Bone marrow biopsy in Hodgkin's lymphoma.

abstract：:Skeletal morbidity is a major problem in multiple myeloma. Histomorphometric studies have demonstrated that increased bone resorption can be present even in the absence of radiographic abnormalities. To overcome diagnostic problems in estimating the activity of bone resorption, new laboratory parameters that reflect b...

journal_title：European journal of haematology

authors： Jakob C,Zavrski I,Heider U,Brux B,Eucker J,Langelotz C,Sinha P,Possinger K,Sezer O

更新日期：2002-07-01 00:00:00

abstract：:It has been reported that in vitro prednisolone (PDN) resistance provides a prognostic value in childhood acute lymphoblastic leukaemia (ALL). This study aimed at investigating the biological and clinical significance of in vitro PDN resistance in adult ALL. Blast cells from 30 patients were exposed to PDN (0.1 microM...

journal_title：European journal of haematology

authors： Tosi P,Visani G,Ottaviani E,Manfroi S,Tura S

更新日期：1996-08-01 00:00:00

abstract：:The effect of human recombinant interferon alpha 2 (IFN alpha 2) on hairy cells obtained from 16 patients was evaluated. All patients promptly responded to induction of remission with 2 X 10(6) U/m2 interferon alpha 2 b, three times a week, sc. In order to achieve a more detailed insight into the mode of action of int...

journal_title：European journal of haematology

authors： Schwarzmeier JD,Schwabe M,Prischl F,Wagner L,Lion T,Micksche M,Köller U

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To correlate the clinical and hematological features of β-globin gene haplotypes with the oxidative stress status in pediatric patients with sickle cell disease (SCD). METHODS:A total of 95 patients with SCD and 40 healthy children were studied. The β-globin cluster, plasma lipid peroxidation (LPO) and plasm...

journal_title：European journal of haematology

authors： Rusanova I,Escames G,Cossio G,de Borace RG,Moreno B,Chahboune M,López LC,Díez T,Acuña-Castroviejo D

更新日期：2010-12-01 00:00:00

abstract：:A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis in whole blood, and avoidance of in vitro artefacts rela...

journal_title：European journal of haematology

authors： Li N,Halldén G,Hjemdahl P

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30...

journal_title：European journal of haematology

authors： Mirre E,Brousse V,Berteloot L,Lambot-Juhan K,Verlhac S,Boulat C,Dumont MD,Lenoir G,de Montalembert M

更新日期：2010-03-01 00:00:00

abstract：:506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic nodal tumour burden, ...

journal_title：European journal of haematology

authors： Specht L,Nissen NI

更新日期：1989-08-01 00:00:00

abstract：:GM-CSF may induce pulmonary complications, such as dyspnea with temporary decreases in oxygen saturation described as first dose effect for higher dosages of intravenous rhGM-CSF. This study investigated possible pulmonary disturbances in adult de novo AML patients receiving yeast rhGM-CSF 24 h prior to chemotherapy u...

journal_title：European journal of haematology

authors： Zühlsdorf M,von Eiff M,Thomas M,Büchner T

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVES:As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. METHODS:We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 an...

journal_title：European journal of haematology

authors： Lennmyr E,Karlsson K,Ahlberg L,Garelius H,Hulegårdh E,Izarra AS,Joelsson J,Kozlowski P,Moicean A,Tomaszewska-Toporska B,Lübking A,Hallböök H,Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL).

