Bone marrow immunoregulatory peptides (myelopeptides): isolation, structure, and functional activity.

Abstract:

:Myelopeptides (MPs) are bioregulatory mediators of bone marrow origin. Several individual MPs have been isolated from the supernatant of porcine bone marrow cell culture by successive solid phase extraction and reversed-phase high performance liquid chromatography. Two of them, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), were synthesized and their biological activities were comprehensively studied. Both hexapeptides display pronounced immunoregulatory activity but their final effects as well as mechanisms of action are different. Peptides MP-1 and MP-2 are identical to conservative fragments 33-38 alpha- and 31-36 beta-chains of hemoglobin, respectively. The sequences of other isolated MPs have no homology with any functional protein. The role of MPs in bioregulatory processes in vivo is discussed.

journal_name

Biopolymers

journal_title

Biopolymers

authors

Petrov RV,Mikhailova AA,Fonina LA

doi

10.1002/(SICI)1097-0282(1997)43:2<139::AID-BIP7>3.

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

139-46

issue

2

eissn

0006-3525

issn

1097-0282

pii

10.1002/(SICI)1097-0282(1997)43:2<139::AID-BIP7>3.

journal_volume

43

pub_type

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