Is higher income and educational status associated with poorer outcome in patients with Hodgkin's disease?


OBJECTIVES:The aim of the study was to determine the impact of socioeconomic status on relapse-free survival (RFS) in patients with Hodgkin's disease. METHODS:A number of factors were analyzed for their impact on relapse-free and overall survival in Hodgkin's disease using Cox regression. These factors included socioeconomic status (as defined by education and income), different treatment modalities and established clinical risk factors [e.g. age at diagnosis, stage of disease, involvement of three or more lymph nodes, presence or absence of a large mediastinal mass, E stages or elevation of erythrocyte sedimentation rate (ESR)]. The study used an initial sample of 126 patients recruited between 1969 and 1995 and a larger sample of 218 patients (recruited until 2002). Clinical data on disease and treatment characteristics were collected from medical records. RESULTS:In a univariate analysis, the following parameters had impact on RFS: treatment modality (combined treatment resulted in an improved RFS compared with patients treated with chemo- or radiotherapy alone), educational status and income. The 5- and 10-yr relapse-free survival rates were found to increase with decreasing educational level and decreasing average income per month. These results were significant in the initial and total samples and were also significant using multivariate analysis (hazard ratio for highest vs. lowest education group: 5.88; 95% confidence interval 1.87-18.52; for highest vs. lowest income group: 4.36; 95% confidence interval 1.35-14.05). CONCLUSION:Hodgkin's disease appears to be a striking exception from the usual positive correlation between high socioeconomic status and favorable treatment outcome in patients suffering from tumor. It is suggested that future studies on tumor genetics and biology and more detailed analysis of further socioeconomic parameters may be useful in clarifying this observation.


Eur J Haematol


Holzner B,Fischhofer M,Kemmler G,Kopp M,Sperner-Unterweger B,Krugmann J,Dirnhofer S,Greil R




Has Abstract


2004-11-01 00:00:00














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    authors: Pornprasert S,Sukunthamala K

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    abstract::We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried...

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    authors: Ciaudo M,Doco-Lecompte T,Guettier C,d'Agay MF,David F,Rioual N,Buu-Hoi A,Molina JM,Kazatchkine M,Modai J

    更新日期:1994-09-01 00:00:00

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    abstract::Neonatal alloimmune thrombocytopenia (NAIT) occurs because of transplacentally acquired maternal platelet alloantibodies. Most of the alloantibodies are against human platelet antigens, but the alloantibody against CD36 is rare. A full-term female baby was delivered by a mother who experienced two spontaneous abortion...

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    authors: Taketani T,Ito K,Mishima S,Kanai R,Uchiyama A,Hirata Y,Kumakura S,Ishikura H,Yamaguchi S

    更新日期:2008-07-01 00:00:00

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    abstract::We report a case of T-cell hairy-cell leukemia with a dual rearrangement of Ig- and T-cell receptor genes. The cytochemical, transmission electron microscopy, and surface antigens data (CD3+, CD8+, CD11+, HLA-DR+, CD19-, CD20-) were consistent with a T-cell hairy-cell leukemia. Molecular analysis according to Southern...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Palumbo AP,Corradini P,Battaglio S,Omedè P,Coda R,Boccadoro M,Pileri A

    更新日期:1991-02-01 00:00:00

  • Treatment of consecutive patients with chronic myeloid leukaemia in the cooperating centres from the Czech Republic and the whole of Slovakia after 2000--a report from the population-based CAMELIA Registry.

    abstract:BACKGROUND:Most results on the treatment of chronic myeloid leukaemia (CML) with imatinib were obtained from clinical trials that may differ from the routine practice. We report the results of treatment of consecutive patients with CML at ten major centres during 2000-2008. PATIENTS AND METHODS:Data reporting was retr...

