Inhibitory effect of peak 2-4 of uremic middle molecules on platelet aggregation.

abstract：OBJECTIVES:Here, we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in cord blood (CB) CD34+ cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. METHODS:Human M-CSF was overexpressed in cord blood CD34+ cells using a lentiviral vector. RESULTS:We show that ...

journal_title：European journal of haematology

authors： Montano Almendras CP,Thudium CS,Löfvall H,Moscatelli I,Schambach A,Henriksen K,Richter J

更新日期：2017-05-01 00:00:00

abstract：:We have previously shown that basic fibroblast growth factor (bFGF) stimulates megakaryocytopoiesis and granulopoiesis in vitro and that normal haematopoietic cells and several leukaemic cell lines express FGF receptors. In this paper, we demonstrate by reverse transcriptase-mediated polymerase chain reaction (RT-PCR)...

journal_title：European journal of haematology

authors： Gu XF,Bikfalvi A,Chen YZ,Caen JP,Han ZC

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVES:In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30...

journal_title：European journal of haematology

authors： Mirre E,Brousse V,Berteloot L,Lambot-Juhan K,Verlhac S,Boulat C,Dumont MD,Lenoir G,de Montalembert M

更新日期：2010-03-01 00:00:00

abstract：:This study is designed to investigate whether apoptosis occurs in vivo in pediatric patients with acute leukemia during induction therapy. When patients with common acute lymphoblastic leukemia (cALL) and acute myeloblastic leukemia (AML) were treated with prednisolone (60 mg/m2/day, p.o. or i.v.) and etoposide (150 m...

journal_title：European journal of haematology

authors： Matsubara K,Kubota M,Adachi S,Kuwakado K,Hirota H,Wakazono Y,Akiyama Y,Mikawa H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von Willebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is know...

journal_title：European journal of haematology

authors： Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

更新日期：2013-08-01 00:00:00

abstract：:We tested the immunosuppressive effect of cord blood (CB) natural killer (NK) cells using highly purified CB NK cells in mixed lymphocyte cultures (MLC) containing autologous CB T cells as responders. Control cultures were done without NK cells. Our findings revealed that CB NK cells induced a dose-dependent inhibitio...

journal_title：European journal of haematology

authors： El Marsafy S,Dosquet C,Coudert MC,Bensussan A,Carosella E,Gluckman E

更新日期：2001-04-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism. It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL). Most studies on relation of MTHFR polymorphisms to ALL susceptibility have been in pediatric populat...

journal_title：European journal of haematology

authors： Lv L,Wu C,Sun H,Zhu S,Yang Y,Chen X,Fu H,Bao L

更新日期：2010-06-01 00:00:00

abstract：:The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic ris...

journal_title：European journal of haematology

authors： Purdy JC,Shatzel JJ

更新日期：2020-12-03 00:00:00

abstract：:From a retrospective multivariate study on 107 multiple myeloma (MM) patients, serum beta 2-microglobulin (beta 2M) proved to be the best prognostic discriminator, better than each of the currently used staging systems (Durie and Salmon's [DS], Merlini, Waldenström and Jayakar's [MWJ] and the British Medical Research ...

journal_title：European journal of haematology

authors： Gobbi PG,Bertoloni D,Grignani G,Pieresca C,Rossi A,Rutigliano L,Merlini G,Riccardi A,Ascari E

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:Diagnosing myeloid sarcoma remains challenging, and we aimed to provide clinicopathological features to facilitate diagnosis. METHOD:Clinicopathological data from 41 patients with de novo and 31 with secondary myeloid sarcoma were reviewed. RESULTS:Most de novo cases presented with isolated myeloid sarcoma ...

journal_title：European journal of haematology

authors： Claerhout H,Van Aelst S,Melis C,Tousseyn T,Gheysens O,Vandenberghe P,Dierickx D,Boeckx N

更新日期：2018-06-01 00:00:00

abstract：:The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...

journal_title：European journal of haematology

authors： Tuthill M,Crook T,Corbet T,King J,Webb A

更新日期：2009-04-01 00:00:00

abstract：:Whole blood from splenectomized subjects (n = 8) contained a substantial percentage of vacuolated ('pitted') red cells (34.7 +/- 8.3%), while blood from controls revealed none. The percentage of haemoglobin A1 (HbA1) had increased significantly compared with controls (p less than 0.01). Fractionation on cell density r...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:Cell cycle arrest by FOXO transcription factors involves in transcriptional activation of p27(kip1), although the exact mechanism remains unclear. And it has been evidenced that reduced level of p27(kip1) which is frequently occurred in human cancers has been associated with poor prognosis. In this study, our...

journal_title：European journal of haematology

authors： Zhao Y,Fei M,Wang Y,Lu M,Cheng C,Shen A

更新日期：2008-08-01 00:00:00

abstract：:Externalization of phosphatidylserine (PS) is thought to contribute to sickle cell disease (SCD) pathophysiology. The red blood cell (RBC) aminophospholipid translocase (APLT) mediates the transport of PS from the outer to the inner RBC membrane leaflet to maintain an asymmetric distribution of PL, while phospholipid ...

journal_title：European journal of haematology

authors： Barber LA,Palascak MB,Qi X,Joiner CH,Franco RS

更新日期：2015-11-01 00:00:00

abstract：:Treatment with recombinant erythropoietin (EPO) can alleviate anaemia in patients with myelodysplastic syndromes (MDS). The present study, based on a long-term follow-up of 68 MDS patients (26RA, 16 RAS, 26 RAEB) treated with EPO alone, pinpoints pre-treatment variables associated with response induction, response dur...

