Abstract:
BACKGROUND:Abnormal coagulation parameters have been reported in COVID-19-infected patients. Although the underlying mechanism of COVID-19 coagulopathy remains unknown, it has been suggested to be a form of disseminated intravascular coagulation (DIC). OBJECTIVES:The aim of our study was to analyze the coagulation parameters of patients with COVID-19, determine whether coagulation factors consumption occurs and identify potential prognostic biomarkers of the disease. PATIENTS/METHODS:Blood samples from hospitalized patients with COVID-19 pneumonia were collected. We performed basic coagulation tests and quantification of coagulation factors and physiological inhibitor proteins. Laboratory data were compared with clinical data and outcomes. RESULTS:The study involved 206 patients (63.6% male). D-dimer was particularly elevated (median 450 ng/mL; IQR 222.5-957.3). Free protein S levels were below the normal range (median 56.6%; IQR: 43.6-68.9), and factor VIII showed an increasing trend (median 173.4%; IQR: 144.1-214.9). However, all coagulation factors were within normal limits. We found no correlation between abnormal coagulation parameters and thrombosis, except for higher D-dimer (HR 1.99; 95% CI 1.3-3.1; P = .002). CONCLUSIONS:COVID-19 is associated with coagulopathy that correlates with poor prognosis. However, we did not demonstrate a consumption of coagulation factors, as seen in DIC.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Martín-Rojas RM,Pérez-Rus G,Delgado-Pinos VE,Domingo-González A,Regalado-Artamendi I,Alba-Urdiales N,Demelo-Rodríguez P,Monsalvo S,Rodríguez-Macías G,Ballesteros M,Osorio-Prendes S,Díez-Martín JL,Pascual Izquierdo Cdoi
10.1111/ejh.13501subject
Has Abstractpub_date
2020-12-01 00:00:00pages
741-750issue
6eissn
0902-4441issn
1600-0609journal_volume
105pub_type
杂志文章abstract::Skin necrosis caused by heparins is a rare complication. We report a case of a 71-yr-old white woman who developed painful diffuse skin lesions, most probably related to enoxaparin treatment. Other causes of skin necrosis, including heparin induced thrombocytopenia, disseminated intravascular coagulation, protein C/pr...
journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2006.00668.x
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abstract::Immune reconstitution may be delayed after CD34-selected compared with unmanipulated autologous peripheral blood stem cell transplantation (PBSCT), resulting in a theoretically increased risk of infections. In a case-control matched study we compared the incidence of infection in 25 recipients of CD34-selected PBSC (C...
journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.2005.00569.x
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abstract::Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3-ITD-positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. In this study, we retrospectively collected data on the off-label use of the tyrosine kinase inhi...
journal_title:European journal of haematology
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doi:10.1111/ejh.12647
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1993.tb00083.x
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2004.00362.x
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journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.2004.00374.x
更新日期:2005-02-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/ejh.13075
更新日期:2018-04-04 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1996.tb01397.x
更新日期:1996-11-01 00:00:00
abstract:INTRODUCTION:Tumor cells of primary cutaneous T-cell lymphomas are able to adopt a regulatory T-cell phenotype in vitro. The significance of this finding in vivo is matter of debate. METHODS:We stained five cases with transformed mycosis fungoides (MF) with an antibody against FOXP3, which is a sensitive and specific ...
journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.2006.00809.x
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journal_title:European journal of haematology
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doi:10.1034/j.1600-0609.2003.00024.x
更新日期:2003-03-01 00:00:00
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1998.tb01005.x
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journal_title:European journal of haematology
pub_type: 杂志文章,评审
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1994.tb00647.x
更新日期:1994-04-01 00:00:00
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journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.2009.01212.x
更新日期:2009-04-01 00:00:00
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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doi:10.1034/j.1600-0609.2003.00113.x
更新日期:2003-09-01 00:00:00
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0609.1992.tb01586.x
更新日期:1992-04-01 00:00:00
abstract::Cytomegalovirus (CMV) infection is one of the most common causes of morbidity and mortality after allogeneic marrow transplantation. We studied 14 consecutive CMV-seropositive patients adding ganciclovir (2.5 mg/kg i.v. every 8 hours for 7 days prior to transplant and 6 mg/kg three times a week after neutrophils becam...
journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:1991-11-01 00:00:00
abstract::Tissue factor (TF) production is under strict control in mature monocytic cells. However, constitutive expression of TF can be found in myelomonocytic cells and in haematopoietic cells arrested at an early stage of differentiation. In this paper we show that TF expression is down-regulated during the monocyte/granuloc...
journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1999.tb01124.x
更新日期:1999-08-01 00:00:00