Abstract:
:Hydrophobicity has proven to be an extremely useful parameter in small molecule drug discovery programmes given that it can be used as a predictive tool to enable rational design. For larger molecules, including peptoids, where folding is possible, the situation is more complicated and the average hydrophobicity (as determined by RP-HPLC retention time) may not always provide an effective predictive tool for rational design. Herein, we report the first ever application of partitioning experiments to determine the log D values for a series of peptoids. By comparing log D and average hydrophobicities we highlight the potential advantage of employing the former as a predictive tool in the rational design of biologically active peptoids.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Bolt HL,Williams CEJ,Brooks RV,Zuckermann RN,Cobb SL,Bromley EHCdoi
10.1002/bip.23014subject
Has Abstractpub_date
2017-07-01 00:00:00issue
4eissn
0006-3525issn
1097-0282journal_volume
108pub_type
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