Genetic variations in multiple myeloma I: effect on risk of multiple myeloma.

abstract：:In secondary erythrocytosis, the elevated red cell count is powered by factors outside the erythroid compartment, for instance by raised erythropoietin (EPO) synthesis based on congenital defects of the oxygen-sensing pathway. The principal transcriptional regulator of EPO synthesis is endothelial PAS domain-containin...

journal_title：European journal of haematology

authors： Schelker RC,Herr W,Grassinger J

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Constitutive activation of STAT5 (by phosphorylation) has been identified in a number of malignancies, including acute myeloid leukemia (AML). OBJECTIVES:We investigated whether the level of phosphorylated STAT5 (pSTAT5) expression correlates with clinical outcome in AML. METHODS:Adult patients with newly ...

journal_title：European journal of haematology

authors： Brady A,Gibson S,Rybicki L,Hsi E,Saunthararajah Y,Sekeres MA,Tiu R,Copelan E,Kalaycio M,Sobecks R,Bates J,Advani AS

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Beta thalassaemia major (β-TM) and sickle-cell disease (SCD) are severe haemogobinopathies requiring life-lasting, advanced medical management. In the Mediterranean region, both conditions occur with high frequency. We assessed the efficacy of the National Program for the Prevention of Haemoglobinopathies in...

journal_title：European journal of haematology

authors： Ladis V,Karagiorga-Lagana M,Tsatra I,Chouliaras G

更新日期：2013-04-01 00:00:00

abstract：:BLyS and APRIL share two receptors - transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) - and BLyS binds to a third receptor, BAFF-R. We previously reported that TACI gene expression is a good indicator of a BLyS-binding receptor in human multipl...

journal_title：European journal of haematology

authors： Moreaux J,Sprynski AC,Dillon SR,Mahtouk K,Jourdan M,Ythier A,Moine P,Robert N,Jourdan E,Rossi JF,Klein B

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES AND METHODS:We conducted a retrospective analysis to evaluate the outcomes of 28 heavily pretreated (median 3 (2-6) treatment lines, sixteen (57%) allotransplanted) relapsed/refractory acute myeloid leukemia patients who had failed salvage venetoclax-based therapies. RESULTS:The median age was 59 years (20-...

journal_title：European journal of haematology

authors： Zucenka A,Pileckyte R,Trociukas I,Peceliunas V,Vaitekenaite V,Maneikis K,Davainis L,Zvirblis T,Stoskus M,Gineikiene E,Norvilas R,Dirse V,Surauciute A,Zucenkiene E,Griskevicius L

更新日期：2021-01-01 00:00:00

abstract：:In the study of patients with Hodgkin's lymphoma (HL) the evaluation of bone marrow biopsy (BMB) can be difficult. In this review we analyze the main diagnostic features and the clinical risk factors of BM involvement. Although the role of BMB is criticized by some authors, its value is irreplaceable in the staging of...

journal_title：European journal of haematology

authors： Franco V,Tripodo C,Rizzo A,Stella M,Florena AM

更新日期：2004-09-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is one of the most common causes of morbidity and mortality after allogeneic marrow transplantation. We studied 14 consecutive CMV-seropositive patients adding ganciclovir (2.5 mg/kg i.v. every 8 hours for 7 days prior to transplant and 6 mg/kg three times a week after neutrophils becam...

journal_title：European journal of haematology

authors： Yau JC,Dimopoulos MA,Huan SD,Tarrand JJ,Spencer V,Spitzer G,Meneghetti CM,Wallerstein RO,Andersson BS,LeMaistre CF

更新日期：1991-11-01 00:00:00

abstract：:Infectious mononucleosis may occasionally be complicated by purpura, but the mechanism of the thrombocytopenia is not known in detail. In the present study, 3 children with mononucleosis-associated purpura were found to have marked elevations of platelet-associated immunoglobulins and circulating platelet binding IgG ...

journal_title：European journal of haematology

authors： Winiarski J

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVES:Some patients with myelodysplastic syndrome (MDS) show a marked increase in the percentage of immature platelet fraction (IPF%) despite the absence of severe thrombocytopenia. To determine the significance of such an unbalanced increase in the IPF%, we investigated the IPF% and other laboratory findings of 5...

journal_title：European journal of haematology

authors： Sugimori N,Kondo Y,Shibayama M,Omote M,Takami A,Sugimori C,Ishiyama K,Yamazaki H,Nakao S

