Alkaline phosphatase-positive B cell lymphomas.

Abstract:

:Alkaline phosphatase (ALP) activity of 70 cases of non-Hodgkin's lymphomas of the B-cell type was studied. ALP activity was found in malignant lymphoma (ML), follicular, small cleaved cell (1/5 cases); ML, diffuse, small cleaved cell (3/13 cases); and mantle zone lymphoma (intermediate lymphocytic lymphoma) (2/2 cases). The ALP-positive neoplastic cells simultaneously displayed the characteristic immunophenotype of mantle zone (MZ) B lymphocytes of secondary follicle (SIg D+, BA-1+, IL-2R+ and Leu-1+). All other B-cell lymphomas, including ML, follicular, mixed small cleaved and large cell (9 cases); ML, follicular, large cell (4 cases); ML, mixed small and large cell (7 cases); ML, diffuse, large cell (27 cases); and ML, small noncleaved cell (3 cases), were consistently negative for ALP. The present study indicates that ALP-positive lymphomas including follicular lymphomas and diffuse lymphomas may be neoplastic counterparts of ALP-positive MZ B lymphocytes.

journal_name

Eur J Haematol

authors

Abe M,Nozawa Y,Wachi E,Tominaga K,Hojo H,Wakasa H

doi

10.1111/j.1600-0609.1988.tb01185.x

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

223-9

issue

3

eissn

0902-4441

issn

1600-0609

journal_volume

41

pub_type

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