解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Bacteria contain a diverse set of RNAs to provide tight regulation of gene expression in response to environmental stimuli. Bacterial small RNAs (sRNAs) work in conjunction with protein cofactors to bind complementary mRNA sequences in the cell, leading to up- or downregulation of protein synthesis. In vivo imaging of...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23394
更新日期:2021-01-01 00:00:00
abstract::Spiders can produce up to seven different types of silks or glues with different mechanical properties. Of these, flagelliform (Flag) silk is the most elastic, and aciniform (AcSp1) silk is the toughest. To produce a chimeric spider silk (spidroin) FlagR -AcSp1R , we fused one repetitive module of flagelliform silk fr...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23404
更新日期:2020-12-01 00:00:00
abstract::Recently, the use of hybrid double network (DN) hydrogels has become prominent due to their enhanced mechanical properties, which has opened the door for new applications of these soft materials. Only a few of these gels have demonstrated both injectable and moldable capabilities. In this work, we report the mechanica...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23355
更新日期:2020-06-01 00:00:00
abstract::The pharmacological therapy for gastrointestinal (GI) diseases, such as inflammatory bowel diseases, continues to present challenges in targeting efficacy. The need for maximal local drug exposure at the inflamed regions of the GI tract has led research to focus on a disease-targeted drug delivery approach. Smart nano...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.23336
更新日期:2020-01-01 00:00:00
abstract::Through optimization of the linker region and key stabilizing mutations, it has been possible to improve the stability of the circularly permuted (cp) Trp-cage miniprotein. However, even the most stable Trp-cage circular permutants are still less stable than the analogous standard topology (std) Trp-cages. Extending m...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23327
更新日期:2019-12-01 00:00:00
abstract::The formation of the KRas4B-PDEδ complex activates different signaling pathways required for the development and maintenance of cancer. Previous experimental and theoretical studies have allowed researchers to design an inhibitor of the KRas4B-PDEδ complex, "Deltarasin." This inhibitor binds to the prenyl-binding pock...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23333
更新日期:2019-11-01 00:00:00
abstract::Oxaliplatin (OXA) was coupled to PEGylated polyamidoamine dendrimers of fourth generation (G4-PEG@OXA) in the comparison to PEGylated ones of odd generation (G3.5-PEG@OXA). Proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy were used to confirm the successful incorporation of OXA as well as ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23272
更新日期:2019-07-01 00:00:00
abstract::Surfactant protein C (SP-C) is an important constituent of lung surfactant (LS) and, along with SP-B, is included in exogenous surfactant replacement therapies for treating respiratory distress syndrome (RDS). SP-C's biophysical activity depends upon the presence of a rigid C-terminal helix, of which the secondary str...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23277
更新日期:2019-06-01 00:00:00
abstract::A desire to replicate the structural and functional complexity of proteins with structured, sequence-specific oligomers motivates study of the structural features of water-soluble peptoids (N-substituted glycine oligomers). Understanding the molecular-level details of peptoid self-assembly in water is essential to adv...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23248
更新日期:2019-04-01 00:00:00
abstract::Gold nanoparticles are known to aggregate in the presence of proper multifunctional compounds. For those larger than 3 nm, the process can be followed with the naked eye because the surface plasmon absorption band of the particles shifts to longer wavelengths and the solution color changes from red to blue. To exploit...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23111
更新日期:2018-08-01 00:00:00
abstract::Differential scanning calorimetry measurements performed on RNase A in aqueous binary solutions containing different concentrations of urea, tetramethylurea, guanidinium chloride, and guanidinium thiocyanate, and in aqueous ternary solutions, containing the same denaturants plus 1 M trimethylamine N-oxide, TMAO, demon...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23104
更新日期:2018-08-01 00:00:00
abstract::Purified integral membrane proteins require amphipathic molecules to maintain their solubility in aqueous solutions. These complexes, in turn, are used in studies to characterise the protein structures by a variety of biophysical and structural techniques, including spectroscopy, crystallography, and cryo-electron mic...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23067
更新日期:2018-08-01 00:00:00
abstract::Fe(III)-Mimochrome VI (MC6) is a recently reported artificial heme-peptide conjugate system with a high peroxidase-like activity. By design, its structure features a five-coordinated Fe(III)-deuteroporphyrin active site, embedded in a compact α-helix-heme-α-helix "sandwich" motif. Up to now, no detailed MC6 structural...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23225
更新日期:2018-08-01 00:00:00
