Abnormality of platelet size and T-lymphocyte proliferation in an autosomal recessive form of dyskeratosis congenita.

abstract：:In patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), expression of the hematopoietic stem cell marker CD34 has been associated with a poorer prognosis. CD34 is usually analyzed by flow cytometry (FC), but may also be analyzed using immunohistochemistry (IH). The present study was undertak...

journal_title：European journal of haematology

authors： Kanter-Lewensohn L,Hellström-Lindberg E,Kock Y,Elmhorn-Rosenborg A,Ost A

更新日期：1996-03-01 00:00:00

abstract：:We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (DLI) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T-cell depletion. We also investigated progno...

journal_title：European journal of haematology

authors： Yan CH,Wang JZ,Liu DH,Xu LP,Chen H,Liu KY,Huang XJ

更新日期：2013-10-01 00:00:00

abstract：UNLABELLED:Protein C (PC) deficiency is an autosomal dominant inherited disorder associated with spontaneous and recurrent thrombotic events. Factor V Leiden (FVL) increases the risk of thrombosis in PC-deficient type I families. We have investigated the relationship between PC deficiency genotype and clinical phenotyp...

journal_title：European journal of haematology

authors： Cafolla A,D'Andrea G,Baldacci E,Margaglione M,Mazzucconi MG,Foà R

更新日期：2012-04-01 00:00:00

abstract：:Most cytostatic drugs exert their effect on cells in active cell cycle. To improve the effect of cytostatic drugs we have tried, prior to treatment in vitro, to recruit tumor cells from G0 with growth factors. Leukemic cells from the bone marrows of 26 patients with AML and CML in blast crisis were incubated with G-CS...

journal_title：European journal of haematology

authors： Sundman-Engberg B,Tidefelt U,Paul C

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:Secondary antibody deficiency (SAD), associated with severe, recurrent or persistent infections, is common in patients with haematological malignancies (HM), but unifying guidance on immunoglobulin replacement therapy (IgRT) in these patients is lacking. We aimed to develop consensus statements for the use o...

journal_title：European journal of haematology

authors： Jolles S,Michallet M,Agostini C,Albert MH,Edgar D,Ria R,Trentin L,Lévy V

更新日期：2021-01-16 00:00:00

abstract：:The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

journal_title：European journal of haematology

authors： Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To retrospectively identify characteristics and risk factors of viral encephalitis (VE) in patients who underwent a haplo-identical hematopoietic stem cell transplant (HSCT). METHODS:A nested case-control study was designed. Cases with VE and controls were identified from a cohort composed of 1274 patients w...

journal_title：European journal of haematology

authors： Zhang XH,Zhang JM,Han W,Chen H,Chen YH,Wang FR,Wang JZ,Zhang YY,Mo XD,Chen Y,Wang Y,Chang YJ,Xu LP,Liu KY,Huang XJ

更新日期：2017-05-01 00:00:00

abstract：:The molecular defects of the factor XIII A subunit gene were studied in a patient with factor XIII deficiency. Mutation analysis was performed on amplified DNA from each exon of this gene by single-strand conformation polymorphism (SSCP) and DNA sequencing techniques. A substitution of guanine by adenine at nucleotide...

journal_title：European journal of haematology

authors： Kangsadalampai S,Yenchitsomanus P,Chelvanayagam G,Sawasdee N,Laosombat V,Board P

更新日期：2000-10-01 00:00:00

abstract：INTRODUCTION:PI3K inhibitors are evaluated for relapsed and refractory Diffuse large B-cell lymphoma (DLBCL) patients. OBJECTIVE:As rituximab has shown to influence B-cell receptor (BCR) signaling, we investigated the interaction of anti-CD20 antibody rituximab and the new type II glycoengineered anti-CD20 antibody ob...

journal_title：European journal of haematology

authors： Zoellner AK,Peter N,Zimmermann Y,Hutter G,Hiddemann W,Dreyling M

更新日期：2018-04-04 00:00:00

abstract：OBJECTIVE:Diagnosing myeloid sarcoma remains challenging, and we aimed to provide clinicopathological features to facilitate diagnosis. METHOD:Clinicopathological data from 41 patients with de novo and 31 with secondary myeloid sarcoma were reviewed. RESULTS:Most de novo cases presented with isolated myeloid sarcoma ...

journal_title：European journal of haematology

authors： Claerhout H,Van Aelst S,Melis C,Tousseyn T,Gheysens O,Vandenberghe P,Dierickx D,Boeckx N

更新日期：2018-06-01 00:00:00

abstract：:Paraneoplastic neurologic syndromes may develop in Hodgkin's disease (HD). We describe three young female patients with neurological disorders, not explained by other causes, preceding diagnosis or relapse of HD. The lack of response of the paraneoplastic syndrome to successful treatment of HD among our three patients...

