Complete donor chimaerism of Langerhans cells in lymph node early after allogeneic bone marrow transplantation.

abstract：:The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

journal_title：European journal of haematology

authors： Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To assess the outcome of the measurement of apoptotic index in myeloma patients treated by conventional chemotherapy and novel drugs with biological mechanism of action, thalidomide and bortezomib. PATIENTS AND METHODS:In a cohort of 189 patients with newly diagnosed multiple myeloma from November 1997 throu...

journal_title：European journal of haematology

authors： Minarik J,Scudla V,Ordeltova M,Bacovsky J,Pika T,Langova K

更新日期：2009-12-01 00:00:00

abstract：:We investigated the significance of cytokines (soluble interleukin-2 receptor, granulocyte-macrophage colony-stimulating factor, interleukin-6, and interferon-gamma) and CD68-positive microparticles in immune thrombocytopenic purpura. Cytokines were measured by enzyme-linked immunosorbent assay and microparticles were...

journal_title：European journal of haematology

authors： Nomura S,Yanabu M,Kido H,Lan XG,Ichiyoshi H,Katsura K,Miyake T,Miyazaki Y,Kagawa H,Fukuhara S

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVES:Infections are the major cause of morbidity and mortality in patients with acute myeloid leukaemia (AML). They primarily occur during the first course of induction chemotherapy and may increase the risk of leukaemia relapse, due to a significant delay in consolidation therapy. The intensification of inductio...

journal_title：European journal of haematology

authors： Malagola M,Peli A,Damiani D,Candoni A,Tiribelli M,Martinelli G,Piccaluga PP,Paolini S,De Rosa F,Lauria F,Bocchia M,Gobbi M,Pierri I,Zaccaria A,Zuffa E,Mazza P,Priccolo G,Gugliotta L,Bonini A,Visani G,Skert C,Ber

更新日期：2008-11-01 00:00:00

abstract：:Emicizumab, a bispecific humanised monoclonal antibody restoring to some extent the function of activated FVIII deficient in haemophilia A, represents a major therapeutic advance in the management of haemophilia A patients. No dosage adjustment is required, which leads to a major change for patients used to regular bi...

journal_title：European journal of haematology

authors： Nougier C,Jeanpierre E,Ternisien C,Proulle V,Hezard N,Pouplard C,Lasne D,With contributions from the Working Group on Biology of Haemorrhagic Disorders (BIMHO, Under the Aegis of GFHT).

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:The role of growth hormone (GH) for maintaining normal erythropoiesis among non-GH-deficient elderly subjects is not known. OBJECTIVES:To determine relationships between the concentrations of serum insulin-like growth factor-1 (IGF-1) and it's carrier protein insulin-like growth factor binding protein 3 (IG...

journal_title：European journal of haematology

authors： Nilsson-Ehle H,Bengtsson BA,Lindstedt G,Mellström D

更新日期：2005-02-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 8) in a steady state an increased number of reticulocytes was observed (14.0 +/- 7.8% versus 3.6 +/- 2.4% controls: p less than 0.05). Cell fractionation on density showed that reticulocytes, as in normals, are more or less confined to the least dense fraction; cell fra...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-07-01 00:00:00

abstract：:The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...

journal_title：European journal of haematology

authors： Tuthill M,Crook T,Corbet T,King J,Webb A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:In vivo T-cell depletion with anti-thymocyte globulin is a commonly used strategy for the prevention of graft-versus-host disease (GVHD) and to avoid rejection after hematopoietic stem cell transplantation (HSCT). METHODS:We compared 36 patients given Campath (alemtuzumab) as part of the conditioning with a...

journal_title：European journal of haematology

authors： Norlin AC,Remberger M

更新日期：2011-01-01 00:00:00

abstract：:10 patients with CLL and 2 with CML were treated with gradually increasing doses of 1 alpha(OH)D3, up to 4 micrograms daily during 6 wk. 3 patients with preleukemia and 1 with myelofibrosis were treated with 2 micrograms daily of 1 alpha(OH)D3 for a prolonged period up to 17 wk. The treatment with 1 alpha (OH)D3 did n...

