Discrepant ratios of arterial vs. venous thrombosis in hemophilias A and B as compared to FVII deficiency.

abstract：:In an attempt to improve treatment outcome high-dose methylprednisolone (HDMP, 20-30 mg/kg, once a day orally) was used instead of a conventional dose of steroid (2 mg/kg/d, in 3 divided doses) in children with acute lymphoblastic leukemia (ALL) with increased risk factors. HDMP combined with cytotoxic agents (vincris...

journal_title：European journal of haematology

authors： Hiçsönmez G,Gümrük F,Zamani PV,Tuncer MA,Yetgin S,Gürgey A,Atahan L,Ozsoylu S

更新日期：1997-01-01 00:00:00

abstract：:Many cost analyses of stem-cell transplantations are available, which is in sharp contrast to the level of cost analyses on first-line chemotherapy for aggressive non-Hodgkin's lymphoma (NHL). Given the scarcity of cost analyses of first-line chemotherapy for NHL, it is difficult to assess the economic impact of upcom...

journal_title：European journal of haematology

authors： van Agthoven M,Faber LM,Uyl-de Groot CA,Sonneveld P,Verdonck LF,Willemze R,Kluin-Nelemans JC,Löwenberg B,Huijgens PC

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION/OBJECTIVES:Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74/100 000 men and 1.37/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of...

journal_title：European journal of haematology

authors： Silla L,Dulley F,Saboya R,Kerbauy F,de Moraes Arantes A,Pezzi A,Gross LG,Paton E,Hamerschlak N

更新日期：2017-02-01 00:00:00

abstract：:Our aim was to assess liver iron content, in thalassaemic patients, by using three different MR protocols and compare their data. Ninety-four thalassaemic patients (44 M and 50 F, mean age 25.82 +/- 8.3 yrs), were enrolled in the study. In each patient, three measurements of the liver iron content were performed, with...

journal_title：European journal of haematology

authors： Christoforidis A,Perifanis V,Spanos G,Vlachaki E,Economou M,Tsatra I,Athanassiou-Metaxa M

更新日期：2009-05-01 00:00:00

abstract：:Older patients with haemophilia (PWH) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing. This article discusses the clinical experience published about the high prevalence of diseases in older PWH. These conditions are managed in the general population by hea...

journal_title：European journal of haematology

authors： Canaro M,Goranova-Marinova V,Berntorp E

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently lin...

journal_title：European journal of haematology

authors： Koren-Michowitz M,Eting E,Rahimi-Levene N,Garach-Jehoshua O,Volcheck Y,Kornberg A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Limited progress had been made in prognostic stratification of patients with Hodgkin lymphoma (HL) until recent studies suggested that the number of CD68-expressing macrophages is prognostic in classical HL. However, its significance in Asian patients with HL has not been explored yet perhaps because of its ...

journal_title：European journal of haematology

authors： Yoon DH,Koh YW,Kang HJ,Kim S,Park CS,Lee SW,Suh C,Huh J

更新日期：2012-04-01 00:00:00

abstract：:Host-derived Langerhans cells (LCs) are crucial antigen-presenting cells that cause graft-vs.-host disease after allogeneic haematopoietic stem cell transplantation (HSCT). However, chimaerism of LCs after allogeneic HSCT is largely unknown in humans. We here report a case that developed dermatopathic lymphadenitis ac...

journal_title：European journal of haematology

authors： Ikeda K,Shichishima T,Teshima T,Ogawa K,Nakamura-Shichishima A,Tajima H,Noji H,Hashimoto Y,Takeyama K,Ishibashi T,Ohto H,Abe M,Maruyama Y

更新日期：2006-03-01 00:00:00

abstract：:Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematolo...

journal_title：European journal of haematology

authors： Halfdanarson TR,Kumar N,Li CY,Phyliky RL,Hogan WJ

更新日期：2008-06-01 00:00:00

abstract：:A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis in whole blood, and avoidance of in vitro artefacts rela...

