Chiral interaction in Gly-capped N-terminal motif of 3(10)-helix and domino-type induction in helix sense.

abstract：:It has recently been reported that synthetic peptides corresponding to the C-terminal sequence of G alpha, can be used to study the molecular mechanisms of interaction between this protein and G protein coupled receptors (Hamm et al., Science, 1988, Vol. 241, pp. 832-835). A conformational analysis on a 11 amino acids...

journal_title：Biopolymers

authors： Albrizio S,D'Ursi A,Fattorusso C,Galoppini C,Greco G,Mazzoni MR,Novellino E,Rovero P

更新日期：2000-09-01 00:00:00

abstract：:A new series of oxy-peptide nucleic acids (pyrrolidine-based oxy-peptide nucleic acids = POPNAs) of four different stereoisomeric forms (cis-L, cis-D, trans-L, trans-D) have been synthesized. To find a favorable stereoisomer of POPNA for hybridization with DNA or RNA, thermodynamic parameters and conformations of the ...

journal_title：Biopolymers

authors： Kitamatsu M,Shigeyasu M,Saitoh M,Sisido M

更新日期：2006-01-01 00:00:00

abstract：:The kinetics of the hydrodynamic volume change associated with the unfolding and refolding of a globular protein can be observed using high performance size exclusion chromatography. Chromatographic profiles that evidence such dynamics can be simulated using equations in which chromatographic partitioning and the conf...

journal_title：Biopolymers

authors： Shalongo W,Jagannadham M,Stellwagen E

更新日期：1993-01-01 00:00:00

abstract：:The conformational study on Arg-Gly-Asp (RGD)-containing tetrapeptides in the unhydrated and hydrated states has been carried out using the force field ECEPP/3 and the hydration shell model. The tetrapeptides studied here are H-RGDX-OH (X = Trp, Tyr, Phe, Leu, Val, Cys, Gln, and Ser), which show the inhibitory activit...

journal_title：Biopolymers

authors： Park HS,Kim C,Kang YK

更新日期：2002-04-15 00:00:00

abstract：:Electronic absorbance and fluorescence titrations are used to probe the interaction of chlorobenzylidine with DNA. The binding of chlorobenzylidine to DNA results in hypochromism, a small shift to a longer wavelength in the absorption spectra, and emission quenching in the fluorescence spectra. These spectral characte...

journal_title：Biopolymers

authors： Zhong W,Yu JS,Huang W,Ni K,Liang Y

更新日期：2001-01-01 00:00:00

abstract：:An unusual class of nanoscopic, ring-shaped, single-walled biopolymers arises when alphabeta-tubulin is mixed with certain small peptides obtained from various marine organisms and cyanobacteria. The single-ring structures, whose mean molecular weight depends on the specific peptide added to the reaction mixture, usua...

journal_title：Biopolymers

authors： Boukari H,Sackett DL,Schuck P,Nossal RJ

更新日期：2007-08-05 00:00:00

abstract：:High-level quantum-chemical and quantum-dynamics calculations are reported on the tautomerization equilibrium and rate constants of guanine and its complexes with one and two water molecules. The results are used to estimate the fraction of guanine present in the cell during DNA synthesis as the unwanted tautomer that...

journal_title：Biopolymers

authors： Gorb L,Podolyan Y,Leszczynski J,Siebrand W,Fernández-Ramos A,Smedarchina Z

更新日期：2001-01-01 00:00:00

abstract：:A theoretical study is presented of the influence of salt bridges between cationic side chains and DNA phosphates on DNA conformation and flexibility. The DNA sequence studied is that of the catabolite activator protein binding oligomer from the crystallized complex. The effect of salt bridges is modeled by neutraliza...

journal_title：Biopolymers

authors： Gurlie R,Duong TH,Zakrzewska K

更新日期：1999-04-01 00:00:00

abstract：:Molecular modeling is used to demonstrate that the major structural deformations of DNA caused by four different minor groove binding proteins, TBP, SRY, LEF-1, and PurR, can all be mimicked by stretching the double helix between two 3'-phosphate groups flanking the binding region. This deformation reproduces the wide...

journal_title：Biopolymers

authors： Lebrun A,Lavery R

更新日期：1999-04-15 00:00:00

abstract：:Among the most exciting functional features of G-protein coupled receptors (GPCRs) that are coming into focus lately are those relating to the role and structural characteristics of their oligomerization (mostly homo- and heterodimers). The structural underpinnings of these novel functional insights are still not clea...

