当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HAEMATOLOGY期刊下所有文献 > PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction.

PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction.

Abstract：

BACKGROUND:Levels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT). PATIENTS AND METHODS:We measured levels of PlGF, sFlt-1 and vWF:antigen in patients with NTDT of beta-thalassemia genotype, and correlated them with erythrocytic indices and markers of iron overload, inflammation, and tissue hypoxia. Thirty-four NTDT patients with mean hemoglobin level of 8.4 g/dL were included in the study along with 20 apparently healthy individuals who served as controls. RESULTS:Ferritin, LDH, and hs-CRP were higher in patients as compared to controls. We found significant differences between patients and controls in regard to levels of PlGF (52.2 vs 17.2 pg/mL, P < .001), sFlt-1/PlGF (2 vs 4.7, P < .001), and vWF:antigen (88 vs 77.1 IU/dL, P < .01). There was a strong correlation of ferritin with PlGF (r = .653, P < .001) and with vWF:antigen (r = .503, P = .003). CONCLUSIONS:In this study, we demonstrated an association between increased PlGF and iron overload and the degree of tissue hypoxia in patients with NTDT. High vWF:antigen expressing endothelial damage may be associated with specific NTDT comorbidities.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Kelaidi C,Kattamis A,Apostolakou F,Poziopoulos C,Lazaropoulou C,Delaporta P,Kanavaki I,Papassotiriou I

doi

10.1111/ejh.13061

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

630-635

issue

6

eissn

0902-4441

issn

1600-0609

journal_volume

100

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF HAEMATOLOGY文献大全
  • Bone marrow biopsy in Hodgkin's lymphoma.

    abstract：:In the study of patients with Hodgkin's lymphoma (HL) the evaluation of bone marrow biopsy (BMB) can be difficult. In this review we analyze the main diagnostic features and the clinical risk factors of BM involvement. Although the role of BMB is criticized by some authors, its value is irreplaceable in the staging of...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2004.00292.x

    authors： Franco V,Tripodo C,Rizzo A,Stella M,Florena AM

    更新日期：2004-09-01 00:00:00

  • Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation.

    abstract：:Anaemia of inflammation (AI) is a frequent complication in patients suffering from chronic inflammatory disorders including infections, autoimmune and malignant disease. Cytokine imbalance with a shift towards T-helper (Th)1-type immune response seems to be important in the pathogenesis of this type of anaemia. Interf...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.0902-4441.2003.00197.x

    authors： Weiss G,Schroecksnadel K,Mattle V,Winkler C,Konwalinka G,Fuchs D

    更新日期：2004-02-01 00:00:00

  • Acute myelogenous leukemia in an adult with thrombocytopenia with absent radii syndrome.

    abstract：:Acute myelogenous leukemia with t(8;21)(q22;q22) developed in a 42-yr-old woman having thrombocytopenia with absent radii syndrome (TARS). Standard induction and postremission therapies were safely administered. With each successive chemotherapy, the onset of platelet recovery was not delayed, but peak platelet counts...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1034/j.1600-0609.2003.00054.x

    authors： Go RS,Johnston KL

    更新日期：2003-04-01 00:00:00

  • Renal aspects of thalassaemia a changing paradigm.

    abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2012.01819.x

    authors： Bhandari S,Galanello R

    更新日期：2012-09-01 00:00:00

  • WNT receptors profile expression in mature blood cells and immature leukemic cells: RYK emerges as a hallmark receptor of acute leukemia.

    abstract：BACKGROUND:Wnt signaling induces a plethora of intracellular responses that dictate normal or abnormal cellular behavior. Abnormal WNT signaling has been related to the development of leukemogenic processes. In this regard, it is important to know the expression profile of WNT receptors in normal and malignant cells, i...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12698

    authors： Alvarez-Zavala M,Riveros-Magaña AR,García-Castro B,Barrera-Chairez E,Rubio-Jurado B,Garcés-Ruíz OM,Ramos-Solano M,Aguilar-Lemarroy A,Jave-Suarez LF

    更新日期：2016-08-01 00:00:00

  • Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning regimen in children: a single-center experience.

