Abstract:
:The acquisition of new aberrations during the course of chronic lymphocytic leukemia (CLL) named clonal evolution (CE) is usually detected by one of the two methods: chromosome banding analysis (CBA) and interphase fluorescence in situ hybridization (I-FISH). The purpose of this study was to compare the usefulness of FISH and CBA for detecting CE and to evaluate its influence on clinical outcome. FISH and CBA were performed at two time points: baseline and follow-up. Thirty-eight previously untreated patients with CLL were included in this study. CBA and I-FISH revealed CE in 15 (39.5%) and 10 (26.3%) patients, respectively. High-risk CE was detected in six cases by CBA and in five cases by I-FISH. In four cases with CE-dependent 17p abnormalities detected by CBA, metaphase FISH was needed for the confirmation of 17p13.1 deletion. Time from first-line to second-line treatment (TTST) and overall survival (OS) did not differ between patients with and without CE, irrespective of the CE-detecting method used. However, shorter OS (P = 0.043) and TTST (P = 0.006) were observed for the patients with potentially relevant CE (rCE) detected by CBA, in which acquired aberrations were present in at least 20% of undivided cells and/or changed baseline karyotype to abnormal or complex and were not resulting from 13q deletion. Our results suggest that some, but not all, CE-dependent aberrations detected by CBA influence clinical outcome. Moreover, I-FISH, which was aimed at detecting aberrations of prognostic significance, was found to be more precise than CBA in their detection, especially TP53 deletion.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Wawrzyniak E,Kotkowska A,Blonski JZ,Siemieniuk-Rys M,Ziolkowska E,Giannopoulos K,Robak T,Korycka-Wolowiec Adoi
10.1111/ejh.12215subject
Has Abstractpub_date
2014-02-01 00:00:00pages
91-101issue
2eissn
0902-4441issn
1600-0609journal_volume
92pub_type
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.1996.tb01933.x
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1998.tb01098.x
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1997.tb00958.x
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abstract::Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the co...
journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2012.01776.x
更新日期:2012-06-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/ejh.13293
更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1034/j.1600-0609.2001.066004215.x
更新日期:2001-04-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1034/j.1600-0609.2000.065004279.x
更新日期:2000-10-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.0902-4441.2005.00589.x
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/ejh.12615
更新日期:2016-05-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1988.tb00818.x
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pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:1995-02-01 00:00:00
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pub_type: 历史文章,杂志文章
doi:10.1111/ejh.12980
更新日期:2018-01-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1991.tb01536.x
更新日期:1991-05-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1034/j.1600-0609.2001.00152.x
更新日期:2001-01-01 00:00:00
abstract::ECHELON-1 study is a randomized open-labeled controlled trial investigating whether addition of brentuximab vedotin to chemotherapy offers benefit over the standard chemotherapy regimen in advanced Hodgkin lymphoma. After a median follow-up of 24.6 months, it has met its primary endpoint the reduction of modified prog...
journal_title:European journal of haematology
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2007.00907.x
更新日期:2007-09-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2005.00416.x
更新日期:2005-07-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2005.00504.x
更新日期:2005-09-01 00:00:00