Zoledronate-induced remission of acute panmyelosis with myelofibrosis.


:Acute panmyelosis with myelofibrosis is a rare and aggressive form of acute myeloid leukemia. We describe a new case with a huge proliferation of megakaryocytes, blast cells and reticulin fibers. The patient was treated with zoledronate, a third-generation bisphosphonate, and a gradual recovery from pancytopenia was observed. A new bone marrow biopsy performed 4 months later showed a surprising disappearance of the leukemic infiltration. Ten months after the diagnosis, the patient is still in healthy condition. This may support the recently described anti-tumor activity of zoledronate.


Eur J Haematol


Español I,Romagosa V,Berlanga J,Domingo A,Losa F,Heras L,Janáriz J




Has Abstract


2004-09-01 00:00:00














  • BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation.

    abstract:BACKGROUND:Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA-haploidentical transplantation. Adoptive immunotransfer of virus-specific T cells from the donor is a promising therapeutic approach, although ...

    journal_title:European journal of haematology



    authors: Pello OM,Innes AJ,Bradshaw A,Finn SA,Uddin S,Bray E,Olavarria E,Apperley JF,Pavlů J

    更新日期:2017-06-01 00:00:00

  • Cost analysis of CHOP (-like) chemotherapy regimens for patients with newly diagnosed aggressive non-Hodgkin's lymphoma.

    abstract::Many cost analyses of stem-cell transplantations are available, which is in sharp contrast to the level of cost analyses on first-line chemotherapy for aggressive non-Hodgkin's lymphoma (NHL). Given the scarcity of cost analyses of first-line chemotherapy for NHL, it is difficult to assess the economic impact of upcom...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: van Agthoven M,Faber LM,Uyl-de Groot CA,Sonneveld P,Verdonck LF,Willemze R,Kluin-Nelemans JC,Löwenberg B,Huijgens PC

    更新日期:2002-10-01 00:00:00

  • Dialysate concentration and pharmacokinetics of 2F-Ara-A in a patient with acute renal failure.

    abstract::Fludarabine is frequently used for treatment of B-cell chronic lymphocytic leukemia and in conditioning regimes for hematopoietic cell transplantations. The total body clearance of the principal metabolite 2-fluoro-ara-A (2F-Ara-A) correlates with the creatinine clearance. We report data on total dialysate concentrati...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Kielstein JT,Stadler M,Czock D,Keller F,Hertenstein B,Radermacher J

    更新日期:2005-06-01 00:00:00

  • A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy.

    abstract::We report the case of an Epstein-Barr virus (EBV)- and human immunodeficiency virus-serum negative patient suffering from repeatedly relapsing classical Hodgkin's Lymphoma (cHL) associated with a histological picture of plasma cell-hyaline vascular (PC-HV) form of Castleman's disease (CD). The CD30- and CD15-positive,...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Falchi L,Capello D,Palumbo B,Rauco A,Emili R,Cianciulli M,Pace R,Capparella V,Liberati F,Liberati AM

    更新日期:2007-11-01 00:00:00

  • Treatment of acute lymphoblastic leukaemia (ALL).

    abstract::Forty-six consecutive patients with acute lymphoblastic leukaemia (ALL), having a median age of 23 years (range 14 to 64), underwent induction and consolidation chemotherapy with weekly parenteral vincristine, adriamycin, l-asparaginase and daily oral prednisone (VAAP), followed by standard central nervous system (CNS...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jacobs P,Wood L

    更新日期:1992-08-01 00:00:00

  • The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities.

    abstract::Cobalamin levels are frequently low in patients with dementia, but it is unclear if they represent definable deficiency and what the mechanisms are. Therefore, patients being evaluated for dementia who had low cobalamin levels but no obvious evidence of deficiency were studied hematologically, neurologically and with ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Carmel R,Gott PS,Waters CH,Cairo K,Green R,Bondareff W,DeGiorgio CM,Cummings JL,Jacobsen DW,Buckwalter G

