Paraneoplastic cerebellar degeneration and nephrotic syndrome preceding Hodgkin's disease: case report and review of the literature.

abstract：:The present study aims at expressing a reporter gene in hematopoietic cells in vivo by introducing it into primitive hematopoietic cells with a 2-gene retroviral vector. Various constructs of retroviral vectors containing the human IL-2 receptor alpha chain gene (TAC) as the reporter and the neomycin phosphotransferas...

journal_title：European journal of haematology

authors： Asami N,Germeraad WT,Fujimoto S,Nagai S,Izumi T,Katsura Y

更新日期：1996-10-01 00:00:00

abstract：:In addition to BCR, various rare fusion partners for the ABL1 gene have been reported in leukemia. We have identified the fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient. Cytogenetic analysis detected this fusion gene ari...

journal_title：European journal of haematology

authors： Masuzawa A,Kiyotani C,Osumi T,Shioda Y,Iijima K,Tomita O,Nakabayashi K,Oboki K,Yasuda K,Sakamoto H,Ichikawa H,Hata K,Yoshida T,Matsumoto K,Kiyokawa N,Mori T

更新日期：2014-03-01 00:00:00

abstract：:Downregulation of cereblon (CRBN) gene expression is associated with resistance to the immunomodulatory drug lenalidomide and poor survival outcomes in multiple myeloma (MM) patients. However, the importance of CRBN gene expression in patients with myelodysplastic syndrome (MDS) and its impact on lenalidomide therapy ...

journal_title：European journal of haematology

authors： Jonasova A,Bokorova R,Polak J,Vostry M,Kostecka A,Hajkova H,Neuwirtova R,Siskova M,Sponerova D,Cermak J,Mikulenkova D,Cervinek L,Brezinova J,Michalova K,Fuchs O

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. METHODS:We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 an...

journal_title：European journal of haematology

authors： Lennmyr E,Karlsson K,Ahlberg L,Garelius H,Hulegårdh E,Izarra AS,Joelsson J,Kozlowski P,Moicean A,Tomaszewska-Toporska B,Lübking A,Hallböök H,Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL).

更新日期：2019-08-01 00:00:00

abstract：:In a prognostic univariate analysis of a series of 80 patients with idiopathic myelofibrosis the Hb-concentration, the platelet count and osteomyelosclerosis emerged as factors with prognostic significance. A Hb-concentration less than 10 g/dl was associated with a significantly shorter survival than a Hb-concentratio...

journal_title：European journal of haematology

authors： Hasselbalch H,Jensen BA

更新日期：1990-03-01 00:00:00

abstract：:Human red blood cells (RBC) are heterogeneous with respect to their size; the physiological significance of this heterogeneity has not yet been fully elucidated. To further investigate this problem, some characteristics of human RBC fractionated according to their mean corpuscular volume (MCV) by counterflow centrifug...

journal_title：European journal of haematology

authors： Vaysse J,Gattegno L,Pilardeau P

更新日期：1992-02-01 00:00:00

abstract：:The β⁰-thalassemia/Hb-E causes a wide range of severe conditions. A high medical cost is incurred in severe cases. Thus, the prevention of new cases of β⁰-thalassemia/Hb-E is required. The aim of this study is to use the SYTO9 and SYBR GREEN1 high-resolution melting (HRM) analysis for prenatal diagnosis of β⁰-thalasse...

journal_title：European journal of haematology

authors： Pornprasert S,Sukunthamala K

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:Homoharringtonine (HHT) was efficient in therapying patients with acute myeloid leukemia (AML) in China, but little is known about the mechanism of its action. As the abnormal activation of JAK2 associated pathway is important to AML, we try to explore the effect of HHT on JAK2-STAT pathway in AML cells, thu...

journal_title：European journal of haematology

authors： Tong H,Ren Y,Zhang F,Jin J

更新日期：2008-10-01 00:00:00

abstract：:Whereas beta-2-microglobulin (beta2M) has mainly been used as a prognostic factor in patients with lymphoproliferative disorders, some studies have reported the value of beta2M in myeloproliferative disorders (MPD). In order to investigate a potential role in the pathogenesis of MPD and to find a possible value as ind...

journal_title：European journal of haematology

authors： Bourantas KL,Hatzimichael EC,Makis AC,Chaidos A,Kapsali ED,Tsiara S,Mavridis A

更新日期：1999-07-01 00:00:00

abstract：:Forty-six consecutive patients with acute lymphoblastic leukaemia (ALL), having a median age of 23 years (range 14 to 64), underwent induction and consolidation chemotherapy with weekly parenteral vincristine, adriamycin, l-asparaginase and daily oral prednisone (VAAP), followed by standard central nervous system (CNS...

