Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic leukaemia.

abstract：OBJECTIVES:Mantle cell lymphoma (MCL) is an incurable disease with an aggressive course and novel treatment strategies are urgently needed. The purpose of this study was to evaluate the effects of histone deacetylase (HDAC) inhibitors, a new group of antiproliferative agents, on human MCL cells. METHODS:Three MCL cell...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Sterz J,Zavrski I,Jakob C,Fleissner C,Eucker J,Possinger K,Sezer O

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Little prospective data regarding factors determining patient outcomes in myelodysplastic syndromes (MDS) are available. To establish features of early mortality in MDS, we compare characteristics of patients dying within 1 year of diagnosis with those surviving longer. METHODS:We prospectively enrolled adul...

journal_title：European journal of haematology

authors： Jacobsen AM,Poynter JN,Richardson MR,Nguyen PL,Hirsch B,Cioc A,Roesler MA,Warlick ED

更新日期：2019-07-01 00:00:00

abstract：:Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7-8 May 2015 in Amsterdam, The Netherlands, aimed to prom...

journal_title：European journal of haematology

authors： Berntorp E,Hart D,Mancuso ME,d'Oiron R,Perry D,O'Mahony B,Kaczmarek R,Crato M,Pasi J,Miners A,Carlsson KS,Kitchen S,Boehlen F,Giangrande P,Cebura E,Uitslager N,Osooli M,Janeckova D,Haldon R,Rivolta GF

更新日期：2016-07-01 00:00:00

abstract：:The purpose of this study was to analyse the influence of the hospital size, measured as the number of annual patient enrolments in the Finnish Leukaemia Group trials in the period 1979-85, on response rate and survival after conventional chemotherapy for multiple myeloma. The 432 myeloma patients for this study were ...

journal_title：European journal of haematology

authors： Oivanen T,Kellokumpu-Lehtinen P,Koivisto AM,Koivunen E

更新日期：1999-10-01 00:00:00

abstract：:Patients with ARF and haematological malignancy (excluding myeloma), presenting to a single unit over 10 years were analyzed to see if patients likely to benefit from intensive renal supportive therapy could be identified. 31 episodes of ARF were identified in 29 patients (mean age 51 +/- 2.9 yr): 19 were associated w...

journal_title：European journal of haematology

authors： Harris KP,Hattersley JM,Feehally J,Walls J

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To correlate the clinical and hematological features of β-globin gene haplotypes with the oxidative stress status in pediatric patients with sickle cell disease (SCD). METHODS:A total of 95 patients with SCD and 40 healthy children were studied. The β-globin cluster, plasma lipid peroxidation (LPO) and plasm...

journal_title：European journal of haematology

authors： Rusanova I,Escames G,Cossio G,de Borace RG,Moreno B,Chahboune M,López LC,Díez T,Acuña-Castroviejo D

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:Current prognostic models for myelodysplastic syndrome (MDS) do not consider the prognostic value of a bone marrow blast level that is <5%. Exploring the prognostic value of the International Prognostic Scoring System (IPSS) and a marrow blast level that is <5% may lead to better risk-adapted therapeutic str...

journal_title：European journal of haematology

authors： Wang H,Wang XQ,Xu XP,Lin GW

更新日期：2009-12-01 00:00:00

abstract：:We describe a case of acute promyelocytic leukemia in a 61-yr-old woman with a cryptic insertion of RARA gene into PML gene. Using a combination of cytogenetic and molecular methods, we confirmed the insertion and presence of the PML-RARA transcript and lack of the reciprocal RARA-PML transcript. Although such cryptic...

journal_title：European journal of haematology

authors： Fan H,Ortega V,Fanasch HM,Wang Y,Holder KN,Higgins RA,Mendiola C,Mohamed G,Vadlamudi K,Velagaleti G

更新日期：2014-10-01 00:00:00

abstract：:The development of an autoantibody to human Factor VIII is rare and presents many problems for diagnosis and treatment. We have seen several cases at our institution recently with widely heterogenous clinical and laboratory presentations. A wide range of treatment modalities were used in these cases with no gold stand...

journal_title：European journal of haematology

authors： Hall RL,Leahy MF

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:An excessive intramedullar progenitor cell apoptosis, to which elevated expression of tumor necrosis factor-alpha (TNF-alpha) might contribute, is considered the main cause of inefficient hematopoiesis in myelodysplastic syndromes (MDS). Enhanced bone marrow (BM) angiogenesis is regarded as an essential cofa...

