Incidence of bacterial and fungal infections in newly diagnosed acute myeloid leukaemia patients younger than 65 yr treated with induction regimens including fludarabine: retrospective analysis of 224 cases.


OBJECTIVES:Infections are the major cause of morbidity and mortality in patients with acute myeloid leukaemia (AML). They primarily occur during the first course of induction chemotherapy and may increase the risk of leukaemia relapse, due to a significant delay in consolidation therapy. The intensification of induction chemotherapy and the use of non-conventional drugs such as fludarabine are considered responsible for the increased risk of infections. METHODS:In this study, we retrospectively analysed the infections occurred in 224 newly diagnosed AML patients


Eur J Haematol


Malagola M,Peli A,Damiani D,Candoni A,Tiribelli M,Martinelli G,Piccaluga PP,Paolini S,De Rosa F,Lauria F,Bocchia M,Gobbi M,Pierri I,Zaccaria A,Zuffa E,Mazza P,Priccolo G,Gugliotta L,Bonini A,Visani G,Skert C,Ber




Has Abstract


2008-11-01 00:00:00














  • Analysis of low and high grade B-cell lymphoma subtypes using semi-nested PCR and two primer sets.

    abstract::Immunoglobulin gene rearrangements in B-cell lymphoma subtypes may not always be detected by PCR if only one primer set is applied. We therefore analysed a range of low and high grade B-cell lymphoma subtypes for monoclonality using PCR, to determine appropriate primer selection strategies for routine diagnostic use. ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Essop MF,Blakolmer K,Close PM,Manuel YE,Cornelius S

    更新日期:1997-09-01 00:00:00

  • A plea to overcome the concept of "staging" and related inadequacy in multiple myeloma.

    abstract::From a retrospective multivariate study on 107 multiple myeloma (MM) patients, serum beta 2-microglobulin (beta 2M) proved to be the best prognostic discriminator, better than each of the currently used staging systems (Durie and Salmon's [DS], Merlini, Waldenström and Jayakar's [MWJ] and the British Medical Research ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Gobbi PG,Bertoloni D,Grignani G,Pieresca C,Rossi A,Rutigliano L,Merlini G,Riccardi A,Ascari E

    更新日期:1991-03-01 00:00:00

  • Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.

    abstract::Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Brähler S,Thielen I,Schwabe H,Engels M,Kreuzer KA,Wolf J,Ansén S

    更新日期:2014-06-01 00:00:00

  • An overview of current trends and gaps in patient-reported outcome measures used in haemophilia.

    abstract:AIM:This review summarises the importance, recent progress and issues in measuring patient-reported outcomes (PROs) in haemophilia research. METHODS:A critical review of recent advances and trends in measuring haemophilia-related PROs was conducted, using current regulatory guidelines and methodological recommendation...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Pocoski J,Benjamin K,Michaels LA,Flood E,Sasane R

    更新日期:2014-06-01 00:00:00

  • Low-dose cyclophosphamide effectively mobilizes peripheral blood stem cells in patients with autoimmune disease.

    abstract::For patients with severe and refractory autoimmune diseases, high-dose chemotherapy and autologous hematopoietic stem cell transplantation has been established as a considerable therapeutic option in recent years. In this retrospective single-center analysis, we assessed the feasibility and efficacy of peripheral bloo...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Blank N,Lisenko K,Pavel P,Bruckner T,Ho AD,Wuchter P

    更新日期:2016-07-01 00:00:00

  • Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning regimen in children: a single-center experience.

    abstract::This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

    更新日期:2012-06-01 00:00:00

  • Renal aspects of thalassaemia a changing paradigm.

    abstract::Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Bhandari S,Galanello R

    更新日期:2012-09-01 00:00:00

  • Engraftment of human myelodysplastic syndrome derived cell line in transgenic severe combined immunodeficient (TG-SCID) mice expressing human GM-CSF and IL-3.

