Expression of c-myc and c-ras oncogenes in the neoplastic and non-neoplastic cells of Hodgkin's disease.

Abstract:

:The oncogenes c-myc and c-ras are known to elicit a cooperative tumorigenicity. In this study we investigated their role in the pathogenesis of Hodgkin's disease. The expression of these oncogenes was determined in Hodgkin's disease patients by avidin-biotin peroxidase complex immunohistochemical staining and was compared to their expression in patients with non-Hodgkin's lymphomas and inflammatory reactive lymph nodes. Of 29 examined patients with different histological types of Hodgkin's disease, 21 (72.4%) showed an elevated expression of c-myc and 28 (96.5%) of c-ras. Although this expression was marked especially in the neoplastic Reed-Sternberg cells, it was also noted in the numerous reactive cells present in the involved lymph nodes. By contrast, a much lower frequency of increased expression of these oncogenes was recorded in 19 patients with different grades of non-Hodgkin's lymphoma and in 29 patients with inflammatory reactive lymph nodes. The elevated expression of c-myc and c-ras in the neoplastic Reed-Sternberg cells may reflect an oncogenic event that directly activates these genes. However, their increased expression in the surrounding non-neoplastic cells probably results from signal transduction induced by certain growth-promoting factors possibly released by the Reed-Sternberg cells and that act paracrinally to stimulate the proliferation of the neighboring cells. Furthermore, the continuous c-ras elevation may impair the normal cell cycle control and thereby promote mutagenesis and overt malignancy.

journal_name

Eur J Haematol

authors

Benharroch D,Yermiahu T,Geffen DB,Prinsloo I,Gopas J,Segal S,Aboud M

doi

10.1111/j.1600-0609.1995.tb00247.x

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

178-83

issue

3

eissn

0902-4441

issn

1600-0609

journal_volume

55

pub_type

杂志文章
  • An antecedent diagnosis of refractory anemia with excess blasts has no influence on mobilization of peripheral blood stem cells and hematopoietic recovery after autologous stem cell transplantation in acute myeloid leukemia.

    abstract::Several studies have reported data on factors influencing mobilization of peripheral blood stem cells (PBSC) in non-myeloid malignancies. On the contrary, data from patients with acute myeloid leukemia (AML) are very limited, in particular, as the impact of an antecedent diagnosis of refractory anemia with excess blas...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2006.00777.x

    authors: Viola A,Falco C,D'Elia R,D'Amico MR,Vicari L,Tambaro FP,Correale P,Laudati D,Palmieri S,Ferrara F

    更新日期:2007-01-01 00:00:00

  • Severe IgA-mediated auto-immune haemolytic anaemia in a 48-yr-old woman.

    abstract::Auto-immune haemolytic anaemia (AIHA) is characterised by haemolysis associated with the presence of the immunoglobulins IgG, IgM or IgA, and/or components of the complement system on the red cell membrane. The immunoglobulins react as auto-antibodies against the red cell antigens of the patient. IgG antibodies and th...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0609.2003.02846.x

    authors: Bardill B,Mengis C,Tschopp M,Wuillemin WA

    更新日期:2003-01-01 00:00:00

  • Dialysate concentration and pharmacokinetics of 2F-Ara-A in a patient with acute renal failure.

    abstract::Fludarabine is frequently used for treatment of B-cell chronic lymphocytic leukemia and in conditioning regimes for hematopoietic cell transplantations. The total body clearance of the principal metabolite 2-fluoro-ara-A (2F-Ara-A) correlates with the creatinine clearance. We report data on total dialysate concentrati...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2005.00439.x

    authors: Kielstein JT,Stadler M,Czock D,Keller F,Hertenstein B,Radermacher J

    更新日期:2005-06-01 00:00:00

  • Immunological typing of acute leukemias: immunoenzymatic staining of fixed cells compared with immunofluorescence staining of unfixed cells in suspension.

    abstract::A panel of 14 monoclonal antibodies (McAb) against hematopoietic cell surface antigens was applied on mononuclear blood or bone marrow cells from 40 cases of acute leukemia in order to compare immunoenzymatic staining (IE) (alkaline phosphatase) of fixed cells with immunofluorescence staining (IF) of unfixed suspended...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1988.tb00884.x

    authors: Ly B,Beiske K,Larsen N

    更新日期:1988-08-01 00:00:00

  • Synchronous FIP1L1-PDGFRA-positive chronic eosinophilic leukemia and T-cell lymphoblastic lymphoma: a bilineal clonal malignancy.

