Dose-escalated CHOP and tailored intensification with IFE according to early response and followed by BEAM/autologous stem-cell transplantation in poor-risk aggressive B-cell lymphoma: a prospective study from the GEL-TAMO Study Group.

Abstract:

OBJECTIVES:The role of high-dose therapy and autologous stem-cell transplantation (HDT/ASCT) in the up-front treatment of poor-risk aggressive lymphoma is still unknown. We conducted a prospective multi-centre trial with dose-escalated CHOP (MegaCHOP) and tailored intensification prior to HDT/ASCT according to early response assessed by CT and gallium scan (Ga67S). PATIENTS AND METHODS:Eighty-six patients with newly diagnosed and Ga-67 avid aggressive B-cell lymphoma received MegaCHOP for three courses and were evaluated for response by CT and Ga67S. Patients with CT response and negative Ga67S received another MegaCHOP cycle followed by BEAM and ASCT. Those patients with positive Ga67S or without CT response received salvage treatment with two courses of ifosfamide and etoposide (IFE) followed, whenever response had been achieved, by BEAM and ASCT. RESULTS:Response rate before HDT/ASCT was 85% and, with 34 months of median follow-up, progression-free survival (PFS), overall survival (OS) and treatment-related mortality were 56%, 64% and 7%, respectively. For transplanted patients (81% of the whole series), PFS and OS were 67% and 74%, respectively. No different outcomes were observed between patients achieving an early negative Ga67S response treated with MegaCHOP and BEAM/ASCT and patients with mid-treatment positive Ga67S who received IFE prior BEAM/ASCT. CONCLUSIONS:This response-adapted strategy including early treatment modifications prior HDT/ASCT have yielded encouraging PFS and OS in patients with poor-risk B aggressive non-Hodgkin's lymphoma.

journal_name

Eur J Haematol

authors

Arranz R,Conde E,Grande C,Mateos MV,Gandarillas M,Albo C,Lahuerta JJ,Fernández-Rañada JM,Hernández MT,Alonso N,García Vela JA,Garzón S,Rodríguez J,Caballero D,Grupo Español de Linfomas\/Trasplante Autólogo de Médula Osea (GEL

doi

10.1111/j.1600-0609.2007.01020.x

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

227-35

issue

3

eissn

0902-4441

issn

1600-0609

pii

EJH1020

journal_volume

80

pub_type

杂志文章,多中心研究,随机对照试验
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    doi:10.1111/j.1600-0609.1988.tb00182.x

    authors: Friche E,Hansen MM,Wieslander S

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  • Kinetics of circulating selectin levels during bone marrow aplasia.

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    doi:10.1111/j.1600-0609.1998.tb01058.x

    authors: Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

    更新日期:1998-07-01 00:00:00

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    更新日期:2017-07-01 00:00:00

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    doi:10.1111/ejh.12326

    authors: Fan H,Ortega V,Fanasch HM,Wang Y,Holder KN,Higgins RA,Mendiola C,Mohamed G,Vadlamudi K,Velagaleti G

    更新日期:2014-10-01 00:00:00

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    doi:10.1111/j.1600-0609.1999.tb01131.x

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    更新日期:1999-11-01 00:00:00

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    更新日期:2008-04-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0609.2004.00292.x

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    更新日期:2004-09-01 00:00:00

  • Aplastic anemia successfully treated with rituximab: the possible role of aplastic anemia-associated autoantibodies as a marker for response.

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    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.2011.01612.x

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    更新日期:2011-06-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章,多中心研究

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    authors: Nagai H,Ogura M,Kusumoto S,Takahashi N,Yamaguchi M,Takayama N,Kinoshita T,Motoji T,Ohyashiki K,Kosugi H,Matsuda S,Ohnishi K,Omachi K,Hotta T

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    doi:10.1111/j.1600-0609.1990.tb00469.x

    authors: Monti M,Brandt L,Ikomi-Kumm J,Olsson H

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    authors: Nachbaur D,Clausen J,Kircher B

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1989.tb00309.x

    authors: Demeter J,Pálóczi K,Földi J,Hokland M,Hokland P,Benczúr M,Lehoczky D

    更新日期:1989-10-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章

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    authors: Browett PJ,Pattinson J,Pinkney J,Hoffbrand AV,Norton JD

    更新日期:1988-02-01 00:00:00

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    journal_title:European journal of haematology

    pub_type:

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    authors: Berntorp E,Hart D,Mancuso ME,d'Oiron R,Perry D,O'Mahony B,Kaczmarek R,Crato M,Pasi J,Miners A,Carlsson KS,Kitchen S,Boehlen F,Giangrande P,Cebura E,Uitslager N,Osooli M,Janeckova D,Haldon R,Rivolta GF