    更新日期:1995-04-01 00:00:00

  • Neurological toxicity of long-term (>1 yr) thalidomide therapy in patients with multiple myeloma.

    abstract:OBJECTIVE:Thalidomide is remarkably active in advanced relapsed and refractory multiple myeloma (MM), so that its use has been recently proposed either in newly diagnosed patients or as maintenance treatment after conventional or high-dose therapy. This latter therapeutic approach has risen the concern of side-effects ...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Tosi P,Zamagni E,Cellini C,Plasmati R,Cangini D,Tacchetti P,Perrone G,Pastorelli F,Tura S,Baccarani M,Cavo M

    更新日期:2005-03-01 00:00:00

  • Atypical hemoglobin H disease in a Thai patient resulting from a combination of alpha-thalassemia 1 and hemoglobin Constant Spring with hemoglobin J Bangkok heterozygosity.

    abstract::A case of hemoglobin H disease in combination with hemoglobin Constant Spring and a beta-globin chain variant is reported in a 3-yr-old Thai girl. On routine cellulose acetate electrophoresis, one abnormal band in addition to the hemoglobins A, A2, H, Bart's and Constant Spring was detected. The amount of this abnorma...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Fucharoen S,Ayukarn K,Sanchaisuriya K,Fucharoen G

    更新日期:2001-05-01 00:00:00

  • Discrepant ratios of arterial vs. venous thrombosis in hemophilias A and B as compared to FVII deficiency.

    abstract:BACKGROUND:The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von Willebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is know...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

    更新日期:2013-08-01 00:00:00

  • Plasma and cellular pharmacokinetics of m-AMSA related to in vitro toxicity towards normal and leukemic clonogenic bone marrow cells (CFU-GM, CFU-L).

    abstract::Plasma and cellular pharmacokinetics of m-AMSA were investigated in 5 patients with acute leukemia, using HPLC. The pharmacokinetic data served as a guideline for in vitro toxicity tests on clonogenic bone marrow cells. m-AMSA was administered as a 3-hour intravenous infusion of 100 mg/m2. Median plasma and nucleated ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Linssen P,Brons P,Knops G,Wessels H,de Witte T

    更新日期:1993-03-01 00:00:00

  • Hereditary protein C deficiency and thrombosis risk: genotype and phenotype relation in a large Italian family.

    abstract:UNLABELLED:Protein C (PC) deficiency is an autosomal dominant inherited disorder associated with spontaneous and recurrent thrombotic events. Factor V Leiden (FVL) increases the risk of thrombosis in PC-deficient type I families. We have investigated the relationship between PC deficiency genotype and clinical phenotyp...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Cafolla A,D'Andrea G,Baldacci E,Margaglione M,Mazzucconi MG,Foà R

    更新日期:2012-04-01 00:00:00

  • The ageing patient with haemophilia.

    abstract::Older patients with haemophilia (PWH) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing. This article discusses the clinical experience published about the high prevalence of diseases in older PWH. These conditions are managed in the general population by hea...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Canaro M,Goranova-Marinova V,Berntorp E

    更新日期:2015-02-01 00:00:00

  • Rapid infusion of rituximab over 60 min.

    abstract::The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Tuthill M,Crook T,Corbet T,King J,Webb A

    更新日期:2009-04-01 00:00:00

  • Flow cytometric identification of myeloid disorders by asynchronous expression of the CD14 and CD66 antigens.

    abstract::Using a multiparameter flow cytometry assay enumerating cells positive for CD13, CD14 and CD66 antigens, we determined the asynchronous CD14/CD66 co-expression in unselected bone marrow and peripheral blood samples with suspected malignant blood disorders. CD14/CD66 co-expression > or = 5% were found in 131/691 bone m...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Hansen I,Meyer K,Hokland P

    更新日期:1998-11-01 00:00:00

  • Hypocholesterolemia in adult patients with thalassemia: a link with the severity of genotype in thalassemia intermedia patients.

