Macrophages in spleen and liver direct the migration pattern of rat neutrophils during inflammation.

abstract：OBJECTIVE:A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). METHODS:Patients received lenalidomide 10 mg/d (days 1-21; n = 47) or ...

journal_title：European journal of haematology

authors： Giagounidis A,Mufti GJ,Mittelman M,Sanz G,Platzbecker U,Muus P,Selleslag D,Beyne-Rauzy O,te Boekhorst P,del Cañizo C,Guerci-Bresler A,Nilsson L,Lübbert M,Quesnel B,Ganser A,Bowen D,Schlegelberger B,Göhring G,Fu T,Be

更新日期：2014-11-01 00:00:00

abstract：:Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Pro...

journal_title：European journal of haematology

authors： Miesbach W,Berntorp E

更新日期：2017-02-01 00:00:00

abstract：:It is well-known that uremic patients present prolonged bleeding times as a common complication. Factors responsible for this disorder have been extensively investigated. In order to elucidate the possible role of uremic middle molecules as responsible for the bleeding tendency observed in uremia, we have studied the ...

journal_title：European journal of haematology

authors： Palés JL,López A,Asensio A,Merola E,Company X,Deulofeu R,Garcia M,Balagué A

更新日期：1987-09-01 00:00:00

abstract：:Development of resistance to cytotoxic agents is a common problem in the treatment of acute leukemia. In cell lines having multidrug resistance (MDR) phenotype, a decrease in the intracellular accumulation of drugs has been closely related to the overexpression of P-glycoprotein/mdr1 genes. We analyzed the relationshi...

journal_title：European journal of haematology

authors： Kato S,Ideguchi H,Muta K,Nishimura J,Nawata H

更新日期：1991-08-01 00:00:00

abstract：:A 1-yr-old Japanese male infant developed hepatitis-associated aplastic anemia (AA), and anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) was administered without any appreciable effects. Laboratory examination of the patient's serum obtained before therapy revealed various autoantibodies, such as PA-IgG, anti-...

journal_title：European journal of haematology

authors： Takamatsu H,Yagasaki H,Takahashi Y,Hama A,Saikawa Y,Yachie A,Koizumi S,Kojima S,Nakao S

更新日期：2011-06-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：:We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried...

journal_title：European journal of haematology

authors： Ciaudo M,Doco-Lecompte T,Guettier C,d'Agay MF,David F,Rioual N,Buu-Hoi A,Molina JM,Kazatchkine M,Modai J

更新日期：1994-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...

journal_title：European journal of haematology

authors： Olsson I,Lantz M,Nilsson E,Peetre C,Thysell H,Grubb A,Adolf G

更新日期：1989-03-01 00:00:00

abstract：:A patient who represented acute hemolytic crisis was studied. Analysis of the erythrocyte membrane proteins by SDS-PAGE revealed a deficiency of band 4.2. In the family, the sister of the patient who had been clinically normal was also shown to be deficient in band 4.2. Binding studies showed that the propositus' memb...

journal_title：European journal of haematology

authors： Iwamoto S,Kajii E,Omi T,Kamesaki T,Akifuji Y,Ikemoto S

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVES:Myeloma bone disease is a result of excessive osteoclast activation and impaired osteoblast function. Recent in vitro studies suggested that proteasome inhibitors might increase osteoblast function. METHODS:We analyzed serum markers of osteoblast activity in 25 patients with multiple myeloma receiving borte...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Müller C,Jakob C,Zavrski I,Schulz CO,Fleissner C,Hecht M,Sezer O

更新日期：2006-09-01 00:00:00

abstract：:Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

journal_title：European journal of haematology

authors： Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Diamond-Blackfan anemia (DBA) is characterized by hypoplastic anemia, congenital anomalies, and a predisposition for malignancies. Most of our understanding of this disorder stems from molecular studies combined with extensive data input from international patient registries. OBJECTIVES:To create an overv...

journal_title：European journal of haematology

authors： van Dooijeweert B,van Ommen CH,Smiers FJ,Tamminga RYJ,Te Loo MW,Donker AE,Peters M,Granzen B,Gille HJJP,Bierings MB,MacInnes AW,Bartels M

