Treatment of consecutive patients with chronic myeloid leukaemia in the cooperating centres from the Czech Republic and the whole of Slovakia after 2000--a report from the population-based CAMELIA Registry.


BACKGROUND:Most results on the treatment of chronic myeloid leukaemia (CML) with imatinib were obtained from clinical trials that may differ from the routine practice. We report the results of treatment of consecutive patients with CML at ten major centres during 2000-2008. PATIENTS AND METHODS:Data reporting was retrospective in 2000-2004 and prospective from 2005 on. A total of 661 patients [301 women and 360 men; median age 51 (range, 15-83)] with Ph+CML were registered. The median follow-up was 46.1 months (0-122.2). RESULTS:Most patients were treated with first- (379; 57.3%) or second-line (193; 29.2%) imatinib; some of the patients underwent allogeneic hematopoietic stem cell transplantation (AHSCT) (83; 12.6%), but 6.1% were treated with other modalities [40 patients; median age 66 (range, 32-83)]. The probability of overall survival (OS) at 5 years, according to Kaplan and Meier, was 88.9%, 77.5% and 68.7% for chronic-phase patients treated with first-line imatinib, second-line imatinib and first-line AHSCT, respectively, but only 25.2% for patients receiving other modalities. The OS was dependent on the disease phase and Sokal, Hasford and European group for blood and marrow transplantation (EBMT) risk scores (P<0.001; each). Only 46.2% of deaths in patients treated with other modalities were attributable to CML. Elderly patients over 65 years achieved similar response rates and progression-free survival to the younger ones. There was a trend for inferior results of AHSCT performed after the failure of imatinib (P=0.075), probably as a result of differences in EBMT risk scores (P<0.001). CONCLUSIONS:The ability to achieve results comparable to those of previous clinical studies in our CML cohort was influenced by centralised care. Decisions not to initiate imatinib or to delay AHSCT may have a negative impact on OS, but comorbidities may limit the treatment potential of imatinib in the elderly.


Eur J Haematol


Faber E,Mužík J,Koza V,Demečková E,Voglová J,Demitrovičová L,Chudej J,Markuljak I,Cmunt E,Kozák T,Tóthová E,Jarošová M,Dušek L,Indrák K




Has Abstract


2011-08-01 00:00:00












  • Congenital haemolytic anaemia in a low birth weight infant due to congenital stomatocytosis.

    abstract::A baby girl born at 31 weeks gestation showed severe haemolytic anaemia and hyperbilirubinaemia which led to exchange transfusion within the first 12 hours of life. There was no blood group incompatibility between mother and child but there was a marked stomatocytosis of the baby's red blood cells. Family history reve...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Huppi PS,Ott P,Amato M,Schneider H

    更新日期:1991-07-01 00:00:00

  • Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis.

    abstract:OBJECTIVES:Overexpression of FK506 binding protein 51 (FKBP51) in megakaryocytic progenitor cells generated from purified CD34+ cells in patients with idiopathic myelofibrosis (IMF) has been demonstrated. It has been suggested that FKBP51 is involved in the dysregulation of the apoptotic programme with consecutive prol...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Bock O,Neusch M,Büsche G,Mengel M,Kreipe H

    更新日期:2004-04-01 00:00:00

  • Protein Z levels and central retinal vein or artery occlusion.

    abstract:OBJECTIVES:Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently lin...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Koren-Michowitz M,Eting E,Rahimi-Levene N,Garach-Jehoshua O,Volcheck Y,Kornberg A

    更新日期:2005-11-01 00:00:00

  • Zoledronate-induced remission of acute panmyelosis with myelofibrosis.

    abstract::Acute panmyelosis with myelofibrosis is a rare and aggressive form of acute myeloid leukemia. We describe a new case with a huge proliferation of megakaryocytes, blast cells and reticulin fibers. The patient was treated with zoledronate, a third-generation bisphosphonate, and a gradual recovery from pancytopenia was o...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Español I,Romagosa V,Berlanga J,Domingo A,Losa F,Heras L,Janáriz J

    更新日期:2004-09-01 00:00:00

  • Real-world outcomes for 205 patients with chronic lymphocytic leukemia treated with ibrutinib.

    abstract::Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. OBJECTIVES:To report outcomes and AEs in a population-b...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Aarup K,Rotbain EC,Enggaard L,Pedersen RS,Bergmann OJ,Thomsen RH,Frederiksen M,Frederiksen H,Nielsen T,Christiansen I,Andersen MA,Niemann CU

