Levels of soluble angiogenin in chronic myeloid malignancies: clinical implications.

abstract：:A 32-year-old male presented with isolated neutropenia 6 months after allogeneic bone marrow transplantation for CML from his HLA-matched brother. The presence of granulocyte-specific IgM and IgG antibodies in the patient's serum indicated an immune-mediated basis for the neutropenia. A variety of manoeuvres to suppre...

journal_title：European journal of haematology

authors： Koeppler H,Goldman JM

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:To investigate whether the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) combined with the selective MDM2 antagonist idasanutlin (RG7388) offers superior efficacy to monotherapy in treating B-lymphoid malignancies in preclinical models. METHODS:The combined effect of obinutuzuma...

journal_title：European journal of haematology

authors： Herting F,Herter S,Friess T,Muth G,Bacac M,Sulcova J,Umana P,Dangl M,Klein C

更新日期：2016-11-01 00:00:00

abstract：:CD200R is an inhibitory receptor involved in the regulation of myeloid cells. It recruits Dok-1 and Dok-2, which are potent inhibitors of the Ras signalling pathway used by colony-stimulating factor (CSF) receptors. Dok-1/Dok-2 double knockout (DKO) mice develop leukaemia at 10-12 months of age. We investigated whethe...

journal_title：European journal of haematology

authors： Rijkers ES,de Ruiter T,Buitenhuis M,Veninga H,Hoek RM,Meyaard L

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Cell cycle arrest by FOXO transcription factors involves in transcriptional activation of p27(kip1), although the exact mechanism remains unclear. And it has been evidenced that reduced level of p27(kip1) which is frequently occurred in human cancers has been associated with poor prognosis. In this study, our...

journal_title：European journal of haematology

authors： Zhao Y,Fei M,Wang Y,Lu M,Cheng C,Shen A

更新日期：2008-08-01 00:00:00

abstract：:T-cell lymphoma is an aggressive lymphoma that cannot be cured despite aggressive therapy, including autologous stem cell transplantation. Thalidomide is an immunomodulatory drug with numerous properties that has proven effective in relapsed multiple myeloma and, to a lesser extent, in other hematologic diseases. We r...

journal_title：European journal of haematology

authors： Damaj G,Bouabdallah R,Vey N,Bilger K,Mohty M,Gastaut JA

更新日期：2005-02-01 00:00:00

abstract：AIMS:Aim of the study is to investigate diffuse large B-cell lymphoma (DLBCL) for the presence of BCL3 gene rearrangement and protein expression and to correlate these with immunophenotypic subsets of DLBCL. We aimed to investigate the pathogenetic implication of BCL3 in DLBCL. METHODS AND RESULTS:Tissue microarray se...

journal_title：European journal of haematology

authors： Ibrahim HA,Amen F,Reid AG,Naresh KN

更新日期：2011-12-01 00:00:00

abstract：:A 1-yr-old Japanese male infant developed hepatitis-associated aplastic anemia (AA), and anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) was administered without any appreciable effects. Laboratory examination of the patient's serum obtained before therapy revealed various autoantibodies, such as PA-IgG, anti-...

journal_title：European journal of haematology

authors： Takamatsu H,Yagasaki H,Takahashi Y,Hama A,Saikawa Y,Yachie A,Koizumi S,Kojima S,Nakao S

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:Human Disabled-2 (Dab2), a putative tumor suppressor gene, is frequently down-regulated in human tumors. This study aims to explore the association between Dab2 methylation status and expression in newly diagnosed myelodysplastic syndrome (MDS) patients and patients who received 5-aza-2'-deoxycytidine (decit...

journal_title：European journal of haematology

authors： Yang Y,Zhang Q,Xu F,Chang C,Li X

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:MicroRNAs engaged in angiogenesis and hematopoiesis can influence hematopoietic stem cells (HSCs) homing after transplantation by targeting bone marrow niche microenvironment. This study aimed to examine the kinetics of miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 in autologous HSC transplantatio...

journal_title：European journal of haematology

authors： Nowicki M,Szemraj J,Wierzbowska A,Misiewicz M,Małachowski R,Pluta A,Grzybowska-Izydorczyk O,Robak T,Szmigielska-Kapłon A

更新日期：2018-05-01 00:00:00

abstract：:A hairy cell leukaemia (HCL) patient is presented in whom the peripheral blood mononuclear cells (PBMCs) carried suppressor T-cell markers (CD3+, CD2+, CD8+/CD4-, CD38+). Analysis of genomic DNA of PBMNC showed the presence of a monoclonal population of T cells, the T-cell receptor (TCR) beta-chain gene being rearrang...

