Abstract:
:Relevant parameters and stereochemical consequences of helices [alpha-helix, 3(10)-helix, beta-bend ribbon spiral, gamma-helix, 2.0(5)-helix, poly(Pro)(n) type-I and -II helices, and collagen triple helix] of peptides based on alpha-amino acids for use as templates in various branches of chemistry are briefly discussed.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Crisma M,Formaggio F,Moretto A,Toniolo Cdoi
10.1002/bip.20357subject
Has Abstractpub_date
2006-01-01 00:00:00pages
3-12issue
1eissn
0006-3525issn
1097-0282journal_volume
84pub_type
杂志文章,评审相关文献
BIOPOLYMERS文献大全abstract::Additive physical properties of DNA double strand polymers have been expanded in terms of 8 irreducible parameters. This provided consistency relations among the corresponding 10 duplex dimer contributions. To allow for oligomer analysis, end parameters were often added, and this would add extra degrees of freedom to ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22214
更新日期:2013-08-01 00:00:00
abstract::We have previously proposed a model for the delta-opioid receptor binding conformation of the high affinity tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) based on experimental and theoretical conformational analysis of this peptide and a correlation of conformational preferences of further conformationally restricted...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/(sici)1097-0282(199609)39:3<287::aid-bip2>
更新日期:1996-09-01 00:00:00
abstract::Ubiquitin (Ub) is a small 76 amino acid long protein that is highly conserved in all eukaryotes studied to date. In humans, more than 600 ligases are involved in the reversible modification of specific lysine side-chain amines in substrate proteins by conjugation with the C-terminal carboxylate of Ub. Initially monoub...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22253
更新日期:2014-02-01 00:00:00
abstract::Core peptide is a hydrophobic peptide derived from the T-cell antigen receptor-alpha chain (TCR-alpha) transmembrane region with therapeutic potential. The mechanism by which the peptide inserts into the membrane, including any requirements to change conformational or association states during the insertion, is unclea...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.21423
更新日期:2011-01-01 00:00:00
abstract::The interaction of an RGD-containing epitope from the hepatitis A virus VP3 capsid protein and its RGA-analogue with lipid membranes was studied by biophysical methods. Two types of model membrane were used: vesicles and monolayers spread at the air/water interface, with a composition that closely resembles the lipid ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/1097-0282(200101)58:1<63::AID-BIP70>3.0.CO
更新日期:2001-01-01 00:00:00
abstract::Functional RNAs such as ribosomal RNA and structured domains of mRNA are targets for small molecule ligands that can act as modulators of the RNA biological activity. Natural ligands for RNA display a bewildering structural and chemical complexity that has yet to be matched by synthetic RNA binders. Comparison of natu...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.10410
更新日期:2003-09-01 00:00:00
abstract::The 83-residue conopeptide (p21a) and its corresponding nonhydroxylated analog were isolated from the injected venom of Conus purpurascens. The complete conopeptide sequences were derived from Edman degradation sequencing of fragments from tryptic, chymotryptic and cyanogen bromide digestions, p21a has a unique, 10-cy...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.21406
更新日期:2011-01-01 00:00:00
abstract::Alpha-synuclein (alpha-Syn) has been identified as a component of intracellular fibrillar deposits in Parkinson's disease. Though the real pathogenesis is still unknown, many investigations have revealed that conformational alteration and fibril formation of alpha-Syn protein have an important role in causing the dise...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20550
更新日期:2006-10-15 00:00:00
abstract::The crystal and molecular structure of the pentapeptide Boc-D-Ala-delta Phe-Gly-delta Phe-D-Ala-OMe, containing two dehydrophenylalanine residues, was determined by x-ray diffraction. The molecule crystallizes in the orthorombic P2(1)2(1)2(1) space group, with a = 10.439(3), b = 15.319(3) and c = 21.099(4) A. In the s...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360300906
更新日期:1990-01-01 00:00:00
abstract::The use of alpha,alpha-disubstituted amino acids represents a valuable strategy to exercise conformational control in peptides. Incorporation of the nonstereogenic alpha-aminoisobutyryl-glycyl (Aib-Gly) dipeptidyl sequence into i+1 and i+2 positions of an acyclic peptide sequence, originally designed and investigated ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20738
更新日期:2007-01-01 00:00:00
abstract::Understanding the high temperature behavior of collagen and collagenous tissue is important for surgical procedures and biomaterials processing for the food, pharmaceutical, and cosmetics industries. One primary event for proteins is thermal denaturation that involves unfolding the polypeptide chains while maintaining...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23017
更新日期:2017-06-01 00:00:00
abstract::The pulsed-field gel electrophoresis (PFG) is a newly developing technique used in the fractionation of large DNA fragments. Advances in PFG demand a better understanding in the corresponding mechanisms of DNA dynamics in the gel network. Detailed experiments are needed to verify and to extend existing theoretical pre...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360290408
更新日期:1990-03-01 00:00:00
abstract::The preferred helical screw senses of chiral α-amino acids with a C(α)-tetrasubstituted α-carbon atom, as determined in the crystal state by X-ray diffraction analyses on derivatives and peptides, are reviewed. This survey covers C(α)-methylated and C(α)-ethylated α-amino acids, as well as α-amino acids cyclized on th...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22581
更新日期:2015-01-01 00:00:00
abstract::In this paper, we studied the quenching mechanism of intrinsic fluorescence of type I collagen by a new type photosensitizer and fluorescence quencher, hypocrellin B (HB). It was indicated that type I collagen can emit Tyr-intrinsic fluorescence with the excitation wavelength of Tyr (lambda(ex) = 269 nm). Its fluoresc...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0282(199708)42:2<219::AID-BIP10
更新日期:1997-08-01 00:00:00
