Abstract:
:Calculations of the normal mode spectrum of a netropsin-DNA complex, an isolated DNA helix of the same sequence, and a free netropsin molecule were carried out and compared with observations. We find that the frequency of modes of the complex that are primarily vibrations localized to the helix are relatively unchanged from the frequencies found for similar modes of the isolated helix. On the other hand, the frequencies of thosemodes of the complex that are found to be primarily in the netropsin are found to change significantly in the complex from that of the free netropsin. Further analysis indicates that the changes in the "netropsin modes" are primarily due to the conformational deformation induced in the netropsin by formation of the complex. All the frequencies and shifts in frequency are in good agreement with recent Raman measurements.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Chen YZ,Prohofsky EWdoi
10.1002/bip.360350611subject
Has Abstractpub_date
1995-06-01 00:00:00pages
657-66issue
6eissn
0006-3525issn
1097-0282journal_volume
35pub_type
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