    更新日期:2020-11-01 00:00:00

  • Bridging antifungal prophylaxis with 50 mg or 100 mg micafungin in allogeneic stem cell transplantation: A retrospective analysis.

    abstract:OBJECTIVE:Fluconazole or posaconazole is a standard of care in antifungal prophylaxis for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). However, many patients need to interrupt standard prophylaxis due to intolerability, drug-drug interactions, or toxicity. Micafungin has come to promin...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Rothe A,Claßen A,Carney J,Hallek M,Mellinghoff SC,Scheid C,Holtick U,von Bergwelt-Baildon M

    更新日期:2020-04-01 00:00:00

  • BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma.

    abstract:AIMS:Aim of the study is to investigate diffuse large B-cell lymphoma (DLBCL) for the presence of BCL3 gene rearrangement and protein expression and to correlate these with immunophenotypic subsets of DLBCL. We aimed to investigate the pathogenetic implication of BCL3 in DLBCL. METHODS AND RESULTS:Tissue microarray se...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Ibrahim HA,Amen F,Reid AG,Naresh KN

    更新日期:2011-12-01 00:00:00

  • Plasma cell leukemia: from biology to treatment.

    abstract::Plasma cell leukemia (PCL) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary PCL occuring 'de novo', or as secondary PCL in patients with relapsed/refractory multiple myeloma. Primary PCL is a distinct cli...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Jelinek T,Kryukov F,Rihova L,Hajek R

    更新日期:2015-07-01 00:00:00

  • Effect of splenectomy on iron balance in patients with β-thalassemia major: a long-term follow-up.

    abstract:OBJECTIVE:A retrospective study was performed to explore the effect of splenectomy on iron balance in thalassemia major (TM). METHODS:Twenty two TM patients treated with splenectomy were compared with a control group (non-splenectomized patients) matched for sex, age, pretransfusional Hb, chelation therapy, and durati...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Casale M,Cinque P,Ricchi P,Costantini S,Spasiano A,Prossomariti L,Minelli S,Frega V,Filosa A

    更新日期:2013-07-01 00:00:00

  • Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment.

    abstract:OBJECTIVES:Myeloma bone disease is a result of excessive osteoclast activation and impaired osteoblast function. Recent in vitro studies suggested that proteasome inhibitors might increase osteoblast function. METHODS:We analyzed serum markers of osteoblast activity in 25 patients with multiple myeloma receiving borte...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Heider U,Kaiser M,Müller C,Jakob C,Zavrski I,Schulz CO,Fleissner C,Hecht M,Sezer O

    更新日期:2006-09-01 00:00:00

  • Direct oral anticoagulants for atrial fibrillation in patients with congenital factor VII deficiency.

    abstract::The management of anticoagulant therapy (OAT) in patients with factor VII (FVII) deficiency is a very challenging clinical issue, as warfarin further reduces FVII levels, thus potentially increasing bleeding risk. On the other hand, the International Normalized Ratio test is misleading in such patients, as they do not...

    journal_title:European journal of haematology

    pub_type: 杂志文章,meta分析


    authors: Arletti L,Coluccio V,Romagnoli E,Luppi M,Marietta M

    更新日期:2019-07-01 00:00:00

  • Clonal heterogeneity of mantle cell lymphoma revealed by array comparative genomic hybridization.

    abstract::Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) characterized by the translocation t(11;14)(q13;q32). This lymphoma exhibits a poor prognosis and remains incurable with standard chemotherapy approaches. Recently, we have shown that a majority of patients with acute-type adult T-cell leuke...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Liu F,Yoshida N,Suguro M,Kato H,Karube K,Arita K,Yamamoto K,Tsuzuki S,Oshima K,Seto M

    更新日期:2013-01-01 00:00:00

  • Complete and long-lasting cytologic and molecular remission of FIP1L1-PDGFRA-positive acute eosinophil myeloid leukaemia, treated with low-dose imatinib monotherapy.

    abstract::Myeloproliferative neoplasms associated with FIP1L1-PDGFR rearrangements represent a rare subset of myeloid and lymphoid malignancies, characterised by the presence of eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 genes. The fusion product of such genes is a tyrosine kinase oncoprotein sensitive to imatini...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Barraco D,Carobolante F,Candoni A,Simeone E,Piccaluga P,Tabanelli V,Fanin R

