当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HAEMATOLOGY期刊下所有文献 > Survival in adult acute lymphoblastic leukaemia (ALL): A report from the Swedish ALL Registry.

Survival in adult acute lymphoblastic leukaemia (ALL): A report from the Swedish ALL Registry.

Abstract：

OBJECTIVES:As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. METHODS:We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 and 2015. RESULTS:The median age was 53 years. The frequency of Philadelphia (Ph)-positive leukaemia was 34% of examined B-ALL with a peak incidence at 50-59 years. Five-year overall survival (OS) improved between 1997-2006 and 2007-2015; in patients 18-45 years from 50% (95% CI 43-57) to 65% (95% CI 58-72), 46-65 years from 25% (95% CI 18-32) to 46% (95% CI 37-55) and >65 years from 7% (95% CI 2.6-11) to 11% (95% CI 5.9-16) (P < 0.05). Men with Ph-neg B-ALL 46-65 years had inferior OS compared with women (P < 0.01). Standardised mortality ratio was 5.7 (95% CI 5.0-6.3) for patients who survived 5 years from diagnosis. In multivariable analysis, Ph-positive disease was not associated with impaired prognosis but with lower risk of death in 2007-2015. CONCLUSIONS:In a population-based cohort, OS has improved in adult ALL, especially for Ph-positive disease but for middle-aged men with Ph-negative B-ALL outcome was poor. Cure without late toxicity or relapse is still desired.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Lennmyr E,Karlsson K,Ahlberg L,Garelius H,Hulegårdh E,Izarra AS,Joelsson J,Kozlowski P,Moicean A,Tomaszewska-Toporska B,Lübking A,Hallböök H,Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL).

doi

10.1111/ejh.13247

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

88-98

issue

2

eissn

0902-4441

issn

1600-0609

journal_volume

103

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF HAEMATOLOGY文献大全
  • Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature.

    abstract：:Spontaneous remission in patients with acute myeloid leukemia (AML) is a rarely reported phenomenon of usually short duration. The etiology remains unclear, but an association with preceding blood transfusions or bacterial infections has been reported. Triggered immune responses are suggested to play a potential role ...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2004.00248.x

    authors： Müller CI,Trepel M,Kunzmann R,Lais A,Engelhardt R,Lübbert M

    更新日期：2004-07-01 00:00:00

  • Persistent altered fusion transcript splicing identifies RUNX1-RUNX1T1+ AML patients likely to relapse.

    abstract：:In acute myeloid leukemia (AML) mouse models, the RUNX1-RUNX1T1 fusion protein has failed to produce leukemia by itself, but alternative splicing of exon 9a of the RUNX1-RUNX1T1 fusion transcript (FT) has recently been shown to enhance the leukemogenic potential. We have analyzed 138 diagnosis and follow-up samples fr...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2009.01371.x

    authors： Ommen HB,Ostergaard M,Yan M,Braendstrup K,Zhang DE,Hokland P

    更新日期：2010-02-01 00:00:00

  • An Arg545----Cys545 substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease.

    abstract：:Type IIB is a special variant of von Willebrand's disease, characterized by an abnormal von Willebrand factor which shows an increased interaction with platelets. This interaction sometimes causes platelet aggregation and thrombocytopenia in vivo. It involves the glycoprotein-Ib (GPIb) receptor on platelets and corres...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1991.tb01858.x

    authors： Donnér M,Andersson AM,Kristoffersson AC,Nilsson IM,Dahlbäck B,Holmberg L

    更新日期：1991-11-01 00:00:00

  • Bronchiolitis obliterans organizing pneumonia in a patient with chronic myelogenous leukemia developing after initiation of interferon and cytosine arabinoside.

    abstract：:A 59-yr-old man developed fevers, shortness of breath, persistent cough and weight loss, shortly after initiation of therapy with interferon-alpha 2a and cytosine arabinoside for treatment of chronic myelogenous leukemia. Radiologic pulmonary infiltrates and lung tissue biopsy were consistent with bronchiolitis oblite...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2001.00503.x

    authors： Patel M,Ezzat W,Pauw KL,Lowsky R

    更新日期：2001-11-01 00:00:00

  • Hereditary protein C deficiency and thrombosis risk: genotype and phenotype relation in a large Italian family.

    abstract：UNLABELLED:Protein C (PC) deficiency is an autosomal dominant inherited disorder associated with spontaneous and recurrent thrombotic events. Factor V Leiden (FVL) increases the risk of thrombosis in PC-deficient type I families. We have investigated the relationship between PC deficiency genotype and clinical phenotyp...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2011.01742.x

    authors： Cafolla A,D'Andrea G,Baldacci E,Margaglione M,Mazzucconi MG,Foà R

    更新日期：2012-04-01 00:00:00

  • Bone marrow histopathology in primary myelofibrosis: clinical and haematologic correlations and prognostic evaluation.

