Sequestration patterns of transfused rat neutrophilic granulocytes under normal and inflammatory conditions.

abstract：OBJECTIVES:Some patients with myelodysplastic syndrome (MDS) show a marked increase in the percentage of immature platelet fraction (IPF%) despite the absence of severe thrombocytopenia. To determine the significance of such an unbalanced increase in the IPF%, we investigated the IPF% and other laboratory findings of 5...

journal_title：European journal of haematology

authors： Sugimori N,Kondo Y,Shibayama M,Omote M,Takami A,Sugimori C,Ishiyama K,Yamazaki H,Nakao S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...

journal_title：European journal of haematology

authors： Kalpoe JS,van der Heiden PL,Barge RM,Houtzager S,Lankester AC,van Tol MJ,Kroes AC

更新日期：2007-04-01 00:00:00

abstract：:Severe iron overload is frequent in dehydrated hereditary stomatocytosis (DHSt) despite well-compensated hemolysis and no or little transfusion requirement. We investigated 4 patients with proven DHSt, in whom the degree of hemolysis was closely related to iron status. Genetic modifiers increasing iron stores (HFE:pCy...

journal_title：European journal of haematology

authors： Orvain C,Da Costa L,Van Wijk R,Pissard S,Picard V,Mansour-Hendili L,Cunat S,Giansily-Blaizot M,Cartron G,Schved JF,Aguilar-Martinez P

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30...

journal_title：European journal of haematology

authors： Mirre E,Brousse V,Berteloot L,Lambot-Juhan K,Verlhac S,Boulat C,Dumont MD,Lenoir G,de Montalembert M

更新日期：2010-03-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：:Chronic isolated hereditary macrothrombocytopenia (CHMT) is a congenital form of macrothrombocytopenia that seems to be due to defective production secondary to a disturbance in megakaryocyte fragmentation. To better understand the pathogenesis of thrombopoiesis in this hereditary thrombocytopenic disorder, we determi...

journal_title：European journal of haematology

authors： Fabris F,Cordiano I,Steffan A,Ramon R,Scandellari R,Nichol JL,Girolami A

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evalua...

journal_title：European journal of haematology

authors： Catherwood MA,Matthews C,Niblock R,Dobbin E,Morris TC,Alexander HD

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (T...

journal_title：European journal of haematology

authors： Zhang Z,Li X,Guo J,Xu F,He Q,Zhao Y,Yang Y,Gu S,Zhang Y,Wu L,Chang C

更新日期：2013-05-01 00:00:00

abstract：:Signal transduction via receptors for N-formylmethionyl peptide chemoattractants (FPR) on human neutrophils is a highly regulated process. It involves direct interaction of receptors with heterotrimeric G-proteins and may be under the control of cytoskeletal elements. Evidence exists suggesting that the cytoskeleton a...

journal_title：European journal of haematology

authors： Jesaitis AJ,Klotz KN

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. METHODS:We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 an...

journal_title：European journal of haematology

authors： Lennmyr E,Karlsson K,Ahlberg L,Garelius H,Hulegårdh E,Izarra AS,Joelsson J,Kozlowski P,Moicean A,Tomaszewska-Toporska B,Lübking A,Hallböök H,Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL).

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Transfusional iron overload is of major concern in hematological disease. Iron-overload-related dyserythropoiesis and reactive oxygen species (ROS)-related damage to hematopoietic stem cell (HSC) function are major setbacks in treatment for such disorders. We therefore aim to investigate the effect of iron o...

journal_title：European journal of haematology

authors： Lu W,Zhao M,Rajbhandary S,Xie F,Chai X,Mu J,Meng J,Liu Y,Jiang Y,Xu X,Meng A

更新日期：2013-09-01 00:00:00

abstract：:A 62-yr-old man with two healthy daughters was diagnosed with osteomyelofibrosis. To our surprise, a female XX-karyotype was observed in bone marrow and confirmed in PHA-stimulated T-lymphocytes from peripheral blood. Further molecular genetic investigation revealed a submicroscopic translocation between the short arm...

journal_title：European journal of haematology

authors： Schanz J,Haase D,Steuernagel P,Shirneshan K,Bäsecke J

更新日期：2015-09-01 00:00:00

abstract：:Upshaw-Schulman syndrome (USS) is due to severe congenital deficiency of von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 domains, nr 13) activity resulting in the presence of unusually large forms of VWF in the circulation, causing intravascular plat...

journal_title：European journal of haematology

authors： Rank CU,Kremer Hovinga J,Taleghani MM,Lämmle B,Gøtze JP,Nielsen OJ

更新日期：2014-02-01 00:00:00

abstract：:Fourty-three episodes of fungaemia encountered from 1978 to 1991 in 43 patients with haematological malignancies are reviewed here to analyse the risk factors for death and to evaluate the efficacy of early antifungal therapy. Low serum cholinesterase and elevated serum blood urea nitrogen were significantly associate...

journal_title：European journal of haematology

authors： Iwama A,Yoshida M,Miwa A,Obayashi T,Sakamoto S,Miura Y

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. Mel-TBI causes more early toxicity and is more...

journal_title：European journal of haematology

authors： Munker R,Baghian A,Koleva Y,Andrews P,Matharoo GS,Wright AE,Saba NS,Weiner RS,Safah H

更新日期：2017-07-01 00:00:00

abstract：:Mononuclear phagocytes play an important role in the regulation of hematopoiesis, not only by producing regulatory monokines such as prostaglandins, tumor necrosis factor and interleukin-1 (IL-1), but also by the production of colony-stimulating activity (CSA). Previously, we have demonstrated that granulocyte-macroph...