journal_title：European journal of haematology

authors： Wieslander SB,Mortensen BT,Binderup L,Nissen NI

更新日期：1987-07-01 00:00:00

abstract：:Ten patients, who received cadaveric kidneys, were followed for 24 wk with serial measurements of serum erythropoietin (S-Epo), transferrin receptor (S-TfR) and iron variables. The mean pretransplant creatinine clearance was 8.2 (range 0-22) ml/min and the mean haemoglobin (Hb) level was 99 +/- 18.6 (range 66-124) g/l...

journal_title：European journal of haematology

authors： Beshara S,Birgegård G,Goch J,Wahlberg J,Wikström B,Danielson BG

更新日期：1997-03-01 00:00:00

abstract：:Platelet refractoriness arising from HLA immunization develops in 20-50% of multitransfused patients with hematologic malignancies. We retrospectively analyzed the efficiency of leukocyte-depleted blood components in preventing refractoriness in 140 adult patients with acute myeloid leukemia (AML), treated according t...

journal_title：European journal of haematology

authors： Oksanen K

更新日期：1994-08-01 00:00:00

abstract：:We have demonstrated that the intracellular processing of transferrin to effect iron removal involves two pathways, one sensitive to rotenone and the other not. We have also found that the effect of the rotenone is dependent on the transferrin concentration: iron uptake was suppressed with concentrations of transferri...

journal_title：European journal of haematology

authors： Zhan H,Pollack S,Weaver J

更新日期：1990-07-01 00:00:00

abstract：:The development of an unusual case of primary pleural effusion in a 90-year-old human immunodeficiency virus (HIV)-negative Japanese woman with no identifiable tumor mass has been described. Pleural effusion specimens contained large diffuse lymphoma cells, with the phenotype and genotype of a B-cell lineage (positive...

journal_title：European journal of haematology

authors： Shimazaki M,Fujita M,Tsukamoto K,Matsuki T,Iwata M,Takahashi H,Doi A,Hyakkoku M,Yamauchi K,Genda S,Kikuiri T,Sakamoto T,Nojiri S,Ashie T

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evalua...

journal_title：European journal of haematology

authors： Catherwood MA,Matthews C,Niblock R,Dobbin E,Morris TC,Alexander HD

更新日期：2006-04-01 00:00:00

abstract：:Cellular accumulation of vincristine (VCR) and doxorubicin (DOX) was studied in 15 patients with low-grade B-cell malignancies. Their leukemic lymphocytes were isolated and the effect of verapamil on drug uptake was studied. The immunophenotype was characterized using anti-IgM, -IgD, -B 1, monoclonal antibodies. The m...

journal_title：European journal of haematology

authors： Reizenstein P,Kapoor R,Gruber A,Peterson C

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:Hepatocyte growth factor (HGF) is a constituent of the myeloma microenvironment and is elevated in sera from myeloma patients compared to healthy individuals. Increased levels of serum HGF predict a poor prognosis. It has previously been shown by us and others HGF can act as a growth factor to myeloma cells ...

journal_title：European journal of haematology

authors： Hov H,Tian E,Holien T,Holt RU,Våtsveen TK,Fagerli UM,Waage A,Børset M,Sundan A

更新日期：2009-04-01 00:00:00

abstract：:Despite a wide spectrum of treatment options, mantle cell lymphoma (MCL) remains a challenging hematologic malignancy to manage. Advances in front-line therapy, including the monoclonal antibody rituximab and increasing use of cytarabine, have improved remission rates. Autologous hematopoietic cell transplantation (HC...

journal_title：European journal of haematology

authors： Cohen JB,Burns LJ,Bachanova V

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:To evaluate differences in clinical results according to age among patients with chronic myeloid leukemia (CML). METHODS:207 consecutive CML patients treated with imatinib frontline were revised, dividing them in young adults (>20 < 45 years) (YA), middle-aged adults (≥45 < 65 years) (MA) and elderly (≥65 y...

journal_title：European journal of haematology

authors： Latagliata R,Breccia M,Carmosino I,Cesini L,De Benedittis D,Mohamed S,Vozella F,Molica M,Campanelli M,De Luca ML,Colafigli G,Quattrocchi L,Loglisci MG,Massaro F,Canichella M,Diverio D,Mancini M,Alimena G,Foà R