    abstract：:In 51 patients with primary myelofibrosis the initial bone marrow biopsy findings were evaluated by morphometric methods, correlated with the patients' main clinical and haematologic data and analysed for prognostic significance. The high variability of the marrow features was the most striking finding of the morpholo...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1990.tb00357.x

    authors： Pereira A,Cervantes F,Brugues R,Rozman C

    更新日期：1990-02-01 00:00:00

  • Clinical course and risk factors for mortality from COVID-19 in patients with haematological malignancies.

    abstract：BACKGROUND:The impact of coronavirus disease 2019 (COVID-19) in haematological patients (HP) has not been comprehensively reported. METHODS:We analysed 39 patients with SARS-CoV-2 infection and haematological malignancies. Clinical characteristics and outcomes were compared to a matched control group of 53 non-cancer ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.13493

    authors： Sanchez-Pina JM,Rodríguez Rodriguez M,Castro Quismondo N,Gil Manso R,Colmenares R,Gil Alos D,Paciello ML,Zafra D,Garcia-Sanchez C,Villegas C,Cuellar C,Carreño-Tarragona G,Zamanillo I,Poza M,Iñiguez R,Gutierrez X,Alonso R

    更新日期：2020-11-01 00:00:00

  • A fatal case of enoxaparin induced skin necrosis and thrombophilia.

    abstract：:Skin necrosis caused by heparins is a rare complication. We report a case of a 71-yr-old white woman who developed painful diffuse skin lesions, most probably related to enoxaparin treatment. Other causes of skin necrosis, including heparin induced thrombocytopenia, disseminated intravascular coagulation, protein C/pr...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2006.00668.x

    authors： Nadir Y,Mazor Y,Reuven B,Sarig G,Brenner B,Krivoy N

    更新日期：2006-08-01 00:00:00

  • Thirty-year experience in preventing haemoglobinopathies in Greece: achievements and potentials for optimisation.

    abstract：OBJECTIVES:Beta thalassaemia major (β-TM) and sickle-cell disease (SCD) are severe haemogobinopathies requiring life-lasting, advanced medical management. In the Mediterranean region, both conditions occur with high frequency. We assessed the efficacy of the National Program for the Prevention of Haemoglobinopathies in...

    journal_title：European journal of haematology

    pub_type： 历史文章,杂志文章

    doi：10.1111/ejh.12076

    authors： Ladis V,Karagiorga-Lagana M,Tsatra I,Chouliaras G

    更新日期：2013-04-01 00:00:00

  • Immunocytochemical detection of bone marrow-invasive neuroblastoma cells.

    abstract：:We evaluated the utility of an immunocytochemical technique employing the commercially available anti-CD56 monoclonal antibody, NKH 1. The utility and sensitivity of this technique in the detection of invasive neuroblastoma (NB) cells in the bone marrow were compared with those of Wright-Giemsa staining. The correlati...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1994.tb01868.x

    authors： Nagai J,Kigasawa H,Tomioka K,Koga N,Nishihira H,Nagao T

    更新日期：1994-08-01 00:00:00

  • Magnetic resonance imaging is superior to computed tomography and ultrasonography in imaging infectious liver foci in acute leukaemia.

    abstract：:We conducted a prospective study in order to compare ultrasonography, computed tomography and magnetic resonance imaging in the detection of liver foci in patients with acute leukaemia and clinical suspicion of hepatic candidiasis. 28 adult patients fulfilling set entry criteria after recovery from neutropenia were st...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1996.tb00300.x

    authors： Anttila VJ,Lamminen AE,Bondestam S,Korhola O,Färkkilä M,Sivonen A,Ruutu T,Ruutu P

    更新日期：1996-01-01 00:00:00

  • Dose-escalated CHOP and tailored intensification with IFE according to early response and followed by BEAM/autologous stem-cell transplantation in poor-risk aggressive B-cell lymphoma: a prospective study from the GEL-TAMO Study Group.

    abstract：OBJECTIVES:The role of high-dose therapy and autologous stem-cell transplantation (HDT/ASCT) in the up-front treatment of poor-risk aggressive lymphoma is still unknown. We conducted a prospective multi-centre trial with dose-escalated CHOP (MegaCHOP) and tailored intensification prior to HDT/ASCT according to early re...