abstract::Suppressors of Cytokine Signaling (SOCS) proteins are negative regulators of JAK proteins that are receptor-associated tyrosine kinases, which play key roles in the phosphorylation and subsequent activation of several transcription factors named STATs. Unlike the other SOCS proteins, SOCS1 and 3 show, in the N-termina...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23082
更新日期:2017-11-20 00:00:00
abstract::Short peptides composed of phenylalanine and sequences derived from amyloidogenic peptides have the ability to self-assemble to form nanostructures including hydrogels. The self-assembly of peptides composed of only hydrophobic amino acids and aliphatic protecting groups have not been investigated in detail. We have e...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23033
更新日期:2017-11-01 00:00:00
abstract::TACC3 is a centrosomal adaptor protein that plays important roles during mitotic spindle assembly. It interacts with chTOG/XMAP215, which catalyzes the addition of tubulin dimers during microtubule growth. A 3D coiled-coil model for this interaction is available but the structural details are not well described. To ch...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23039
更新日期:2017-11-01 00:00:00
abstract::Contact lens (CL) wear is a risk factor for development of microbial keratitis, a vision threatening infection of the eye. Adverse events associated with colonization of lenses, especially by the multi-drug resistant and biofilm forming bacterium Pseudomonas aeruginosa remain a major safety issue. Therefore, novel str...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23074
更新日期:2017-10-31 00:00:00
abstract::In the past two decades, keratin biomaterials have shown impressive results as scaffolds for tissue engineering, wound healing, and nerve regeneration. In addition to its intrinsic biocompatibility, keratin interacts with specific cell receptors eliciting beneficial biochemical cues. However, during extraction from na...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23037
更新日期:2017-10-01 00:00:00
abstract::Methods to generate fibers from hydrogels, with control over mechanical properties, fiber diameter, and crystallinity, while retaining cytocompatibility and degradability, would expand options for biomaterials. Here, we exploited features of silk fibroin protein for the formation of tunable silk hydrogel fibers. The b...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23030
更新日期:2017-09-01 00:00:00
abstract::Despite the positive results observed in vitro and in vivo, clinical trials with bioactive peptides are generally hampered by their fast degradation in the biological system. Two bioactive peptides, P20 (CSSRTMHHC) and the combined peptide C (CVNHPAFACGYGHTMYYHHYQHHL) have been identified as anticancer therapeutics. C...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23029
更新日期:2017-09-01 00:00:00
abstract::The process of protein folding is obviously driven by forces exerted on the atoms of the amino-acid chain. These forces arise from interactions with other parts of the protein itself (direct forces), as well as from interactions with the solvent (solvent-induced forces). We present a statistical-mechanical formalism t...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23020
更新日期:2017-08-01 00:00:00
abstract::Hydrophobicity has proven to be an extremely useful parameter in small molecule drug discovery programmes given that it can be used as a predictive tool to enable rational design. For larger molecules, including peptoids, where folding is possible, the situation is more complicated and the average hydrophobicity (as d...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23014
更新日期:2017-07-01 00:00:00
abstract::In this study, we identified and chemically synthesized three cationic and amphipathic peptides (Glycinin-17, BCAS-16, and BCBS-11) from soybean proteins. These peptides had high isoelectric points, high positive net charges, and included multiple hydrophobic amino acids. Subsequently, we identified multiple functions...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23023
更新日期:2017-07-01 00:00:00
abstract::Understanding the high temperature behavior of collagen and collagenous tissue is important for surgical procedures and biomaterials processing for the food, pharmaceutical, and cosmetics industries. One primary event for proteins is thermal denaturation that involves unfolding the polypeptide chains while maintaining...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23017
更新日期:2017-06-01 00:00:00
abstract::The comprehensive understanding of disassembly mechanism of amyloid fibrils requires nano-scale characterization of the mechanical properties of amyloid fibrils during the disassembly process. In this work, gemini surfactant C12 C6 C12 Br2 micelles were used as a probe to disassemble Aβ(1-40) fibrils. The microstructu...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22992
更新日期:2017-02-01 00:00:00
abstract::A short peptide-based molecule has been found to form a strong hydrogel at phosphate buffer solution of pH 7.46. The hydrogel has been characterized thoroughly using various techniques including field emission scanning electron microscopy (FE-SEM), wide angle powder X-ray diffraction (PXRD), and rheological analysis. ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22915
更新日期:2017-01-01 00:00:00
abstract::Peptide-conjugated polysaccharide matrices using bioactive laminin-derived peptides are useful biomaterials for tissue and cell engineering. Here, we demonstrate an easy handling preparation method for peptide-polysaccharide matrices using polyion complex with both alginate and chitosan. First, aldehyde-alginate was s...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22983