journal_title：European journal of haematology

authors： Demeter J,Pálóczi K,Földi J,Hokland M,Hokland P,Benczúr M,Lehoczky D

更新日期：1989-10-01 00:00:00

abstract：:We report here the first case with Diamond-Blackfan anemia (DBA) who responded to rituximab. The patient is an 8-yr-old Japanese girl with refractory DBA accompanied by complex congenital heart disease. She received two doses of rituximab, 375 mg/m(2)/wk. She became transfusion independent 6 months after the treatment...

journal_title：European journal of haematology

authors： Morimoto A,Kuriyama K,Tsuji K,Isoda K,Hibi S,Todo S,Sugimoto T,Imashuku S

更新日期：2005-05-01 00:00:00

abstract：:We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

journal_title：European journal of haematology

authors： Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

更新日期：2009-11-01 00:00:00

abstract：:In acute myeloid leukemia (AML) mouse models, the RUNX1-RUNX1T1 fusion protein has failed to produce leukemia by itself, but alternative splicing of exon 9a of the RUNX1-RUNX1T1 fusion transcript (FT) has recently been shown to enhance the leukemogenic potential. We have analyzed 138 diagnosis and follow-up samples fr...

journal_title：European journal of haematology

authors： Ommen HB,Ostergaard M,Yan M,Braendstrup K,Zhang DE,Hokland P

更新日期：2010-02-01 00:00:00

abstract：:In the study of patients with Hodgkin's lymphoma (HL) the evaluation of bone marrow biopsy (BMB) can be difficult. In this review we analyze the main diagnostic features and the clinical risk factors of BM involvement. Although the role of BMB is criticized by some authors, its value is irreplaceable in the staging of...

journal_title：European journal of haematology

authors： Franco V,Tripodo C,Rizzo A,Stella M,Florena AM

更新日期：2004-09-01 00:00:00

abstract：:Multiple mutations in the same gene within a haemophilia family are being increasingly reported and raise many issues with regard to the specificity of the mutations in causing the disease. In a proportion of families with multiple mutations, discordant phenotypic severity is often observed among the affected members....

journal_title：European journal of haematology

authors： Shetty S,Bhave M,Ghosh K

更新日期：2011-03-01 00:00:00

abstract：:A patient presented with symptoms of cerebellar degeneration and nephrotic syndrome. A work-up at that time failed to reveal an underlying disease; however, 20 months later Hodgkin's disease was diagnosed. Hodgkin's lymphadenopathy developed 2 wk after prednisone therapy for the nephrotic syndrome had been discontinue...

journal_title：European journal of haematology

authors： Spyridonidis A,Fischer KG,Glocker FX,Fetscher S,Klisch J,Behringer D

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:Imatinib (Glivec, STI571) has been successfully used in patients with chronic myelogenous leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome (Ph). We used imatinib interim therapy for four consecutive patients with newly diagnosed Ph+ acute myeloid leukemia (AML). We monitored the pat...

journal_title：European journal of haematology

authors： Cho BS,Kim HJ,Lee S,Eom KS,Min WS,Lee JW,Kim CC

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:In patients with essential thrombocythemia (ET), vascular complications contribute to both morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score of thrombosis for ET (IPSET-thrombosis) was recently developed. We hereby presented an external validati...

journal_title：European journal of haematology

authors： Fu R,Xuan M,Lv C,Zhang L,Li H,Zhang X,Zhang D,Sun T,Xue F,Liu X,Liang H,Zhang L,Yang R

更新日期：2014-06-01 00:00:00

abstract：:Mononuclear phagocytes play an important role in the regulation of hematopoiesis, not only by producing regulatory monokines such as prostaglandins, tumor necrosis factor and interleukin-1 (IL-1), but also by the production of colony-stimulating activity (CSA). Previously, we have demonstrated that granulocyte-macroph...

journal_title：European journal of haematology

authors： Fibbe WE,Kluck PM,Duinkerken N,Voogt PJ,Willemze R,Falkenburg JH

更新日期：1988-10-01 00:00:00

abstract：:The present trial was designed to test the effects of G-CSF on the duration of the second phase of induction chemotherapy in children with newly diagnosed acute lymphoblastic leukemia (ALL). A total of 32 patients were assigned randomly to a group that received (14 patients; group A) or a group that did not receive (1...

