Comparison of poly- and monoclonal antibodies for determination of B-cell clonal excess in an routine clinical laboratory.

abstract：OBJECTIVES:Hepatocyte growth factor (HGF) is a constituent of the myeloma microenvironment and is elevated in sera from myeloma patients compared to healthy individuals. Increased levels of serum HGF predict a poor prognosis. It has previously been shown by us and others HGF can act as a growth factor to myeloma cells ...

journal_title：European journal of haematology

authors： Hov H,Tian E,Holien T,Holt RU,Våtsveen TK,Fagerli UM,Waage A,Børset M,Sundan A

更新日期：2009-04-01 00:00:00

abstract：:Endothelial cell dysfunction is likely to be important in the pathophysiology of ischaemic heart disease and increased levels of endothelial cell markers soluble E-selectin and soluble thrombomodulin may reflect this damage. To determine whether increased levels of these markers were predictive of disease progression,...

journal_title：European journal of haematology

authors： Blann AD,Amiral J,McCollum CN

更新日期：1997-08-01 00:00:00

abstract：:Lactoferrin, unlabelled or 125I-labelled by 2 different methods, was given intravenously to rats. Blood, tissue and liver cell radioactivity was measured. Both of the radiolabelled preparations were eliminated by the liver, and some deposited extrahepatically. One preparation formed large aggregates--here 90% of the h...

journal_title：European journal of haematology

authors： Peen E,Johansson A,Engquist M,Skogh T

更新日期：1998-09-01 00:00:00

abstract：:Monoclonal antibodies 8A and 62B1, recognizing plasma cell-associated antigens, were covalently linked to saporin 6, a ribosome-inactivating protein similar to the A-chain of ricin. Both immunotoxins were tested on target human cell lines U266 and Raji, on non-target K562 cell line and on myeloid CFU-GM progenitors. T...

journal_title：European journal of haematology

authors： Barbieri L,Dinota A,Gobbi M,Tazzari PL,Rizzi S,Bontadini A,Lemoli RM,Tura S,Stirpe F

更新日期：1989-03-01 00:00:00

abstract：:We have studied the kinetics of plasma levels of circulating (c)selectins in 8 patients undergoing bone marrow or stem cell transplantation to gain estimates for the distribution and half-life of (c)selectins and to potentially identify an endothelial source of cP-selectin in patients who are deprived of platelets and...

journal_title：European journal of haematology

authors： Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

更新日期：1998-07-01 00:00:00

abstract：:506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic nodal tumour burden, ...

journal_title：European journal of haematology

authors： Specht L,Nissen NI

更新日期：1989-08-01 00:00:00

abstract：:A 59-yr-old man developed fevers, shortness of breath, persistent cough and weight loss, shortly after initiation of therapy with interferon-alpha 2a and cytosine arabinoside for treatment of chronic myelogenous leukemia. Radiologic pulmonary infiltrates and lung tissue biopsy were consistent with bronchiolitis oblite...

journal_title：European journal of haematology

authors： Patel M,Ezzat W,Pauw KL,Lowsky R

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To retrospectively identify characteristics and risk factors of viral encephalitis (VE) in patients who underwent a haplo-identical hematopoietic stem cell transplant (HSCT). METHODS:A nested case-control study was designed. Cases with VE and controls were identified from a cohort composed of 1274 patients w...

journal_title：European journal of haematology

authors： Zhang XH,Zhang JM,Han W,Chen H,Chen YH,Wang FR,Wang JZ,Zhang YY,Mo XD,Chen Y,Wang Y,Chang YJ,Xu LP,Liu KY,Huang XJ

更新日期：2017-05-01 00:00:00

abstract：:Plasma cell leukemia (PCL) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary PCL occuring 'de novo', or as secondary PCL in patients with relapsed/refractory multiple myeloma. Primary PCL is a distinct cli...

journal_title：European journal of haematology

authors： Jelinek T,Kryukov F,Rihova L,Hajek R

更新日期：2015-07-01 00:00:00

abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

journal_title：European journal of haematology

authors： Bhandari S,Galanello R

更新日期：2012-09-01 00:00:00

abstract：:Multiple myeloma (MM) is considered to be an essentially incurable haematological malignant disease, probably because of the existence of resistant clonal precursor cell with self-renewal capacity. Recent data have indicated that the myeloma cell hierarchy includes circulating clonal memory B cells, which differ consi...