更新日期:2017-01-01 00:00:00
abstract::Proteases play crucial roles in various biological processes, and their activities are essential for all living organisms-from viruses to humans. Since their functions are closely associated with many pathogenic mechanisms, their inhibitors or activators are important molecular targets for developing treatments for va...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22780
更新日期:2016-11-04 00:00:00
abstract::Peptide-polysaccharide matrices can mimic extracellular matrix structure and function and are useful for tissue and cell engineering. The spacer between the peptide and the polysaccharide is important for both peptide conformation and the interaction between the peptide and receptors. Here, the effect of a spacer on t...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22785
更新日期:2016-11-04 00:00:00
abstract::Combinatorial library composed of rigid rod-like peptides with a triple-helical scaffold was constructed. The component peptides were designed to have various combinations of basic and neutral (or hydrophobic) amino acid residues based on collagen-like (Gly-Pro-Yaa)-repeating sequences, inspired from the basic and amp...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22791
更新日期:2016-11-04 00:00:00
abstract::To date, several antigens based on the amino-terminal leucine/isoleucine heptad repeat (NHR) region of an HIV-1 envelope protein gp41 and fusion inhibitors based on the carboxy-terminal leucine/isoleucine heptad repeat (CHR) region of gp41 have been reported. We have developed a synthetic antigen targeting the membran...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22782
更新日期:2016-11-04 00:00:00
abstract::A new family of small plant peptides was recently described and found to be widespread throughout the Millereae and Heliantheae tribes of the sunflower family Asteraceae. These peptides originate from the post-translational processing of unusual seed-storage albumin genes, and have been termed PawS-derived peptides (P...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22901
更新日期:2016-11-01 00:00:00
abstract::Guanine-rich sequences are able to form quadruplexes consisting of G-quartet structural units. Quadruplexes play an important role in the regulation of gene expression and have therapeutic and biotechnological potential. The HIV-1 integrase inhibitor, (GGGT)4 , and its variants demonstrate unusually high thermal stabi...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22916
更新日期:2016-11-01 00:00:00
abstract::Cyclotides are multifunctional plant cyclic peptides containing 28-37 amino acid residues and a pattern of three disulfide bridges, forming a motif known as the cyclic cystine knot. Due to their high biotechnological potential, the sequencing and characterization of cyclotide genes are crucial not only for cloning and...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22938
更新日期:2016-11-01 00:00:00
abstract::Calcium ions (Ca(2+) ) play key roles in various fundamental biological processes such as cell signaling and brain function. Molecular dynamics (MD) simulations have been used to study such interactions, however, the accuracy of the Ca(2+) models provided by the standard MD force fields has not been rigorously tested....
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22868
更新日期:2016-10-01 00:00:00
abstract::Human saliva contains hundreds of small proline-rich peptides originated by the proteolytic cleavage of the salivary basic Proline-Rich Proteins. Nevertheless only for few of them a specific biological activity has been assigned to date. Among them, the 1932 Da peptide (p1932) has been patented as an anti-HIV agent. I...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22889
更新日期:2016-09-01 00:00:00
abstract::A novel approach to sequentially degrade peptoid N-terminal N-(substituted)glycine residues on the solid-phase using very mild conditions is reported. This method relies on the treatment of resin-bound, bromoacetylated peptoids with silver perchlorate in THF, leading to an intramolecular cyclization reaction to libera...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22884
更新日期:2016-09-01 00:00:00
abstract::Antimicrobial peptides (AMPs) have been the focus of intense research towards the finding of a viable alternative to current small-molecule antibiotics, owing to their commonly observed and naturally occurring resistance against pathogens. However, natural peptides have many problems such as low bioavailability and hi...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22885
更新日期:2016-09-01 00:00:00
abstract::Translational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome. Despite the high degree of evolutionary conservation in the sequences of their GTP-binding domains, the rates of GTP hydrolysis and nucleotide exchange vary broadly between different trGTPases. EF-Tu, one of the best-ch...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22832
更新日期:2016-08-01 00:00:00
abstract::Myosins are a large family of molecular motors that use the common P-loop, Switch 1 and Switch 2 nucleotide binding motifs to recognize ATP, to create a catalytic site than can efficiently hydrolyze ATP and to communicate the state of the nucleotide pocket to other allosteric binding sites on myosin. The energy of ATP...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22853
更新日期:2016-08-01 00:00:00