journal_title：European journal of haematology

authors： Dibenedetto SP,Ragusa R,Ippolito AM,Lo Nigro L,Di Cataldo A,D'Amico S,Miraglia V

更新日期：1995-08-01 00:00:00

abstract：:We have studied the kinetics of plasma levels of circulating (c)selectins in 8 patients undergoing bone marrow or stem cell transplantation to gain estimates for the distribution and half-life of (c)selectins and to potentially identify an endothelial source of cP-selectin in patients who are deprived of platelets and...

journal_title：European journal of haematology

authors： Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

更新日期：1998-07-01 00:00:00

abstract：:The purpose of this study was to analyse the influence of the hospital size, measured as the number of annual patient enrolments in the Finnish Leukaemia Group trials in the period 1979-85, on response rate and survival after conventional chemotherapy for multiple myeloma. The 432 myeloma patients for this study were ...

journal_title：European journal of haematology

authors： Oivanen T,Kellokumpu-Lehtinen P,Koivisto AM,Koivunen E

更新日期：1999-10-01 00:00:00

abstract：:Little is known about the S100B⁺ lymphocytes, which are unique human peripheral blood lymphocytes (PBL) containing the S100B protein. It has recently been shown that S100B is released from various types of S100B⁺ cells and exhibits varied cytokine-like activities. In this study, we precisely characterized the S100B⁺ l...

journal_title：European journal of haematology

authors： Miki Y,Gion Y,Mukae Y,Hayashi A,Sato H,Yoshino T,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：:Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1-PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophi...

journal_title：European journal of haematology

authors： Capovilla M,Cayuela JM,Bilhou-Nabera C,Gardin C,Letestu R,Baran-Marzak F,Fenaux P,Martin A

更新日期：2008-01-01 00:00:00

abstract：:The Hermansky-Pudlak syndrome (HPS) is a rare genetically heterogeneous autosomal recessive disorder, characterized by tyrosinase-positive oculocutaneous albinism, platelet dysfunction and lysosomal ceroid lipofuscin storage. This is caused by defects in lysosome-related organelles. In humans eight different types of ...

journal_title：European journal of haematology

authors： Korswagen LA,Huizing M,Simsek S,Janssen JJ,Zweegman S

更新日期：2008-04-01 00:00:00

abstract：UNLABELLED:Historically, treatment of invasive fungal infections (IFI) has consisted of amphotericin B. However, new therapeutic agents have recently been introduced. At the same time, the relatively low incidence of IFI and the progress in the diagnostic accuracy of IFI have made routine use of empirical antifungal th...

journal_title：European journal of haematology

authors： Cherif H,Kalin M,Björkholm M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:An increased rate of platelet production is a possible cause of reduced antithrombotic response to once-daily aspirin. Markers of immature platelets (IPs), such as immature platelet count (IPC), immature platelet fraction (IPF), and mean platelet volume (MPV) might be useful for identifying patients who have...

journal_title：European journal of haematology

authors： Xu K,Chan NC,Hirsh J,Ginsberg JS,Bhagirath V,Kruger P,Dale B,Crowther M,Whitlock RP,Li C,Eikelboom JW

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Diamond-Blackfan anemia (DBA) is characterized by hypoplastic anemia, congenital anomalies, and a predisposition for malignancies. Most of our understanding of this disorder stems from molecular studies combined with extensive data input from international patient registries. OBJECTIVES:To create an overv...

journal_title：European journal of haematology

authors： van Dooijeweert B,van Ommen CH,Smiers FJ,Tamminga RYJ,Te Loo MW,Donker AE,Peters M,Granzen B,Gille HJJP,Bierings MB,MacInnes AW,Bartels M

更新日期：2018-02-01 00:00:00

abstract：:We investigated whether depressed plasma antithrombin and protein C activity, considered as a specific finding of disseminated intravascular coagulation (DIC), is due to consumption coagulopathy in septic patients with DIC. An analysis of hemostatic parameters was performed in 139 septic patients (68 with DIC and 71 w...

journal_title：European journal of haematology

authors： Asakura H,Ontachi Y,Mizutani T,Kato M,Ito T,Saito M,Morishita E,Yamazaki M,Aoshima K,Takami A,Yoshida T,Suga Y,Miyamoto K,Nakao S

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von Willebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is know...

journal_title：European journal of haematology

authors： Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

更新日期：2013-08-01 00:00:00