Abstract:
OBJECTIVES:To compare the gene expression pattern in children and adults with acute lymphoblastic leukaemia (ALL) in order to improve our understanding of the difference in disease biology and prognosis. METHODS:The gene expression profiles in diagnostic samples from 29 children and 15 adults with ALL were analysed using the oligonucleotide chip Hu95ver2a, produced by Affymetrix. RESULTS:Unsupervised hierarchical cluster analysis revealed that, in spite of differences in outcome, patients clustered irrespective of age, first by T-cell or B-precursor immunophenotype, and second by cytogenetic changes within the B-precursor group. The expression pattern analysis allowed the reclassification of some samples into the proper cytogenetic group. We also showed that separate clustering of samples with the BCR/ABL translocation could be explained by different breakpoint regions in the BCR. No significant difference in gene expression was observed between samples with and without CDKN2A deletion within the B-precursor group. Analysis of different age groups revealed a similarity in expression profiles when infants with the MLL translocation and adults over 40 yr of age were compared irrespective of karyotype. CONCLUSIONS:In spite of the difference in clinical outcome, the gene expression pattern in children and adults with ALL is very similar and is primarily dependent on immunophenotype and cytogenetic aberrations. However, when age groups are compared, the expression patterns of infants and adults over 40 show a remarkable similarity.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Kuchinskaya E,Heyman M,Grandér D,Linderholm M,Söderhäll S,Zaritskey A,Nordgren A,Porwit-Macdonald A,Zueva E,Pawitan Y,Corcoran M,Nordenskjöld M,Blennow Edoi
10.1111/j.1600-0609.2005.00433.xsubject
Has Abstractpub_date
2005-06-01 00:00:00pages
466-80issue
6eissn
0902-4441issn
1600-0609pii
EJH433journal_volume
74pub_type
杂志文章abstract::The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic ris...
journal_title:European journal of haematology
pub_type: 杂志文章,评审
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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abstract:BACKGROUND:Interleukin-6 (IL-6) is a multifunctional cytokine that plays roles in the immune response, inflammation and hematopoiesis. Serum IL-6 levels have reported to reflect disease severity and high tumor burden in multiple myeloma (MM) patients and to correlate with several other laboratory parameters. Serum-solu...
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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journal_title:European journal of haematology
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.1988.tb00204.x
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00
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pub_type:
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更新日期:2019-10-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章,多中心研究
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1600-0609.2006.00711.x
更新日期:2006-10-01 00:00:00