    abstract：:This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2012.01776.x

    authors： Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

    更新日期：2012-06-01 00:00:00

  • Treatment of consecutive patients with chronic myeloid leukaemia in the cooperating centres from the Czech Republic and the whole of Slovakia after 2000--a report from the population-based CAMELIA Registry.

    abstract：BACKGROUND:Most results on the treatment of chronic myeloid leukaemia (CML) with imatinib were obtained from clinical trials that may differ from the routine practice. We report the results of treatment of consecutive patients with CML at ten major centres during 2000-2008. PATIENTS AND METHODS:Data reporting was retr...

    journal_title：European journal of haematology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1600-0609.2011.01637.x

    authors： Faber E,Mužík J,Koza V,Demečková E,Voglová J,Demitrovičová L,Chudej J,Markuljak I,Cmunt E,Kozák T,Tóthová E,Jarošová M,Dušek L,Indrák K

    更新日期：2011-08-01 00:00:00

  • Isolation and characterization of a tumor necrosis factor binding protein from urine.

    abstract：:Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1989.tb00111.x

    authors： Olsson I,Lantz M,Nilsson E,Peetre C,Thysell H,Grubb A,Adolf G

    更新日期：1989-03-01 00:00:00

  • Constitutive and selective expression of basic fibroblast growth factor in human leukaemia cell lines.

    abstract：:We have previously shown that basic fibroblast growth factor (bFGF) stimulates megakaryocytopoiesis and granulopoiesis in vitro and that normal haematopoietic cells and several leukaemic cell lines express FGF receptors. In this paper, we demonstrate by reverse transcriptase-mediated polymerase chain reaction (RT-PCR)...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1995.tb00249.x

    authors： Gu XF,Bikfalvi A,Chen YZ,Caen JP,Han ZC

    更新日期：1995-09-01 00:00:00

  • Increasing incidence of primary central nervous system lymphoma but no improvement in survival in Sweden 2000-2013.

    abstract：OBJECTIVES:This study aims to characterize the epidemiology of immunocompetent Primary central nervous system lymphoma (PCNSL) diagnosed 2000-2013 in Sweden. METHODS:Cases were identified in the population-based Swedish Lymphoma Register. Incidence per 100 000 person-years and 95% confidence intervals (CI) were calcul...

    journal_title：European journal of haematology

    pub_type： 历史文章,杂志文章

    doi：10.1111/ejh.12980

    authors： Eloranta S,Brånvall E,Celsing F,Papworth K,Ljungqvist M,Enblad G,Ekström-Smedby K

    更新日期：2018-01-01 00:00:00

  • Use of rituximab to treat refractory Diamond-Blackfan anemia.

    abstract：:We report here the first case with Diamond-Blackfan anemia (DBA) who responded to rituximab. The patient is an 8-yr-old Japanese girl with refractory DBA accompanied by complex congenital heart disease. She received two doses of rituximab, 375 mg/m(2)/wk. She became transfusion independent 6 months after the treatment...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2004.00394.x

    authors： Morimoto A,Kuriyama K,Tsuji K,Isoda K,Hibi S,Todo S,Sugimoto T,Imashuku S

    更新日期：2005-05-01 00:00:00

  • Kinetics of circulating selectin levels during bone marrow aplasia.

    abstract：:We have studied the kinetics of plasma levels of circulating (c)selectins in 8 patients undergoing bone marrow or stem cell transplantation to gain estimates for the distribution and half-life of (c)selectins and to potentially identify an endothelial source of cP-selectin in patients who are deprived of platelets and...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1600-0609.1998.tb01058.x

    authors： Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

    更新日期：1998-07-01 00:00:00

  • Congenital haemolytic anaemia in a low birth weight infant due to congenital stomatocytosis.

    abstract：:A baby girl born at 31 weeks gestation showed severe haemolytic anaemia and hyperbilirubinaemia which led to exchange transfusion within the first 12 hours of life. There was no blood group incompatibility between mother and child but there was a marked stomatocytosis of the baby's red blood cells. Family history reve...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1991.tb00554.x

    authors： Huppi PS,Ott P,Amato M,Schneider H

    更新日期：1991-07-01 00:00:00

  • Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.

