B-chronic lymphocytic leukaemia in Latvia: epidemiological aspects.

abstract：OBJECTIVE:Warfarin represents the most commonly prescribed oral anticoagulants, which functions as an antagonist of vitamin K, an essential factor of blood coagulation cascade. Warfarin has a narrow therapeutic index. An insufficient dose can cause failure of antithrombotic effect, and an overdose increases a risk of b...

journal_title：European journal of haematology

authors： Krajčíová L,Petrovič R,Déžiová L,Chandoga J,Turčáni P

更新日期：2014-10-01 00:00:00

abstract：:Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

journal_title：European journal of haematology

authors： Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Secondary antibody deficiency (SAD), associated with severe, recurrent or persistent infections, is common in patients with haematological malignancies (HM), but unifying guidance on immunoglobulin replacement therapy (IgRT) in these patients is lacking. We aimed to develop consensus statements for the use o...

journal_title：European journal of haematology

authors： Jolles S,Michallet M,Agostini C,Albert MH,Edgar D,Ria R,Trentin L,Lévy V

更新日期：2021-01-16 00:00:00

abstract：:Very high-dose chemotherapy with autologous blood stem cell (BSC) rescue becomes more and more widely performed. In order to simplify the technique, a large volume apheresis programme combined with an uncontrolled rate cryopreservation at -80 degrees C was developed. Twenty-six patients suffering from multiple myeloma...

journal_title：European journal of haematology

authors： Feremans WW,Bastin G,Moine FL,Ravoet C,Delville JP,Pradier O,Wallef G,Dupont E,Capel P,Lambermont M

更新日期：1996-05-01 00:00:00

abstract：:Endothelial cell dysfunction is likely to be important in the pathophysiology of ischaemic heart disease and increased levels of endothelial cell markers soluble E-selectin and soluble thrombomodulin may reflect this damage. To determine whether increased levels of these markers were predictive of disease progression,...

journal_title：European journal of haematology

authors： Blann AD,Amiral J,McCollum CN

更新日期：1997-08-01 00:00:00

abstract：:It is well-known that uremic patients present prolonged bleeding times as a common complication. Factors responsible for this disorder have been extensively investigated. In order to elucidate the possible role of uremic middle molecules as responsible for the bleeding tendency observed in uremia, we have studied the ...

journal_title：European journal of haematology

authors： Palés JL,López A,Asensio A,Merola E,Company X,Deulofeu R,Garcia M,Balagué A

更新日期：1987-09-01 00:00:00

abstract：:Patients with ARF and haematological malignancy (excluding myeloma), presenting to a single unit over 10 years were analyzed to see if patients likely to benefit from intensive renal supportive therapy could be identified. 31 episodes of ARF were identified in 29 patients (mean age 51 +/- 2.9 yr): 19 were associated w...

journal_title：European journal of haematology

authors： Harris KP,Hattersley JM,Feehally J,Walls J

更新日期：1991-08-01 00:00:00

abstract：:Kostmann syndrome (KS) is an inherited hematological disorder characterized by an absolute neutrophil count (ANC) <0.2 x 109/L and life-threatening bacterial infections. Granulocyte-colony stimulating factor (G-CSF) makes it possible to reach an ANC of 1.0 x 109/L and consequently to reduce significantly the occurrenc...

journal_title：European journal of haematology

authors： Dallorso S,Manzitti C,Dodero P,Faraci M,Rosanda C,Castagnola E

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:Hypocholesterolemia has been previously described in patients affected by thalassemia. In this study we retrospectively evaluated the cholesterol level in two groups of patients affected by either thalassemia major (TM) or thalassemia intermedia (TI), with the aim of establishing factors correlated to hypoch...

journal_title：European journal of haematology

authors： Ricchi P,Ammirabile M,Spasiano A,Costantini S,Di Matola T,Cinque P,Pagano L,Prossomariti L

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:On the basis of two population-based registries, our study aims to calculate the real-world cost-effectiveness of rituximab maintenance compared with observation in relapsed or refractory follicular lymphoma patients who responded to second-line chemotherapy. METHODS:Data were obtained from the EORTC20981 t...