journal_title：European journal of haematology

authors： Björkstrand B,Rasmussen T,Remes K,Gruber A,Pelliniemi TT,Johnsen HE

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:To investigate whether the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) combined with the selective MDM2 antagonist idasanutlin (RG7388) offers superior efficacy to monotherapy in treating B-lymphoid malignancies in preclinical models. METHODS:The combined effect of obinutuzuma...

journal_title：European journal of haematology

authors： Herting F,Herter S,Friess T,Muth G,Bacac M,Sulcova J,Umana P,Dangl M,Klein C

更新日期：2016-11-01 00:00:00

abstract：:Emicizumab, a bispecific humanised monoclonal antibody restoring to some extent the function of activated FVIII deficient in haemophilia A, represents a major therapeutic advance in the management of haemophilia A patients. No dosage adjustment is required, which leads to a major change for patients used to regular bi...

journal_title：European journal of haematology

authors： Nougier C,Jeanpierre E,Ternisien C,Proulle V,Hezard N,Pouplard C,Lasne D,With contributions from the Working Group on Biology of Haemorrhagic Disorders (BIMHO, Under the Aegis of GFHT).

更新日期：2020-12-01 00:00:00

abstract：:This study shows that the ingestion of ethanol provokes alterations in iron metabolism which may lead to iron overload. Impaired release of reticuloendothelial iron was shown by a decrease of the maximum red blood cell utilization when radioactive iron was supplied as colloidal iron. An impairment in the erythropoieti...

journal_title：European journal of haematology

authors： Sánchez J,Casas M,Rama R

更新日期：1988-10-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is one of the most common causes of morbidity and mortality after allogeneic marrow transplantation. We studied 14 consecutive CMV-seropositive patients adding ganciclovir (2.5 mg/kg i.v. every 8 hours for 7 days prior to transplant and 6 mg/kg three times a week after neutrophils becam...

journal_title：European journal of haematology

authors： Yau JC,Dimopoulos MA,Huan SD,Tarrand JJ,Spencer V,Spitzer G,Meneghetti CM,Wallerstein RO,Andersson BS,LeMaistre CF

更新日期：1991-11-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) characterized by the translocation t(11;14)(q13;q32). This lymphoma exhibits a poor prognosis and remains incurable with standard chemotherapy approaches. Recently, we have shown that a majority of patients with acute-type adult T-cell leuke...

journal_title：European journal of haematology

authors： Liu F,Yoshida N,Suguro M,Kato H,Karube K,Arita K,Yamamoto K,Tsuzuki S,Oshima K,Seto M

更新日期：2013-01-01 00:00:00

abstract：:Although cladribine has been reported to be an active purine analog against indolent B-cell non-Hodgkin lymphoma (B-NHL), there are few reports of combination use of cladribine and rituximab. This multicenter phase II study evaluated the efficacy and toxicity of cladribine with rituximab (R-2-CdA) therapy in relapsed ...

journal_title：European journal of haematology

authors： Nagai H,Ogura M,Kusumoto S,Takahashi N,Yamaguchi M,Takayama N,Kinoshita T,Motoji T,Ohyashiki K,Kosugi H,Matsuda S,Ohnishi K,Omachi K,Hotta T

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. OBJECTIVE:In this study, the role of the polymorphism was investiga...

journal_title：European journal of haematology

authors： Willander K,Ungerbäck J,Karlsson K,Fredrikson M,Söderkvist P,Linderholm M

更新日期：2010-09-01 00:00:00

abstract：:The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

journal_title：European journal of haematology

authors： Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To determine the safety, dose-limiting toxicity and maximum tolerated dose (MTD) of the novel hydroxamate histone deacetylase inhibitor belinostat (PXD101) in patients with advanced hematological neoplasms. PATIENTS AND METHODS:Sequential dose-escalating cohorts of three to six patients with hematological mali...

journal_title：European journal of haematology

authors： Gimsing P,Hansen M,Knudsen LM,Knoblauch P,Christensen IJ,Ooi CE,Buhl-Jensen P

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:Recent studies have indicated that patients who receive stem cell transplantation (SCT) and rituximab demonstrate an increased risk of developing hypogammaglobulinemia. Such hypogammaglobulinemia has been found to be due to delayed recovery of memory B cells with an abnormal cell marker expression and impair...

