Zoledronate-induced remission of acute panmyelosis with myelofibrosis.

Abstract:

:Acute panmyelosis with myelofibrosis is a rare and aggressive form of acute myeloid leukemia. We describe a new case with a huge proliferation of megakaryocytes, blast cells and reticulin fibers. The patient was treated with zoledronate, a third-generation bisphosphonate, and a gradual recovery from pancytopenia was observed. A new bone marrow biopsy performed 4 months later showed a surprising disappearance of the leukemic infiltration. Ten months after the diagnosis, the patient is still in healthy condition. This may support the recently described anti-tumor activity of zoledronate.

journal_name

Eur J Haematol

authors

Español I,Romagosa V,Berlanga J,Domingo A,Losa F,Heras L,Janáriz J

doi

10.1111/j.1600-0609.2004.00277.x

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

215-8

issue

3

eissn

0902-4441

issn

1600-0609

pii

EJH277

journal_volume

73

pub_type

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