Transient antagonism of anti-CD20 monoclonal antibodies and PI3K inhibitor idelalisib in DLBCL cell lines.

abstract：:Endothelial cell dysfunction is likely to be important in the pathophysiology of ischaemic heart disease and increased levels of endothelial cell markers soluble E-selectin and soluble thrombomodulin may reflect this damage. To determine whether increased levels of these markers were predictive of disease progression,...

journal_title：European journal of haematology

authors： Blann AD,Amiral J,McCollum CN

更新日期：1997-08-01 00:00:00

abstract：:This study describes a retrospective analysis on the transplant outcome of 56 consecutive patients with myelodysplastic syndrome (MDS) according to their response to hypomethylating agents (HMA). While 2-yr disease-free survival (DFS) of patients who transformed to acute myeloid leukemia (n = 12) was 25%, that of the ...

journal_title：European journal of haematology

authors： Yahng SA,Yoon JH,Shin SH,Lee SE,Cho BS,Lee DG,Eom KS,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Lee JW,Min WS,Kim TG,Park CW,Kim YJ

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Infections remain a leading cause of morbidity and mortality in patients with reduced immunity caused by haematological disease and chemotherapy-induced neutropenia. We evaluated the clinical and microbiological impact of discontinuing fluoroquinolone prophylaxis in these patients. METHODS:We analysed 154 a...

journal_title：European journal of haematology

authors： Verlinden A,Jansens H,Goossens H,van de Velde AL,Schroyens WA,Berneman ZN,Gadisseur AP

更新日期：2014-10-01 00:00:00

abstract：:The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). E...

journal_title：European journal of haematology

authors： Joly P,Garnier N,Kebaili K,Renoux C,Dony A,Cheikh N,Renard C,Ceraulo A,Cuzzubbo D,Pondarré C,Martin C,Pialoux V,Francina A,Bertrand Y,Connes P

更新日期：2016-04-01 00:00:00

abstract：:The European LeukemiaNet (ELN) is composed of several work packages, four of them being directly involved in the various aspects of diagnosis. On the occasion of the annual ELN meeting of 2015 in Mannheim, these four work packages collectively examined the current situation and future prospects of cytomorphology, flow...

journal_title：European journal of haematology

authors： Béné MC,Grimwade D,Haferlach C,Haferlach T,Zini G,European LeukemiaNet.

更新日期：2015-10-01 00:00:00

abstract：:Tissue factor (TF) production is under strict control in mature monocytic cells. However, constitutive expression of TF can be found in myelomonocytic cells and in haematopoietic cells arrested at an early stage of differentiation. In this paper we show that TF expression is down-regulated during the monocyte/granuloc...

journal_title：European journal of haematology

authors： Tenno T,Oberg F,Nilsson K,Siegbahn A

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:This study aims to characterize the epidemiology of immunocompetent Primary central nervous system lymphoma (PCNSL) diagnosed 2000-2013 in Sweden. METHODS:Cases were identified in the population-based Swedish Lymphoma Register. Incidence per 100 000 person-years and 95% confidence intervals (CI) were calcul...

journal_title：European journal of haematology

authors： Eloranta S,Brånvall E,Celsing F,Papworth K,Ljungqvist M,Enblad G,Ekström-Smedby K

更新日期：2018-01-01 00:00:00

abstract：:Vertical and horizontal interactions between membrane constituents account for integrity, strength and deformability of the erythrocyte. Disruption of vertical interactions caused by membrane protein deficiencies in hereditary spherocytosis (HS), favor membrane vesiculation with development of spherocytic cells. Our a...

journal_title：European journal of haematology

authors： Rocha S,Rebelo I,Costa E,Catarino C,Belo L,Castro EM,Cabeda JM,Barbot J,Quintanilha A,Santos-Silva A

更新日期：2005-05-01 00:00:00

abstract：:Bcl-2 expression, the number of apoptotic cells and the growth and differentiation of early bone marrow progenitor cells were studied in patients with confirmed diagnosis of acute myeloid leukaemia (AML). Bone marrow cells from normal individuals were used as controls. We observed an increased percentage of bcl-2-mono...

journal_title：European journal of haematology

authors： Bincoletto C,Saad ST,da Silva ES,Queiroz ML

更新日期：1999-01-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is a rare familial hematologic disorder that has various modes of inheritance. We have studied 2 siblings with DC. 1 sibling had thrombocytopenia, which responded to therapy with nandrolone decanoate and oxymetholone. Platelets were abnormally small, which indicates that a qualitatively abn...

