The ageing patient with haemophilia.

abstract：:During the period 1978-1982 in the three northernmost countries of Sweden all 143 patients with a registered diagnosis of chronic lymphocytic leukemia (CLL) were retrospectively analyzed. After re-evaluation, 122 cases remained in the study. The mean age was 71 years and the male/female ratio was 2.2:1. Sixty-one pati...

journal_title：European journal of haematology

authors： Erlanson M,Osterman B,Jonsson H,Lenner P

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:The impact of coronavirus disease 2019 (COVID-19) in haematological patients (HP) has not been comprehensively reported. METHODS:We analysed 39 patients with SARS-CoV-2 infection and haematological malignancies. Clinical characteristics and outcomes were compared to a matched control group of 53 non-cancer ...

journal_title：European journal of haematology

authors： Sanchez-Pina JM,Rodríguez Rodriguez M,Castro Quismondo N,Gil Manso R,Colmenares R,Gil Alos D,Paciello ML,Zafra D,Garcia-Sanchez C,Villegas C,Cuellar C,Carreño-Tarragona G,Zamanillo I,Poza M,Iñiguez R,Gutierrez X,Alonso R

更新日期：2020-11-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：:Treatment with recombinant erythropoietin (EPO) can alleviate anaemia in patients with myelodysplastic syndromes (MDS). The present study, based on a long-term follow-up of 68 MDS patients (26RA, 16 RAS, 26 RAEB) treated with EPO alone, pinpoints pre-treatment variables associated with response induction, response dur...

journal_title：European journal of haematology

authors： Wallvik J,Stenke L,Bernell P,Nordahl G,Hippe E,Hast R

更新日期：2002-03-01 00:00:00

abstract：:Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence i...

journal_title：European journal of haematology

authors： Thomas X

更新日期：2015-02-16 00:00:00

abstract：OBJECTIVE:Thalidomide is remarkably active in advanced relapsed and refractory multiple myeloma (MM), so that its use has been recently proposed either in newly diagnosed patients or as maintenance treatment after conventional or high-dose therapy. This latter therapeutic approach has risen the concern of side-effects ...

journal_title：European journal of haematology

authors： Tosi P,Zamagni E,Cellini C,Plasmati R,Cangini D,Tacchetti P,Perrone G,Pastorelli F,Tura S,Baccarani M,Cavo M

更新日期：2005-03-01 00:00:00

abstract：:Development of resistance to cytotoxic agents is a common problem in the treatment of acute leukemia. In cell lines having multidrug resistance (MDR) phenotype, a decrease in the intracellular accumulation of drugs has been closely related to the overexpression of P-glycoprotein/mdr1 genes. We analyzed the relationshi...

journal_title：European journal of haematology

authors： Kato S,Ideguchi H,Muta K,Nishimura J,Nawata H

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:Diffuse large B-cell lymphoma (DLBCL) can be classified as germinal center B cell-like (GCB) or activated B cell-like (ABC)/non-GCB based on cell-of-origin (COO) classification. This study evaluated the prognostic significance of COO classification in 250 patients diagnosed with de novo DLBCL who received R-C...

journal_title：European journal of haematology

authors： Xu J,Liu JL,Medeiros LJ,Huang W,Khoury JD,McDonnell TJ,Tang G,Schlette E,Yin CC,Bueso-Ramos CE,Lin P,Li S

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

journal_title：European journal of haematology

authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate serum leptin levels in idiopathic thrombocytopenic purpura (ITP), in order to determine the influence of leptin on the pathogenesis of ITP. SUBJECTS AND METHODS:Forty-six untreated patients with chronic ITP were compared with 40 healthy people of similar age, sex an...

journal_title：European journal of haematology

authors： Zhan M,Zhao H,Yang R,Han ZC

更新日期：2004-05-01 00:00:00

abstract：:Intravascular lymphoma (IVL) is a rare type of extranodal lymphoma in which the lymphoma cells proliferate exclusively in lumina of small vessels. Here, we report a clinicopathological study of 13 cases IVL diagnosed at our institution between March 1999 and July 2007, and evaluated the clinical characteristics, usefu...

