Design and characterization of a model alpha beta peptide.

abstract：:Calculations of the normal mode spectrum of a netropsin-DNA complex, an isolated DNA helix of the same sequence, and a free netropsin molecule were carried out and compared with observations. We find that the frequency of modes of the complex that are primarily vibrations localized to the helix are relatively unchange...

journal_title：Biopolymers

authors： Chen YZ,Prohofsky EW

更新日期：1995-06-01 00:00:00

abstract：:Laminins are a multifunctional molecule with numerous active sites that have been identified in short peptide sequences. Mixed peptide-conjugated chitosan membranes using laminin-derived active peptides have been previously demonstrated to be useful as a biomaterial for tissue engineering. In this study, two syndecan-...

journal_title：Biopolymers

authors： Otagiri D,Yamada Y,Hozumi K,Katagiri F,Kikkawa Y,Nomizu M

更新日期：2013-11-01 00:00:00

abstract：:The existence of an "RNA world" as an early step in the history of life increases the interest for the characterization of these biomolecules. The hairpin ribozyme studied here is a self-cleaving/ligating motif found in the minus strand of the satellite RNA associated with Tobacco ringspot virus. Surface-enhanced Rama...

journal_title：Biopolymers

authors： Percot A,Lecomte S,Vergne J,Maurel MC

更新日期：2009-05-01 00:00:00

abstract：:To obtain information about the structure-activity relationships of analgesic peptides, we modified the previously reported tripeptide, H-Lys-Pro-Thr-OH (C). The proline part in C was replaced with various analogues of unconventional amino acids [(3aS, 7aS)-octahydroindole-2-carboxylic acid (Oic), (S,S,S,)-2-azabicicl...

journal_title：Biopolymers

authors： Caliendo G,Greco G,Grieco P,Perissutti E,Santagada V,Ialenti A,Maffia P,Albrizio S,Santini A

更新日期：1996-01-01 00:00:00

abstract：:Recently, the use of hybrid double network (DN) hydrogels has become prominent due to their enhanced mechanical properties, which has opened the door for new applications of these soft materials. Only a few of these gels have demonstrated both injectable and moldable capabilities. In this work, we report the mechanica...

journal_title：Biopolymers

authors： Qiao Z,Mieles M,Ji HF

更新日期：2020-06-01 00:00:00

abstract：:Recent advances in the application of solid state nmr spectroscopy to uniformly aligned biopolymers have opened a window through which to view the detailed structure of biological macromolecules that are unable to be seen with standard techniques for structure determination such as x-ray diffraction. Atomic resolution...

journal_title：Biopolymers

authors： Nicholson LK,Asakura T,Demura M,Cross TA

更新日期：1993-05-01 00:00:00

abstract：:The ion atmosphere created by monovalent (Na(+) ) or divalent (Mg(2+) ) cations surrounding a B-form DNA duplex were examined using atomistic molecular dynamics (MD) simulations and the nonlinear Poisson-Boltzmann (PB) equation. The ion distributions predicted by the two methods were compared using plots of radial and...

journal_title：Biopolymers

authors： Robbins TJ,Ziebarth JD,Wang Y

更新日期：2014-08-01 00:00:00

abstract：:The formation mechanism of an alanine-based peptide has been studied by all-atom molecular dynamics simulations with a recently developed all-atom point-charge force field and the Generalize Born continuum solvent model at an effective salt concentration of 0.2M. Thirty-two simulations were conducted. Each simulation ...

journal_title：Biopolymers

authors： Chowdhury S,Zhang W,Wu C,Xiong G,Duan Y

更新日期：2003-01-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) plays a central role in the cellular transduction network. In particular, during chronic heart failure GRK2 is upregulated and believed to contribute to disease progression. Thereby, its inhibition offers a potential therapeutic solution to several pathological conditions. In...

journal_title：Biopolymers

authors： Gomez-Monterrey I,Carotenuto A,Cipolletta E,Sala M,Vernieri E,Limatola A,Bertamino A,Musella S,Grieco P,Trimarco B,Novellino E,Iaccarino G,Campiglia P

更新日期：2014-01-01 00:00:00

abstract：:Intermolecular NOE experiments have been used to explore interactions of water and ethanol molecules in 35% ethanol/65% water (v/v) with the peptide Trp-cage at temperatures from 5 to 25 degrees C. Magnetic dipole-dipole cross-relaxation terms sigma(HH) (NOE) and sigma(HH) (ROE) for interaction of solvent components w...