journal_title：Biopolymers

authors： Filizola M,Weinstein H

更新日期：2002-01-01 00:00:00

abstract：:Aqueous solutions of DNA fragments with a contour length (500 A) near the persistence length at DNA concentrations ranging from 10 to 290 mg/mL solvent and a constant supporting electrolyte concentration of 0.01 M (predominantly NaCl) were examined by 23Na-nmr spectroscopy at temperatures of 20, 40, and 60 degrees C. ...

journal_title：Biopolymers

authors： Strzelecka TE,Rill RL

更新日期：1990-01-01 00:00:00

abstract：:The conformational heterogeneity of several quinoxaline antibiotics, a class of naturally occurring quinoxaline peptides with antitumor properties, and their synthetic analogues was investigated in polar and nonpolar solvents by high performance liquid chromatography (HPLC) with uv photodiode array detection, uv-absor...

journal_title：Biopolymers

authors： Alfredson TV,Maki AH,Waring MJ

更新日期：1991-12-01 00:00:00

abstract：:A theoretical method is proposed to identify structural domains in proteins of known structures. It is based on the distribution of the local axes of the polypeptide chain. In particular, a statistical analysis is applied to the contributions of the local axes to the absolute writhing number, a topological property of...

journal_title：Biopolymers

authors： Anselmi C,Bocchinfuso G,Scipioni A,De Santis P

更新日期：2001-02-01 00:00:00

abstract：:Myelopeptides (MPs) are bioregulatory mediators of bone marrow origin. Several individual MPs have been isolated from the supernatant of porcine bone marrow cell culture by successive solid phase extraction and reversed-phase high performance liquid chromatography. Two of them, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 ...

journal_title：Biopolymers

authors： Petrov RV,Mikhailova AA,Fonina LA

更新日期：1997-01-01 00:00:00

abstract：:In Monte Carlo simulations of polymeric chains, the chains are most often represented as spheres, or cylinders with flat ends. In this methodological paper, we adopt a representation of the chains as spherocylinders (continuous cylinders ending in semispheres). With such a representation the testing for chain overlap,...

journal_title：Biopolymers

authors： Yeramian E,Schaeffer F,Caudron B,Claverie P,Buc H

更新日期：1989-12-01 00:00:00

abstract：:Ubiquitin (Ub) is a small 76 amino acid long protein that is highly conserved in all eukaryotes studied to date. In humans, more than 600 ligases are involved in the reversible modification of specific lysine side-chain amines in substrate proteins by conjugation with the C-terminal carboxylate of Ub. Initially monoub...

journal_title：Biopolymers

authors： Weller CE,Pilkerton ME,Chatterjee C

更新日期：2014-02-01 00:00:00

abstract：:We analyzed the CD and uv absorption spectra of 5S RNA from Escherichia coli using the method developed in the preceding paper. The analysis of spectra of 5S RNA at 20 degrees C in 0.1M NaClO4, 2.5 mM Na+ (phosphate), pH 7.0, and 0.5 mM MgSO4 gave 7 +/- 3.6 A.U base pairs, 25 +/- 3.6 G.C base pairs, and 7.5 +/- 3.6 G....

journal_title：Biopolymers

authors： Johnson KH,Gray DM

更新日期：1991-03-01 00:00:00

abstract：:The effects of inserting 16 base pair (bp) of alternating CG [(CG)8] near the middle of a much longer restriction fragment (1097 bp) are investigated by measuring various properties that are sensitive to secondary and tertiary structure. Results for this fragment are compared with those for a control fragment (1089 bp...

journal_title：Biopolymers

authors： Kim US,Fujimoto BS,Furlong CE,Sundstrom JA,Humbert R,Teller DC,Schurr JM

更新日期：1993-11-01 00:00:00

abstract：:A series of iota-carrageenans containing different amounts of nu-carrageenan (0-23 monomer %) have been prepared from neutrally extracted carrageenan of Eucheuma denticulatum. nu-Carrageenan is the biochemical precursor of iota-carrageenan. The conformational order-disorder transition and rheological properties of the...

journal_title：Biopolymers

authors： van de Velde F,Rollema HS,Grinberg NV,Burova TV,Grinberg VY,Tromp RH

更新日期：2002-11-15 00:00:00

abstract：:Study of model beta-hairpin peptides allows for better understanding of the factors involved in the formation of beta-sheet secondary structure in proteins. It is known that turn sequence, sidechain-sidechain interactions, interstrand hydrogen bonding, and beta-sheet propensity of residues are all important for beta-h...