journal_title：European journal of haematology

authors： Wallvik J,Stenke L,Bernell P,Nordahl G,Hippe E,Hast R

更新日期：2002-03-01 00:00:00

abstract：:We evaluated the serum/plasma levels of cytokines [interleukin (IL)-6, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-beta2] and markers of coagulation, fibrinolysis, endothelial and platelet activation during the first 4 wk of treatment with the thalidomide analogue Actimid (CC-4047) in 1...

journal_title：European journal of haematology

authors： Streetly M,Hunt BJ,Parmar K,Jones R,Zeldis J,Schey S

更新日期：2005-04-01 00:00:00

abstract：:Administration of both glycosylated and non-glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) induces an immediate transient granulocytopenia of 1-3 hours' duration. In order to explore this phenomenon, granulocytes were labelled with 111Indium and the effect on the kinetics of...

journal_title：European journal of haematology

authors： Hovgaard D,Schifter S,Rabøl A,Mortensen BT,Nissen NI

更新日期：1992-04-01 00:00:00

abstract：:In recent years, several direct-acting oral anticoagulants (DOAC) have become available for use in Europe and other regions in indications related to prophylaxis and treatment of venous and arterial thromboembolism. They include the oral direct thrombin inhibitor dabigatran etexilate (Pradaxa, Boehringer Ingelheim) an...

journal_title：European journal of haematology

authors： Gómez-Outes A,Suárez-Gea ML,Lecumberri R,Terleira-Fernández AI,Vargas-Castrillón E

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to determine the impact of socioeconomic status on relapse-free survival (RFS) in patients with Hodgkin's disease. METHODS:A number of factors were analyzed for their impact on relapse-free and overall survival in Hodgkin's disease using Cox regression. These factors included socioe...

journal_title：European journal of haematology

authors： Holzner B,Fischhofer M,Kemmler G,Kopp M,Sperner-Unterweger B,Krugmann J,Dirnhofer S,Greil R

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To assess the outcome of the measurement of apoptotic index in myeloma patients treated by conventional chemotherapy and novel drugs with biological mechanism of action, thalidomide and bortezomib. PATIENTS AND METHODS:In a cohort of 189 patients with newly diagnosed multiple myeloma from November 1997 throu...

journal_title：European journal of haematology

authors： Minarik J,Scudla V,Ordeltova M,Bacovsky J,Pika T,Langova K

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Homoharringtonine (HHT) was efficient in therapying patients with acute myeloid leukemia (AML) in China, but little is known about the mechanism of its action. As the abnormal activation of JAK2 associated pathway is important to AML, we try to explore the effect of HHT on JAK2-STAT pathway in AML cells, thu...

journal_title：European journal of haematology

authors： Tong H,Ren Y,Zhang F,Jin J

更新日期：2008-10-01 00:00:00

abstract：:Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the co...

journal_title：European journal of haematology

authors： Tsutsumi Y,Tanaka J,Kanamori H,Musashi M,Minami H,Fukushima A,Yamato H,Ehira N,Kawamura T,Obara S,Ogura N,Asaka M,Imamura M,Masauzi N

更新日期：2004-12-01 00:00:00

abstract：:Immune reconstitution may be delayed after CD34-selected compared with unmanipulated autologous peripheral blood stem cell transplantation (PBSCT), resulting in a theoretically increased risk of infections. In a case-control matched study we compared the incidence of infection in 25 recipients of CD34-selected PBSC (C...

journal_title：European journal of haematology

authors： Frère P,Pereira M,Fillet G,Beguin Y

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Patients with hematologic malignancies are at substantial risk of developing invasive fungal infections (IFI) that are associated with substantial morbidity and mortality. This article reviews the epidemiology, risk factors, and efficacy of antifungal prophylaxis in patients with hematologic malignancies. ME...

journal_title：European journal of haematology

authors： Maertens J

更新日期：2007-04-01 00:00:00

abstract：:Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...

journal_title：European journal of haematology

authors： Brähler S,Thielen I,Schwabe H,Engels M,Kreuzer KA,Wolf J,Ansén S

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To correlate different polymorphisms of the beta-globin cluster with fetal hemoglobin (HbF) level in beta-thalassemia and E-beta thalassemia patients. METHODS:Fifteen thalassemia patients, seven with high HbF and not requiring transfusion, eight with lower HbF and requiring transfusion were studied for beta-...

journal_title：European journal of haematology

authors： Bandyopadhyay S,Mondal BC,Sarkar P,Chandra S,Das MK,Dasgupta UB

更新日期：2005-07-01 00:00:00

abstract：AIMS:Platelets retain cytoplasmic messenger RNA and are capable of protein biosynthesis. Several diseases are known to impact the platelet transcriptome but the effect of non-valvular atrial fibrillation (NVAF) on platelet RNA transcript is essentially unknown. The aim of this study was to evaluate the impact of NVAF o...

journal_title：European journal of haematology

authors： Wysokinski WE,Tafur A,Ammash N,Asirvatham SJ,Wu Y,Gosk-Bierska I,Grill DE,Slusser JP,Mruk J,McBane RD

更新日期：2017-06-01 00:00:00

abstract：:We investigated whether depressed plasma antithrombin and protein C activity, considered as a specific finding of disseminated intravascular coagulation (DIC), is due to consumption coagulopathy in septic patients with DIC. An analysis of hemostatic parameters was performed in 139 septic patients (68 with DIC and 71 w...

journal_title：European journal of haematology

authors： Asakura H,Ontachi Y,Mizutani T,Kato M,Ito T,Saito M,Morishita E,Yamazaki M,Aoshima K,Takami A,Yoshida T,Suga Y,Miyamoto K,Nakao S

更新日期：2001-09-01 00:00:00

abstract：:The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

journal_title：European journal of haematology

authors： Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

更新日期：2015-06-01 00:00:00