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PML-RARA fusion resulting from a cryptic insertion of RARA gene into PML gene without the reciprocal RARA-PML fusion: clinical, cytogenetic, and molecular characterization and prognosis.

Abstract：

:We describe a case of acute promyelocytic leukemia in a 61-yr-old woman with a cryptic insertion of RARA gene into PML gene. Using a combination of cytogenetic and molecular methods, we confirmed the insertion and presence of the PML-RARA transcript and lack of the reciprocal RARA-PML transcript. Although such cryptic insertions leading to a PML-RARA fusion have been previously reported, we show that such variant insertions, based on our case, appear to have the same prognostic significance as the classical t(15;17)(q22;q21).

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Fan H,Ortega V,Fanasch HM,Wang Y,Holder KN,Higgins RA,Mendiola C,Mohamed G,Vadlamudi K,Velagaleti G

doi

10.1111/ejh.12326

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

354-8

issue

4

eissn

0902-4441

issn

1600-0609

journal_volume

93

pub_type

杂志文章

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