Abstract:
BACKGROUND:Levels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT). PATIENTS AND METHODS:We measured levels of PlGF, sFlt-1 and vWF:antigen in patients with NTDT of beta-thalassemia genotype, and correlated them with erythrocytic indices and markers of iron overload, inflammation, and tissue hypoxia. Thirty-four NTDT patients with mean hemoglobin level of 8.4 g/dL were included in the study along with 20 apparently healthy individuals who served as controls. RESULTS:Ferritin, LDH, and hs-CRP were higher in patients as compared to controls. We found significant differences between patients and controls in regard to levels of PlGF (52.2 vs 17.2 pg/mL, P < .001), sFlt-1/PlGF (2 vs 4.7, P < .001), and vWF:antigen (88 vs 77.1 IU/dL, P < .01). There was a strong correlation of ferritin with PlGF (r = .653, P < .001) and with vWF:antigen (r = .503, P = .003). CONCLUSIONS:In this study, we demonstrated an association between increased PlGF and iron overload and the degree of tissue hypoxia in patients with NTDT. High vWF:antigen expressing endothelial damage may be associated with specific NTDT comorbidities.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Kelaidi C,Kattamis A,Apostolakou F,Poziopoulos C,Lazaropoulou C,Delaporta P,Kanavaki I,Papassotiriou Idoi
10.1111/ejh.13061subject
Has Abstractpub_date
2018-06-01 00:00:00pages
630-635issue
6eissn
0902-4441issn
1600-0609journal_volume
100pub_type
杂志文章abstract::In the study of patients with Hodgkin's lymphoma (HL) the evaluation of bone marrow biopsy (BMB) can be difficult. In this review we analyze the main diagnostic features and the clinical risk factors of BM involvement. Although the role of BMB is criticized by some authors, its value is irreplaceable in the staging of...
journal_title:European journal of haematology
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abstract::Anaemia of inflammation (AI) is a frequent complication in patients suffering from chronic inflammatory disorders including infections, autoimmune and malignant disease. Cytokine imbalance with a shift towards T-helper (Th)1-type immune response seems to be important in the pathogenesis of this type of anaemia. Interf...
journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1988.tb00816.x
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00