    abstract::Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1-PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophi...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2007.00973.x

    authors: Capovilla M,Cayuela JM,Bilhou-Nabera C,Gardin C,Letestu R,Baran-Marzak F,Fenaux P,Martin A

    更新日期:2008-01-01 00:00:00

  • A population-based study on serious inpatient bacterial infections in patients with chronic lymphocytic leukemia and their impact on survival.

    abstract:OBJECTIVE:Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single-center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. ...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.13477

    authors: Steingrímsson V,Gíslason GK,Aspelund T,Turesson I,Björkholm M,Landgren O,Kristinsson SY

    更新日期:2020-11-01 00:00:00

  • Assessment of the value of treatment with granulocyte colony-stimulating factor in children with acute lymphoblastic leukemia: a randomized clinical trial.

    abstract::The present trial was designed to test the effects of G-CSF on the duration of the second phase of induction chemotherapy in children with newly diagnosed acute lymphoblastic leukemia (ALL). A total of 32 patients were assigned randomly to a group that received (14 patients; group A) or a group that did not receive (1...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0609.1995.tb01816.x

    authors: Dibenedetto SP,Ragusa R,Ippolito AM,Lo Nigro L,Di Cataldo A,D'Amico S,Miraglia V

    更新日期:1995-08-01 00:00:00

  • Clinical course and risk factors for mortality from COVID-19 in patients with haematological malignancies.

    abstract:BACKGROUND:The impact of coronavirus disease 2019 (COVID-19) in haematological patients (HP) has not been comprehensively reported. METHODS:We analysed 39 patients with SARS-CoV-2 infection and haematological malignancies. Clinical characteristics and outcomes were compared to a matched control group of 53 non-cancer ...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.13493

    authors: Sanchez-Pina JM,Rodríguez Rodriguez M,Castro Quismondo N,Gil Manso R,Colmenares R,Gil Alos D,Paciello ML,Zafra D,Garcia-Sanchez C,Villegas C,Cuellar C,Carreño-Tarragona G,Zamanillo I,Poza M,Iñiguez R,Gutierrez X,Alonso R

    更新日期:2020-11-01 00:00:00

  • Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.

    abstract::Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.12254

    authors: Brähler S,Thielen I,Schwabe H,Engels M,Kreuzer KA,Wolf J,Ansén S

    更新日期:2014-06-01 00:00:00

  • Immunological effects in patients with steroid-refractory graft-versus-host disease following treatment with basiliximab, a CD25 monoclonal antibody.

    abstract::Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. Studies have shown a response in up to 80% of patients with this condition after treatment with the CD25 monoclonal antibody, basiliximab. Despite the good responses...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.12691

    authors: Chakupurakal G,García-Márquez MA,Shimabukuro-Vornhagen A,Theurich S,Holtick U,Hallek M,Scheid C,von Bergwelt-Baildon M

    更新日期:2016-08-01 00:00:00

  • Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis.

    abstract:OBJECTIVES:Overexpression of FK506 binding protein 51 (FKBP51) in megakaryocytic progenitor cells generated from purified CD34+ cells in patients with idiopathic myelofibrosis (IMF) has been demonstrated. It has been suggested that FKBP51 is involved in the dysregulation of the apoptotic programme with consecutive prol...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.0902-4441.2003.00204.x

    authors: Bock O,Neusch M,Büsche G,Mengel M,Kreipe H

    更新日期:2004-04-01 00:00:00

  • PIP4KIIA and beta-globin: transcripts differentially expressed in reticulocytes and associated with high levels of Hb H in two siblings with Hb H disease.

    abstract::We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2009.01325.x

    authors: Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

    更新日期:2009-11-01 00:00:00

  • Small-dose oral iron absorption test in anaemic and non-anaemic elderly hospitalized patients.

    abstract::The small-dose (20 mg) oral iron absorption test (OIAT) was performed in 76 hospitalized elderly patients and 30 healthy adults. Of the elderly patients, 34 were considered as iron deficient (serum ferritin level < 20 micrograms/L) of whom 23 were anaemic and 11 not anaemic, 21 had the anaemia of chronic disorders (AC...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1997.tb00931.x

    authors: Joosten E,Vander Elst B,Billen J

    更新日期:1997-02-01 00:00:00

  • Plasma cell leukemia: from biology to treatment.

