Abstract:
:Myelopeptides (MPs) are bioregulatory mediators of bone marrow origin. Several individual MPs have been isolated from the supernatant of porcine bone marrow cell culture by successive solid phase extraction and reversed-phase high performance liquid chromatography. Two of them, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), were synthesized and their biological activities were comprehensively studied. Both hexapeptides display pronounced immunoregulatory activity but their final effects as well as mechanisms of action are different. Peptides MP-1 and MP-2 are identical to conservative fragments 33-38 alpha- and 31-36 beta-chains of hemoglobin, respectively. The sequences of other isolated MPs have no homology with any functional protein. The role of MPs in bioregulatory processes in vivo is discussed.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Petrov RV,Mikhailova AA,Fonina LAdoi
10.1002/(SICI)1097-0282(1997)43:2<139::AID-BIP7>3.subject
Has Abstractpub_date
1997-01-01 00:00:00pages
139-46issue
2eissn
0006-3525issn
1097-0282pii
10.1002/(SICI)1097-0282(1997)43:2<139::AID-BIP7>3.journal_volume
43pub_type
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