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    pub_type: 杂志文章,多中心研究


    authors: Faber E,Mužík J,Koza V,Demečková E,Voglová J,Demitrovičová L,Chudej J,Markuljak I,Cmunt E,Kozák T,Tóthová E,Jarošová M,Dušek L,Indrák K

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    abstract:INTRODUCTION:Tumor cells of primary cutaneous T-cell lymphomas are able to adopt a regulatory T-cell phenotype in vitro. The significance of this finding in vivo is matter of debate. METHODS:We stained five cases with transformed mycosis fungoides (MF) with an antibody against FOXP3, which is a sensitive and specific ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Hallermann C,Niermann C,Schulze HJ

    更新日期:2007-03-01 00:00:00

  • Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-beta1 by bone marrow stromal cells.

    abstract::Previous studies in our laboratory have shown that patients with chronic idiopathic neutropenia of adults (CINA) have increased serum levels of inflammatory cytokines including IL-1beta. Since IL-1beta may affect bone marrow stromal cell function, a study was designed to investigate the capacity of patients' stromal c...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Papadaki HA,Giouremou K,Eliopoulos GD

    更新日期:1999-09-01 00:00:00

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    abstract::It is well-documented that iron chelation by desferrioxamine protects/improves the cardiac function in blood transfusion-dependent children suffering from beta-thalassaemia. In patients who do not become dependent upon blood transfusion until adulthood (ANT-patients), iron chelation by desferrioxamine may affect the c...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Jensen PD,Olsen N,Bagger JP,Jensen FT,Christensen T,Ellegaard J

    更新日期:1997-10-01 00:00:00

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    abstract::Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of malignant lymphomas, which lacks well-defined diagnostic and therapeutic protocols. OBJECTIVES:To describe PPL clinical, diagnostic and histological characteristics, together with therapy and outcome, in a relatively large series of patients. M...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Facchinelli D,Sina S,Boninsegna E,Borin A,Tisi MC,Piazza F,Scapinello G,Maiolo E,Hohaus S,Zamò A,Merli M,Stefani PM,Mellone F,Basso M,Sartori R,Rusconi C,Parisi A,Manfrin E,Krampera M,Ruggeri M,Visco C,Tecchio C

    更新日期:2020-10-01 00:00:00

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    authors: Betts DR,Ammann RA,Hirt A,Hengartner H,Beck-Popovic M,Kuhne T,Nobile L,Caflisch U,Wacker P,Niggli FK

    更新日期:2007-06-01 00:00:00

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    authors: Willander K,Ungerbäck J,Karlsson K,Fredrikson M,Söderkvist P,Linderholm M

    更新日期:2010-09-01 00:00:00

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    authors: Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

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    pub_type: 杂志文章,多中心研究


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    更新日期:2016-06-01 00:00:00

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    authors: Schanz J,Haase D,Steuernagel P,Shirneshan K,Bäsecke J

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    authors: Lv L,Wu C,Sun H,Zhu S,Yang Y,Chen X,Fu H,Bao L

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    pub_type: 杂志文章


    authors: Fabris F,Cordiano I,Steffan A,Ramon R,Scandellari R,Nichol JL,Girolami A

    更新日期:2000-03-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Devalet B,Mullier F,Chatelain B,Dogné JM,Chatelain C

    更新日期:2015-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Palés JL,López A,Asensio A,Merola E,Company X,Deulofeu R,Garcia M,Balagué A

    更新日期:1987-09-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Bourantas KL,Tsiara S,Christou L

    更新日期:1995-10-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Schulman A,Connors LH,Weinberg J,Mendelson LM,Joshi T,Shelton AC,Sanchorawala V

    更新日期:2020-10-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Gjaerde LK,Ostrowski SR,Minculescu L,Andersen NS,Friis LS,Kornblit B,Petersen SL,Schjødt I,Sengeløv H

    更新日期:2020-12-12 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Knudsen E,Benestad HB,Seierstad T,Iversen PO

    更新日期:2004-08-01 00:00:00

  • High levels of serum prostate-specific antigen due to PSA producing follicular non-Hodgkin's lymphoma.

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Oosterheert JJ,Budel LM,Vos P,Wittebol S

    更新日期:2007-08-01 00:00:00

  • Long-term haemopoietic injury in mice after repeated irradiation: precursor-cell cycling and its regulation.

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Tejero C,Lord BI,Mason TM,Hendry JH

    更新日期:1988-09-01 00:00:00

  • Discrepant ratios of arterial vs. venous thrombosis in hemophilias A and B as compared to FVII deficiency.

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

    更新日期:2013-08-01 00:00:00