Colony-stimulating factor and leukemia cell-growth factor produced by a murine endothelial cell line, MKM-O.

abstract：OBJECTIVES:An aberrant pattern of expression of L-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). METHODS:In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICA...

journal_title：European journal of haematology

authors： Buccisano F,Maurillo L,Tamburini A,Del Poeta G,Del Principe MI,Ammatuna E,Consalvo MI,Campagna S,Ottaviani L,Sarlo C,Renzi D,Faccia S,Fraboni D,Lo Coco F,Amadori S,Venditti A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30...

journal_title：European journal of haematology

authors： Mirre E,Brousse V,Berteloot L,Lambot-Juhan K,Verlhac S,Boulat C,Dumont MD,Lenoir G,de Montalembert M

更新日期：2010-03-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：:We have previously shown that basic fibroblast growth factor (bFGF) stimulates megakaryocytopoiesis and granulopoiesis in vitro and that normal haematopoietic cells and several leukaemic cell lines express FGF receptors. In this paper, we demonstrate by reverse transcriptase-mediated polymerase chain reaction (RT-PCR)...

journal_title：European journal of haematology

authors： Gu XF,Bikfalvi A,Chen YZ,Caen JP,Han ZC

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:Patients with hematologic malignancies are at substantial risk of developing invasive fungal infections (IFI) that are associated with substantial morbidity and mortality. This article reviews the epidemiology, risk factors, and efficacy of antifungal prophylaxis in patients with hematologic malignancies. ME...

journal_title：European journal of haematology

authors： Maertens J

更新日期：2007-04-01 00:00:00

abstract：:Whereas beta-2-microglobulin (beta2M) has mainly been used as a prognostic factor in patients with lymphoproliferative disorders, some studies have reported the value of beta2M in myeloproliferative disorders (MPD). In order to investigate a potential role in the pathogenesis of MPD and to find a possible value as ind...

journal_title：European journal of haematology

authors： Bourantas KL,Hatzimichael EC,Makis AC,Chaidos A,Kapsali ED,Tsiara S,Mavridis A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Cord blood (CB) transplantation has advantages in terms of incidence and severity of acute graft-versus-host disease (GVHD), while it has disadvantages in terms of infection. Our aim is to elucidate the molecular mechanism underlying the immune response of CB-derived cells during acute GVHD and infection fol...

journal_title：European journal of haematology

authors： Takahashi N,Nakaoka T,Yamashita N

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Aberrant DNA methylation at CpG islands within promoters is increasingly recognised as a common event in human cancers and has been associated with the silencing of important tumour suppressor genes. Epigenetic therapy using hypomethylating agents has demonstrated clinical effectiveness; the drugs azacitidin...

journal_title：European journal of haematology

authors： Poloni A,Goteri G,Zizzi A,Serrani F,Trappolini S,Costantini B,Mariani M,Olivieri A,Catarini M,Centurioni R,Alesiani F,Giantomassi F,Stramazzotti D,Biagetti S,Alfonsi S,Berardinelli E,Leoni P

更新日期：2013-09-01 00:00:00

abstract：:Cellular accumulation of vincristine (VCR) and doxorubicin (DOX) was studied in 15 patients with low-grade B-cell malignancies. Their leukemic lymphocytes were isolated and the effect of verapamil on drug uptake was studied. The immunophenotype was characterized using anti-IgM, -IgD, -B 1, monoclonal antibodies. The m...

journal_title：European journal of haematology

authors： Reizenstein P,Kapoor R,Gruber A,Peterson C

更新日期：1989-11-01 00:00:00

abstract：:Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3-ITD-positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. In this study, we retrospectively collected data on the off-label use of the tyrosine kinase inhi...

journal_title：European journal of haematology

authors： De Freitas T,Marktel S,Piemontese S,Carrabba MG,Tresoldi C,Messina C,Lupo Stanghellini MT,Assanelli A,Corti C,Bernardi M,Peccatori J,Vago L,Ciceri F

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To retrospectively identify characteristics and risk factors of viral encephalitis (VE) in patients who underwent a haplo-identical hematopoietic stem cell transplant (HSCT). METHODS:A nested case-control study was designed. Cases with VE and controls were identified from a cohort composed of 1274 patients w...