    更新日期:2014-06-01 00:00:00

  • Hematopoietic clonal dominance, stem cell mutations, and evolutionary pattern of JAK2V617F allele burden in polycythemia vera.

    abstract:OBJECTIVES:Clonal dominance is characteristic of patients with post-polycythemia vera myelofibrosis (post-PV MF), whereas patients in chronic phase usually display polyclonal hematopoiesis. The aim of this work was to study the mutational burden of JAK2V617F at the progenitor level in patients with PV and correlate it ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Angona A,Alvarez-Larrán A,Bellosillo B,Martínez-Avilés L,Camacho L,Fernández-Rodríguez C,Pairet S,Longarón R,Ancochea Á,Senín A,Florensa L,Besses C

    更新日期:2015-03-01 00:00:00

  • Factors influencing release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes.

    abstract::Mononuclear phagocytes play an important role in the regulation of hematopoiesis, not only by producing regulatory monokines such as prostaglandins, tumor necrosis factor and interleukin-1 (IL-1), but also by the production of colony-stimulating activity (CSA). Previously, we have demonstrated that granulocyte-macroph...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Fibbe WE,Kluck PM,Duinkerken N,Voogt PJ,Willemze R,Falkenburg JH

    更新日期:1988-10-01 00:00:00

  • Clonal evolution in CLL patients as detected by FISH versus chromosome banding analysis, and its clinical significance.

    abstract::The acquisition of new aberrations during the course of chronic lymphocytic leukemia (CLL) named clonal evolution (CE) is usually detected by one of the two methods: chromosome banding analysis (CBA) and interphase fluorescence in situ hybridization (I-FISH). The purpose of this study was to compare the usefulness of ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Wawrzyniak E,Kotkowska A,Blonski JZ,Siemieniuk-Rys M,Ziolkowska E,Giannopoulos K,Robak T,Korycka-Wolowiec A

    更新日期:2014-02-01 00:00:00

  • Cancer-related anemia in a rat model: alpha2-macroglobulin from Yoshida sarcoma shortens erythrocyte survival.

    abstract::Implantation of Yoshida ascites sarcoma in rats was found to lead to a reduction in the hemoglobin content, the erythrocyte count and the packed cell volume of blood to 30% of normal in 4 d; however, there was no decrease in the mean cell hemoglobin, the mean cell volume and the mean corpuscular hemoglobin concentrati...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Bhanushali AA,Raghunathan R,Kalraiya RD,Mehta NG

    更新日期:2002-01-01 00:00:00

  • Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study.

    abstract:OBJECTIVE:A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). METHODS:Patients received lenalidomide 10 mg/d (days 1-21; n = 47) or ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,随机对照试验


    authors: Giagounidis A,Mufti GJ,Mittelman M,Sanz G,Platzbecker U,Muus P,Selleslag D,Beyne-Rauzy O,te Boekhorst P,del Cañizo C,Guerci-Bresler A,Nilsson L,Lübbert M,Quesnel B,Ganser A,Bowen D,Schlegelberger B,Göhring G,Fu T,Be

    更新日期:2014-11-01 00:00:00

  • Altered erythropoiesis and iron metabolism in carriers of thalassemia.

    abstract::The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

    更新日期:2015-06-01 00:00:00

  • BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation.

    abstract:BACKGROUND:Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA-haploidentical transplantation. Adoptive immunotransfer of virus-specific T cells from the donor is a promising therapeutic approach, although ...

    journal_title:European journal of haematology



    authors: Pello OM,Innes AJ,Bradshaw A,Finn SA,Uddin S,Bray E,Olavarria E,Apperley JF,Pavlů J

    更新日期:2017-06-01 00:00:00

  • Poor survival in t(8;21) (q22;q22)-associated acute myeloid leukaemia with leukocytosis.

    abstract::Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 1...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Billström R,Johansson B,Fioretos T,Garwicz S,Malm C,Zettervall O,Mitelman F

    更新日期:1997-07-01 00:00:00

  • A novel mutation in a Turkish patient with Hermansky-Pudlak syndrome type 5.

    abstract::The Hermansky-Pudlak syndrome (HPS) is a rare genetically heterogeneous autosomal recessive disorder, characterized by tyrosinase-positive oculocutaneous albinism, platelet dysfunction and lysosomal ceroid lipofuscin storage. This is caused by defects in lysosome-related organelles. In humans eight different types of ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Korswagen LA,Huizing M,Simsek S,Janssen JJ,Zweegman S