journal_title：Biopolymers

authors： Neuman RC Jr,Gerig JT

更新日期：2008-10-01 00:00:00

abstract：:Lung cancer is usually fatal once it becomes metastatic. However, in order to develop metastases, a tumor usually invades the basal membrane and enters the vascular or lymphatic system. In this study, a three-dimensional artificial membrane using collagen type I, one of the main components of basal membranes, was esta...

journal_title：Biopolymers

authors： Yang Y,Sulé-Suso J,Sockalingum GD,Kegelaer G,Manfait M,El Haj AJ

更新日期：2005-08-15 00:00:00

abstract：:Using a variety of spectroscopic techniques, a number of molecular functionalities have been studied in relation to the adsorption process of proteins to air-water interfaces. While ellipsometry and drop tensiometry are used to derive information on adsorbed amount and exerted surface pressure, external reflection cir...

journal_title：Biopolymers

authors： de Jongh HH,Kosters HA,Kudryashova E,Meinders MB,Trofimova D,Wierenga PA

更新日期：2004-05-01 00:00:00

abstract：:The presence of non-native kinetic traps in the free energy landscape of a protein may significantly lengthen the overall folding time so that the folding process becomes unreliable. We use a computational model alpha-helical hairpin peptide to calculate structural free energy landscapes and relate them to the kinetic...

journal_title：Biopolymers

authors： Chapagain PP,Gerstman BS

更新日期：2006-02-15 00:00:00

abstract：:Cyclic pentapeptides are excellent models for reverse turns and have been used extensively in our laboratory to explore the influence of different amino acid sequences on turn preference. This paper is divided into two parts: In the first, we review our previous studies of cyclic pentapeptides. We summarize work that ...

journal_title：Biopolymers

authors： Stradley SJ,Rizo J,Bruch MD,Stroup AN,Gierasch LM

更新日期：1990-01-01 00:00:00

abstract：:Over the past decade a large number of studies have focused attention on the role of nucleosomes as negative and positive regulators of specific nuclear functions. Due to the lack of an analytical method to determine the higher order conformation of the nucleosomal arrays that encompass specific genetic loci (e.g., pr...

journal_title：Biopolymers

authors： Georgel PT,Hansen JC

更新日期：2003-04-01 00:00:00

abstract：:Gelsolin is an actin-severing protein whose action is initiated by Ca(2+) and inhibited by binding to phosphorylated inositol lipid or phosphoinositides. The regions of gelsolin responsible for phosphoinositide binding are comprised of residues 150-169 (G150-169) and 135-142 (G135-142). The corresponding peptides poss...

journal_title：Biopolymers

authors： Liepiņa I,Czaplewski C,Janmey P,Liwo A

更新日期：2003-01-01 00:00:00

abstract：:We present a novel infrared method to investigate the functionality of a protein monolayer tethered to a metal substrate. The approach employs Surface Enhanced Infrared Absorption Spectroscopy (SEIRAS), which renders high surface sensitivity by enhancing the signal of the adsorbed protein by up to approximately 2 orde...

journal_title：Biopolymers

authors： Ataka K,Heberle J

更新日期：2006-07-01 00:00:00

abstract：:Circular dichroic spectra and oscillator strengths of the π-π transition near 190 nm are calculated for helical (Gly)6 and (Ala)6 at 30° intervals of the backbone torsion angles (ϕ,ψ) over the range -180° ≤ ϕ ≤ -60°, -60° ≤ ψ ≤ 180°, using the partially dispersive normal mode treatment of the dipole interaction model....

journal_title：Biopolymers

authors： Applequist J

更新日期：1981-02-01 00:00:00

abstract：:Small multidisulfide-containing proteins are attractive structural templates to produce a biologically active conformation that mimics the binding surface of natural large proteins. In particular, the structural motif that is evolutionary conserved in all scorpion toxins has a small size (30-40 amino acid residues), a...

journal_title：Biopolymers

authors： Vita C,Vizzavona J,Drakopoulou E,Zinn-Justin S,Gilquin B,Ménez A

更新日期：1998-01-01 00:00:00

abstract：:Dermaseptins, small polycationic peptides synthesized by amphibians, exert a lytic action on bacteria, protozoa, yeast, and filamentous fungi at micromolar concentrations, but unlike polylysines, show little hemolytic activity. Dermaseptins S are active only against bacteria and form aggregates at high peptide/lipid r...