journal_title：European journal of haematology

authors： Zhang XH,Zhang JM,Han W,Chen H,Chen YH,Wang FR,Wang JZ,Zhang YY,Mo XD,Chen Y,Wang Y,Chang YJ,Xu LP,Liu KY,Huang XJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Although there are two major scoring systems for the clinical diagnosis of disseminated intravascular coagulation (DIC), the validity of these systems for leukemia-associated DIC remains to be confirmed. METHODS:By analyzing 125 newly diagnosed acute leukemia patients, we investigated clinical and laborator...

journal_title：European journal of haematology

authors： Yanada M,Matsushita T,Suzuki M,Kiyoi H,Yamamoto K,Kinoshita T,Kojima T,Saito H,Naoe T

更新日期：2006-10-01 00:00:00

abstract：:Reduced-intensity conditioning regimens have demonstrated lower toxicity but increased relapse rates in the context of allogeneic hematopoietic stem cell transplantation (aSCT) for patients with acute myelogenous leukemia (AML). The FLAMSA- reduced-intensity conditioning (RIC) regimen, combining a cytoreductive and a ...

journal_title：European journal of haematology

authors： Holtick U,Shimabukuro-Vornhagen A,Chakupurakal G,Theurich S,Leitzke S,Burst A,Hallek M,von Bergwelt-Baildon M,Scheid C,Chemnitz JM

更新日期：2016-05-01 00:00:00

abstract：:Endothelial cell dysfunction is likely to be important in the pathophysiology of ischaemic heart disease and increased levels of endothelial cell markers soluble E-selectin and soluble thrombomodulin may reflect this damage. To determine whether increased levels of these markers were predictive of disease progression,...

journal_title：European journal of haematology

authors： Blann AD,Amiral J,McCollum CN

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single-center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. ...

journal_title：European journal of haematology

authors： Steingrímsson V,Gíslason GK,Aspelund T,Turesson I,Björkholm M,Landgren O,Kristinsson SY

更新日期：2020-11-01 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia (NAIT) occurs because of transplacentally acquired maternal platelet alloantibodies. Most of the alloantibodies are against human platelet antigens, but the alloantibody against CD36 is rare. A full-term female baby was delivered by a mother who experienced two spontaneous abortion...

journal_title：European journal of haematology

authors： Taketani T,Ito K,Mishima S,Kanai R,Uchiyama A,Hirata Y,Kumakura S,Ishikura H,Yamaguchi S

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently lin...

journal_title：European journal of haematology

authors： Koren-Michowitz M,Eting E,Rahimi-Levene N,Garach-Jehoshua O,Volcheck Y,Kornberg A

更新日期：2005-11-01 00:00:00

abstract：:Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...

journal_title：European journal of haematology

authors： Brähler S,Thielen I,Schwabe H,Engels M,Kreuzer KA,Wolf J,Ansén S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Abnormal coagulation parameters have been reported in COVID-19-infected patients. Although the underlying mechanism of COVID-19 coagulopathy remains unknown, it has been suggested to be a form of disseminated intravascular coagulation (DIC). OBJECTIVES:The aim of our study was to analyze the coagulation par...

journal_title：European journal of haematology

authors： Martín-Rojas RM,Pérez-Rus G,Delgado-Pinos VE,Domingo-González A,Regalado-Artamendi I,Alba-Urdiales N,Demelo-Rodríguez P,Monsalvo S,Rodríguez-Macías G,Ballesteros M,Osorio-Prendes S,Díez-Martín JL,Pascual Izquierdo C

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Outcome of patients with standard-risk (SR) multiple myeloma (MM) has improved; however, subsets of patients do worse than expected. We sought to identify the factors associated with inferior outcome. METHODS:We evaluated 51 patients with SR MM that received upfront autologous hematopoietic stem cell tran...

journal_title：European journal of haematology

authors： Badar T,Srour S,Bashir Q,Shah N,Al-Atrash G,Hosing C,Popat U,Nieto Y,Orlowski RZ,Champlin R,Qazilbash MH

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the activation of clotting systems in patients with sickle cell disease (SCD) by measuring the plasma D-dimer level and to determine the effect of low-dose warfarin on D-dimer level during vaso-occlusive crisis. METHODS:Plasma D-dimer level was measured in 65 blood samples of 37 adult patients wi...

journal_title：European journal of haematology

authors： Ahmed S,Siddiqui AK,Iqbal U,Sison CP,Shahid RK,Sheth M,Patel DV,Russo LA