journal_title：European journal of haematology

authors： Matsue K,Asada N,Takeuchi M,Yamakura M,Kimura S,Odawara J,Aoki T

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Wnt signaling induces a plethora of intracellular responses that dictate normal or abnormal cellular behavior. Abnormal WNT signaling has been related to the development of leukemogenic processes. In this regard, it is important to know the expression profile of WNT receptors in normal and malignant cells, i...

journal_title：European journal of haematology

authors： Alvarez-Zavala M,Riveros-Magaña AR,García-Castro B,Barrera-Chairez E,Rubio-Jurado B,Garcés-Ruíz OM,Ramos-Solano M,Aguilar-Lemarroy A,Jave-Suarez LF

更新日期：2016-08-01 00:00:00

abstract：:It has been recently demonstrated that ecto-5'nucleotidase (5'NT) activity is significantly decreased in the peripheral blood lymphocytes (PBL) of homosexual men. This paper reports a study of PBL 5'NT activity in 38 hemophiliacs at risk for the acquired immunodeficiency syndrome (AIDS). The enzyme activity was correl...

journal_title：European journal of haematology

authors： Massaia M,Pioppo P,Dianzani U,Guerra MG,Peyretti F,Pileri A,Tamponi G

更新日期：1987-04-01 00:00:00

abstract：:Many cost analyses of stem-cell transplantations are available, which is in sharp contrast to the level of cost analyses on first-line chemotherapy for aggressive non-Hodgkin's lymphoma (NHL). Given the scarcity of cost analyses of first-line chemotherapy for NHL, it is difficult to assess the economic impact of upcom...

journal_title：European journal of haematology

authors： van Agthoven M,Faber LM,Uyl-de Groot CA,Sonneveld P,Verdonck LF,Willemze R,Kluin-Nelemans JC,Löwenberg B,Huijgens PC

更新日期：2002-10-01 00:00:00

abstract：:We report a patient with multiple myeloma presenting with a paraspinal plasmacytoma with a marked dissociation between the response obtained in bone marrow (BM) infiltration and that achieved in soft tissue masses. While a complete remission was reached and maintained in BM, extramedullary plasmacytomas were refractor...

journal_title：European journal of haematology

authors： López-Anglada L,Gutiérrez NC,García JL,Mateos MV,Flores T,San Miguel JF

更新日期：2010-04-01 00:00:00

abstract：:Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7-8 May 2015 in Amsterdam, The Netherlands, aimed to prom...

journal_title：European journal of haematology

authors： Berntorp E,Hart D,Mancuso ME,d'Oiron R,Perry D,O'Mahony B,Kaczmarek R,Crato M,Pasi J,Miners A,Carlsson KS,Kitchen S,Boehlen F,Giangrande P,Cebura E,Uitslager N,Osooli M,Janeckova D,Haldon R,Rivolta GF

更新日期：2016-07-01 00:00:00

abstract：:The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non-Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade l...

journal_title：European journal of haematology

authors： Monti M,Brandt L,Ikomi-Kumm J,Olsson H

更新日期：1990-11-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism. It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL). Most studies on relation of MTHFR polymorphisms to ALL susceptibility have been in pediatric populat...

journal_title：European journal of haematology

authors： Lv L,Wu C,Sun H,Zhu S,Yang Y,Chen X,Fu H,Bao L

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:A retrospective study was performed to explore the effect of splenectomy on iron balance in thalassemia major (TM). METHODS:Twenty two TM patients treated with splenectomy were compared with a control group (non-splenectomized patients) matched for sex, age, pretransfusional Hb, chelation therapy, and durati...

journal_title：European journal of haematology

authors： Casale M,Cinque P,Ricchi P,Costantini S,Spasiano A,Prossomariti L,Minelli S,Frega V,Filosa A

更新日期：2013-07-01 00:00:00

abstract：:Haemoglobin (Hb) Hope [beta136(H14)Gly-->Asp(GGT-->GAT)] is one of the unstable haemoglobin variants of the beta-globin chain, which is demonstrated in people of various ethnic backgrounds. Here we report a Thai female patient with clinical thalassaemia intermedia since childhood. This patient had experienced neither ...

journal_title：European journal of haematology

authors： Sura T,Busabaratana M,Youngcharoen S,Wisedpanichkij R,Viprakasit V,Trachoo O