journal_title：European journal of haematology

authors： Jacobs P,Wood L

更新日期：1992-08-01 00:00:00

abstract：:In acute myeloid leukemia (AML) mouse models, the RUNX1-RUNX1T1 fusion protein has failed to produce leukemia by itself, but alternative splicing of exon 9a of the RUNX1-RUNX1T1 fusion transcript (FT) has recently been shown to enhance the leukemogenic potential. We have analyzed 138 diagnosis and follow-up samples fr...

journal_title：European journal of haematology

authors： Ommen HB,Ostergaard M,Yan M,Braendstrup K,Zhang DE,Hokland P

更新日期：2010-02-01 00:00:00

abstract：:Immunoglobulin gene rearrangements in B-cell lymphoma subtypes may not always be detected by PCR if only one primer set is applied. We therefore analysed a range of low and high grade B-cell lymphoma subtypes for monoclonality using PCR, to determine appropriate primer selection strategies for routine diagnostic use. ...

journal_title：European journal of haematology

authors： Essop MF,Blakolmer K,Close PM,Manuel YE,Cornelius S

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Interleukin-6 (IL-6) is a multifunctional cytokine that plays roles in the immune response, inflammation and hematopoiesis. Serum IL-6 levels have reported to reflect disease severity and high tumor burden in multiple myeloma (MM) patients and to correlate with several other laboratory parameters. Serum-solu...

journal_title：European journal of haematology

authors： Hatzimichael EC,Christou L,Bai M,Kolios G,Kefala L,Bourantas KL

更新日期：2001-01-01 00:00:00

abstract：:506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic nodal tumour burden, ...

journal_title：European journal of haematology

authors： Specht L,Nissen NI

更新日期：1989-08-01 00:00:00

abstract：:A murine cultured cell line (MKM-O) was established from a tumor of a BALB/C (nu/nu) mouse that had been subcutaneously inoculated with human hepatoma tissue fragments in the same location. The MKM-O cell line was proven to be of endothelial origin by morphological examinations and positive staining with fluorescein-l...

journal_title：European journal of haematology

authors： Yoshimura T,Miyanomae T,Tanaka M,Iwai Y,Mayumi M,Mikawa H

更新日期：1987-08-01 00:00:00

abstract：:Administration of both glycosylated and non-glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) induces an immediate transient granulocytopenia of 1-3 hours' duration. In order to explore this phenomenon, granulocytes were labelled with 111Indium and the effect on the kinetics of...

journal_title：European journal of haematology

authors： Hovgaard D,Schifter S,Rabøl A,Mortensen BT,Nissen NI

更新日期：1992-04-01 00:00:00

abstract：:Heparin binds to platelets and can cause platelet proaggregating and potentiating effects, possibly causing thrombocytopenia, particularly in patients in intensive care with hyperaggregable platelets. In this study we compared the platelet proaggregating and potentiating effects of unfractionated heparin (UH), 2 low m...

journal_title：European journal of haematology

authors： Burgess JK,Chong BH

更新日期：1997-04-01 00:00:00

abstract：:For patients with severe and refractory autoimmune diseases, high-dose chemotherapy and autologous hematopoietic stem cell transplantation has been established as a considerable therapeutic option in recent years. In this retrospective single-center analysis, we assessed the feasibility and efficacy of peripheral bloo...

journal_title：European journal of haematology

authors： Blank N,Lisenko K,Pavel P,Bruckner T,Ho AD,Wuchter P

更新日期：2016-07-01 00:00:00

abstract：:Development of resistance to cytotoxic agents is a common problem in the treatment of acute leukemia. In cell lines having multidrug resistance (MDR) phenotype, a decrease in the intracellular accumulation of drugs has been closely related to the overexpression of P-glycoprotein/mdr1 genes. We analyzed the relationshi...

journal_title：European journal of haematology

authors： Kato S,Ideguchi H,Muta K,Nishimura J,Nawata H

更新日期：1991-08-01 00:00:00

abstract：:It has been reported that in vitro prednisolone (PDN) resistance provides a prognostic value in childhood acute lymphoblastic leukaemia (ALL). This study aimed at investigating the biological and clinical significance of in vitro PDN resistance in adult ALL. Blast cells from 30 patients were exposed to PDN (0.1 microM...