    abstract：:Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12254

    authors： Brähler S,Thielen I,Schwabe H,Engels M,Kreuzer KA,Wolf J,Ansén S

    更新日期：2014-06-01 00:00:00

  • Increased susceptibility of microcytic red blood cells to in vitro oxidative stress.

    abstract：:Oxidative damage to erythrocytes in thalassaemia has been related to generation of free radicals by an excess of denaturated alpha- or beta-globin chains, intracellular iron overload and low concentration of normal haemoglobin (HGB). Two good indicators of such oxidative damage are the high red blood cell (RBC) malony...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1995.tb00705.x

    authors： Vives Corrons JL,Miguel-García A,Pujades MA,Miguel-Sosa A,Cambiazzo S,Linares M,Dibarrart MT,Calvo MA

    更新日期：1995-11-01 00:00:00

  • Macrophages in spleen and liver direct the migration pattern of rat neutrophils during inflammation.

    abstract：OBJECTIVE:The exact fate of polymorphonuclear neutrophilic granulocytes (PMN; neutrophils) after their mobilization from the bone marrow is not known. It is believed that they, after a relatively short lifespan (1-3 d), become apoptotic and phagocytosed by macrophages. We have recently shown that transfused neutrophils...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2004.00263.x

    authors： Knudsen E,Benestad HB,Seierstad T,Iversen PO

    更新日期：2004-08-01 00:00:00

  • Effect of chronic ethanol administration on iron metabolism in the rat.

    abstract：:This study shows that the ingestion of ethanol provokes alterations in iron metabolism which may lead to iron overload. Impaired release of reticuloendothelial iron was shown by a decrease of the maximum red blood cell utilization when radioactive iron was supplied as colloidal iron. An impairment in the erythropoieti...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00204.x

    authors： Sánchez J,Casas M,Rama R

    更新日期：1988-10-01 00:00:00

  • Hereditary protein C deficiency and thrombosis risk: genotype and phenotype relation in a large Italian family.

    abstract：UNLABELLED:Protein C (PC) deficiency is an autosomal dominant inherited disorder associated with spontaneous and recurrent thrombotic events. Factor V Leiden (FVL) increases the risk of thrombosis in PC-deficient type I families. We have investigated the relationship between PC deficiency genotype and clinical phenotyp...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2011.01742.x

    authors： Cafolla A,D'Andrea G,Baldacci E,Margaglione M,Mazzucconi MG,Foà R

    更新日期：2012-04-01 00:00:00

  • On the interaction between cytosine arabinoside and etoposide in vivo and in vitro.

    abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1993.tb00069.x

    authors： Liliemark J,Knochenhauer E,Gruber A,Pettersson B,Björkholm M,Peterson C

    更新日期：1993-01-01 00:00:00

  • An Arg545----Cys545 substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease.

    abstract：:Type IIB is a special variant of von Willebrand's disease, characterized by an abnormal von Willebrand factor which shows an increased interaction with platelets. This interaction sometimes causes platelet aggregation and thrombocytopenia in vivo. It involves the glycoprotein-Ib (GPIb) receptor on platelets and corres...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1991.tb01858.x

    authors： Donnér M,Andersson AM,Kristoffersson AC,Nilsson IM,Dahlbäck B,Holmberg L

    更新日期：1991-11-01 00:00:00

  • Forced expression of human macrophage colony-stimulating factor in CD34+ cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro.

    abstract：OBJECTIVES:Here, we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in cord blood (CB) CD34+ cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. METHODS:Human M-CSF was overexpressed in cord blood CD34+ cells using a lentiviral vector. RESULTS:We show that ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12867

    authors： Montano Almendras CP,Thudium CS,Löfvall H,Moscatelli I,Schambach A,Henriksen K,Richter J

    更新日期：2017-05-01 00:00:00

  • The hematologic consequences of obesity.

