COVID-19 coagulopathy: An in-depth analysis of the coagulation system.

Abstract:

BACKGROUND:Abnormal coagulation parameters have been reported in COVID-19-infected patients. Although the underlying mechanism of COVID-19 coagulopathy remains unknown, it has been suggested to be a form of disseminated intravascular coagulation (DIC). OBJECTIVES:The aim of our study was to analyze the coagulation parameters of patients with COVID-19, determine whether coagulation factors consumption occurs and identify potential prognostic biomarkers of the disease. PATIENTS/METHODS:Blood samples from hospitalized patients with COVID-19 pneumonia were collected. We performed basic coagulation tests and quantification of coagulation factors and physiological inhibitor proteins. Laboratory data were compared with clinical data and outcomes. RESULTS:The study involved 206 patients (63.6% male). D-dimer was particularly elevated (median 450 ng/mL; IQR 222.5-957.3). Free protein S levels were below the normal range (median 56.6%; IQR: 43.6-68.9), and factor VIII showed an increasing trend (median 173.4%; IQR: 144.1-214.9). However, all coagulation factors were within normal limits. We found no correlation between abnormal coagulation parameters and thrombosis, except for higher D-dimer (HR 1.99; 95% CI 1.3-3.1; P = .002). CONCLUSIONS:COVID-19 is associated with coagulopathy that correlates with poor prognosis. However, we did not demonstrate a consumption of coagulation factors, as seen in DIC.

journal_name

Eur J Haematol

authors

Martín-Rojas RM,Pérez-Rus G,Delgado-Pinos VE,Domingo-González A,Regalado-Artamendi I,Alba-Urdiales N,Demelo-Rodríguez P,Monsalvo S,Rodríguez-Macías G,Ballesteros M,Osorio-Prendes S,Díez-Martín JL,Pascual Izquierdo C

doi

10.1111/ejh.13501

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

741-750

issue

6

eissn

0902-4441

issn

1600-0609

journal_volume

105

pub_type

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