更新日期：2018-06-13 00:00:00

abstract：OBJECTIVE:To characterize the underlying genetic and molecular defects in a consanguineous family with lifelong blood disorder manifested with thrombocytopenia (low platelets count) and anemia. METHODS:Genetic linkage analysis, exome sequencing, and functional genomics were carried out to identify and characterize the...

journal_title：European journal of haematology

authors： Melhem M,Abu-Farha M,Antony D,Madhoun AA,Bacchelli C,Alkayal F,AlKhairi I,John S,Alomari M,Beales PL,Alsmadi O

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Human Disabled-2 (Dab2), a putative tumor suppressor gene, is frequently down-regulated in human tumors. This study aims to explore the association between Dab2 methylation status and expression in newly diagnosed myelodysplastic syndrome (MDS) patients and patients who received 5-aza-2'-deoxycytidine (decit...

journal_title：European journal of haematology

authors： Yang Y,Zhang Q,Xu F,Chang C,Li X

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

journal_title：European journal of haematology

authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study is to assess the quality of life (QoL) of Chinese adults with idiopathic thrombocytopenic purpura (ITP). METHODS:The Chinese (mainland) version of Medical Outcome Study SF-36 form (SF-36) Health Survey was used to measure health-related QoL of 236 adults with ITP in a cross-sectional s...

journal_title：European journal of haematology

authors： Zhou Z,Yang L,Chen Z,Chen X,Guo Y,Wang X,Dong X,Wang T,Zhang L,Qiu Z,Yang R

更新日期：2007-06-01 00:00:00

abstract：:Kostmann syndrome (KS) is an inherited hematological disorder characterized by an absolute neutrophil count (ANC) <0.2 x 109/L and life-threatening bacterial infections. Granulocyte-colony stimulating factor (G-CSF) makes it possible to reach an ANC of 1.0 x 109/L and consequently to reduce significantly the occurrenc...

journal_title：European journal of haematology

authors： Dallorso S,Manzitti C,Dodero P,Faraci M,Rosanda C,Castagnola E

更新日期：2003-05-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has been shown to inhibit in vitro growth of multiple myeloma (MM) cells, and this effect can be further potentiated by the addition of Dexamethasone (DEX). We here extended this study by testing the activity of 9-cis retinoic acid (9-cis RA) and 13-cis retinoic acid (13-cis RA), both al...

journal_title：European journal of haematology

authors： Tosi P,Pellacani A,Visani G,Ottaviani E,Ronconi S,Zamagni E,Benni M,Cavo M,Tura S

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:Acquired trisomy 21 is one of the most common numerical abnormalities in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), and MDS/MPN; however, little is known about its pathogenic impact, accompanying submicroscopic changes, and its relation to other clinical...

journal_title：European journal of haematology

authors： Larsson N,Lilljebjörn H,Lassen C,Johansson B,Fioretos T

更新日期：2012-02-01 00:00:00

abstract：:By recent advanced techniques, blood platelets have proved to be varied in size and metabolism in various hematologic disorders. We examined platelet volume and intraplatelet adenine nucleotides in 36 patients with various hematologic disorders in order to clarify the quantitative platelet abnormalities. Platelet volu...

journal_title：European journal of haematology

authors： Nozaki H,Nagao T,Arimori S

更新日期：1988-01-01 00:00:00

abstract：:The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic ris...

journal_title：European journal of haematology

authors： Purdy JC,Shatzel JJ

更新日期：2020-12-03 00:00:00

abstract：OBJECTIVE:Patients with hematologic malignancies are at substantial risk of developing invasive fungal infections (IFI) that are associated with substantial morbidity and mortality. This article reviews the epidemiology, risk factors, and efficacy of antifungal prophylaxis in patients with hematologic malignancies. ME...

journal_title：European journal of haematology

authors： Maertens J

更新日期：2007-04-01 00:00:00

abstract：:This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

journal_title：European journal of haematology

authors： Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

更新日期：2012-06-01 00:00:00