    abstract::Plasma cell leukemia (PCL) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary PCL occuring 'de novo', or as secondary PCL in patients with relapsed/refractory multiple myeloma. Primary PCL is a distinct cli...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/ejh.12533

    authors: Jelinek T,Kryukov F,Rihova L,Hajek R

    更新日期:2015-07-01 00:00:00

  • Aberrant increase in the immature platelet fraction in patients with myelodysplastic syndrome: a marker of karyotypic abnormalities associated with poor prognosis.

    abstract:OBJECTIVES:Some patients with myelodysplastic syndrome (MDS) show a marked increase in the percentage of immature platelet fraction (IPF%) despite the absence of severe thrombocytopenia. To determine the significance of such an unbalanced increase in the IPF%, we investigated the IPF% and other laboratory findings of 5...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2008.01156.x

    authors: Sugimori N,Kondo Y,Shibayama M,Omote M,Takami A,Sugimori C,Ishiyama K,Yamazaki H,Nakao S

    更新日期:2009-01-01 00:00:00

  • Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

    abstract::Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2004.00318.x

    authors: Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

    更新日期:2005-01-01 00:00:00

  • Hematopoietic stem cell transplantation for sickle cell disease: state of the science.

    abstract::Sickle cell disease (SCD) is an inherited disorder secondary to a point mutation at the sixth position of the beta chain of human hemoglobin resulting in the replacement of valine for glutamic acid. This recessive genetic abnormality precipitates the polymerization of the deoxygenated form of hemoglobin S inducing a m...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/ejh.12447

    authors: Talano JA,Cairo MS

    更新日期:2015-05-01 00:00:00

  • ZAP-70 mRNA quantification in B-cell chronic lymphocytic leukaemia.

    abstract:OBJECTIVE:The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evalua...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0609.2005.00619.x

    authors: Catherwood MA,Matthews C,Niblock R,Dobbin E,Morris TC,Alexander HD

    更新日期:2006-04-01 00:00:00

  • Causes of hypereosinophilia in 100 consecutive patients.

    abstract:BACKGROUND:Hypereosinophilia (HE, persistent peripheral blood eosinophilia > 1.5 × 109 /L) and hypereosinophilic syndrome (HES, HE with end-organ damage) are classified as primary (due to a myeloid clone), secondary (due to a wide variety of reactive causes), or idiopathic. Diagnostic evaluation of eosinophilia is chal...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.13437

    authors: Moller D,Tan J,Gauiran DTV,Medvedev N,Hudoba M,Carruthers MN,Dehghan N,van den Berghe J,Bruyère H,Chen LYC

    更新日期:2020-09-01 00:00:00

  • Gene transduction into murine primitive hematopoietic cells with 2-gene retroviral vectors using a Transwell coculture system.

    abstract::The present study aims at expressing a reporter gene in hematopoietic cells in vivo by introducing it into primitive hematopoietic cells with a 2-gene retroviral vector. Various constructs of retroviral vectors containing the human IL-2 receptor alpha chain gene (TAC) as the reporter and the neomycin phosphotransferas...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1996.tb01378.x

    authors: Asami N,Germeraad WT,Fujimoto S,Nagai S,Izumi T,Katsura Y

    更新日期:1996-10-01 00:00:00

  • High rate of hematological responses to sorafenib in FLT3-ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation.

    abstract::Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3-ITD-positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. In this study, we retrospectively collected data on the off-label use of the tyrosine kinase inhi...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.12647

    authors: De Freitas T,Marktel S,Piemontese S,Carrabba MG,Tresoldi C,Messina C,Lupo Stanghellini MT,Assanelli A,Corti C,Bernardi M,Peccatori J,Vago L,Ciceri F

    更新日期:2016-06-01 00:00:00

  • HIV+ MALT lymphoma remission induced by highly active antiretroviral therapy alone.

    abstract::MALT lymphoma is usually described in association with Helicobacter pylori, HCV, HHV8, Campylobacter jejuni or in a setting of overreactive immunity. In HIV(+) patients, MALT lymphoma is most commonly described in children. We describe here an original case of HIV(+) MALT lymphoma with bronchial, conjuctival and laryn...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2004.00339.x

    authors: Girard T,Luquet-Besson I,Baran-Marszak F,Raphaël M,Boué F

    更新日期:2005-01-01 00:00:00

  • Chronic lymphocytic leukemia: a retrospective study of 122 cases.