journal_title：European journal of haematology

authors： Blommestein HM,Issa DE,Pompen M,Ten Hoor G,Hogendoorn M,Joosten P,Zweegman S,Huijgens PC,Uyl-de Groot CA

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Beta thalassaemia major (β-TM) and sickle-cell disease (SCD) are severe haemogobinopathies requiring life-lasting, advanced medical management. In the Mediterranean region, both conditions occur with high frequency. We assessed the efficacy of the National Program for the Prevention of Haemoglobinopathies in...

journal_title：European journal of haematology

authors： Ladis V,Karagiorga-Lagana M,Tsatra I,Chouliaras G

更新日期：2013-04-01 00:00:00

abstract：:The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). E...

journal_title：European journal of haematology

authors： Joly P,Garnier N,Kebaili K,Renoux C,Dony A,Cheikh N,Renard C,Ceraulo A,Cuzzubbo D,Pondarré C,Martin C,Pialoux V,Francina A,Bertrand Y,Connes P

更新日期：2016-04-01 00:00:00

abstract：:Plasma and cellular pharmacokinetics of m-AMSA were investigated in 5 patients with acute leukemia, using HPLC. The pharmacokinetic data served as a guideline for in vitro toxicity tests on clonogenic bone marrow cells. m-AMSA was administered as a 3-hour intravenous infusion of 100 mg/m2. Median plasma and nucleated ...

journal_title：European journal of haematology

authors： Linssen P,Brons P,Knops G,Wessels H,de Witte T

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To determine the sensitivity and specificity of single-tube osmotic fragility (SOFT) and its different methods as screening test for thalassemia trait. METHODS:A cross-sectional study was conducted at Omair Sana Foundation. A total of 400 participants were included in the study. Three hundred were known thal...

journal_title：European journal of haematology

authors： Ansari SH,Hanifa A,Saleem A,Ali SM,Hussain Z,Zohaib M,Akbar M,Rehman S,Hussain SR

更新日期：2014-12-01 00:00:00

abstract：:Central nervous system (CNS) involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages with lymph node or visceral involvement. We describe a patient with advanced stage MF in large-cell transformation who presented with profound hearing loss after chemotherapy. Despite an initial differenti...

journal_title：European journal of haematology

authors： Chua SL,Seymour JF,Prince HM

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Limited progress had been made in prognostic stratification of patients with Hodgkin lymphoma (HL) until recent studies suggested that the number of CD68-expressing macrophages is prognostic in classical HL. However, its significance in Asian patients with HL has not been explored yet perhaps because of its ...

journal_title：European journal of haematology

authors： Yoon DH,Koh YW,Kang HJ,Kim S,Park CS,Lee SW,Suh C,Huh J

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVES:An aberrant pattern of expression of L-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). METHODS:In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICA...

journal_title：European journal of haematology

authors： Buccisano F,Maurillo L,Tamburini A,Del Poeta G,Del Principe MI,Ammatuna E,Consalvo MI,Campagna S,Ottaviani L,Sarlo C,Renzi D,Faccia S,Fraboni D,Lo Coco F,Amadori S,Venditti A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Despite effective preemptive and prophylactic therapeutic strategies, cytomegalovirus (CMV) seropositivity of either recipient and/or donor still remains an important parameter for outcome even after reduced-intensity allogeneic stem cell transplantation (SCT). Whether CMV seropositivity of the donor might h...

journal_title：European journal of haematology

authors： Nachbaur D,Clausen J,Kircher B

更新日期：2006-05-01 00:00:00

abstract：:Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral va...

journal_title：European journal of haematology

authors： Farmakis D,Deftereos S,Giakoumis A,Polymeropoulos E,Aessopos A

更新日期：2004-04-01 00:00:00

abstract：:A murine cultured cell line (MKM-O) was established from a tumor of a BALB/C (nu/nu) mouse that had been subcutaneously inoculated with human hepatoma tissue fragments in the same location. The MKM-O cell line was proven to be of endothelial origin by morphological examinations and positive staining with fluorescein-l...

journal_title：European journal of haematology

authors： Yoshimura T,Miyanomae T,Tanaka M,Iwai Y,Mayumi M,Mikawa H

更新日期：1987-08-01 00:00:00

abstract：:Iron-related changes in peripheral blood and variations in liver and spleen iron concentrations during alternating periods of hypoxia and normoxia have been investigated in iron-supplemented mice by chemical and histological methods. During hypoxia, packed cell volume increased from 40 to 70%. The iron content of the ...