    abstract:OBJECTIVES:Hypocholesterolemia has been previously described in patients affected by thalassemia. In this study we retrospectively evaluated the cholesterol level in two groups of patients affected by either thalassemia major (TM) or thalassemia intermedia (TI), with the aim of establishing factors correlated to hypoch...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Ricchi P,Ammirabile M,Spasiano A,Costantini S,Di Matola T,Cinque P,Pagano L,Prossomariti L

    更新日期:2009-03-01 00:00:00

  • Isolation and characterization of a tumor necrosis factor binding protein from urine.

    abstract::Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Olsson I,Lantz M,Nilsson E,Peetre C,Thysell H,Grubb A,Adolf G

    更新日期:1989-03-01 00:00:00

  • Evaluation of the genetic basis of phenotypic heterogeneity in north Indian patients with thalassemia major.

    abstract:OBJECTIVES:To assess the molecular basis of phenotypic heterogeneity in north Indian patients with thalassemia major (TM). METHODS:To determine the clinical severity, 130 patients of TM were studied for the age of first presentation and frequency of blood transfusion. The type of beta mutations, Xmn-1(G)gamma polymorp...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Sharma N,Das R,Kaur J,Ahluwalia J,Trehan A,Bansal D,Panigrahi I,Marwaha RK

    更新日期:2010-06-01 00:00:00

  • Patient-specific analysis of FLT3 internal tandem duplications for the prognostication and monitoring of acute myeloid leukemia.

    abstract:OBJECTIVES:Internal tandem duplications (ITDs) of the fms-like tyrosine kinase 3 ( FLT3) gene occur in 13-35% of patients with acute myeloid leukemia (AML). FLT3-ITD is associated with poor clinical outcome and is an indication for allogeneic stem cell transplantation (allo-SCT). METHODS:To investigate FLT3-ITD length...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Schiller J,Praulich I,Krings Rocha C,Kreuzer KA

    更新日期:2012-07-01 00:00:00

  • Serum erythropoietin (EPO) levels correlate with survival and independently predict response to EPO treatment in patients with myelodysplastic syndromes.

    abstract::Treatment with recombinant erythropoietin (EPO) can alleviate anaemia in patients with myelodysplastic syndromes (MDS). The present study, based on a long-term follow-up of 68 MDS patients (26RA, 16 RAS, 26 RAEB) treated with EPO alone, pinpoints pre-treatment variables associated with response induction, response dur...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Wallvik J,Stenke L,Bernell P,Nordahl G,Hippe E,Hast R

    更新日期:2002-03-01 00:00:00

  • Leucopoiesis versus concentration of cytokines in diffusion chamber cultures of mouse bone marrow cells: clues to the physiological roles of growth factors.

    abstract::Physiological mechanisms that regulate formation of neutrophil granulocytes, macrophages and their precursor cells were studied with the diffusion chamber (DC) technique. DC inoculated with mouse bone marrow cells were implanted intraperitoneally into host mice. When these in vivo cultures had been established and the...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Benestad HB,Løvhaug D,Strøm-Gundersen I

    更新日期:1989-01-01 00:00:00

  • Altered erythropoiesis and iron metabolism in carriers of thalassemia.

    abstract::The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

    更新日期:2015-06-01 00:00:00

  • miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 expressions in autologous hematopoietic stem cell transplantation and their impact on engraftment.

    abstract:OBJECTIVE:MicroRNAs engaged in angiogenesis and hematopoiesis can influence hematopoietic stem cells (HSCs) homing after transplantation by targeting bone marrow niche microenvironment. This study aimed to examine the kinetics of miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 in autologous HSC transplantatio...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Nowicki M,Szemraj J,Wierzbowska A,Misiewicz M,Małachowski R,Pluta A,Grzybowska-Izydorczyk O,Robak T,Szmigielska-Kapłon A