journal_title：European journal of haematology

authors： Li N,Halldén G,Hjemdahl P

更新日期：2000-07-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：:Cells from 3 patients with B-chronic lymphocytic leukaemia (B-CLL) and 1 with B-prolymphocytic leukaemia (B-PLL) were treated in vitro with the phorbol ester 12-0-tetradecanoylphorbol (TPA), the calcium ionophore A23187, or a combination of TPA and A23187. TPA induced the cells to adhere to the culture flask or to clu...

journal_title：European journal of haematology

authors： Drexler HG,Brenner MK,Gignac SM,Hoffbrand AV

更新日期：1988-09-01 00:00:00

abstract：:Central nervous system (CNS) involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages with lymph node or visceral involvement. We describe a patient with advanced stage MF in large-cell transformation who presented with profound hearing loss after chemotherapy. Despite an initial differenti...

journal_title：European journal of haematology

authors： Chua SL,Seymour JF,Prince HM

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Although there are two major scoring systems for the clinical diagnosis of disseminated intravascular coagulation (DIC), the validity of these systems for leukemia-associated DIC remains to be confirmed. METHODS:By analyzing 125 newly diagnosed acute leukemia patients, we investigated clinical and laborator...

journal_title：European journal of haematology

authors： Yanada M,Matsushita T,Suzuki M,Kiyoi H,Yamamoto K,Kinoshita T,Kojima T,Saito H,Naoe T

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Patients with hematologic malignancies are at substantial risk of developing invasive fungal infections (IFI) that are associated with substantial morbidity and mortality. This article reviews the epidemiology, risk factors, and efficacy of antifungal prophylaxis in patients with hematologic malignancies. ME...

journal_title：European journal of haematology

authors： Maertens J

更新日期：2007-04-01 00:00:00

abstract：:The cycling rate of haemopoietic stem cells (day 9 CFU-S) and granulocyte-macrophage colony forming cells (GM-CFC) in mouse femora was, in response to reduced numbers, elevated at all times of sampling between 3 weeks and 10 months after 4 repeated doses of 4.5 Gy X-rays (3 wk between doses). The level of a stimulator...

journal_title：European journal of haematology

authors： Tejero C,Lord BI,Mason TM,Hendry JH

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVES:Pulmonary hypertension (PH) is commonly reported in Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). PH may be diagnosed directly by right heart catheterization (RHC) or estimated by transthoracic ec...

journal_title：European journal of haematology

authors： Ferrari A,Scandura J,Masciulli A,Krichevsky S,Gavazzi A,Barbui T

更新日期：2021-02-01 00:00:00

abstract：:Cellular accumulation of vincristine (VCR) and doxorubicin (DOX) was studied in 15 patients with low-grade B-cell malignancies. Their leukemic lymphocytes were isolated and the effect of verapamil on drug uptake was studied. The immunophenotype was characterized using anti-IgM, -IgD, -B 1, monoclonal antibodies. The m...

journal_title：European journal of haematology

authors： Reizenstein P,Kapoor R,Gruber A,Peterson C

更新日期：1989-11-01 00:00:00

abstract：:Using a multiparameter flow cytometry assay enumerating cells positive for CD13, CD14 and CD66 antigens, we determined the asynchronous CD14/CD66 co-expression in unselected bone marrow and peripheral blood samples with suspected malignant blood disorders. CD14/CD66 co-expression > or = 5% were found in 131/691 bone m...

journal_title：European journal of haematology

authors： Hansen I,Meyer K,Hokland P

更新日期：1998-11-01 00:00:00

abstract：:Tissue factor (TF) production is under strict control in mature monocytic cells. However, constitutive expression of TF can be found in myelomonocytic cells and in haematopoietic cells arrested at an early stage of differentiation. In this paper we show that TF expression is down-regulated during the monocyte/granuloc...

journal_title：European journal of haematology

authors： Tenno T,Oberg F,Nilsson K,Siegbahn A

更新日期：1999-08-01 00:00:00

abstract：:Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, CD33, HLA-DR) were studied in 53 cases of acute myeloid leukemia...