journal_title：European journal of haematology

authors： Juneja HS,Elder FF,Gardner FH

更新日期：1987-10-01 00:00:00

abstract：:Alkaline phosphatase (ALP) activity of 70 cases of non-Hodgkin's lymphomas of the B-cell type was studied. ALP activity was found in malignant lymphoma (ML), follicular, small cleaved cell (1/5 cases); ML, diffuse, small cleaved cell (3/13 cases); and mantle zone lymphoma (intermediate lymphocytic lymphoma) (2/2 cases...

journal_title：European journal of haematology

authors： Abe M,Nozawa Y,Wachi E,Tominaga K,Hojo H,Wakasa H

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVES:Acquired trisomy 21 is one of the most common numerical abnormalities in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), and MDS/MPN; however, little is known about its pathogenic impact, accompanying submicroscopic changes, and its relation to other clinical...

journal_title：European journal of haematology

authors： Larsson N,Lilljebjörn H,Lassen C,Johansson B,Fioretos T

更新日期：2012-02-01 00:00:00

abstract：:8 patients with chronic myeloid leukaemia in the chronic phase who had previously received chemotherapy were given alpha-interferon (Intron A). The Intron A was administered subcutaneously at a dose of 2 x 10(6) I.U./m2 three times a week and this was increased to 4-5 million I.U./m2 daily if no response was obtained ...

journal_title：European journal of haematology

authors： Friche E,Hansen MM,Wieslander S

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVES AND METHODS:We conducted a retrospective analysis to evaluate the outcomes of 28 heavily pretreated (median 3 (2-6) treatment lines, sixteen (57%) allotransplanted) relapsed/refractory acute myeloid leukemia patients who had failed salvage venetoclax-based therapies. RESULTS:The median age was 59 years (20-...

journal_title：European journal of haematology

authors： Zucenka A,Pileckyte R,Trociukas I,Peceliunas V,Vaitekenaite V,Maneikis K,Davainis L,Zvirblis T,Stoskus M,Gineikiene E,Norvilas R,Dirse V,Surauciute A,Zucenkiene E,Griskevicius L

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:MicroRNAs engaged in angiogenesis and hematopoiesis can influence hematopoietic stem cells (HSCs) homing after transplantation by targeting bone marrow niche microenvironment. This study aimed to examine the kinetics of miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 in autologous HSC transplantatio...

journal_title：European journal of haematology

authors： Nowicki M,Szemraj J,Wierzbowska A,Misiewicz M,Małachowski R,Pluta A,Grzybowska-Izydorczyk O,Robak T,Szmigielska-Kapłon A

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Northern Norway consists of a multiethnic population of Sámi and non-Sámi. We evaluated iron status in these two groups with respect to gender, age and residence. METHODS:In 2002-2004, a cross-sectional study of health and living conditions in areas with both Sámi and Norwegian populations, SAMINOR, was per...

journal_title：European journal of haematology

authors： Broderstad AR,Melhus M,Lund E

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) play key roles in a wide variety of normal and pathological cellular processes. A number of studies identified hematopoietic-specific miRNAs that are necessary for correct function of blood cells. Out of our microarray data, we chose 13 miRNAs that showed differential expression in periphe...

journal_title：European journal of haematology

authors： Merkerova M,Belickova M,Bruchova H

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Beta thalassaemia major (β-TM) and sickle-cell disease (SCD) are severe haemogobinopathies requiring life-lasting, advanced medical management. In the Mediterranean region, both conditions occur with high frequency. We assessed the efficacy of the National Program for the Prevention of Haemoglobinopathies in...

journal_title：European journal of haematology

authors： Ladis V,Karagiorga-Lagana M,Tsatra I,Chouliaras G

更新日期：2013-04-01 00:00:00

abstract：:T-cell lymphoma is an aggressive lymphoma that cannot be cured despite aggressive therapy, including autologous stem cell transplantation. Thalidomide is an immunomodulatory drug with numerous properties that has proven effective in relapsed multiple myeloma and, to a lesser extent, in other hematologic diseases. We r...