    abstract：:The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic ris...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.13560

    authors： Purdy JC,Shatzel JJ

    更新日期：2020-12-03 00:00:00

  • Acute myeloid leukemia in the pregnant patient.

    abstract：:Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients, the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence ...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.12479

    authors： Thomas X

    更新日期：2015-08-01 00:00:00

  • Chromosome abnormalities defined by conventional cytogenetics in plasma cell leukemia: what have we learned about its biology?

    abstract：:Cancer cells are characterized by having chromosomal abnormalities. The number of aberrations and the specific chromosomes affected are likely correlated with tumor progression. In this study, we analyzed the karyotype of 126 plasma cell leukemia (PCL) patients to identify the most frequently occurring imbalances and ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2011.01629.x

    authors： Jimenez-Zepeda VH,Neme-Yunes Y,Braggio E

    更新日期：2011-07-01 00:00:00

  • Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases.

    abstract：:Treatment with all-trans retinoic acid (ATRA) improves the prognosis of patients with acute promyelocytic leukemia (APL), but ATRA syndrome may occur as a possible fatal side effect, especially in cases refractory to medication or involving pulmonary hemorrhage. We describe two patients with APL who suffered from intr...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.0902-4441.2006.t01-1-EJH2852.x

    authors： Kawasaki K,Akaike H,Miyauchi A,Ouchi K

    更新日期：2006-11-01 00:00:00

  • The first Team Haemophilia Education meeting, 2015, Amsterdam, The Netherlands.

    abstract：:Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7-8 May 2015 in Amsterdam, The Netherlands, aimed to prom...

    journal_title：European journal of haematology

    pub_type：

    doi：10.1111/ejh.12760

    authors： Berntorp E,Hart D,Mancuso ME,d'Oiron R,Perry D,O'Mahony B,Kaczmarek R,Crato M,Pasi J,Miners A,Carlsson KS,Kitchen S,Boehlen F,Giangrande P,Cebura E,Uitslager N,Osooli M,Janeckova D,Haldon R,Rivolta GF

    更新日期：2016-07-01 00:00:00

  • Minor populations of paroxysmal nocturnal hemoglobinuria-type cells in patients with chronic idiopathic neutropenia.

    abstract：:Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor cells under the influence of pro-inflammatory mediators and oligoclonal/monoclonal T-lymphocytes. Because patients with immune-mediated BM failure display ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12766

    authors： Damianaki A,Stagakis E,Mavroudi I,Spanoudakis M,Koutala H,Papadogiannis F,Kanellou P,Pontikoglou C,Papadaki HA

    更新日期：2016-12-01 00:00:00

  • Treatment of acute lymphoblastic leukaemia (ALL).

    abstract：:Forty-six consecutive patients with acute lymphoblastic leukaemia (ALL), having a median age of 23 years (range 14 to 64), underwent induction and consolidation chemotherapy with weekly parenteral vincristine, adriamycin, l-asparaginase and daily oral prednisone (VAAP), followed by standard central nervous system (CNS...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1600-0609.1992.tb00030.x

    authors： Jacobs P,Wood L

    更新日期：1992-08-01 00:00:00

  • M-2 protocol for melphalan-resistant and relapsing multiple myeloma.

    abstract：:33 patients with advanced refractory multiple myeloma received a combination of vincristine, cyclophosphamide, carmustine, melphalan and steroids (M-2 protocol). 20 of them had failed prior chemotherapy with alkylating agents and the remaining 13 patients had relapsed after a response to these drugs. An objective tumo...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00816.x

    authors： Cavo M,Galieni P,Tassi C,Gobbi M,Tura S

    更新日期：1988-02-01 00:00:00

  • APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop.

    abstract：:BLyS and APRIL share two receptors - transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) - and BLyS binds to a third receptor, BAFF-R. We previously reported that TACI gene expression is a good indicator of a BLyS-binding receptor in human multipl...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2009.01262.x

    authors： Moreaux J,Sprynski AC,Dillon SR,Mahtouk K,Jourdan M,Ythier A,Moine P,Robert N,Jourdan E,Rossi JF,Klein B

    更新日期：2009-08-01 00:00:00