journal_title：European journal of haematology

authors： Maslovsky I,Volchek L,Blumental R,Ducach A,Lugassy G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Infections remain a leading cause of morbidity and mortality in patients with reduced immunity caused by haematological disease and chemotherapy-induced neutropenia. We evaluated the clinical and microbiological impact of discontinuing fluoroquinolone prophylaxis in these patients. METHODS:We analysed 154 a...

journal_title：European journal of haematology

authors： Verlinden A,Jansens H,Goossens H,van de Velde AL,Schroyens WA,Berneman ZN,Gadisseur AP

更新日期：2014-10-01 00:00:00

abstract：:Forty-one patients with codon 17, A-T mutation of beta-thalassemia, which is commonly found in Thailand, were studied to determine whether it is possible to predict phenotypic severity from genetic factors. The clinical phenotype of homozygotes for codon 17, A-T and compound heterozygotes for codon 17, A-T and beta+-t...

journal_title：European journal of haematology

authors： Laosombat V,Wongchanchailert M,Sattayasevana B,Wiriyasateinkul A,Fucharoen S

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Approximately 40% of idiopathic thrombotic thrombocytopenic purpura (TTP) patients will suffer an exacerbation (recurrence of TTP within 30 d after their last plasma exchange (PE) procedure), but there are no data to predict who is at greater risk. We studied the clinical utility of demographic and ADAMTS13 b...

journal_title：European journal of haematology

authors： Cataland SR,Yang SB,Witkoff L,Kraut EH,Lin S,George JN,Wu HM

更新日期：2009-12-01 00:00:00

abstract：:For patients with severe and refractory autoimmune diseases, high-dose chemotherapy and autologous hematopoietic stem cell transplantation has been established as a considerable therapeutic option in recent years. In this retrospective single-center analysis, we assessed the feasibility and efficacy of peripheral bloo...

journal_title：European journal of haematology

authors： Blank N,Lisenko K,Pavel P,Bruckner T,Ho AD,Wuchter P

更新日期：2016-07-01 00:00:00

abstract：:The aim of this study was to evaluate the usefulness of serum osteocalcin (OC) levels in multiple myeloma (MM) in order to assess its significance and activity, and to predict its course. Serum OC was measurement in 117 patients with MM and 116 healthy controls matched for age and sex. Serum OC levels were weakly corr...

journal_title：European journal of haematology

authors： Mejjad O,Le Loët X,Basuyau JP,Ménard JF,Jego P,Grisot C,Daragon A,Grosbois B,Euller-Ziegler L,Monconduit M

更新日期：1996-01-01 00:00:00

abstract：:There are established guidelines for treatment and monitoring of chronic myeloid leukemia (CML) but little is known about routine care. Data on ICD-10 codes as well as prescribed medications were available for 10.5 million patients in the statutory health insurance system in Bavaria for the years 2010 to 2016. Also, d...

journal_title：European journal of haematology

authors： Lauseker M,Gerlach R,Worseg W,Haferlach T,Tauscher M,Hasford J,Hoffmann VS

更新日期：2019-10-01 00:00:00

abstract：:Forty-six consecutive patients with acute lymphoblastic leukaemia (ALL), having a median age of 23 years (range 14 to 64), underwent induction and consolidation chemotherapy with weekly parenteral vincristine, adriamycin, l-asparaginase and daily oral prednisone (VAAP), followed by standard central nervous system (CNS...

journal_title：European journal of haematology

authors： Jacobs P,Wood L

更新日期：1992-08-01 00:00:00

abstract：:Whole blood from splenectomized subjects (n = 8) contained a substantial percentage of vacuolated ('pitted') red cells (34.7 +/- 8.3%), while blood from controls revealed none. The percentage of haemoglobin A1 (HbA1) had increased significantly compared with controls (p less than 0.01). Fractionation on cell density r...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-11-01 00:00:00

abstract：:In an attempt to clarify the significance of hydrocortisone (HC) in human long-term bone marrow cultures, the production of colony-stimulating activity (CSA) and colony-enhancing activity (CEA) by human bone marrow-derived adherent cells (MDAC) and the modulation by HC were examined. The CSA production by MDAC was dem...

journal_title：European journal of haematology

authors： Hirata J,Kaneko S,Nishimura J,Motomura S,Ibayashi H

更新日期：1988-03-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has been shown to inhibit in vitro growth of multiple myeloma (MM) cells, and this effect can be further potentiated by the addition of Dexamethasone (DEX). We here extended this study by testing the activity of 9-cis retinoic acid (9-cis RA) and 13-cis retinoic acid (13-cis RA), both al...