journal_title：European journal of haematology

authors： Damaj G,Bouabdallah R,Vey N,Bilger K,Mohty M,Gastaut JA

更新日期：2005-02-01 00:00:00

abstract：:A panel of 14 monoclonal antibodies (McAb) against hematopoietic cell surface antigens was applied on mononuclear blood or bone marrow cells from 40 cases of acute leukemia in order to compare immunoenzymatic staining (IE) (alkaline phosphatase) of fixed cells with immunofluorescence staining (IF) of unfixed suspended...

journal_title：European journal of haematology

authors： Ly B,Beiske K,Larsen N

更新日期：1988-08-01 00:00:00

abstract：:Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the...

journal_title：European journal of haematology

authors： Kamezaki K,Shimoda K,Numata A,Aoki K,Kato K,Takase K,Nakajima H,Ihara K,Haro T,Ishikawa F,Imamura R,Miyamoto T,Nagafuji K,Gondo H,Hara T,Harada M

更新日期：2003-12-01 00:00:00

abstract：:Development of resistance to cytotoxic agents is a common problem in the treatment of acute leukemia. In cell lines having multidrug resistance (MDR) phenotype, a decrease in the intracellular accumulation of drugs has been closely related to the overexpression of P-glycoprotein/mdr1 genes. We analyzed the relationshi...

journal_title：European journal of haematology

authors： Kato S,Ideguchi H,Muta K,Nishimura J,Nawata H

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:Human Disabled-2 (Dab2), a putative tumor suppressor gene, is frequently down-regulated in human tumors. This study aims to explore the association between Dab2 methylation status and expression in newly diagnosed myelodysplastic syndrome (MDS) patients and patients who received 5-aza-2'-deoxycytidine (decit...

journal_title：European journal of haematology

authors： Yang Y,Zhang Q,Xu F,Chang C,Li X

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION/OBJECTIVES:Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74/100 000 men and 1.37/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of...

journal_title：European journal of haematology

authors： Silla L,Dulley F,Saboya R,Kerbauy F,de Moraes Arantes A,Pezzi A,Gross LG,Paton E,Hamerschlak N

更新日期：2017-02-01 00:00:00

abstract：:Intravascular lymphoma (IVL) is a rare type of extranodal lymphoma in which the lymphoma cells proliferate exclusively in lumina of small vessels. Here, we report a clinicopathological study of 13 cases IVL diagnosed at our institution between March 1999 and July 2007, and evaluated the clinical characteristics, usefu...

journal_title：European journal of haematology

authors： Matsue K,Asada N,Takeuchi M,Yamakura M,Kimura S,Odawara J,Aoki T

更新日期：2008-03-01 00:00:00

abstract：:Recent studies have greatly illuminated the genomic landscape of the myelodysplastic syndromes (MDS), and the pace of discovery is accelerating. The most common mutations found in MDS occur in genes involved in RNA splicing (including SF3B1, SRSF2, U2AF1, and ZRSR2) and epigenetic modification (including TET2, ASXL1, ...

journal_title：European journal of haematology

authors： Pellagatti A,Boultwood J

更新日期：2015-07-01 00:00:00

abstract：:Recombinant human erythropoietin (rhEpo) is a mainstay in the treatment of anaemia, primarily in renal failure. Because the half-life of circulating rhEpo is relatively short (4-8 h), the drug is usually administered 2-3 times weekly. Recently, a novel erythropoiesis-stimulating protein (NESP) with a longer half-life ...

journal_title：European journal of haematology

authors： Jelkmann W

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von Willebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is know...

journal_title：European journal of haematology

authors： Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

更新日期：2013-08-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has been shown to inhibit in vitro growth of multiple myeloma (MM) cells, and this effect can be further potentiated by the addition of Dexamethasone (DEX). We here extended this study by testing the activity of 9-cis retinoic acid (9-cis RA) and 13-cis retinoic acid (13-cis RA), both al...

journal_title：European journal of haematology

authors： Tosi P,Pellacani A,Visani G,Ottaviani E,Ronconi S,Zamagni E,Benni M,Cavo M,Tura S

更新日期：1999-03-01 00:00:00

abstract：:Marrow fibroblast colony formation was studied in patients with myeloproliferative disorders, using human serum or platelet-derived growth factor plus plasma-derived serum as growth-stimulating factors. Colony numbers negatively correlated with the patient's age, but were not different from those of controls. However,...

journal_title：European journal of haematology

authors： Kimura A,Katoh O,Hyodo H,Kusumi S,Kuramoto A

更新日期：1990-05-01 00:00:00