journal_title：European journal of haematology

authors： Nishio M,Endo T,Fujimoto K,Yamamoto S,Obara M,Yamaguchi K,Takeda Y,Goto H,Kasahara I,Sato N,Koike T

更新日期：2009-02-01 00:00:00

abstract：:Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. OBJECTIVES:To report outcomes and AEs in a population-b...

journal_title：European journal of haematology

authors： Aarup K,Rotbain EC,Enggaard L,Pedersen RS,Bergmann OJ,Thomsen RH,Frederiksen M,Frederiksen H,Nielsen T,Christiansen I,Andersen MA,Niemann CU

更新日期：2020-11-01 00:00:00

abstract：UNLABELLED:Historically, treatment of invasive fungal infections (IFI) has consisted of amphotericin B. However, new therapeutic agents have recently been introduced. At the same time, the relatively low incidence of IFI and the progress in the diagnostic accuracy of IFI have made routine use of empirical antifungal th...

journal_title：European journal of haematology

authors： Cherif H,Kalin M,Björkholm M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30...

journal_title：European journal of haematology

authors： Mirre E,Brousse V,Berteloot L,Lambot-Juhan K,Verlhac S,Boulat C,Dumont MD,Lenoir G,de Montalembert M

更新日期：2010-03-01 00:00:00

abstract：:Few risk factors have been established for the plasma cell disorder multiple myeloma, but some of these like African American ethnicity and a family history of B-cell lymphoproliferative diseases suggest a genetic component for the disease. Genetic variation represents the genetic basis of variability in a population....

journal_title：European journal of haematology

authors： Vangsted A,Klausen TW,Vogel U

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To estimate the clinical significance of low serum concentrations of mannose-binding lectin (MBL) in patients with acute myeloid leukaemia (AML) during initial cancer chemotherapy. PATIENTS AND METHODS:80 consecutive, newly diagnosed, and unselected AML patients (age 18-77 yr) undergoing remission induction ch...

journal_title：European journal of haematology

authors： Bergmann OJ,Christiansen M,Laursen I,Bang P,Hansen NE,Ellegaard J,Koch C,Andersen V

更新日期：2003-02-01 00:00:00

abstract：:This study describes a retrospective analysis on the transplant outcome of 56 consecutive patients with myelodysplastic syndrome (MDS) according to their response to hypomethylating agents (HMA). While 2-yr disease-free survival (DFS) of patients who transformed to acute myeloid leukemia (n = 12) was 25%, that of the ...

journal_title：European journal of haematology

authors： Yahng SA,Yoon JH,Shin SH,Lee SE,Cho BS,Lee DG,Eom KS,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Lee JW,Min WS,Kim TG,Park CW,Kim YJ

更新日期：2013-02-01 00:00:00

abstract：:In 18 beta-thalassaemia families from the Ferrara area the incidence of an inherited low flavin mononucleotide (FMN)-dependent pyridoxine phosphate (PNP) oxidase activity, a sensitive indicator of red-cell FMN deficiency, is higher in related members in these families than in the unrelated spouses and controls subject...

journal_title：European journal of haematology

authors： Anderson BB,Perry GM,Clements JE,Studds C,Fashola R,Salsini G,Vullo C

更新日期：1989-04-01 00:00:00

abstract：:Reduced-intensity conditioning regimens have demonstrated lower toxicity but increased relapse rates in the context of allogeneic hematopoietic stem cell transplantation (aSCT) for patients with acute myelogenous leukemia (AML). The FLAMSA- reduced-intensity conditioning (RIC) regimen, combining a cytoreductive and a ...

journal_title：European journal of haematology

authors： Holtick U,Shimabukuro-Vornhagen A,Chakupurakal G,Theurich S,Leitzke S,Burst A,Hallek M,von Bergwelt-Baildon M,Scheid C,Chemnitz JM

更新日期：2016-05-01 00:00:00

abstract：:We investigated the significance of cytokines (soluble interleukin-2 receptor, granulocyte-macrophage colony-stimulating factor, interleukin-6, and interferon-gamma) and CD68-positive microparticles in immune thrombocytopenic purpura. Cytokines were measured by enzyme-linked immunosorbent assay and microparticles were...

journal_title：European journal of haematology

authors： Nomura S,Yanabu M,Kido H,Lan XG,Ichiyoshi H,Katsura K,Miyake T,Miyazaki Y,Kagawa H,Fukuhara S

更新日期：1995-07-01 00:00:00