journal_title：Biopolymers

authors： Riemen AJ,Waters ML

更新日期：2008-01-01 00:00:00

abstract：:The hinge region links the antigen binding Fab part to the constant Fc domain in immunoglobulins. For the hinge peptide derivative [AcThr(OtBu)-Cys-Pro-Pro-Cys-Pro-Ala-ProNH2]2 the assignment of the 1H and 13C resonances was achieved by two-dimensional nmr techniques: total correlation spectroscopy (TOCSY), nuclear Ov...

journal_title：Biopolymers

authors： Kessler H,Mronga S,Müller G,Moroder L,Huber R

更新日期：1991-09-01 00:00:00

abstract：:This article measures the rates of folding and unfolding of the collagen-like peptide (Pro-Hyp-Gly)(10) over overlapping concentration and temperature ranges. The data allow calculation of the orders of the folding and the unfolding reactions, the effective Arrhenius activation energies, and numerical solution of the ...

journal_title：Biopolymers

authors： Miles CA

更新日期：2007-09-01 00:00:00

abstract：:The structures of the helices II-III region and the helix IV region of B. megaterium 5S rRNA have been examined by means of energy minimization and molecular dynamics calculations. Calculated distances between neighboring hydrogen-bonded imino protons in helices II, III, and IV were between 3.5 and 4.5 A. The overall ...

journal_title：Biopolymers

authors： Kim JH,Marshall AG

更新日期：1992-09-01 00:00:00

abstract：:TC5b is a 20 residue polypeptide notable for its compact tertiary structure, a rarity for a short peptide. This structure is due to the "Trp-cage" motif, an association of aromatic, Pro, and Gly residues. The structure of TC5b has been fully characterized by NMR and electronic circular dichroism (ECD) studies, but has...

journal_title：Biopolymers

authors： Copps J,Murphy RF,Lovas S

更新日期：2007-01-01 00:00:00

abstract：:The large abundance of bioactive single- and multiple-stranded cystine-rich peptides in nature has fostered the development of orthogonal thiol-protection schemes and of efficient chemistries for regioselective disulfide formation in synthetic replica for decades. In parallel to these entirely synthetic strategies, an...

journal_title：Biopolymers

authors： Moroder L,Musiol HJ,Götz M,Renner C

更新日期：2005-01-01 00:00:00

abstract：:The occurrence of a highly conserved 11-mer repeating motif in the primary sequence is a major characteristic of group 3 late embryogenesis abundant (LEA3) proteins, which are strongly associated with abiotic stress tolerance of the plants. In this study, the three-dimensional structure, mimetic membrane association, ...

journal_title：Biopolymers

authors： Xue R,Liu Y,Zheng Y,Wu Y,Li X,Pei F,Ni J

更新日期：2012-01-01 00:00:00

abstract：:Multiple, independent sites or domains behave, on chemical change, in a manner predicted by Langmuir. Distortions of this behavior have been attributed to interactions between the domains, which vary with the progress of the changes occurring at the sites or domains. The two main models for nearest neighbor interactio...

journal_title：Biopolymers

authors： Saroff HA,Kiefer JE

更新日期：1999-05-01 00:00:00

abstract：:Solid-state nmr spectroscopy provides a robust method for investigating polypeptides that have been prepared by chemical synthesis and that are immobilized by strong interactions with solid surfaces or large macroscopic complexes. Solid-state nmr spectroscopy has been widely used to investigate membrane polypeptides o...

journal_title：Biopolymers

authors： Bechinger B,Kinder R,Helmle M,Vogt TC,Harzer U,Schinzel S

更新日期：1999-01-01 00:00:00

abstract：:A three-dimensional model of DNA/RNA triple helix that contains a poly(L-deoxyadenosine) (L-dA) chain is proposed based on computer-assisted model building and energy calculations. The model building was performed by a new method that systematically searches possible conformations of nucleotide units in the helical ch...

journal_title：Biopolymers

authors： Tomioka N,Itai A

更新日期：1992-12-01 00:00:00

abstract：:H-Pro-Pro-Asp-NH2 is a highly active and selective catalyst for asymmetric aldol reactions. Here, the versatility of H-Pro-Pro-Asp-NH2 has been further improved by immobilization on a solid support and functionalization with a short polyethylene glycol linker at the C-terminus. The development, synthesis, and the cata...

journal_title：Biopolymers

authors： Revell JD,Gantenbein D,Krattiger P,Wennemers H

更新日期：2006-01-01 00:00:00