journal_title：European journal of haematology

authors： Stifter G,Heiss S,Gastl G,Tzankov A,Stauder R

更新日期：2005-12-01 00:00:00

abstract：:An unusual case having IgM monoclonal gammopathy with clinical and pathologic features of multiple myeloma (MM) in association with neutrophilia and nephrotic syndrome is reported. The patient showed lytic bone lesions, decreased IgG and IgA levels, Bence-Jones proteinuria, nephrotic proteinuria with edema, and histol...

journal_title：European journal of haematology

authors： Gnerre P,Ottonello L,Montecucco F,Boero M,Dallegri F

更新日期：2007-07-01 00:00:00

abstract：:We investigated the significance of cytokines (soluble interleukin-2 receptor, granulocyte-macrophage colony-stimulating factor, interleukin-6, and interferon-gamma) and CD68-positive microparticles in immune thrombocytopenic purpura. Cytokines were measured by enzyme-linked immunosorbent assay and microparticles were...

journal_title：European journal of haematology

authors： Nomura S,Yanabu M,Kido H,Lan XG,Ichiyoshi H,Katsura K,Miyake T,Miyazaki Y,Kagawa H,Fukuhara S

更新日期：1995-07-01 00:00:00

abstract：:We evaluated the utility of an immunocytochemical technique employing the commercially available anti-CD56 monoclonal antibody, NKH 1. The utility and sensitivity of this technique in the detection of invasive neuroblastoma (NB) cells in the bone marrow were compared with those of Wright-Giemsa staining. The correlati...

journal_title：European journal of haematology

authors： Nagai J,Kigasawa H,Tomioka K,Koga N,Nishihira H,Nagao T

更新日期：1994-08-01 00:00:00

abstract：:Our aim was to assess liver iron content, in thalassaemic patients, by using three different MR protocols and compare their data. Ninety-four thalassaemic patients (44 M and 50 F, mean age 25.82 +/- 8.3 yrs), were enrolled in the study. In each patient, three measurements of the liver iron content were performed, with...

journal_title：European journal of haematology

authors： Christoforidis A,Perifanis V,Spanos G,Vlachaki E,Economou M,Tsatra I,Athanassiou-Metaxa M

更新日期：2009-05-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently lin...

journal_title：European journal of haematology

authors： Koren-Michowitz M,Eting E,Rahimi-Levene N,Garach-Jehoshua O,Volcheck Y,Kornberg A

更新日期：2005-11-01 00:00:00

abstract：:This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

journal_title：European journal of haematology

authors： Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

更新日期：2012-06-01 00:00:00

abstract：:We report a case of T-cell hairy-cell leukemia with a dual rearrangement of Ig- and T-cell receptor genes. The cytochemical, transmission electron microscopy, and surface antigens data (CD3+, CD8+, CD11+, HLA-DR+, CD19-, CD20-) were consistent with a T-cell hairy-cell leukemia. Molecular analysis according to Southern...

journal_title：European journal of haematology

authors： Palumbo AP,Corradini P,Battaglio S,Omedè P,Coda R,Boccadoro M,Pileri A

更新日期：1991-02-01 00:00:00

abstract：:BLyS and APRIL share two receptors - transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) - and BLyS binds to a third receptor, BAFF-R. We previously reported that TACI gene expression is a good indicator of a BLyS-binding receptor in human multipl...

journal_title：European journal of haematology

authors： Moreaux J,Sprynski AC,Dillon SR,Mahtouk K,Jourdan M,Ythier A,Moine P,Robert N,Jourdan E,Rossi JF,Klein B

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Increased levels of Wilms' tumor (WT1) mRNA have been used to establish risk categories in patients with acute myeloid leukemia (AML). Raised values of WT1 have been associated with progression in myelodysplastic syndrome (MDS). METHODS:We retrospectively analyzed the available bone marrow (BM) samples fr...

journal_title：European journal of haematology

authors： Santaliestra M,Garrido A,Carricondo M,Bussaglia E,Pratcorona M,Blanco ML,Gich I,Hoyos M,Esquirol A,García-Cadenas I,Brunet S,Martino R,Sierra J,Nomdedéu JF

更新日期：2019-09-01 00:00:00

abstract：:To characterize the process of the establishment of complete chimerism after allogeneic peripheral blood stem cell transplantation (allo-PBSCT), we determined the origin of leukocytes in peripheral blood (PB) obtained from 23 patients in the very early period after allo-PBSCT using amplification of mini- or microsatel...