    abstract::A transgenic SCID (TG-SCID) mouse expressing the human cytokines interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) has been generated with the aim of making a model system allowing the in vivo proliferation of human hematopoietic cells. Using TG-SCID mice expressing high levels (30-35 ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Kim DK,Kojima M,Fukushima T,Miyasaka M,Nakauchi H

    更新日期:1998-08-01 00:00:00

  • Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature.

    abstract::Spontaneous remission in patients with acute myeloid leukemia (AML) is a rarely reported phenomenon of usually short duration. The etiology remains unclear, but an association with preceding blood transfusions or bacterial infections has been reported. Triggered immune responses are suggested to play a potential role ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Müller CI,Trepel M,Kunzmann R,Lais A,Engelhardt R,Lübbert M

    更新日期:2004-07-01 00:00:00

  • Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin.

    abstract::The aim of the present study was to determine whether angelicin is able to increase the expression of gamma-globin genes in human erythroid cells. Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for their antiproliferative activity in treatment of different skin dis...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Lampronti I,Bianchi N,Borgatti M,Fibach E,Prus E,Gambari R

    更新日期:2003-09-01 00:00:00

  • Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

    abstract::Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

    更新日期:2005-01-01 00:00:00

  • Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning.

    abstract:OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Kalpoe JS,van der Heiden PL,Barge RM,Houtzager S,Lankester AC,van Tol MJ,Kroes AC

    更新日期:2007-04-01 00:00:00

  • Long-term complication in follicular lymphoma: assessing the risk of secondary neoplasm in 242 patients treated or not with 90-yttrium-ibritumomab-tiuxetan.

    abstract:BACKGROUND:Non-Hodgkin lymphoma patients have a 25% increased risk of secondary primary neoplasms (SPNs). Regarding the controversy about the increased risk of SPN in patients exposed to radioimmunotherapy (RIT), we have analyzed this issue in a cohort of follicular lymphoma (FL) patients treated with/without RIT. PAT...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Andrade-Campos MM,Liévano P,Espinosa-Lara N,Soro-Alcubierre G,Grasa-Ulrich JM,López-Gómez L,Baringo T,Giraldo P

    更新日期:2016-12-01 00:00:00

  • Hematopoietic clonal dominance, stem cell mutations, and evolutionary pattern of JAK2V617F allele burden in polycythemia vera.

    abstract:OBJECTIVES:Clonal dominance is characteristic of patients with post-polycythemia vera myelofibrosis (post-PV MF), whereas patients in chronic phase usually display polyclonal hematopoiesis. The aim of this work was to study the mutational burden of JAK2V617F at the progenitor level in patients with PV and correlate it ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Angona A,Alvarez-Larrán A,Bellosillo B,Martínez-Avilés L,Camacho L,Fernández-Rodríguez C,Pairet S,Longarón R,Ancochea Á,Senín A,Florensa L,Besses C

    更新日期:2015-03-01 00:00:00

  • Whole blood folate values in pernicious anaemia: relation to treatment.

    abstract::27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed. After vitamin B12 treatment, a peak whole blood folate value some 70% higher than the ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Magnus EM

    更新日期:1987-07-01 00:00:00

  • Assessment of the response to imatinib in chronic myeloid leukemia patients--comparison between the FISH, multiplex and RT-PCR methods.

    abstract:OBJECTIVE:The objective of this study was to evaluate the kinetics of molecular response in chronic myeloid leukemia (CML) patients treated with imatinib and to compare between the fluorescent in situ hybridization (FISH), multiplex and real-time quantitative RT-PCR (RQ-PCR) methods with this respect. METHODS:Molecula...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Raanani P,Ben-Bassat I,Gan S,Trakhtenbrot L,Mark Z,Ashur-Fabian O,Itskovich S,Brok-Simoni F,Rechavi G,Amariglio N,Nagler A

    更新日期:2004-10-01 00:00:00

  • The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis.

    abstract::Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Kamezaki K,Shimoda K,Numata A,Aoki K,Kato K,Takase K,Nakajima H,Ihara K,Haro T,Ishikawa F,Imamura R,Miyamoto T,Nagafuji K,Gondo H,Hara T,Harada M