更新日期：2018-02-01 00:00:00

abstract：UNLABELLED:The role of growth hormone (GH) for maintaining normal erythropoiesis among non-GH-deficient elderly subjects is not known. OBJECTIVES:To determine relationships between the concentrations of serum insulin-like growth factor-1 (IGF-1) and it's carrier protein insulin-like growth factor binding protein 3 (IG...

journal_title：European journal of haematology

authors： Nilsson-Ehle H,Bengtsson BA,Lindstedt G,Mellström D

更新日期：2005-02-01 00:00:00

abstract：:The candidate tumour suppressor gene MMAC1/PTEN located at chromosome 10q23.3 has been reported to be frequently mutated in a number of solid tumours. Less is known about its status in leukaemia. In the present study we first analysed 13 leukaemia cell lines for mutations and homozygous deletions in MMAC1/PTEN using P...

journal_title：European journal of haematology

authors： Aggerholm A,Grønbaek K,Guldberg P,Hokland P

更新日期：2000-08-01 00:00:00

abstract：:Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non-coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have con...

journal_title：European journal of haematology

authors： Azzouzi I,Schmugge M,Speer O

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Serum lactate dehydrogenase (LDH) has been an adverse prognostic factor for myeloma but does not feature in the International Staging System (ISS). We examined whether elevated serum LDH at diagnosis remains an adverse risk factor independent of ISS for survivals transplant-eligible myeloma patients receivin...

journal_title：European journal of haematology

authors： Chim CS,Sim J,Tam S,Tse E,Lie AK,Kwong YL

更新日期：2015-04-01 00:00:00

abstract：:Downregulation of cereblon (CRBN) gene expression is associated with resistance to the immunomodulatory drug lenalidomide and poor survival outcomes in multiple myeloma (MM) patients. However, the importance of CRBN gene expression in patients with myelodysplastic syndrome (MDS) and its impact on lenalidomide therapy ...

journal_title：European journal of haematology

authors： Jonasova A,Bokorova R,Polak J,Vostry M,Kostecka A,Hajkova H,Neuwirtova R,Siskova M,Sponerova D,Cermak J,Mikulenkova D,Cervinek L,Brezinova J,Michalova K,Fuchs O

更新日期：2015-07-01 00:00:00

abstract：:Cellular accumulation of vincristine (VCR) and doxorubicin (DOX) was studied in 15 patients with low-grade B-cell malignancies. Their leukemic lymphocytes were isolated and the effect of verapamil on drug uptake was studied. The immunophenotype was characterized using anti-IgM, -IgD, -B 1, monoclonal antibodies. The m...

journal_title：European journal of haematology

authors： Reizenstein P,Kapoor R,Gruber A,Peterson C

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:Infections are the major cause of morbidity and mortality in patients with acute myeloid leukaemia (AML). They primarily occur during the first course of induction chemotherapy and may increase the risk of leukaemia relapse, due to a significant delay in consolidation therapy. The intensification of inductio...

journal_title：European journal of haematology

authors： Malagola M,Peli A,Damiani D,Candoni A,Tiribelli M,Martinelli G,Piccaluga PP,Paolini S,De Rosa F,Lauria F,Bocchia M,Gobbi M,Pierri I,Zaccaria A,Zuffa E,Mazza P,Priccolo G,Gugliotta L,Bonini A,Visani G,Skert C,Ber

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:Granulocyte colony-stimulating factor-mobilized peripheral blood hematopoietic stem cell transplantation (HSCT) provides a valuable and increasingly used alternative to bone marrow transplantation (BMT). This retrospective study aimed at determining whether the stem cell source is predictive for outcome, rel...