    journal_title：European journal of haematology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1600-0609.2007.01020.x

    authors： Arranz R,Conde E,Grande C,Mateos MV,Gandarillas M,Albo C,Lahuerta JJ,Fernández-Rañada JM,Hernández MT,Alonso N,García Vela JA,Garzón S,Rodríguez J,Caballero D,Grupo Español de Linfomas\/Trasplante Autólogo de Médula Osea (GEL

    更新日期：2008-03-01 00:00:00

  • Biosynthesis and processing of myeloperoxidase--a marker for myeloid cell differentiation.

    abstract：:Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophils. Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products. MPO is synthesized during the promyelocytic stage of myeloid ...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.1988.tb00805.x

    authors： Nauseef WM,Olsson I,Arnljots K

    更新日期：1988-02-01 00:00:00

  • Rapid infusion of rituximab over 60 min.

    abstract：:The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2009.01215.x

    authors： Tuthill M,Crook T,Corbet T,King J,Webb A

    更新日期：2009-04-01 00:00:00

  • The hematologic consequences of obesity.

    abstract：:The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic ris...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.13560

    authors： Purdy JC,Shatzel JJ

    更新日期：2020-12-03 00:00:00

  • An increase in basophils in a case of acute myelomonocytic leukaemia associated with marrow eosinophilia and inversion of chromosome 16.

    abstract：:A patient with acute myelomonocytic leukaemia (M4 subtype) with pericentric inversion of chromosome 16, inv(16)(p13q22), and a marked basophilia is described. Results from transmission electron microscopy suggested that the basophils were immature. Clinically, although leukaemic cells had a tendency to infiltrate a nu...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1987.tb01456.x

    authors： Matsuura Y,Sato N,Kimura F,Shimomura S,Yamamoto K,Enomoto Y,Takatani O

    更新日期：1987-11-01 00:00:00

  • Serum leptin levels in patients with idiopathic thrombocytopenic purpura.

    abstract：OBJECTIVES:The purpose of this study was to evaluate serum leptin levels in idiopathic thrombocytopenic purpura (ITP), in order to determine the influence of leptin on the pathogenesis of ITP. SUBJECTS AND METHODS:Forty-six untreated patients with chronic ITP were compared with 40 healthy people of similar age, sex an...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2004.00231.x

    authors： Zhan M,Zhao H,Yang R,Han ZC

    更新日期：2004-05-01 00:00:00

  • Macrophages in spleen and liver direct the migration pattern of rat neutrophils during inflammation.

    abstract：OBJECTIVE:The exact fate of polymorphonuclear neutrophilic granulocytes (PMN; neutrophils) after their mobilization from the bone marrow is not known. It is believed that they, after a relatively short lifespan (1-3 d), become apoptotic and phagocytosed by macrophages. We have recently shown that transfused neutrophils...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2004.00263.x

    authors： Knudsen E,Benestad HB,Seierstad T,Iversen PO

    更新日期：2004-08-01 00:00:00

  • Chromosome abnormalities defined by conventional cytogenetics in plasma cell leukemia: what have we learned about its biology?

    abstract：:Cancer cells are characterized by having chromosomal abnormalities. The number of aberrations and the specific chromosomes affected are likely correlated with tumor progression. In this study, we analyzed the karyotype of 126 plasma cell leukemia (PCL) patients to identify the most frequently occurring imbalances and ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2011.01629.x

    authors： Jimenez-Zepeda VH,Neme-Yunes Y,Braggio E

    更新日期：2011-07-01 00:00:00

  • Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles.

    abstract：OBJECTIVES:To compare the gene expression pattern in children and adults with acute lymphoblastic leukaemia (ALL) in order to improve our understanding of the difference in disease biology and prognosis. METHODS:The gene expression profiles in diagnostic samples from 29 children and 15 adults with ALL were analysed us...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2005.00433.x

    authors： Kuchinskaya E,Heyman M,Grandér D,Linderholm M,Söderhäll S,Zaritskey A,Nordgren A,Porwit-Macdonald A,Zueva E,Pawitan Y,Corcoran M,Nordenskjöld M,Blennow E

    更新日期：2005-06-01 00:00:00

  • On the interaction between cytosine arabinoside and etoposide in vivo and in vitro.

    abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1993.tb00069.x

    authors： Liliemark J,Knochenhauer E,Gruber A,Pettersson B,Björkholm M,Peterson C

    更新日期：1993-01-01 00:00:00

  • Inherited or acquired modifiers of iron status may dramatically affect the phenotype in dehydrated hereditary stomatocytosis.

    abstract：:Severe iron overload is frequent in dehydrated hereditary stomatocytosis (DHSt) despite well-compensated hemolysis and no or little transfusion requirement. We investigated 4 patients with proven DHSt, in whom the degree of hemolysis was closely related to iron status. Genetic modifiers increasing iron stores (HFE:pCy...