    更新日期:2018-05-01 00:00:00

  • Long-term complication in follicular lymphoma: assessing the risk of secondary neoplasm in 242 patients treated or not with 90-yttrium-ibritumomab-tiuxetan.

    abstract:BACKGROUND:Non-Hodgkin lymphoma patients have a 25% increased risk of secondary primary neoplasms (SPNs). Regarding the controversy about the increased risk of SPN in patients exposed to radioimmunotherapy (RIT), we have analyzed this issue in a cohort of follicular lymphoma (FL) patients treated with/without RIT. PAT...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Andrade-Campos MM,Liévano P,Espinosa-Lara N,Soro-Alcubierre G,Grasa-Ulrich JM,López-Gómez L,Baringo T,Giraldo P

    更新日期:2016-12-01 00:00:00

  • Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-beta1 by bone marrow stromal cells.

    abstract::Previous studies in our laboratory have shown that patients with chronic idiopathic neutropenia of adults (CINA) have increased serum levels of inflammatory cytokines including IL-1beta. Since IL-1beta may affect bone marrow stromal cell function, a study was designed to investigate the capacity of patients' stromal c...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Papadaki HA,Giouremou K,Eliopoulos GD

    更新日期:1999-09-01 00:00:00

  • Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene.

    abstract::Upshaw-Schulman syndrome (USS) is due to severe congenital deficiency of von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 domains, nr 13) activity resulting in the presence of unusually large forms of VWF in the circulation, causing intravascular plat...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Rank CU,Kremer Hovinga J,Taleghani MM,Lämmle B,Gøtze JP,Nielsen OJ

    更新日期:2014-02-01 00:00:00

  • Analysis of fetal blood using capillary electrophoresis system: a simple method for prenatal diagnosis of severe thalassemia diseases.

    abstract:INTRODUCTION:Prenatal diagnosis of severe alpha- and beta-thalasssemia diseases is usually performed by DNA analysis. OBJECTIVE:To establish a simple method, we have evaluated the reliability of prenatal diagnosis by fetal blood analysis using automated capillary electrophoresis system. METHODS:Forty-seven fetal bloo...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Srivorakun H,Fucharoen G,Sae-Ung N,Sanchaisuriya K,Ratanasiri T,Fucharoen S

    更新日期:2009-07-01 00:00:00

  • The molecular pathogenesis of the myelodysplastic syndromes.

    abstract::Recent studies have greatly illuminated the genomic landscape of the myelodysplastic syndromes (MDS), and the pace of discovery is accelerating. The most common mutations found in MDS occur in genes involved in RNA splicing (including SF3B1, SRSF2, U2AF1, and ZRSR2) and epigenetic modification (including TET2, ASXL1, ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审


    authors: Pellagatti A,Boultwood J

    更新日期:2015-07-01 00:00:00

  • Intensive remission induction therapy for chronic myeloid leukemia in blast phase with a goal of post-remission bone marrow transplant--a pilot study.

    abstract::An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

    更新日期:1996-07-01 00:00:00

  • Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.

    abstract::The development of an autoantibody to human Factor VIII is rare and presents many problems for diagnosis and treatment. We have seen several cases at our institution recently with widely heterogenous clinical and laboratory presentations. A wide range of treatment modalities were used in these cases with no gold stand...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Hall RL,Leahy MF

    更新日期:2001-03-01 00:00:00

  • Lenalidomide as maintenance treatment for patients with multiple myeloma after autologous stem cell transplantation: A pharmaco-economic assessment.

    abstract:OBJECTIVE:Autologous stem cell transplantation (ASCT) has improved progression-free survival (PFS) and overall survival in eligible patients with newly diagnosed multiple myeloma (NDMM); however, relapse occurs. Maintenance therapy with lenalidomide (Len-Mt) extends survival and delays relapse and the subsequent initia...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Uyl-de Groot CA,Ramsden R,Lee D,Boersma J,Zweegman S,Dhanasiri S

    更新日期:2020-11-01 00:00:00