更新日期：2009-01-01 00:00:00

abstract：:Vertical and horizontal interactions between membrane constituents account for integrity, strength and deformability of the erythrocyte. Disruption of vertical interactions caused by membrane protein deficiencies in hereditary spherocytosis (HS), favor membrane vesiculation with development of spherocytic cells. Our a...

journal_title：European journal of haematology

authors： Rocha S,Rebelo I,Costa E,Catarino C,Belo L,Castro EM,Cabeda JM,Barbot J,Quintanilha A,Santos-Silva A

更新日期：2005-05-01 00:00:00

abstract：:Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1-PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophi...

journal_title：European journal of haematology

authors： Capovilla M,Cayuela JM,Bilhou-Nabera C,Gardin C,Letestu R,Baran-Marzak F,Fenaux P,Martin A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Levels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT...

journal_title：European journal of haematology

authors： Kelaidi C,Kattamis A,Apostolakou F,Poziopoulos C,Lazaropoulou C,Delaporta P,Kanavaki I,Papassotiriou I

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Diamond-Blackfan anemia (DBA) is characterized by hypoplastic anemia, congenital anomalies, and a predisposition for malignancies. Most of our understanding of this disorder stems from molecular studies combined with extensive data input from international patient registries. OBJECTIVES:To create an overv...

journal_title：European journal of haematology

authors： van Dooijeweert B,van Ommen CH,Smiers FJ,Tamminga RYJ,Te Loo MW,Donker AE,Peters M,Granzen B,Gille HJJP,Bierings MB,MacInnes AW,Bartels M

更新日期：2018-02-01 00:00:00

abstract：:Involvement of the central nervous system (CNS) in multiple myeloma (MM) is very uncommon; it has been observed in approximately 1% of the MM patients. This review summarizes the clinical and laboratory characteristics and treatment modalities of 109 patients with CNS myelomatosis (CNS MM) reported in the literature. ...

journal_title：European journal of haematology

authors： Nieuwenhuizen L,Biesma DH

更新日期：2008-01-01 00:00:00

abstract：:Treatment with recombinant erythropoietin (EPO) can alleviate anaemia in patients with myelodysplastic syndromes (MDS). The present study, based on a long-term follow-up of 68 MDS patients (26RA, 16 RAS, 26 RAEB) treated with EPO alone, pinpoints pre-treatment variables associated with response induction, response dur...

journal_title：European journal of haematology

authors： Wallvik J,Stenke L,Bernell P,Nordahl G,Hippe E,Hast R

更新日期：2002-03-01 00:00:00

abstract：:CD200R is an inhibitory receptor involved in the regulation of myeloid cells. It recruits Dok-1 and Dok-2, which are potent inhibitors of the Ras signalling pathway used by colony-stimulating factor (CSF) receptors. Dok-1/Dok-2 double knockout (DKO) mice develop leukaemia at 10-12 months of age. We investigated whethe...

journal_title：European journal of haematology

authors： Rijkers ES,de Ruiter T,Buitenhuis M,Veninga H,Hoek RM,Meyaard L

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Approximately 40% of idiopathic thrombotic thrombocytopenic purpura (TTP) patients will suffer an exacerbation (recurrence of TTP within 30 d after their last plasma exchange (PE) procedure), but there are no data to predict who is at greater risk. We studied the clinical utility of demographic and ADAMTS13 b...

journal_title：European journal of haematology

authors： Cataland SR,Yang SB,Witkoff L,Kraut EH,Lin S,George JN,Wu HM

更新日期：2009-12-01 00:00:00

abstract：:To investigate the role of protein phosphorylation in the early phase of EPO-mediated signal transduction, we EPO-stimulated a murine erythroid cell line ELM-I-1 transformed by plasmids comprised of the c-fos enhancer/promoter linked to the luciferase gene. Using this reporter gene system, we previously showed that EP...

journal_title：European journal of haematology

authors： Tsuda H,Huang RW,Takatsuki K

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVES:To evaluate differences in clinical results according to age among patients with chronic myeloid leukemia (CML). METHODS:207 consecutive CML patients treated with imatinib frontline were revised, dividing them in young adults (>20 < 45 years) (YA), middle-aged adults (≥45 < 65 years) (MA) and elderly (≥65 y...