abstract::A model of protein-chaperone interaction as a two-phase (unfolding/refolding) iterative annealing mechanism able to promote structural segregation of hydrophobic and hydrophilic monomers and thereby facilitate access to nativelike states has recently been applied successfully to two 22-mers of the Honeycutt and Thirum...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.10148
更新日期:2002-07-15 00:00:00
abstract::CD and nmr spectroscopy were used to compare the conformational properties of two related peptides. One of the peptides, Model AB, was designed to adopt a helix-turn-extended strand (alpha beta) tertiary structure in water that might be stabilized by hydrophobic interactions between two leucine residues in the amino-t...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360360202
更新日期:1995-08-01 00:00:00
abstract::High-level quantum-chemical and quantum-dynamics calculations are reported on the tautomerization equilibrium and rate constants of guanine and its complexes with one and two water molecules. The results are used to estimate the fraction of guanine present in the cell during DNA synthesis as the unwanted tautomer that...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/1097-0282(2001)61:1<77::AID-BIP10062>3.0.C
更新日期:2001-01-01 00:00:00
abstract::Although many anticancer drugs exert their biological activity by forming DNA interstrand crosslinks (ICLs), the thermodynamics of biologically relevant long crosslinked DNAs has not been intensively studied in contrast to short duplexes. Here, we carry out computer modeling of the shift of melting temperature of long...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22077
更新日期:2012-10-01 00:00:00
abstract::Side-chain lactam bridges linking amino acid residues that are spaced several residues apart in the linear sequence offer a convenient and flexible method for introducing conformational constraints into a peptide structure. The availability of a variety of selectively cleavable protecting groups for amines and carboxy...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.10203
更新日期:2002-01-01 00:00:00
abstract::Normal mode calculations have been done on a range of disulfide bridge conformations in order to determine how the SS stretch and CS stretch frequencies depend on structure. In addition to varying the C alpha C beta SS and NC alpha C beta S dihedral angles, we have varied the phi, psi of the adjoining peptide groups s...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360320813
更新日期:1992-08-01 00:00:00
abstract::Chiral interaction of helical peptide with chiral molecule, and concomitant induction in its helix sense have been demonstrated in optically inactive nonapeptide (1) possessing Gly at its N-terminus: H-Gly-(Delta(Z)Phe-Aib)(4)-OCH(3) (1: Delta(Z)Phe = Z-dehydrophenylalanine; Aib = alpha-aminoisobutyric acid). Spectros...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20557
更新日期:2006-11-01 00:00:00
abstract::Raman spectra of series of aqueous solutions of peptides containing two amino acids, glycine-X, alanine-X, and serine-X, where X is an uncharged amino acid, show that the amide III band shifts systematically to lower frequencies as the side chain of the X amino acid becomes larger. The range of this shift is about 20 ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360300511
更新日期:1990-01-01 00:00:00
abstract::Constrained azapeptides were designed based on the Ala-Val-Pro-Ile sequence from the second mitochondria-derived activator of caspases (Smac) protein and tested for ability to induce apoptosis in cancer cells. Diels-Alder cyclizations and Alder-ene reactions on azopeptides enabled construction of a set of constrained ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22851
更新日期:2016-05-01 00:00:00
abstract::DNA sequences d-TGAGGAAAGAAGGT (a 14-mer) and d-CTCCTTTCTTCC (a 12-mer) are complementary in parallel orientation forming either Donohue (reverse Watson-Crick) base pairing at neutral pH or Hoogsteen base pairing at slightly acidic pH. The structure of the complex formed by dissolving the two strands in equimolar rati...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0282(199706)41:7<773::AID-BIP6>
更新日期:1997-06-01 00:00:00
abstract::Peptides represent a rich natural source of potential medicines with one notable pharmaceutical limitation being their relatively short duration of action. A particularly good example of this phenomenon is glucagon-like peptide 1 (GLP), a hormone of appreciable interest for the treatment of type II diabetes. In the na...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.21418
更新日期:2010-01-01 00:00:00
abstract::Purified integral membrane proteins require amphipathic molecules to maintain their solubility in aqueous solutions. These complexes, in turn, are used in studies to characterise the protein structures by a variety of biophysical and structural techniques, including spectroscopy, crystallography, and cryo-electron mic...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.23067
更新日期:2018-08-01 00:00:00
abstract::The mode coupling diffusion theory is applied to the derivation of local dynamics in proteins in solution. The rotational dynamics of the bonds along the protein sequence are calculated and compared to the experimentally measured nmr (15)N spin-lattice relaxation time T(1), at 36.5, 60.8, and 81.1 MHz of the vnd/NK-2 ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/1097-0282(200008)54:2<89::AID-BIP2>3.0.CO;
更新日期:2000-08-01 00:00:00
abstract::Combinatorial chemistry has recently burst on the scene as a valuable tool for the discovery of new drug candidates. The ability to synthesize hundreds of compounds for screening is a useful complement to rational drug design. There are many similarities between the design of new therapeutic agents and the development...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.20395
更新日期:2006-01-01 00:00:00
abstract::To validate the existing hypothesis put forward by Navarro et al., we performed single crystal X-ray diffraction structural analysis of a designed model peptide incorporating an unsubstituted achiral γ-aminobutyric acid: Boc-Pro-γ-Abu-OH (1) lacking C-terminal amide group. The analysis established existence of an over...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.21511
更新日期:2010-11-01 00:00:00
abstract::Fourteen tryptic peptides and nine intermediates were identified as products of trypsin digestion of reduced and S-3-(trimethylated amino) propylated lysozyme. Kinetics of the appearance and disappearance of these products were observed by monitoring the peak areas on the chromatogram. In spite of the complicated reac...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.360340208
更新日期:1994-02-01 00:00:00