    更新日期:2003-12-01 00:00:00

  • Low L-selectin (CD62L) expression in acute myeloid leukemia correlates with a bad cytogenetic risk.

    abstract:OBJECTIVES:Interactions between hemopoietic cells and the stromal microenvironment or immunoreactive cells are mediated by specific cell surface receptors. The expression of those molecules may alter the adhesive qualities (mobility and homing) as well as immune response behavior of leukemic blasts. L-Selectin (CD62L) ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Graf M,Reif S,Hecht K,Pelka-Fleischer R,Pfister K,Nuessler V,Schmetzer H

    更新日期:2003-11-01 00:00:00

  • Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene.

    abstract::Upshaw-Schulman syndrome (USS) is due to severe congenital deficiency of von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 domains, nr 13) activity resulting in the presence of unusually large forms of VWF in the circulation, causing intravascular plat...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Rank CU,Kremer Hovinga J,Taleghani MM,Lämmle B,Gøtze JP,Nielsen OJ

    更新日期:2014-02-01 00:00:00

  • Immunotoxins containing saporin 6 and monoclonal antibodies recognizing plasma cell-associated antigens: effects on target cells and on normal myeloid precursors (CFU-GM).

    abstract::Monoclonal antibodies 8A and 62B1, recognizing plasma cell-associated antigens, were covalently linked to saporin 6, a ribosome-inactivating protein similar to the A-chain of ricin. Both immunotoxins were tested on target human cell lines U266 and Raji, on non-target K562 cell line and on myeloid CFU-GM progenitors. T...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Barbieri L,Dinota A,Gobbi M,Tazzari PL,Rizzi S,Bontadini A,Lemoli RM,Tura S,Stirpe F

    更新日期:1989-03-01 00:00:00

  • Prognostic role of immunohistochemical analysis of 5 mc in myelodysplastic syndromes.

    abstract:BACKGROUND:Aberrant DNA methylation at CpG islands within promoters is increasingly recognised as a common event in human cancers and has been associated with the silencing of important tumour suppressor genes. Epigenetic therapy using hypomethylating agents has demonstrated clinical effectiveness; the drugs azacitidin...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Poloni A,Goteri G,Zizzi A,Serrani F,Trappolini S,Costantini B,Mariani M,Olivieri A,Catarini M,Centurioni R,Alesiani F,Giantomassi F,Stramazzotti D,Biagetti S,Alfonsi S,Berardinelli E,Leoni P

    更新日期:2013-09-01 00:00:00

  • Feasibility and efficacy of chronic transfusion for stroke prevention in children with sickle cell disease.

    abstract:OBJECTIVES:In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Mirre E,Brousse V,Berteloot L,Lambot-Juhan K,Verlhac S,Boulat C,Dumont MD,Lenoir G,de Montalembert M

    更新日期:2010-03-01 00:00:00

  • Effect of low-dose warfarin on D-dimer levels during sickle cell vaso-occlusive crisis: a brief report.

    abstract:OBJECTIVE:To evaluate the activation of clotting systems in patients with sickle cell disease (SCD) by measuring the plasma D-dimer level and to determine the effect of low-dose warfarin on D-dimer level during vaso-occlusive crisis. METHODS:Plasma D-dimer level was measured in 65 blood samples of 37 adult patients wi...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Ahmed S,Siddiqui AK,Iqbal U,Sison CP,Shahid RK,Sheth M,Patel DV,Russo LA

    更新日期:2004-03-01 00:00:00

  • Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation.

    abstract:OBJECTIVES:Cord blood (CB) transplantation has advantages in terms of incidence and severity of acute graft-versus-host disease (GVHD), while it has disadvantages in terms of infection. Our aim is to elucidate the molecular mechanism underlying the immune response of CB-derived cells during acute GVHD and infection fol...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Takahashi N,Nakaoka T,Yamashita N