journal_title：European journal of haematology

authors： Tosi P,Pellacani A,Visani G,Ottaviani E,Ronconi S,Zamagni E,Benni M,Cavo M,Tura S

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:The role of high-dose therapy and autologous stem-cell transplantation (HDT/ASCT) in the up-front treatment of poor-risk aggressive lymphoma is still unknown. We conducted a prospective multi-centre trial with dose-escalated CHOP (MegaCHOP) and tailored intensification prior to HDT/ASCT according to early re...

journal_title：European journal of haematology

authors： Arranz R,Conde E,Grande C,Mateos MV,Gandarillas M,Albo C,Lahuerta JJ,Fernández-Rañada JM,Hernández MT,Alonso N,García Vela JA,Garzón S,Rodríguez J,Caballero D,Grupo Español de Linfomas\/Trasplante Autólogo de Médula Osea (GEL

更新日期：2008-03-01 00:00:00

abstract：:Cells from 3 patients with B-chronic lymphocytic leukaemia (B-CLL) and 1 with B-prolymphocytic leukaemia (B-PLL) were treated in vitro with the phorbol ester 12-0-tetradecanoylphorbol (TPA), the calcium ionophore A23187, or a combination of TPA and A23187. TPA induced the cells to adhere to the culture flask or to clu...

journal_title：European journal of haematology

authors： Drexler HG,Brenner MK,Gignac SM,Hoffbrand AV

更新日期：1988-09-01 00:00:00

abstract：:We have studied the kinetics of plasma levels of circulating (c)selectins in 8 patients undergoing bone marrow or stem cell transplantation to gain estimates for the distribution and half-life of (c)selectins and to potentially identify an endothelial source of cP-selectin in patients who are deprived of platelets and...

journal_title：European journal of haematology

authors： Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

更新日期：1998-07-01 00:00:00

abstract：:10 patients with CLL and 2 with CML were treated with gradually increasing doses of 1 alpha(OH)D3, up to 4 micrograms daily during 6 wk. 3 patients with preleukemia and 1 with myelofibrosis were treated with 2 micrograms daily of 1 alpha(OH)D3 for a prolonged period up to 17 wk. The treatment with 1 alpha (OH)D3 did n...

journal_title：European journal of haematology

authors： Wieslander SB,Mortensen BT,Binderup L,Nissen NI

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:For transplantation of cord blood (CB) cells, it is important to select a CB sample that can reconstitute not only myelo-erythropoiesis but also lymphopoiesis in recipients. However, until now the reconstitution ability of CB samples has been assessed by colony forming unit-culture (CFU-C) assay or by simply ...

journal_title：European journal of haematology

authors： Kato M,Masuda K,Kakugawa K,Kawamoto H,Mugishima H,Katsura Y

更新日期：2008-02-01 00:00:00

abstract：:Auto-immune haemolytic anaemia (AIHA) is characterised by haemolysis associated with the presence of the immunoglobulins IgG, IgM or IgA, and/or components of the complement system on the red cell membrane. The immunoglobulins react as auto-antibodies against the red cell antigens of the patient. IgG antibodies and th...

journal_title：European journal of haematology

authors： Bardill B,Mengis C,Tschopp M,Wuillemin WA

更新日期：2003-01-01 00:00:00

abstract：:Chronic isolated hereditary macrothrombocytopenia (CHMT) is a congenital form of macrothrombocytopenia that seems to be due to defective production secondary to a disturbance in megakaryocyte fragmentation. To better understand the pathogenesis of thrombopoiesis in this hereditary thrombocytopenic disorder, we determi...

journal_title：European journal of haematology

authors： Fabris F,Cordiano I,Steffan A,Ramon R,Scandellari R,Nichol JL,Girolami A

更新日期：2000-03-01 00:00:00

abstract：:The development of an autoantibody to human Factor VIII is rare and presents many problems for diagnosis and treatment. We have seen several cases at our institution recently with widely heterogenous clinical and laboratory presentations. A wide range of treatment modalities were used in these cases with no gold stand...

journal_title：European journal of haematology

authors： Hall RL,Leahy MF

更新日期：2001-03-01 00:00:00

abstract：:It is well-known that uremic patients present prolonged bleeding times as a common complication. Factors responsible for this disorder have been extensively investigated. In order to elucidate the possible role of uremic middle molecules as responsible for the bleeding tendency observed in uremia, we have studied the ...

journal_title：European journal of haematology

authors： Palés JL,López A,Asensio A,Merola E,Company X,Deulofeu R,Garcia M,Balagué A

更新日期：1987-09-01 00:00:00