更新日期：2019-08-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：:Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. OBJECTIVES:To report outcomes and AEs in a population-b...

journal_title：European journal of haematology

authors： Aarup K,Rotbain EC,Enggaard L,Pedersen RS,Bergmann OJ,Thomsen RH,Frederiksen M,Frederiksen H,Nielsen T,Christiansen I,Andersen MA,Niemann CU

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:Homoharringtonine (HHT) was efficient in therapying patients with acute myeloid leukemia (AML) in China, but little is known about the mechanism of its action. As the abnormal activation of JAK2 associated pathway is important to AML, we try to explore the effect of HHT on JAK2-STAT pathway in AML cells, thu...

journal_title：European journal of haematology

authors： Tong H,Ren Y,Zhang F,Jin J

更新日期：2008-10-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism. It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL). Most studies on relation of MTHFR polymorphisms to ALL susceptibility have been in pediatric populat...

journal_title：European journal of haematology

authors： Lv L,Wu C,Sun H,Zhu S,Yang Y,Chen X,Fu H,Bao L

更新日期：2010-06-01 00:00:00

abstract：:Physiological mechanisms that regulate formation of neutrophil granulocytes, macrophages and their precursor cells were studied with the diffusion chamber (DC) technique. DC inoculated with mouse bone marrow cells were implanted intraperitoneally into host mice. When these in vivo cultures had been established and the...

journal_title：European journal of haematology

authors： Benestad HB,Løvhaug D,Strøm-Gundersen I

更新日期：1989-01-01 00:00:00

abstract：:Between December, 1984, and May, 1986, 98 CSF samples were sent to a central laboratory by postal express. The samples could be kept in a medium for up to 24 hours after the lumbar puncture. The quality of the cells proved to be good. Excluded were 5 samples delayed in delivery and 13 samples contaminated with blood, ...

journal_title：European journal of haematology

authors： van Wering ER,Veerman AJ,van der Linden-Schrever BE

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Wnt signaling induces a plethora of intracellular responses that dictate normal or abnormal cellular behavior. Abnormal WNT signaling has been related to the development of leukemogenic processes. In this regard, it is important to know the expression profile of WNT receptors in normal and malignant cells, i...

journal_title：European journal of haematology

authors： Alvarez-Zavala M,Riveros-Magaña AR,García-Castro B,Barrera-Chairez E,Rubio-Jurado B,Garcés-Ruíz OM,Ramos-Solano M,Aguilar-Lemarroy A,Jave-Suarez LF

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The clinical severity in thalassaemia major (TM) depends on the underlying mutations of the beta-globin gene and the degree of iron overload. OBJECTIVE:The aim of the study was to investigate the impact of genotype on the development of endocrine complications in TM in our center. SUBJECTS AND METHODS:126 ...

journal_title：European journal of haematology

authors： Skordis N,Michaelidou M,Savva SC,Ioannou Y,Rousounides A,Kleanthous M,Skordos G,Christou S

更新日期：2006-08-01 00:00:00

abstract：:Iron is an important mineral element required for diverse life processes. Its metabolism is almost synonymous to erythrocyte maintenance, erythropoiesis and erythrophagocytosis. Consequently, exercise exertion impacts significantly on red cell haematology. Here, the interactions between exercise and erythropoiesis are...

journal_title：European journal of haematology

authors： Latunde-Dada GO

更新日期：2013-01-01 00:00:00

abstract：:Bcl-2 expression, the number of apoptotic cells and the growth and differentiation of early bone marrow progenitor cells were studied in patients with confirmed diagnosis of acute myeloid leukaemia (AML). Bone marrow cells from normal individuals were used as controls. We observed an increased percentage of bcl-2-mono...

journal_title：European journal of haematology

authors： Bincoletto C,Saad ST,da Silva ES,Queiroz ML

更新日期：1999-01-01 00:00:00

abstract：:The introduction of novel immunomodulatory drugs (IMiDs) has dramatically improved the survival of patients with multiple myeloma (MM). While it has been shown that patients with specific cytogenetic subtypes, namely t(4;14), have the best outcomes when treated with bortezomib-based regimens, the relationship between ...

journal_title：European journal of haematology

authors： Greenberg AJ,Walters DK,Kumar SK,Rajkumar SV,Jelinek DF

更新日期：2013-12-01 00:00:00

abstract：:In this study, Escherichia coli LPS dose-dependently (100-500 microg/ml) and time-dependently (10-60 min) inhibited platelet aggregation in human and rabbit platelets stimulated by agonists. LPS also dose-dependently inhibited the intracellular Ca2+ mobilization in human platelets stimulated by collagen. In addition, ...

