Abstract:
:A theoretical method is proposed to identify structural domains in proteins of known structures. It is based on the distribution of the local axes of the polypeptide chain. In particular, a statistical analysis is applied to the contributions of the local axes to the absolute writhing number, a topological property of a space curve resulting from the number of self-crossings in the curve projections onto a unit sphere. This finding supports the hypothesis that topological requirements should be satisfied in the process of protein folding and in the final organization of the tertiary structures.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Anselmi C,Bocchinfuso G,Scipioni A,De Santis Pdoi
10.1002/1097-0282(200102)58:2<218::AID-BIP100>3.0.subject
Has Abstractpub_date
2001-02-01 00:00:00pages
218-29issue
2eissn
0006-3525issn
1097-0282pii
10.1002/1097-0282(200102)58:2<218::AID-BIP100>3.0.journal_volume
58pub_type
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