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Long-term haemopoietic injury in mice after repeated irradiation: precursor-cell cycling and its regulation.

Abstract：

:The cycling rate of haemopoietic stem cells (day 9 CFU-S) and granulocyte-macrophage colony forming cells (GM-CFC) in mouse femora was, in response to reduced numbers, elevated at all times of sampling between 3 weeks and 10 months after 4 repeated doses of 4.5 Gy X-rays (3 wk between doses). The level of a stimulator of CFU-S cycling was also elevated, and this was observed in both axial and marginal regions of the marrow inside the shaft. However, the rate of production of the stimulator was low; lower than previously reported in marrow regenerating after a single dose of 4.5 Gy, indicating damage to the regulatory stromal cells. The distribution of CFU-S across the axial and marginal zones of femoral marrow was changed from that in normal mice, where higher concentrations were found near the bone surface, to a more uniform distribution.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Tejero C,Lord BI,Mason TM,Hendry JH

doi

10.1111/j.1600-0609.1988.tb01193.x

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

278-84

issue

3

eissn

0902-4441

issn

1600-0609

journal_volume

41

pub_type

杂志文章

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