routine diagnostic use. ...

journal_title：European journal of haematology

authors： Essop MF,Blakolmer K,Close PM,Manuel YE,Cornelius S

更新日期：1997-09-01 00:00:00

abstract：:A consecutive material of 111 untreated patients with non-Hodgkin's lymphoma was studied with respect to fraction of S-phase cells in blood mononuclear cells in relation to presence of monoclonal B cells in blood (MBCB). Fraction of S-phase cells was determined by flow cytometry and estimation of MBCB was performed by...

journal_title：European journal of haematology

authors： Lindh J,Jonsson H,Lenner P,Roos G

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Most results on the treatment of chronic myeloid leukaemia (CML) with imatinib were obtained from clinical trials that may differ from the routine practice. We report the results of treatment of consecutive patients with CML at ten major centres during 2000-2008. PATIENTS AND METHODS:Data reporting was retr...

journal_title：European journal of haematology

authors： Faber E,Mužík J,Koza V,Demečková E,Voglová J,Demitrovičová L,Chudej J,Markuljak I,Cmunt E,Kozák T,Tóthová E,Jarošová M,Dušek L,Indrák K

更新日期：2011-08-01 00:00:00