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Phenotype-genotype correlation in Sicilian patients with Hb H.

Abstract：

:We studied 15 Sicilian subjects with Hb H disease correlating clinical examinations with hematological and molecular data. Seven different alpha-tha1 mutations were identified: four deletion types (--MED --CAL, -alpha3.7, -alpha4.2) and three nondeletion types (alpha(Ncol)alpha, alpha(Hph)alpha, alphaCSalpha). All the patients had a zero-gene chromosome (--MED or --CAL), while the third alpha gene was deleted (-alpha3.7, -alpha4.2) or inactive (alpha(Ncol)alpha, alpha(Hph)alpha, alphaCSalpha). In patients with the nondeletion genotype the analysis of hematological values revealed lower levels of RBC and Hb A2 and significantly higher levels of Hb H. The clinical variability was remarkable, ranging from totally asymptomatic conditions, casually diagnosed, to severe thalassemia intermedia with marked hemolytic crises, liver and spleen enlargement and the necessity for frequent transfusions. The genotype did not justify the gravity of the phenotype in every case, and the differences in clinical manifestations, also notable, are not easily explainable in subjects who apparently have the same genotype.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Mirabile E,Samperi P,Di Cataldo A,Poli A,La Spina M,Schilirò G

doi

10.1034/j.1600-0609.2000.065005306.x

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

306-9

issue

5

eissn

0902-4441

issn

1600-0609

journal_volume

65

pub_type

杂志文章

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