journal_title：Biopolymers

authors： Castiglione-Morelli MA,Cristinziano P,Pepe A,Temussi PA

更新日期：2005-01-01 00:00:00

abstract：:In continuation of our studies on the determination of the structural features of functionalized peptides in solution by combining time-resolved fluorescence data and molecular mechanics results, the conformational features of a series of linear, L-(alphaMe)Val-based peptides have been investigated in methanol. These ...

journal_title：Biopolymers

authors： Pispisa B,Mazzuca C,Palleschi A,Stella L,Venanzi M,Formaggio F,Polese A,Toniolo C

更新日期：2000-01-01 00:00:00

abstract：:DMT1, also known as Nramp2, is an iron transporter, and belongs to the family of Nramp proteins. Disease-causing mutations both in Nramp1 and Nramp2 occurring at the conserved two adjacent glycine residues located within the fourth transmembrane domain (TM4) suggest that TM4 may serve an important biological function....

journal_title：Biopolymers

authors： Li H,Li F,Kwan M,He QY,Sun H

更新日期：2005-03-01 00:00:00

abstract：:The applicability of the FTIR attenuated total reflectance technique for in situ monitoring of plant physiological processes such as leaf senescence and aging has been examined. Difference spectra obtained by subtracting the spectrum of the young plant leaf from that of the older one revealed positive bands at 1650-15...

journal_title：Biopolymers

authors： Ivanova DG,Singh BR

更新日期：2003-01-01 00:00:00

abstract：:The Electrostatically Driven Monte Carlo (EDMC) method was applied in a study of a decamer of glycine whose conformational behavior is described by the Empirical Conformational Energy Program for Peptides (ECEPP/2) potential energy model. When free neutral end groups were used, it was found that conformations that wer...

journal_title：Biopolymers

authors： Ripoll DR,Vásquez MJ,Scheraga HA

更新日期：1991-02-15 00:00:00

abstract：:The chemical synthesis and x-ray crystal structure analysis of a model peptide incorporating a conformationally adaptable unsubstituted beta-Ala residue: Boc-beta-Ala-Acc6-OCH3 (C16H28N2O5, molecular weight = 328.41; 1) has been described. The peptide crystallized in the space group P2(1)2(1)2(1) a = 8.537 (3), b = 8....

journal_title：Biopolymers

authors： Thakur AK,Kishore R

更新日期：2000-05-01 00:00:00

abstract：:Disintegrins, small molecular weight proteins contained in the venom of vipers and rattlesnakes, are high-affinity and selectivity integrin antagonists. Disintegrins inhibitory epitope mainly consists in a tripeptide sequence localized in a mobile loop protruding from the protein core. RTS and/or KTS tripeptide charac...

journal_title：Biopolymers

authors： Calvanese L,Falcigno L,D'Auria G

更新日期：2015-03-01 00:00:00

abstract：:A model of protein-chaperone interaction as a two-phase (unfolding/refolding) iterative annealing mechanism able to promote structural segregation of hydrophobic and hydrophilic monomers and thereby facilitate access to nativelike states has recently been applied successfully to two 22-mers of the Honeycutt and Thirum...

journal_title：Biopolymers

authors： Gorse D

更新日期：2002-07-15 00:00:00

abstract：:The x-ray conformations of 5-, 7-, 9-, and 12-residue loops in bovine pancreatic trypsin inhibitor (BPTI) were predicted by the use of multiple independent Monte Carlo simulating annealing (MCSA) runs starting from random conformations. Four buried water molecules interacted with a 12-residue loop that started at resi...

journal_title：Biopolymers

authors： Carlacci L

更新日期：2001-04-05 00:00:00

abstract：:The IgY antibodies offer an attractive alternative to mammalian IgGs in research, diagnosis and medicine. The isolation of immunoglobulin Y from the egg yolks is efficient and economical, causing minimal suffering to animals. Here we present the methodology for the production of IgY antibodies specific to Staphylococc...

journal_title：Biopolymers

authors： Walczak M,Grzywa R,Łupicka-Słowik A,Skoreński M,Bobrek K,Nowak D,Boivin S,Brown EL,Oleksyszyn J,Sieńczyk M

更新日期：2015-09-01 00:00:00

abstract：:Human islet amyloid polypeptide (hIAPP), or amylin, is a 37 amino acid hormone secreted by pancreatic beta-cells. hIAPP constitutes approximately 90% of the amyloid deposits found in type II diabetic patients. It has been shown that the central region of the peptide (hIAPP(20-29)) constitutes the nucleation site for t...

journal_title：Biopolymers

authors： Mascioni A,Porcelli F,Ilangovan U,Ramamoorthy A,Veglia G

更新日期：2003-05-01 00:00:00