Abstract：
OBJECTIVES:Iron-overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe(2+) uptake in thalassemic cardiomyocytes are mainly mediated by T-type calcium channels (TTCC). Nevertheless, the role of TTCC as well as other transporters such as divalent metal transporter1 (DMT1) and L-type calcium channels (LTCC) as possible portals for iron entry into the heart in in vivo thalassemic mice under an iron-overload condition has not been investigated. METHODS:An iron-overload condition was induced in genetically altered β-thalassemic mice and adult wild-type mice by feeding them with an iron diet (0.2% ferrocene w/w) for 3 months. Then, blockers for LTCC (verapamil and nifedipine), TTCC (efonidipine), and DMT1 (ebselen) as well as iron chelator desferoxamine (DFO) were given for 1 month with continuous iron feeding. RESULTS:Treatment with LTCC, TTCC, DMT1 blockers, and DFO reduced cardiac iron deposit, cardiac malondialdehyde (MDA), plasma non-transferrin-bound iron, and improved heart rate variability and left ventricular (LV) function in thalassemic mice with iron overload. Only TTCC and DMT1 blockers and DFO reduced liver iron accumulation, liver MDA, plasma MDA, and decreased mortality rate in iron-overloaded thalassemic mice. CONCLUSIONS:DMT1, LTCC, and TTCC played important roles for iron entry in the thalassemic heart under an iron-overloaded condition. Unlike LTCC blocker, TTCC blocker provided all benefits including attenuating iron deposit in both the heart and liver, reduced oxidative stress, and decreased mortality in iron-overloaded mice.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Kumfu S,Chattipakorn S,Chinda K,Fucharoen S,Chattipakorn Ndoi
10.1111/j.1600-0609.2012.01779.xsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
535-48issue
6eissn
0902-4441issn
1600-0609journal_volume
88pub_type
杂志文章abstract：:As a component of the MRN complex (which is a heterotrimeric protein complex consisting of MRE11, RAD50 and NBS1), NBS1 plays an important role in cellular response to DNA damage and the maintenance of chromosomal integrity. Leukemia is common in NBS1 germ line-mutated patients. The NBS1 E185Q polymorphism (8360G>C, r...
journal_title：European journal of haematology
pub_type： 杂志文章,多中心研究
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abstract：:Soluble tumour necrosis factor receptors (sTNF-Rs) play a role as modulators of the biological function of tumour necrosis factor-alpha (TNF-alpha) in an agonist/antagonist pattern. In various pathologic states the production and release of sTNF-Rs may mediate host response and determine the course and outcome of dise...
journal_title：European journal of haematology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0609.1995.tb01618.x
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abstract：OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...
journal_title：European journal of haematology
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journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/ejh.12081
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journal_title：European journal of haematology
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doi：10.1111/j.1600-0609.1987.tb00759.x
更新日期：1987-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1600-0609.2005.00416.x
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journal_title：European journal of haematology
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journal_title：European journal of haematology
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doi：10.1111/j.1600-0609.1988.tb00204.x
更新日期：1988-10-01 00:00:00
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journal_title：European journal of haematology
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doi：
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journal_title：European journal of haematology
pub_type： 临床试验,杂志文章
doi：10.1111/ejh.12361
更新日期：2014-11-01 00:00:00
abstract：:Central nervous system (CNS) involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages with lymph node or visceral involvement. We describe a patient with advanced stage MF in large-cell transformation who presented with profound hearing loss after chemotherapy. Despite an initial differenti...
journal_title：European journal of haematology
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doi：10.1034/j.1600-0609.2000.9c119.x
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVES:Cord blood (CB) transplantation has advantages in terms of incidence and severity of acute graft-versus-host disease (GVHD), while it has disadvantages in terms of infection. Our aim is to elucidate the molecular mechanism underlying the immune response of CB-derived cells during acute GVHD and infection fol...
journal_title：European journal of haematology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-0609.2011.01707.x
更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/j.1600-0609.2006.00805.x
更新日期：2007-04-01 00:00:00
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journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1600-0609.2005.00439.x
更新日期：2005-06-01 00:00:00
abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...
journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1600-0609.1993.tb00069.x
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journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1600-0609.2007.00890.x
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doi：10.1111/j.1600-0609.1999.tb01909.x
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journal_title：European journal of haematology
pub_type： 临床试验,杂志文章
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更新日期：2007-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1600-0609.1996.tb01397.x
更新日期：1996-11-01 00:00:00
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journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1600-0609.1997.tb00735.x
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abstract：:The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...
journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1600-0609.2009.01215.x
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doi：10.1034/j.1600-0609.2002.01601.x
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journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/ejh.13477
更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章,评审
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abstract：:Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...
journal_title：European journal of haematology
pub_type： 杂志文章
doi：10.1111/ejh.12254
更新日期：2014-06-01 00:00:00
