Abstract:
:To characterize the process of the establishment of complete chimerism after allogeneic peripheral blood stem cell transplantation (allo-PBSCT), we determined the origin of leukocytes in peripheral blood (PB) obtained from 23 patients in the very early period after allo-PBSCT using amplification of mini- or microsatellite regions of genomic DNA. Donor-specific alleles were amplified from the PB obtained at day 8 post-transplant for 19 allo-PBSCT patients. Among the 19 patients, 12 showed only donor-specific alleles (complete chimerism) while 7 did both donor and host-specific alleles (mixed chimerism). Although donor specific alleles were amplified in 10 of 12 patients who received allogeneic bone marrow transplantation (allo-BMT) similarly to allo-PBSCT, all of these ten showed mixed chimerism. When the chimeric state was examined in PB samples obtained serially at 2-3-day intervals post-transplant, host-specific alleles in allo-PBSCT patients were not detectable in the PB much earlier than those in allo-BMT patients. These findings indicate that the appearance of donor-derived cells associated with the disappearance of host-derived cells in the circulation occurs earlier after allo-PBSCT as compared with allo-BMT, leading to the rapid establishment of complete chimerism.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Nakao S,Zeng W,Yamazaki H,Wang H,Takami A,Sugimori N,Miura Y,Shiobara S,Matsuda T,Shinagawa Y,Harada Mdoi
10.1111/j.1600-0609.1999.tb01756.xsubject
Has Abstractpub_date
1999-04-01 00:00:00pages
265-70issue
4eissn
0902-4441issn
1600-0609journal_volume
62pub_type
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.1991.tb00133.x
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2006.00777.x
更新日期:2007-01-01 00:00:00
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:2007-10-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1999.tb01131.x
更新日期:1999-11-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2008.01111.x
更新日期:2008-10-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2004.00263.x
更新日期:2004-08-01 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1600-0609.2011.01710.x
更新日期:2012-02-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1996.tb01371.x
更新日期:1996-09-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/ejh.12855
更新日期:2017-05-01 00:00:00
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更新日期:2016-12-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1987.tb01168.x
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journal_title:European journal of haematology
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更新日期:2005-05-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1989.tb01247.x
更新日期:1989-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1600-0609.1988.tb00798.x
更新日期:1988-01-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2004.00213.x
更新日期:2004-04-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1600-0609.1994.tb01295.x
更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-07-01 00:00:00