journal_title：European journal of haematology

authors： Latagliata R,Breccia M,Carmosino I,Cesini L,De Benedittis D,Mohamed S,Vozella F,Molica M,Campanelli M,De Luca ML,Colafigli G,Quattrocchi L,Loglisci MG,Massaro F,Canichella M,Diverio D,Mancini M,Alimena G,Foà R

更新日期：2018-06-13 00:00:00

abstract：UNLABELLED:The role of growth hormone (GH) for maintaining normal erythropoiesis among non-GH-deficient elderly subjects is not known. OBJECTIVES:To determine relationships between the concentrations of serum insulin-like growth factor-1 (IGF-1) and it's carrier protein insulin-like growth factor binding protein 3 (IG...

journal_title：European journal of haematology

authors： Nilsson-Ehle H,Bengtsson BA,Lindstedt G,Mellström D

更新日期：2005-02-01 00:00:00

abstract：:The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

journal_title：European journal of haematology

authors： Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

更新日期：2015-06-01 00:00:00

abstract：:Whereas beta-2-microglobulin (beta2M) has mainly been used as a prognostic factor in patients with lymphoproliferative disorders, some studies have reported the value of beta2M in myeloproliferative disorders (MPD). In order to investigate a potential role in the pathogenesis of MPD and to find a possible value as ind...

journal_title：European journal of haematology

authors： Bourantas KL,Hatzimichael EC,Makis AC,Chaidos A,Kapsali ED,Tsiara S,Mavridis A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:A retrospective study was performed to explore the effect of splenectomy on iron balance in thalassemia major (TM). METHODS:Twenty two TM patients treated with splenectomy were compared with a control group (non-splenectomized patients) matched for sex, age, pretransfusional Hb, chelation therapy, and durati...

journal_title：European journal of haematology

authors： Casale M,Cinque P,Ricchi P,Costantini S,Spasiano A,Prossomariti L,Minelli S,Frega V,Filosa A

更新日期：2013-07-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a human herpesvirus 8 (HHV8) associated lymphoproliferative disease characterized by effusions in body cavities, and lack of tumor mass. Valganciclovir is a treatment option in PEL, however, little is known about its clinical efficacy. Ganciclovir has been reported to be effective in...

journal_title：European journal of haematology

authors： Ozbalak M,Tokatlı I,Özdemirli M,Tecimer T,Ar MC,Örnek S,Koroglu A,Laleli Y,Ferhanoglu B

更新日期：2013-11-01 00:00:00

abstract：:Iron is an important mineral element required for diverse life processes. Its metabolism is almost synonymous to erythrocyte maintenance, erythropoiesis and erythrophagocytosis. Consequently, exercise exertion impacts significantly on red cell haematology. Here, the interactions between exercise and erythropoiesis are...

journal_title：European journal of haematology

authors： Latunde-Dada GO

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently lin...

journal_title：European journal of haematology

authors： Koren-Michowitz M,Eting E,Rahimi-Levene N,Garach-Jehoshua O,Volcheck Y,Kornberg A

更新日期：2005-11-01 00:00:00

abstract：:Despite a wide spectrum of treatment options, mantle cell lymphoma (MCL) remains a challenging hematologic malignancy to manage. Advances in front-line therapy, including the monoclonal antibody rituximab and increasing use of cytarabine, have improved remission rates. Autologous hematopoietic cell transplantation (HC...

journal_title：European journal of haematology

authors： Cohen JB,Burns LJ,Bachanova V

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Clonal dominance is characteristic of patients with post-polycythemia vera myelofibrosis (post-PV MF), whereas patients in chronic phase usually display polyclonal hematopoiesis. The aim of this work was to study the mutational burden of JAK2V617F at the progenitor level in patients with PV and correlate it ...

journal_title：European journal of haematology

authors： Angona A,Alvarez-Larrán A,Bellosillo B,Martínez-Avilés L,Camacho L,Fernández-Rodríguez C,Pairet S,Longarón R,Ancochea Á,Senín A,Florensa L,Besses C

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:The extent of disease in patients with multiple myeloma or related conditions may be difficult to assess. In previous small studies, both FDG-PET (PET) and Tc-99m sestamibi scans (MIBI) have identified sites of occult disease in myeloma. METHODS:We reviewed the results for patients at our institution who hav...

journal_title：European journal of haematology

authors： Mileshkin L,Blum R,Seymour JF,Patrikeos A,Hicks RJ,Prince HM

更新日期：2004-01-01 00:00:00