    更新日期:2012-01-01 00:00:00

  • Excellent prognosis and prevalence of HCV infection of primary hepatic and splenic non-Hodgkin's lymphoma.

    abstract:BACKGROUND:Primary Hepatic (PHL) and Primary Splenic (PSL) non-Hodgkin's Lymphoma are rare entities. Small series of PHL and PSL have been reported, suggesting a non-fortuitous association with Hepatitis C Virus (HCV) infection. The prognosis is believed to be dismal, with early recurrence and short survival. PATIENTS...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: De Renzo A,Perna F,Persico M,Notaro R,Mainolfi C,de Sio I,Ciancia G,Picardi M,Del Vecchio L,Pane F,Rotoli B

    更新日期:2008-07-01 00:00:00

  • Increasing incidence of primary central nervous system lymphoma but no improvement in survival in Sweden 2000-2013.

    abstract:OBJECTIVES:This study aims to characterize the epidemiology of immunocompetent Primary central nervous system lymphoma (PCNSL) diagnosed 2000-2013 in Sweden. METHODS:Cases were identified in the population-based Swedish Lymphoma Register. Incidence per 100 000 person-years and 95% confidence intervals (CI) were calcul...

    journal_title:European journal of haematology

    pub_type: 历史文章,杂志文章


    authors: Eloranta S,Brånvall E,Celsing F,Papworth K,Ljungqvist M,Enblad G,Ekström-Smedby K

    更新日期:2018-01-01 00:00:00

  • Inherited or acquired modifiers of iron status may dramatically affect the phenotype in dehydrated hereditary stomatocytosis.

    abstract::Severe iron overload is frequent in dehydrated hereditary stomatocytosis (DHSt) despite well-compensated hemolysis and no or little transfusion requirement. We investigated 4 patients with proven DHSt, in whom the degree of hemolysis was closely related to iron status. Genetic modifiers increasing iron stores (HFE:pCy...

    journal_title:European journal of haematology



    authors: Orvain C,Da Costa L,Van Wijk R,Pissard S,Picard V,Mansour-Hendili L,Cunat S,Giansily-Blaizot M,Cartron G,Schved JF,Aguilar-Martinez P

    更新日期:2018-10-01 00:00:00

  • Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.

    abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder of the hematopoietic stem cell that makes blood cells more sensitive to the action of complement. Patients experience intravascular hemolysis, smooth muscle dystonia, renal failure, arterial and pulmonary hypertension, recurrent infectious diseases and ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Devalet B,Mullier F,Chatelain B,Dogné JM,Chatelain C

    更新日期:2015-09-01 00:00:00

  • Complete donor chimaerism of Langerhans cells in lymph node early after allogeneic bone marrow transplantation.

    abstract::Host-derived Langerhans cells (LCs) are crucial antigen-presenting cells that cause graft-vs.-host disease after allogeneic haematopoietic stem cell transplantation (HSCT). However, chimaerism of LCs after allogeneic HSCT is largely unknown in humans. We here report a case that developed dermatopathic lymphadenitis ac...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Ikeda K,Shichishima T,Teshima T,Ogawa K,Nakamura-Shichishima A,Tajima H,Noji H,Hashimoto Y,Takeyama K,Ishibashi T,Ohto H,Abe M,Maruyama Y

    更新日期:2006-03-01 00:00:00

  • The clinical and biological features of a series of immunophenotypic variant of B-CLL.

    abstract:OBJECTIVES:To describe the clinical and biological features of a series of immunophenotypic variant of B-CLL (v-CLL) characterised by intermediate RMH score, in the absence of t(11;14)(q13;q32) in FISH analysis in comparison with a series of typical CLL. METHODS:We studied the clinical and biological features of 63 ca...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Cro L,Ferrario A,Lionetti M,Bertoni F,Zucal N N,Nobili L,Fabris S,Todoerti K,Cortelezzi A,Guffanti A,Goldaniga M,Marcheselli L,Neri A,Lambertenghi-Deliliers G,Baldini L

    更新日期:2010-08-01 00:00:00