journal_title：European journal of haematology

authors： Fibbe WE,Kluck PM,Duinkerken N,Voogt PJ,Willemze R,Falkenburg JH

更新日期：1988-10-01 00:00:00

abstract：:The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). E...

journal_title：European journal of haematology

authors： Joly P,Garnier N,Kebaili K,Renoux C,Dony A,Cheikh N,Renard C,Ceraulo A,Cuzzubbo D,Pondarré C,Martin C,Pialoux V,Francina A,Bertrand Y,Connes P

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Warfarin represents the most commonly prescribed oral anticoagulants, which functions as an antagonist of vitamin K, an essential factor of blood coagulation cascade. Warfarin has a narrow therapeutic index. An insufficient dose can cause failure of antithrombotic effect, and an overdose increases a risk of b...

journal_title：European journal of haematology

authors： Krajčíová L,Petrovič R,Déžiová L,Chandoga J,Turčáni P

更新日期：2014-10-01 00:00:00

abstract：:Type 2 dendritic cell (DC2) acute leukemia has been recently described. We report here an unusual case of a 17-yr-old adolescent with overlapping features of DC2 and myeloid/NK cell precursor acute leukemia as defined by Suzuki et al. The patient presented with lymphadenopathy and hepatosplenomegaly without extranodal...

journal_title：European journal of haematology

authors： Anargyrou K,Paterakis G,Boutsis D,Politou M,Papadhimitriou SI,Siakandaris M,Vassiliadis J,Androulakis A,Meletis J,Rombos J,Tassiopoulou A,Vaiopoulos G

更新日期：2003-10-01 00:00:00

abstract：:We studied the chromosomes in the bone marrow of 4 patients who had both diabetes insipidus (DI) and acute non-lymphocytic leukaemia. Clinical findings suggested that, in each case, myelodysplastic syndrome had preceded the onset of acute leukaemia. Two other such patients described in the literature had had a banded ...

journal_title：European journal of haematology

authors： de la Chapelle A,Lahtinen R

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:For transplantation of cord blood (CB) cells, it is important to select a CB sample that can reconstitute not only myelo-erythropoiesis but also lymphopoiesis in recipients. However, until now the reconstitution ability of CB samples has been assessed by colony forming unit-culture (CFU-C) assay or by simply ...

journal_title：European journal of haematology

authors： Kato M,Masuda K,Kakugawa K,Kawamoto H,Mugishima H,Katsura Y

更新日期：2008-02-01 00:00:00

abstract：:Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 1...

journal_title：European journal of haematology

authors： Billström R,Johansson B,Fioretos T,Garwicz S,Malm C,Zettervall O,Mitelman F

更新日期：1997-07-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is an uncommon complication of patients with essential thrombocythaemia (ET). We report a patient with ET which progressed into AML and who had only received a few days of therapy with hydroxyurea (HU) when diagnosed with ET. This is extremely rare, as in large series no patients who were...

journal_title：European journal of haematology

authors： Bolaños-Meade J,López-Arvizu C,Cobos E

更新日期：2002-06-01 00:00:00

abstract：:Cancer cells are characterized by having chromosomal abnormalities. The number of aberrations and the specific chromosomes affected are likely correlated with tumor progression. In this study, we analyzed the karyotype of 126 plasma cell leukemia (PCL) patients to identify the most frequently occurring imbalances and ...

journal_title：European journal of haematology

authors： Jimenez-Zepeda VH,Neme-Yunes Y,Braggio E

更新日期：2011-07-01 00:00:00

abstract：:We generated a 100-kb map of the region 5' of the PML (promyelocytic leukemia) gene on human chromosome 15q22 and identified a new gene provisionally named STORP for stomatin-related protein. The STORP gene is positioned 2 kb upstream of the PML gene in a head-to-head configuration, and contains 7 exons spanning a gen...

journal_title：European journal of haematology

authors： Gilles F,Glenn M,Goy A,Remache Y,Zelenetz AD

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single-center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. ...

journal_title：European journal of haematology

authors： Steingrímsson V,Gíslason GK,Aspelund T,Turesson I,Björkholm M,Landgren O,Kristinsson SY

更新日期：2020-11-01 00:00:00

abstract：:This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

journal_title：European journal of haematology

authors： Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Hypereosinophilia (HE, persistent peripheral blood eosinophilia > 1.5 × 109 /L) and hypereosinophilic syndrome (HES, HE with end-organ damage) are classified as primary (due to a myeloid clone), secondary (due to a wide variety of reactive causes), or idiopathic. Diagnostic evaluation of eosinophilia is chal...

journal_title：European journal of haematology

authors： Moller D,Tan J,Gauiran DTV,Medvedev N,Hudoba M,Carruthers MN,Dehghan N,van den Berghe J,Bruyère H,Chen LYC

更新日期：2020-09-01 00:00:00

abstract：:We demonstrate the in vivo effects of bacterially synthesized, N-methionine-free recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) using a crab-eating monkey model. Monkeys were treated with cyclophosphamide (60 mg/kg) and administered with rh GM-CSF (30 micrograms/kg/d) subcutaneously (s....

journal_title：European journal of haematology

authors： Akashi K,Taniguchi S,Teshima T,Shibuya T,Okamura T,Harada M,Niho Y

更新日期：1990-02-01 00:00:00