journal_title：European journal of haematology

authors： Tosi P,Visani G,Ottaviani E,Manfroi S,Tura S

更新日期：1996-08-01 00:00:00

abstract：:A 59-yr-old man developed fevers, shortness of breath, persistent cough and weight loss, shortly after initiation of therapy with interferon-alpha 2a and cytosine arabinoside for treatment of chronic myelogenous leukemia. Radiologic pulmonary infiltrates and lung tissue biopsy were consistent with bronchiolitis oblite...

journal_title：European journal of haematology

authors： Patel M,Ezzat W,Pauw KL,Lowsky R

更新日期：2001-11-01 00:00:00

abstract：:We conducted a prospective study in order to compare ultrasonography, computed tomography and magnetic resonance imaging in the detection of liver foci in patients with acute leukaemia and clinical suspicion of hepatic candidiasis. 28 adult patients fulfilling set entry criteria after recovery from neutropenia were st...

journal_title：European journal of haematology

authors： Anttila VJ,Lamminen AE,Bondestam S,Korhola O,Färkkilä M,Sivonen A,Ruutu T,Ruutu P

更新日期：1996-01-01 00:00:00

abstract：:In a phase II study 28 patients with advanced multiple myeloma were treated with a five drug regimen consisting of vincristine, BCNU, adriamycin, melphalan and dexamethasone. 11 out of 13 patients without prior chemotherapy showed significant remissions (greater than 25% tumor cells mass reduction), 7 of them had more...

journal_title：European journal of haematology

authors： Peest D,Schmoll HJ,Schedel I,Glück S,Schumacher K,Deicher H

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVES:Acquired trisomy 21 is one of the most common numerical abnormalities in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), and MDS/MPN; however, little is known about its pathogenic impact, accompanying submicroscopic changes, and its relation to other clinical...

journal_title：European journal of haematology

authors： Larsson N,Lilljebjörn H,Lassen C,Johansson B,Fioretos T

更新日期：2012-02-01 00:00:00

abstract：:Little is known about the S100B⁺ lymphocytes, which are unique human peripheral blood lymphocytes (PBL) containing the S100B protein. It has recently been shown that S100B is released from various types of S100B⁺ cells and exhibits varied cytokine-like activities. In this study, we precisely characterized the S100B⁺ l...

journal_title：European journal of haematology

authors： Miki Y,Gion Y,Mukae Y,Hayashi A,Sato H,Yoshino T,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：:Type IIB is a special variant of von Willebrand's disease, characterized by an abnormal von Willebrand factor which shows an increased interaction with platelets. This interaction sometimes causes platelet aggregation and thrombocytopenia in vivo. It involves the glycoprotein-Ib (GPIb) receptor on platelets and corres...

journal_title：European journal of haematology

authors： Donnér M,Andersson AM,Kristoffersson AC,Nilsson IM,Dahlbäck B,Holmberg L

更新日期：1991-11-01 00:00:00

abstract：:We report the first case of primary sclerosing cholangitis (PSC) complicated with plasma cell dyscrasia (PCD) in which liver transplant resulted in unexpected therapeutic benefit of PCD. A 61-year-old man with 12 yr history of PSC presented with a monoclonal gammopathy of undetermined significance (MGUS) with an IgG l...

journal_title：European journal of haematology

authors： Fontana V,Ahn YS,Horstman LH,Tzakis AG,O'Brien CB

更新日期：2006-02-01 00:00:00

abstract：:To estimate the efficacy of human megakaryocyte purification techniques, mixtures of known numbers of megakaryocytes with a known ploidy range and of bone marrow or peripheral blood mononuclear cells were made. These artificial bone marrow samples were submitted to either a counterflow centrifugal elutriation or Perco...

journal_title：European journal of haematology

authors： van Pampus EC,van Geel BJ,Huijgens PC,Wijermans PW,Ossenkoppele GJ,Rodriguez F,Zevenbergen A,Langenhuijsen MM

更新日期：1991-10-01 00:00:00

abstract：:Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral va...

journal_title：European journal of haematology

authors： Farmakis D,Deftereos S,Giakoumis A,Polymeropoulos E,Aessopos A

更新日期：2004-04-01 00:00:00

abstract：:Ten patients, who received cadaveric kidneys, were followed for 24 wk with serial measurements of serum erythropoietin (S-Epo), transferrin receptor (S-TfR) and iron variables. The mean pretransplant creatinine clearance was 8.2 (range 0-22) ml/min and the mean haemoglobin (Hb) level was 99 +/- 18.6 (range 66-124) g/l...

journal_title：European journal of haematology

authors： Beshara S,Birgegård G,Goch J,Wahlberg J,Wikström B,Danielson BG

更新日期：1997-03-01 00:00:00