journal_title：European journal of haematology

authors： Borch-Iohnsen B,Myhre K,Norheim G

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Interleukin-6 (IL-6) is a multifunctional cytokine that plays roles in the immune response, inflammation and hematopoiesis. Serum IL-6 levels have reported to reflect disease severity and high tumor burden in multiple myeloma (MM) patients and to correlate with several other laboratory parameters. Serum-solu...

journal_title：European journal of haematology

authors： Hatzimichael EC,Christou L,Bai M,Kolios G,Kefala L,Bourantas KL

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Tumor cells of primary cutaneous T-cell lymphomas are able to adopt a regulatory T-cell phenotype in vitro. The significance of this finding in vivo is matter of debate. METHODS:We stained five cases with transformed mycosis fungoides (MF) with an antibody against FOXP3, which is a sensitive and specific ...

journal_title：European journal of haematology

authors： Hallermann C,Niermann C,Schulze HJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To determine the safety, dose-limiting toxicity and maximum tolerated dose (MTD) of the novel hydroxamate histone deacetylase inhibitor belinostat (PXD101) in patients with advanced hematological neoplasms. PATIENTS AND METHODS:Sequential dose-escalating cohorts of three to six patients with hematological mali...

journal_title：European journal of haematology

authors： Gimsing P,Hansen M,Knudsen LM,Knoblauch P,Christensen IJ,Ooi CE,Buhl-Jensen P

更新日期：2008-09-01 00:00:00

abstract：:Haemoglobin (Hb) Hope [beta136(H14)Gly-->Asp(GGT-->GAT)] is one of the unstable haemoglobin variants of the beta-globin chain, which is demonstrated in people of various ethnic backgrounds. Here we report a Thai female patient with clinical thalassaemia intermedia since childhood. This patient had experienced neither ...

journal_title：European journal of haematology

authors： Sura T,Busabaratana M,Youngcharoen S,Wisedpanichkij R,Viprakasit V,Trachoo O

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：:CD200R is an inhibitory receptor involved in the regulation of myeloid cells. It recruits Dok-1 and Dok-2, which are potent inhibitors of the Ras signalling pathway used by colony-stimulating factor (CSF) receptors. Dok-1/Dok-2 double knockout (DKO) mice develop leukaemia at 10-12 months of age. We investigated whethe...

journal_title：European journal of haematology

authors： Rijkers ES,de Ruiter T,Buitenhuis M,Veninga H,Hoek RM,Meyaard L

更新日期：2007-11-01 00:00:00

abstract：:A hairy cell leukaemia (HCL) patient is presented in whom the peripheral blood mononuclear cells (PBMCs) carried suppressor T-cell markers (CD3+, CD2+, CD8+/CD4-, CD38+). Analysis of genomic DNA of PBMNC showed the presence of a monoclonal population of T cells, the T-cell receptor (TCR) beta-chain gene being rearrang...

journal_title：European journal of haematology

authors： Demeter J,Pálóczi K,Földi J,Hokland M,Hokland P,Benczúr M,Lehoczky D

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Minimal residual disease (MRD) assessment by PCR in multiple myeloma (MM) has several shortcomings, including the lack of a suitable target. Kappa deleting element (KDE) rearrangements occur in virtually all Ig-lambda B-cell malignancies and in 1/3 of Ig-kappa are not affected by somatic hyper...

journal_title：European journal of haematology

authors： Puig N,Sarasquete ME,Alcoceba M,Balanzategui A,Chillón MC,Sebastián E,Díaz MG,San Miguel JF,García-Sanz R

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Mantle cell lymphoma (MCL) is an incurable disease with an aggressive course and novel treatment strategies are urgently needed. The purpose of this study was to evaluate the effects of histone deacetylase (HDAC) inhibitors, a new group of antiproliferative agents, on human MCL cells. METHODS:Three MCL cell...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Sterz J,Zavrski I,Jakob C,Fleissner C,Eucker J,Possinger K,Sezer O

更新日期：2006-01-01 00:00:00