journal_title：European journal of haematology

authors： Misery L,Campos L,Dezutter-Dambuyant C,Guyotat D,Treille D,Schmitt D,Thivolet J

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To determine the sensitivity and specificity of single-tube osmotic fragility (SOFT) and its different methods as screening test for thalassemia trait. METHODS:A cross-sectional study was conducted at Omair Sana Foundation. A total of 400 participants were included in the study. Three hundred were known thal...

journal_title：European journal of haematology

authors： Ansari SH,Hanifa A,Saleem A,Ali SM,Hussain Z,Zohaib M,Akbar M,Rehman S,Hussain SR

更新日期：2014-12-01 00:00:00

abstract：:We have demonstrated that the intracellular processing of transferrin to effect iron removal involves two pathways, one sensitive to rotenone and the other not. We have also found that the effect of the rotenone is dependent on the transferrin concentration: iron uptake was suppressed with concentrations of transferri...

journal_title：European journal of haematology

authors： Zhan H,Pollack S,Weaver J

更新日期：1990-07-01 00:00:00

abstract：UNLABELLED:Protein C (PC) deficiency is an autosomal dominant inherited disorder associated with spontaneous and recurrent thrombotic events. Factor V Leiden (FVL) increases the risk of thrombosis in PC-deficient type I families. We have investigated the relationship between PC deficiency genotype and clinical phenotyp...

journal_title：European journal of haematology

authors： Cafolla A,D'Andrea G,Baldacci E,Margaglione M,Mazzucconi MG,Foà R

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Outcome of patients with standard-risk (SR) multiple myeloma (MM) has improved; however, subsets of patients do worse than expected. We sought to identify the factors associated with inferior outcome. METHODS:We evaluated 51 patients with SR MM that received upfront autologous hematopoietic stem cell tran...

journal_title：European journal of haematology

authors： Badar T,Srour S,Bashir Q,Shah N,Al-Atrash G,Hosing C,Popat U,Nieto Y,Orlowski RZ,Champlin R,Qazilbash MH

更新日期：2017-03-01 00:00:00

abstract：:In addition to BCR, various rare fusion partners for the ABL1 gene have been reported in leukemia. We have identified the fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient. Cytogenetic analysis detected this fusion gene ari...

journal_title：European journal of haematology

authors： Masuzawa A,Kiyotani C,Osumi T,Shioda Y,Iijima K,Tomita O,Nakabayashi K,Oboki K,Yasuda K,Sakamoto H,Ichikawa H,Hata K,Yoshida T,Matsumoto K,Kiyokawa N,Mori T

更新日期：2014-03-01 00:00:00

abstract：:Eighteen patients with malignant lymphoma, 10 non-Hodgkin's and 8 Hodgkin's, were treated with high-dose CVB (cyclophosphamide 4 x 1.5 g/m2, etoposide 4 x 250-400 mg/m2, carmustine 4 x 150-200 mg/m2), followed by autologous peripheral blood stem cells (PBSC, 13 patients) or bone marrow (BM, 5 patients) transplantation...

journal_title：European journal of haematology

authors： Patti C,Majolino I,Scimè R,Indovina A,Vasta S,Liberti G,Gentile S,Santoro A,Pisa R,Caronia F

更新日期：1993-07-01 00:00:00

abstract：INTRODUCTION:Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (T...

journal_title：European journal of haematology

authors： Zhang Z,Li X,Guo J,Xu F,He Q,Zhao Y,Yang Y,Gu S,Zhang Y,Wu L,Chang C

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Constitutive activation of STAT5 (by phosphorylation) has been identified in a number of malignancies, including acute myeloid leukemia (AML). OBJECTIVES:We investigated whether the level of phosphorylated STAT5 (pSTAT5) expression correlates with clinical outcome in AML. METHODS:Adult patients with newly ...

journal_title：European journal of haematology

authors： Brady A,Gibson S,Rybicki L,Hsi E,Saunthararajah Y,Sekeres MA,Tiu R,Copelan E,Kalaycio M,Sobecks R,Bates J,Advani AS

更新日期：2012-10-01 00:00:00