journal_title：European journal of haematology

authors： Sheu JR,Hung WC,Su CH,Lin CH,Lee LW,Lee YM,Yen MH

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:Myeloma bone disease is a result of excessive osteoclast activation and impaired osteoblast function. Recent in vitro studies suggested that proteasome inhibitors might increase osteoblast function. METHODS:We analyzed serum markers of osteoblast activity in 25 patients with multiple myeloma receiving borte...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Müller C,Jakob C,Zavrski I,Schulz CO,Fleissner C,Hecht M,Sezer O

更新日期：2006-09-01 00:00:00

abstract：:In 51 patients with primary myelofibrosis the initial bone marrow biopsy findings were evaluated by morphometric methods, correlated with the patients' main clinical and haematologic data and analysed for prognostic significance. The high variability of the marrow features was the most striking finding of the morpholo...

journal_title：European journal of haematology

authors： Pereira A,Cervantes F,Brugues R,Rozman C

更新日期：1990-02-01 00:00:00

abstract：:The aim of the present study was to determine whether angelicin is able to increase the expression of gamma-globin genes in human erythroid cells. Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for their antiproliferative activity in treatment of different skin dis...

journal_title：European journal of haematology

authors： Lampronti I,Bianchi N,Borgatti M,Fibach E,Prus E,Gambari R

更新日期：2003-09-01 00:00:00

abstract：:Oxidative damage to erythrocytes in thalassaemia has been related to generation of free radicals by an excess of denaturated alpha- or beta-globin chains, intracellular iron overload and low concentration of normal haemoglobin (HGB). Two good indicators of such oxidative damage are the high red blood cell (RBC) malony...

journal_title：European journal of haematology

authors： Vives Corrons JL,Miguel-García A,Pujades MA,Miguel-Sosa A,Cambiazzo S,Linares M,Dibarrart MT,Calvo MA

更新日期：1995-11-01 00:00:00

abstract：:Haemoglobin (Hb) Hope [beta136(H14)Gly-->Asp(GGT-->GAT)] is one of the unstable haemoglobin variants of the beta-globin chain, which is demonstrated in people of various ethnic backgrounds. Here we report a Thai female patient with clinical thalassaemia intermedia since childhood. This patient had experienced neither ...

journal_title：European journal of haematology

authors： Sura T,Busabaratana M,Youngcharoen S,Wisedpanichkij R,Viprakasit V,Trachoo O

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:In patients with essential thrombocythemia (ET), vascular complications contribute to both morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score of thrombosis for ET (IPSET-thrombosis) was recently developed. We hereby presented an external validati...

journal_title：European journal of haematology

authors： Fu R,Xuan M,Lv C,Zhang L,Li H,Zhang X,Zhang D,Sun T,Xue F,Liu X,Liang H,Zhang L,Yang R

更新日期：2014-06-01 00:00:00

abstract：:Whole blood from splenectomized subjects (n = 8) contained a substantial percentage of vacuolated ('pitted') red cells (34.7 +/- 8.3%), while blood from controls revealed none. The percentage of haemoglobin A1 (HbA1) had increased significantly compared with controls (p less than 0.01). Fractionation on cell density r...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:MicroRNAs engaged in angiogenesis and hematopoiesis can influence hematopoietic stem cells (HSCs) homing after transplantation by targeting bone marrow niche microenvironment. This study aimed to examine the kinetics of miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 in autologous HSC transplantatio...

journal_title：European journal of haematology

authors： Nowicki M,Szemraj J,Wierzbowska A,Misiewicz M,Małachowski R,Pluta A,Grzybowska-Izydorczyk O,Robak T,Szmigielska-Kapłon A

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...

journal_title：European journal of haematology

authors： Kalpoe JS,van der Heiden PL,Barge RM,Houtzager S,Lankester AC,van Tol MJ,Kroes AC

更新日期：2007-04-01 00:00:00