更新日期：2004-03-01 00:00:00

abstract：:Osteolytic lesions with activated osteoclast (OC) and suppressed osteoblast (OB) activity are characteristics of myeloma bone lesion. Recently, it has been shown that bortezomib treatment enhances OB function. To evaluate the effect of bortezomib on myeloma bone lesions, we performed bone scans, where increased uptake...

journal_title：European journal of haematology

authors： Lee SE,Min CK,Yahng SA,Cho BS,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Kim DW,Lee JW,Min WS,Park CW

更新日期：2011-01-01 00:00:00

abstract：:Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. Studies have shown a response in up to 80% of patients with this condition after treatment with the CD25 monoclonal antibody, basiliximab. Despite the good responses...

journal_title：European journal of haematology

authors： Chakupurakal G,García-Márquez MA,Shimabukuro-Vornhagen A,Theurich S,Holtick U,Hallek M,Scheid C,von Bergwelt-Baildon M

更新日期：2016-08-01 00:00:00

abstract：:In 18 beta-thalassaemia families from the Ferrara area the incidence of an inherited low flavin mononucleotide (FMN)-dependent pyridoxine phosphate (PNP) oxidase activity, a sensitive indicator of red-cell FMN deficiency, is higher in related members in these families than in the unrelated spouses and controls subject...

journal_title：European journal of haematology

authors： Anderson BB,Perry GM,Clements JE,Studds C,Fashola R,Salsini G,Vullo C

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:More than 90% of children with sickle cell anemia (SCA) lose splenic function by the age of 2 yrs. Splenic function may improve with hydroxyurea, but previous studies are conflicting. We prospectively evaluated the effect of hydroxyurea on splenic filtrative function. METHODS:Children with SCA enrolled in t...

journal_title：European journal of haematology

authors： Nottage KA,Ware RE,Winter B,Smeltzer M,Wang WC,Hankins JS,Dertinger SD,Shulkin B,Aygun B

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:The benefits of combined chelation therapy with daily deferiprone (DFP) and subcutaneous desferrioxamine (DFO) have been widely reported in literature. We retrospectively evaluated the efficacy of different schedules of combined chelation therapy and the incidence of adverse events. METHODS:We evaluated 36 ...

journal_title：European journal of haematology

authors： Ricchi P,Ammirabile M,Spasiano A,Costantini S,Cinque P,Di Matola T,Pagano L,Prossomariti L

更新日期：2010-07-01 00:00:00

abstract：:Monoclonal antibodies 8A and 62B1, recognizing plasma cell-associated antigens, were covalently linked to saporin 6, a ribosome-inactivating protein similar to the A-chain of ricin. Both immunotoxins were tested on target human cell lines U266 and Raji, on non-target K562 cell line and on myeloid CFU-GM progenitors. T...

journal_title：European journal of haematology

authors： Barbieri L,Dinota A,Gobbi M,Tazzari PL,Rizzi S,Bontadini A,Lemoli RM,Tura S,Stirpe F

更新日期：1989-03-01 00:00:00

abstract：:The aim of this study was to evaluate the usefulness of serum osteocalcin (OC) levels in multiple myeloma (MM) in order to assess its significance and activity, and to predict its course. Serum OC was measurement in 117 patients with MM and 116 healthy controls matched for age and sex. Serum OC levels were weakly corr...

journal_title：European journal of haematology

authors： Mejjad O,Le Loët X,Basuyau JP,Ménard JF,Jego P,Grisot C,Daragon A,Grosbois B,Euller-Ziegler L,Monconduit M

更新日期：1996-01-01 00:00:00

abstract：:We tested the immunosuppressive effect of cord blood (CB) natural killer (NK) cells using highly purified CB NK cells in mixed lymphocyte cultures (MLC) containing autologous CB T cells as responders. Control cultures were done without NK cells. Our findings revealed that CB NK cells induced a dose-dependent inhibitio...

journal_title：European journal of haematology

authors： El Marsafy S,Dosquet C,Coudert MC,Bensussan A,Carosella E,Gluckman E

更新日期：2001-04-01 00:00:00

abstract：AIM:This review summarises the importance, recent progress and issues in measuring patient-reported outcomes (PROs) in haemophilia research. METHODS:A critical review of recent advances and trends in measuring haemophilia-related PROs was conducted, using current regulatory guidelines and methodological recommendation...

journal_title：European journal of haematology

authors： Pocoski J,Benjamin K,Michaels LA,Flood E,Sasane R

更新日期：2014-06-01 00:00:00