journal_title：European journal of haematology

authors： Auberger J,Clausen J,Kircher B,Kropshofer G,Lindner B,Nachbaur D

更新日期：2011-12-01 00:00:00

abstract：:Whole blood from splenectomized subjects (n = 8) contained a substantial percentage of vacuolated ('pitted') red cells (34.7 +/- 8.3%), while blood from controls revealed none. The percentage of haemoglobin A1 (HbA1) had increased significantly compared with controls (p less than 0.01). Fractionation on cell density r...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) diagnostic guidelines recommend single-tube five- to six-color or two-tube four-color assays. PNH clones are detectable in only a fraction of patients at risk, and screening for new PNH cases can be complex and expensive. In this multicenter study, we have validated ...

journal_title：European journal of haematology

authors： Gatti A,Del Vecchio L,Geuna M,Della Porta MG,Brando B

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:The primary objective was to assess the effect of central nervous system involvement in acute myeloid leukemia (CNS-AML) on outcomes after allogeneic hematopoietic stem cell transplant (allo-HCT). The secondary objective was to assess the utility of pretransplant cerebrospinal fluid (CSF) assessment in AML. ...

journal_title：European journal of haematology

authors： Prem S,Atenafu EG,Avena J,Bautista R,Law A,Lam W,Michelis FV,Kim DDH,Viswabandya A,Lipton JH,Mattsson J,Kumar R

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Extracellular vesicles (EVs) are important for intercellular signalling in cancer. Tumour-associated macrophages, expressing the haemoglobin-haptoglobin and mannose receptors CD163 and CD206, are crucial for cancer progression. We recently identified CD163 on EVs in the circulation as a fraction of total sol...

journal_title：European journal of haematology

authors： Kvorning SL,Nielsen MC,Andersen NF,Hokland M,Andersen MN,Møller HJ

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:The current study identified patients with either essential thrombocythemia (ET) or polycythemia vera (PV) who have survived for at least 20 yr without the development of either acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) or myelofibrosis (MF) and compared their presenting features with those i...

journal_title：European journal of haematology

authors： Tefferi A,Gangat N,Wolanskyj AP,Schwager S,Pardanani A,Lasho TL,Mesa R,McClure RF,Li CY,Hanson CA

更新日期：2008-05-01 00:00:00

abstract：:We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

journal_title：European journal of haematology

authors： Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

更新日期：2009-11-01 00:00:00

abstract：:In childhood-onset acute myeloid leukaemia (AML) the clinical value of karyotypic aberrations is now acknowledged, although there is still debate concerning the prognostic significance of some events. To add to this knowledge, cytogenetic analysis was performed on a consecutive series of 84 childhood AML patients diag...

journal_title：European journal of haematology

authors： Betts DR,Ammann RA,Hirt A,Hengartner H,Beck-Popovic M,Kuhne T,Nobile L,Caflisch U,Wacker P,Niggli FK

更新日期：2007-06-01 00:00:00

abstract：:High mobility group box 1 protein (HMGB1), originally described as a non-histone, DNA binding protein, was recently identified as a late mediator of inflammation via its extracellular release from activated macrophages/monocytes. In the present study, we report that intracellular HMGB1 synergizes with a macrophage/mon...

journal_title：European journal of haematology

authors： Mouri F,Tsukada J,Mizobe T,Higashi T,Yoshida Y,Minami Y,Izumi H,Kominato Y,Kohno K,Tanaka Y

更新日期：2008-01-01 00:00:00

abstract：:Whereas beta-2-microglobulin (beta2M) has mainly been used as a prognostic factor in patients with lymphoproliferative disorders, some studies have reported the value of beta2M in myeloproliferative disorders (MPD). In order to investigate a potential role in the pathogenesis of MPD and to find a possible value as ind...

journal_title：European journal of haematology

authors： Bourantas KL,Hatzimichael EC,Makis AC,Chaidos A,Kapsali ED,Tsiara S,Mavridis A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Current prognostic models for myelodysplastic syndrome (MDS) do not consider the prognostic value of a bone marrow blast level that is <5%. Exploring the prognostic value of the International Prognostic Scoring System (IPSS) and a marrow blast level that is <5% may lead to better risk-adapted therapeutic str...

journal_title：European journal of haematology

authors： Wang H,Wang XQ,Xu XP,Lin GW

更新日期：2009-12-01 00:00:00