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    abstract:OBJECTIVES:Combined high-dose Interferon-alpha and psoralen plus ultraviolet A irradiation (PUVA) have been reported to be effective in the treatment of early mycosis fungoides (MF); however, our study is the first controlled prospective study in the literature exploring the activity and tolerability of the combination...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1600-0609.2005.00497.x

    authors: Rupoli S,Goteri G,Pulini S,Filosa A,Tassetti A,Offidani M,Filosa G,Mozzicafreddo G,Giacchetti A,Brandozzi G,Cataldi I,Barulli S,Ranaldi R,Scortechini AR,Capretti R,Fabris G,Leoni P,Marche Regional Multicentric Study Gro

    更新日期:2005-08-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0609.1997.tb01406.x

    authors: Hiçsönmez G,Gümrük F,Zamani PV,Tuncer MA,Yetgin S,Gürgey A,Atahan L,Ozsoylu S

    更新日期:1997-01-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1993.tb00617.x

    authors: Iwama A,Yoshida M,Miwa A,Obayashi T,Sakamoto S,Miura Y

    更新日期:1993-09-01 00:00:00

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    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1034/j.1600-0609.2003.00098.x

    authors: Anargyrou K,Paterakis G,Boutsis D,Politou M,Papadhimitriou SI,Siakandaris M,Vassiliadis J,Androulakis A,Meletis J,Rombos J,Tassiopoulou A,Vaiopoulos G

    更新日期:2003-10-01 00:00:00

  • Acute myeloid leukemia in the pregnant patient.

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    journal_title:European journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/ejh.12479

    authors: Thomas X

    更新日期:2015-08-01 00:00:00

  • Genetic variations in multiple myeloma I: effect on risk of multiple myeloma.

    abstract::Few risk factors have been established for the plasma cell disorder multiple myeloma, but some of these like African American ethnicity and a family history of B-cell lymphoproliferative diseases suggest a genetic component for the disease. Genetic variation represents the genetic basis of variability in a population....

    journal_title:European journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0609.2011.01700.x

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    更新日期:2012-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1990.tb00357.x

    authors: Pereira A,Cervantes F,Brugues R,Rozman C

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    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章,评审

    doi:10.1111/ejh.13560

    authors: Purdy JC,Shatzel JJ

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    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1999.tb01909.x

    authors: Sheu JR,Hung WC,Su CH,Lin CH,Lee LW,Lee YM,Yen MH

    更新日期:1999-05-01 00:00:00

  • Factors influencing release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes.

    abstract::Mononuclear phagocytes play an important role in the regulation of hematopoiesis, not only by producing regulatory monokines such as prostaglandins, tumor necrosis factor and interleukin-1 (IL-1), but also by the production of colony-stimulating activity (CSA). Previously, we have demonstrated that granulocyte-macroph...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1988.tb00209.x

    authors: Fibbe WE,Kluck PM,Duinkerken N,Voogt PJ,Willemze R,Falkenburg JH

    更新日期:1988-10-01 00:00:00

  • Interleukin-17 enhances the production of interferon-γ and tumour necrosis factor-α by bone marrow T lymphocytes from patients with lower risk myelodysplastic syndromes.

    abstract:INTRODUCTION:Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (T...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/ejh.12074

    authors: Zhang Z,Li X,Guo J,Xu F,He Q,Zhao Y,Yang Y,Gu S,Zhang Y,Wu L,Chang C

    更新日期:2013-05-01 00:00:00

  • Accumulation of vincristine and doxorubicin in malignant lymphocytes with different immunophenotypes.

    abstract::Cellular accumulation of vincristine (VCR) and doxorubicin (DOX) was studied in 15 patients with low-grade B-cell malignancies. Their leukemic lymphocytes were isolated and the effect of verapamil on drug uptake was studied. The immunophenotype was characterized using anti-IgM, -IgD, -B 1, monoclonal antibodies. The m...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1989.tb00334.x

    authors: Reizenstein P,Kapoor R,Gruber A,Peterson C

    更新日期:1989-11-01 00:00:00

  • High-dose cyclophosphamide, etoposide and BCNU (CVB) with autologous stem cell rescue in malignant lymphomas.

    abstract::Eighteen patients with malignant lymphoma, 10 non-Hodgkin's and 8 Hodgkin's, were treated with high-dose CVB (cyclophosphamide 4 x 1.5 g/m2, etoposide 4 x 250-400 mg/m2, carmustine 4 x 150-200 mg/m2), followed by autologous peripheral blood stem cells (PBSC, 13 patients) or bone marrow (BM, 5 patients) transplantation...

    journal_title:European journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1600-0609.1993.tb00599.x

    authors: Patti C,Majolino I,Scimè R,Indovina A,Vasta S,Liberti G,Gentile S,Santoro A,Pisa R,Caronia F

    更新日期:1993-07-01 00:00:00