    更新日期:2008-04-01 00:00:00

  • CD1-reactive leukemic cells in bone marrow: presence of Langerhans cell marker on leukemic monocytic cells.

    abstract::Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, CD33, HLA-DR) were studied in 53 cases of acute myeloid leukemia...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Misery L,Campos L,Dezutter-Dambuyant C,Guyotat D,Treille D,Schmitt D,Thivolet J

    更新日期:1992-01-01 00:00:00

  • Expression of Foxo3a in non-Hodgkin's lymphomas is correlated with cell cycle inhibitor p27.

    abstract:OBJECTIVE:Cell cycle arrest by FOXO transcription factors involves in transcriptional activation of p27(kip1), although the exact mechanism remains unclear. And it has been evidenced that reduced level of p27(kip1) which is frequently occurred in human cancers has been associated with poor prognosis. In this study, our...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Zhao Y,Fei M,Wang Y,Lu M,Cheng C,Shen A

    更新日期:2008-08-01 00:00:00

  • On mouse and man: neutrophil gelatinase associated lipocalin is not involved in apoptosis or acute response.

    abstract::Neutrophil gelatinase-associated lipocalin (NGAL) is a siderphore binding molecule present in the specific granules of neutrophils and induced in a variety of epithelial cells during inflammation. Its mouse orthologue, 24p3, is also an acute phase protein synthesized in the liver and adipose tissue during inflammation...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Klausen P,Niemann CU,Cowland JB,Krabbe K,Borregaard N

    更新日期:2005-10-01 00:00:00

  • Colony-stimulating factor and leukemia cell-growth factor produced by a murine endothelial cell line, MKM-O.

    abstract::A murine cultured cell line (MKM-O) was established from a tumor of a BALB/C (nu/nu) mouse that had been subcutaneously inoculated with human hepatoma tissue fragments in the same location. The MKM-O cell line was proven to be of endothelial origin by morphological examinations and positive staining with fluorescein-l...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Yoshimura T,Miyanomae T,Tanaka M,Iwai Y,Mayumi M,Mikawa H

    更新日期:1987-08-01 00:00:00

  • Survivin expression, apoptosis and proliferation in chronic myelomonocytic leukemia.

    abstract::We analyzed the expression of the inhibitor of apoptosis survivin by immunocytochemistry in bone marrow cells from patients with chronic myelomonocytic leukemia (CMML) to evaluate possible abnormalities in comparison with other myelodysplastic (MDS) and myeloproliferative syndromes, and to investigate a possible corre...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Invernizzi R,Travaglino E,Benatti C,Malcovati L,Della Porta M,Cazzola M,Ascari E

    更新日期:2006-06-01 00:00:00

  • Hypoxia and deposition of iron in liver and spleen of mice given iron supplement.

    abstract::Iron-related changes in peripheral blood and variations in liver and spleen iron concentrations during alternating periods of hypoxia and normoxia have been investigated in iron-supplemented mice by chemical and histological methods. During hypoxia, packed cell volume increased from 40 to 70%. The iron content of the ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Borch-Iohnsen B,Myhre K,Norheim G

    更新日期:1990-01-01 00:00:00

  • Brazilian guidelines on hematopoietic stem cell transplantation in acute myeloid leukemia.

    abstract:INTRODUCTION/OBJECTIVES:Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74/100 000 men and 1.37/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of...

    journal_title:European journal of haematology

    pub_type: 杂志文章,实务指引


    authors: Silla L,Dulley F,Saboya R,Kerbauy F,de Moraes Arantes A,Pezzi A,Gross LG,Paton E,Hamerschlak N

    更新日期:2017-02-01 00:00:00

  • Immunologic and virologic findings in hemophiliacs do not correlate with ecto-5'nucleotidase activity of peripheral blood lymphocytes. A difference with homosexual men.

    abstract::It has been recently demonstrated that ecto-5'nucleotidase (5'NT) activity is significantly decreased in the peripheral blood lymphocytes (PBL) of homosexual men. This paper reports a study of PBL 5'NT activity in 38 hemophiliacs at risk for the acquired immunodeficiency syndrome (AIDS). The enzyme activity was correl...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Massaia M,Pioppo P,Dianzani U,Guerra MG,Peyretti F,Pileri A,Tamponi G

    更新日期:1987-04-01 00:00:00