    journal_title：European journal of haematology

    pub_type：

    doi：10.1111/ejh.13135

    authors： Orvain C,Da Costa L,Van Wijk R,Pissard S,Picard V,Mansour-Hendili L,Cunat S,Giansily-Blaizot M,Cartron G,Schved JF,Aguilar-Martinez P

    更新日期：2018-10-01 00:00:00

  • Acute clinical events in 299 homozygous sickle cell patients living in France. French Study Group on Sickle Cell Disease.

    abstract：:A subset of 299 patients with homozygous sickle cell anaemia, enrolled in the cohort of the French Study Group on sickle cell disease (SCD), was investigated in this study. The majority of patients were children (mean age 10.1 +/- 5.8 yr) of first generation immigrants from Western and Central Africa, the others origi...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2000.90210.x

    authors： Neonato MG,Guilloud-Bataille M,Beauvais P,Bégué P,Belloy M,Benkerrou M,Ducrocq R,Maier-Redelsperger M,de Montalembert M,Quinet B,Elion J,Feingold J,Girot R

    更新日期：2000-09-01 00:00:00

  • Activation of protein kinase C by phorbol ester increases red blood cell scramblase activity and external phosphatidylserine.

    abstract：:Externalization of phosphatidylserine (PS) is thought to contribute to sickle cell disease (SCD) pathophysiology. The red blood cell (RBC) aminophospholipid translocase (APLT) mediates the transport of PS from the outer to the inner RBC membrane leaflet to maintain an asymmetric distribution of PL, while phospholipid ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12506

    authors： Barber LA,Palascak MB,Qi X,Joiner CH,Franco RS

    更新日期：2015-11-01 00:00:00

  • Renal aspects of thalassaemia a changing paradigm.

    abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2012.01819.x

    authors： Bhandari S,Galanello R

    更新日期：2012-09-01 00:00:00

  • Predictors of splenic function preservation in children with sickle cell anemia treated with hydroxyurea.

    abstract：BACKGROUND:More than 90% of children with sickle cell anemia (SCA) lose splenic function by the age of 2 yrs. Splenic function may improve with hydroxyurea, but previous studies are conflicting. We prospectively evaluated the effect of hydroxyurea on splenic filtrative function. METHODS:Children with SCA enrolled in t...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/ejh.12361

    authors： Nottage KA,Ware RE,Winter B,Smeltzer M,Wang WC,Hankins JS,Dertinger SD,Shulkin B,Aygun B

    更新日期：2014-11-01 00:00:00

  • Prevalence and risk factors for Pulmonary Hypertension associated with chronic Myeloproliferative Neoplasms.

    abstract：OBJECTIVES:Pulmonary hypertension (PH) is commonly reported in Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). PH may be diagnosed directly by right heart catheterization (RHC) or estimated by transthoracic ec...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.13543

    authors： Ferrari A,Scandura J,Masciulli A,Krichevsky S,Gavazzi A,Barbui T

    更新日期：2021-02-01 00:00:00

  • Antitumour activity of the glycoengineered type II anti-CD20 antibody obinutuzumab (GA101) in combination with the MDM2-selective antagonist idasanutlin (RG7388).

    abstract：OBJECTIVES:To investigate whether the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) combined with the selective MDM2 antagonist idasanutlin (RG7388) offers superior efficacy to monotherapy in treating B-lymphoid malignancies in preclinical models. METHODS:The combined effect of obinutuzuma...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12756

    authors： Herting F,Herter S,Friess T,Muth G,Bacac M,Sulcova J,Umana P,Dangl M,Klein C

    更新日期：2016-11-01 00:00:00

  • Hematological manifestations of copper deficiency: a retrospective review.

    abstract：:Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematolo...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2008.01050.x

    authors： Halfdanarson TR,Kumar N,Li CY,Phyliky RL,Hogan WJ

    更新日期：2008-06-01 00:00:00

  • Y-body study in bone marrow precursors, peripheral blood cells and alveolar macrophages for demonstration of haemopoietic engraftment in allogeneic bone marrow transplantation.

    abstract：:The value of Y-body study for assessment of haemopoietic engraftment was analyzed in 50 consecutive patients submitted to allogeneic bone marrow transplantation (BMT) (sex-matched in 28 cases, sex-mismatched in 22). The study was performed weekly on bone marrow and peripheral blood smears in all cases, and alveolar ma...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00851.x

    authors： Ribera JM,Feliu E,Rozman C,Grañena A,Xaubet A,Vives-Corrons JL,Ballesta F

    更新日期：1988-05-01 00:00:00