更新日期：2007-09-01 00:00:00

abstract：:Downregulation of cereblon (CRBN) gene expression is associated with resistance to the immunomodulatory drug lenalidomide and poor survival outcomes in multiple myeloma (MM) patients. However, the importance of CRBN gene expression in patients with myelodysplastic syndrome (MDS) and its impact on lenalidomide therapy ...

journal_title：European journal of haematology

authors： Jonasova A,Bokorova R,Polak J,Vostry M,Kostecka A,Hajkova H,Neuwirtova R,Siskova M,Sponerova D,Cermak J,Mikulenkova D,Cervinek L,Brezinova J,Michalova K,Fuchs O

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To retrospectively identify characteristics and risk factors of viral encephalitis (VE) in patients who underwent a haplo-identical hematopoietic stem cell transplant (HSCT). METHODS:A nested case-control study was designed. Cases with VE and controls were identified from a cohort composed of 1274 patients w...

journal_title：European journal of haematology

authors： Zhang XH,Zhang JM,Han W,Chen H,Chen YH,Wang FR,Wang JZ,Zhang YY,Mo XD,Chen Y,Wang Y,Chang YJ,Xu LP,Liu KY,Huang XJ

更新日期：2017-05-01 00:00:00

abstract：:The small-dose (20 mg) oral iron absorption test (OIAT) was performed in 76 hospitalized elderly patients and 30 healthy adults. Of the elderly patients, 34 were considered as iron deficient (serum ferritin level < 20 micrograms/L) of whom 23 were anaemic and 11 not anaemic, 21 had the anaemia of chronic disorders (AC...

journal_title：European journal of haematology

authors： Joosten E,Vander Elst B,Billen J

更新日期：1997-02-01 00:00:00

abstract：:Kostmann syndrome (KS) is an inherited hematological disorder characterized by an absolute neutrophil count (ANC) <0.2 x 109/L and life-threatening bacterial infections. Granulocyte-colony stimulating factor (G-CSF) makes it possible to reach an ANC of 1.0 x 109/L and consequently to reduce significantly the occurrenc...

journal_title：European journal of haematology

authors： Dallorso S,Manzitti C,Dodero P,Faraci M,Rosanda C,Castagnola E

更新日期：2003-05-01 00:00:00

abstract：:Ten patients, who received cadaveric kidneys, were followed for 24 wk with serial measurements of serum erythropoietin (S-Epo), transferrin receptor (S-TfR) and iron variables. The mean pretransplant creatinine clearance was 8.2 (range 0-22) ml/min and the mean haemoglobin (Hb) level was 99 +/- 18.6 (range 66-124) g/l...

journal_title：European journal of haematology

authors： Beshara S,Birgegård G,Goch J,Wahlberg J,Wikström B,Danielson BG

更新日期：1997-03-01 00:00:00

abstract：:We studied the chromosomes in the bone marrow of 4 patients who had both diabetes insipidus (DI) and acute non-lymphocytic leukaemia. Clinical findings suggested that, in each case, myelodysplastic syndrome had preceded the onset of acute leukaemia. Two other such patients described in the literature had had a banded ...

journal_title：European journal of haematology

authors： de la Chapelle A,Lahtinen R

更新日期：1987-11-01 00:00:00

abstract：INTRODUCTION:Chimeric antigen receptor (CAR) T cells targeting B cell maturation antigen (BCMA) have shown impressive results in clinical studies for relapsed/refractory multiple myeloma (RRMM). We performed a systematic literature review to summarize the current body of evidence on the role of anti-BCMA CAR T cells fo...

journal_title：European journal of haematology

authors： Gagelmann N,Ayuk F,Atanackovic D,Kröger N

更新日期：2020-04-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has been shown to inhibit in vitro growth of multiple myeloma (MM) cells, and this effect can be further potentiated by the addition of Dexamethasone (DEX). We here extended this study by testing the activity of 9-cis retinoic acid (9-cis RA) and 13-cis retinoic acid (13-cis RA), both al...

journal_title：European journal of haematology

authors： Tosi P,Pellacani A,Visani G,Ottaviani E,Ronconi S,Zamagni E,Benni M,Cavo M,Tura S

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：:Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Pro...

journal_title：European journal of haematology

authors： Miesbach W,Berntorp E

更新日期：2017-02-01 00:00:00