journal_title：European journal of haematology

authors： Nakao S,Zeng W,Yamazaki H,Wang H,Takami A,Sugimori N,Miura Y,Shiobara S,Matsuda T,Shinagawa Y,Harada M

更新日期：1999-04-01 00:00:00

abstract：:Treatment with recombinant erythropoietin (EPO) can alleviate anaemia in patients with myelodysplastic syndromes (MDS). The present study, based on a long-term follow-up of 68 MDS patients (26RA, 16 RAS, 26 RAEB) treated with EPO alone, pinpoints pre-treatment variables associated with response induction, response dur...

journal_title：European journal of haematology

authors： Wallvik J,Stenke L,Bernell P,Nordahl G,Hippe E,Hast R

更新日期：2002-03-01 00:00:00

abstract：:To determine if mutations of the Wilms' tumor predisposing gene (WT1) are associated with haematological malignancies, we have investigated 65 cases of acute leukaemia, including 39 patients in blast crisis of chronic myeloid leukaemia (CML), by amplification of WT1 exons 7, 8 and 9 followed by single-strand conformat...

journal_title：European journal of haematology

authors： Carapeti M,Goldman JM,Cross NC

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. Mel-TBI causes more early toxicity and is more...

journal_title：European journal of haematology

authors： Munker R,Baghian A,Koleva Y,Andrews P,Matharoo GS,Wright AE,Saba NS,Weiner RS,Safah H

更新日期：2017-07-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a human herpesvirus 8 (HHV8) associated lymphoproliferative disease characterized by effusions in body cavities, and lack of tumor mass. Valganciclovir is a treatment option in PEL, however, little is known about its clinical efficacy. Ganciclovir has been reported to be effective in...

journal_title：European journal of haematology

authors： Ozbalak M,Tokatlı I,Özdemirli M,Tecimer T,Ar MC,Örnek S,Koroglu A,Laleli Y,Ferhanoglu B

更新日期：2013-11-01 00:00:00

abstract：:Spontaneous remission in patients with acute myeloid leukemia (AML) is a rarely reported phenomenon of usually short duration. The etiology remains unclear, but an association with preceding blood transfusions or bacterial infections has been reported. Triggered immune responses are suggested to play a potential role ...

journal_title：European journal of haematology

authors： Müller CI,Trepel M,Kunzmann R,Lais A,Engelhardt R,Lübbert M

更新日期：2004-07-01 00:00:00

abstract：:Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematolo...

journal_title：European journal of haematology

authors： Halfdanarson TR,Kumar N,Li CY,Phyliky RL,Hogan WJ

更新日期：2008-06-01 00:00:00

abstract：:A subset of 299 patients with homozygous sickle cell anaemia, enrolled in the cohort of the French Study Group on sickle cell disease (SCD), was investigated in this study. The majority of patients were children (mean age 10.1 +/- 5.8 yr) of first generation immigrants from Western and Central Africa, the others origi...

journal_title：European journal of haematology

authors： Neonato MG,Guilloud-Bataille M,Beauvais P,Bégué P,Belloy M,Benkerrou M,Ducrocq R,Maier-Redelsperger M,de Montalembert M,Quinet B,Elion J,Feingold J,Girot R

更新日期：2000-09-01 00:00:00

abstract：:Plasma cell leukemia (PCL) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary PCL occuring 'de novo', or as secondary PCL in patients with relapsed/refractory multiple myeloma. Primary PCL is a distinct cli...

journal_title：European journal of haematology

authors： Jelinek T,Kryukov F,Rihova L,Hajek R

更新日期：2015-07-01 00:00:00

abstract：:No consecutive analysis of BAALC and WT1 expressions associated with core-binding factor AML (CBF-AML) from diagnosis to hematopoietic stem cell transplantation (HSCT) has yet been reported. We investigated BAALC and WT1 expressions using a method of real-time quantitative polymerase chain reaction (RQ-PCR) at diagnos...

journal_title：European journal of haematology

authors： Yoon JH,Kim HJ,Shin SH,Yahng SA,Lee SE,Cho BS,Eom KS,Kim YJ,Lee S,Min CK,Cho SG,Kim DW,Lee JW,Min WS,Park CW,Lim JH

更新日期：2013-08-01 00:00:00