    abstract::During the period 1978-1982 in the three northernmost countries of Sweden all 143 patients with a registered diagnosis of chronic lymphocytic leukemia (CLL) were retrospectively analyzed. After re-evaluation, 122 cases remained in the study. The mean age was 71 years and the male/female ratio was 2.2:1. Sixty-one pati...

    journal_title:European journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1600-0609.1994.tb01295.x

    authors: Erlanson M,Osterman B,Jonsson H,Lenner P

    更新日期:1994-02-01 00:00:00

  • Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival.

    abstract::Aberrant expression of genes regulating apoptosis/survival seems to be essential in the stepwise development of human multiple myeloma (MM). In this paper we have compared the expression of bcl-2 family pro- and anti-apoptotic genes in MM cell lines, primary MM cells and normal plasma cells. The Bcl-2, Mcl-1, Bcl-xL/S...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0609.2002.01549.x

    authors: Spets H,Strömberg T,Georgii-Hemming P,Siljason J,Nilsson K,Jernberg-Wiklund H

    更新日期:2002-08-01 00:00:00

  • Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.

    abstract::High mobility group box 1 protein (HMGB1), originally described as a non-histone, DNA binding protein, was recently identified as a late mediator of inflammation via its extracellular release from activated macrophages/monocytes. In the present study, we report that intracellular HMGB1 synergizes with a macrophage/mon...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2007.00981.x

    authors: Mouri F,Tsukada J,Mizobe T,Higashi T,Yoshida Y,Minami Y,Izumi H,Kominato Y,Kohno K,Tanaka Y

    更新日期:2008-01-01 00:00:00

  • Comparison of poly- and monoclonal antibodies for determination of B-cell clonal excess in an routine clinical laboratory.

    abstract::Flow cytometry (FCM) has gained wide use in the determination of clonality in B-cell lymphoproliferative diseases and many methodological variations exist. We have compared the suitability of a) dual fluorochrome (FITC/PE)-labelled monoclonal antibodies, b) single fluorochrome (FITC)-labelled monoclonal antibodies and...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1992.tb01793.x

    authors: Agrawal YP,Hämäläinen E,Mahlamäki EK,Aho H,Nousianinen T,Lahtinen R,Penttilä IM

    更新日期:1992-01-01 00:00:00

  • Multicenter validation of a simplified method for paroxysmal nocturnal hemoglobinuria screening.

    abstract:BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) diagnostic guidelines recommend single-tube five- to six-color or two-tube four-color assays. PNH clones are detectable in only a fraction of patients at risk, and screening for new PNH cases can be complex and expensive. In this multicenter study, we have validated ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ejh.12885

    authors: Gatti A,Del Vecchio L,Geuna M,Della Porta MG,Brando B

    更新日期:2017-07-01 00:00:00

  • T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.

    abstract:OBJECTIVES:Iron-overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe(2+) uptake in thalassemic cardiomyocytes are mainly mediated by T-type calci...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2012.01779.x

    authors: Kumfu S,Chattipakorn S,Chinda K,Fucharoen S,Chattipakorn N

    更新日期:2012-06-01 00:00:00

  • Iron metabolism in athletes--achieving a gold standard.

    abstract::Iron is an important mineral element required for diverse life processes. Its metabolism is almost synonymous to erythrocyte maintenance, erythropoiesis and erythrophagocytosis. Consequently, exercise exertion impacts significantly on red cell haematology. Here, the interactions between exercise and erythropoiesis are...

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/ejh.12026

    authors: Latunde-Dada GO

    更新日期:2013-01-01 00:00:00

  • Socioeconomic burden of participation in clinical trials in patients with myeloproliferative neoplasms.

    abstract:OBJECTIVE:To determine the financial and psycho-social impact of participation in clinical trials of patients with BCR/ABL-negative myeloproliferative neoplasms (MPN). METHODS:An international, observational cross-sectional study was performed in 143 consecutive MPN patients (51% myelofibrosis, 36% polycythemia vera, ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ejh.12887

    authors: Goel S,Paoli C,Iurlo A,Pereira A,Efficace F,Barbui T,Tefferi A,Vannucchi AM,Cervantes F

    更新日期:2017-07-01 00:00:00