A rigorous mathematical treatment for the excluded volume effect in Monte Carlo simulations of polymeric chains.

abstract：:The degradation of elastin, the insoluble biopolymer of tropoelastin, can lead to the production of small peptides. These elastin-derived peptides (EDPs) are playing a key role in cellular behavior within the extracellular matrix, showing a great variety of biological effects such as chemotaxis, stimulation of cell pr...

journal_title：Biopolymers

authors： Moroy G,Alix AJ,Héry-Huynh S

更新日期：2005-07-01 00:00:00

abstract：:Actinomycin-D (actD) binds to natural DNA at two different classes of binding sites, weak and strong. The affinity for these sites is highly dependent on DNA sequence and solution conditions, and the interaction appears to be purely entropic driven. Although the entropic character of this reaction has been attributed ...

journal_title：Biopolymers

authors： Ruggiero Neto J,Colombo MF

更新日期：2000-01-01 00:00:00

abstract：:The gel electrophoresis of spherical particles with a radius above 0.2 micron has not been reported yet. In the present study, video phase-contrast light microscopy is used to observe the motion of individual latex spheres, 0.52 micron in radius, during electrophoresis in 0.1% agarose gels. At 2 V/cm, the spheres init...

journal_title：Biopolymers

authors： Griess GA,Serwer P

更新日期：1990-12-01 00:00:00

abstract：:To obtain information about the structure-activity relationships of analgesic peptides, we modified the previously reported tripeptide, H-Lys-Pro-Thr-OH (C). The proline part in C was replaced with various analogues of unconventional amino acids [(3aS, 7aS)-octahydroindole-2-carboxylic acid (Oic), (S,S,S,)-2-azabicicl...

journal_title：Biopolymers

authors： Caliendo G,Greco G,Grieco P,Perissutti E,Santagada V,Ialenti A,Maffia P,Albrizio S,Santini A

更新日期：1996-01-01 00:00:00

abstract：:Targeting double-stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA-PNA chimeras. A 16-mer 5'-DNA-3'-p-(N)PNA(C) has been investigated for its ability to hybridize a complementary d...

journal_title：Biopolymers

authors： Petraccone L,Erra E,Messere A,Montesarchio D,Piccialli G,De Napoli L,Barone G,Giancola C

更新日期：2004-03-01 00:00:00

abstract：:Structural formation of segments plays pivotal roles in protein folding and stability, but how the segment influences the structural ensemble remains elusive. We engineered two hybrid proteins by replacing the central helical segment of immunoglobulin G binding domain of streptococcal protein G with an alpha-helix or ...

journal_title：Biopolymers

authors： Du HN,Zhang TY,Chang YG,Lin DH,Hu HY

更新日期：2005-09-01 00:00:00

abstract：:Although many anticancer drugs exert their biological activity by forming DNA interstrand crosslinks (ICLs), the thermodynamics of biologically relevant long crosslinked DNAs has not been intensively studied in contrast to short duplexes. Here, we carry out computer modeling of the shift of melting temperature of long...

journal_title：Biopolymers

authors： Chang CL,Lando DY,Fridman AS,Hu CK

更新日期：2012-10-01 00:00:00

abstract：:This work theoretically investigates the mechanical properties of a novel silk-derived biopolymer as polymerized in silico from sericin and elastin-like monomers. Molecular Dynamics simulations and Steered Molecular Dynamics were the principal computational methods used, the latter of which applies an external force o...

journal_title：Biopolymers

authors： Golas EI,Czaplewski C

更新日期：2014-09-01 00:00:00

abstract：:Alternating sequences of D and L residues in peptides are directly related to the formation of several kinds of regular helical conformations usually called beta-helices. The major feature of these structures is that they can be associated with the transmembrane ion-conducting channel activity in some natural antibact...

journal_title：Biopolymers

authors： Navarro E,Fenude E,Celda B

更新日期：2004-02-05 00:00:00

abstract：:Normal mode calculations have been done on a range of disulfide bridge conformations in order to determine how the SS stretch and CS stretch frequencies depend on structure. In addition to varying the C alpha C beta SS and NC alpha C beta S dihedral angles, we have varied the phi, psi of the adjoining peptide groups s...

journal_title：Biopolymers

authors： Qian W,Krimm S

更新日期：1992-08-01 00:00:00

abstract：:Human islet amyloid polypeptide (hIAPP), or amylin, is a 37 amino acid hormone secreted by pancreatic beta-cells. hIAPP constitutes approximately 90% of the amyloid deposits found in type II diabetic patients. It has been shown that the central region of the peptide (hIAPP(20-29)) constitutes the nucleation site for t...

journal_title：Biopolymers

authors： Mascioni A,Porcelli F,Ilangovan U,Ramamoorthy A,Veglia G

更新日期：2003-05-01 00:00:00

abstract：:We have studied the use of a new Monte Carlo (MC) chain generation algorithm, introduced by T. Garel and H. Orland [(1990) Journal of Physics A, Vol. 23, pp. L621-L626], for examining the thermodynamics of protein folding transitions and for generating candidate C(alpha) backbone structures as starting points for a de...

journal_title：Biopolymers

authors： Solomon JE,Liney D

更新日期：1995-11-01 00:00:00

abstract：:Translational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome. Despite the high degree of evolutionary conservation in the sequences of their GTP-binding domains, the rates of GTP hydrolysis and nucleotide exchange vary broadly between different trGTPases. EF-Tu, one of the best-ch...

journal_title：Biopolymers

authors： Maracci C,Rodnina MV

更新日期：2016-08-01 00:00:00

abstract：:In this paper, we explore the possibility of using experimental observations in the Monte Carlo chain growth method that we have previously developed. In this method, the macromolecule (peptide, protein, nuclei acid, etc.) is grown atom-by-atom (or residue-by-residue, etc.) and partial chains are replicated according ...

journal_title：Biopolymers

authors： Bascle J,Garel T,Orland H,Velikson B

更新日期：1993-12-01 00:00:00

abstract：:Regulatory, receptor-binding peptides are considered as the agents of choice for diagnostic imaging and therapy of cancers, because their receptors are overexpressed in various human cancer cells. It has been recently indicated that there is a putative role of NPY in breast tumors. The expression of the two best-inves...

journal_title：Biopolymers

authors： Khan IU,Reppich R,Beck-Sickinger AG

更新日期：2007-01-01 00:00:00

abstract：:Deoxyribozyme and aptamer selections are typically conducted in aqueous buffer solutions. Using nonaqueous cosolvents in selection experiments will help expand the activity of deoxyribozymes with non-oligonucleotide substrates and will allow identification of new aptamers for nonprotein targets. We undertook in vitro ...

journal_title：Biopolymers

authors： Behera AK,Schlund KJ,Mason AJ,Alila KO,Han M,Grout RL,Baum DA

更新日期：2013-06-01 00:00:00

abstract：:Fourier transform IR (FTIR) spectroscopy has been successfully applied in recent years to examine the functional and structural properties of the membrane protein rhodopsin, a prototype G protein coupled receptor. Unlike UV-visible spectroscopy, FTIR spectroscopy is structurally sensitive. It may give us both global i...

journal_title：Biopolymers

authors： Vogel R,Siebert F

更新日期：2003-01-01 00:00:00

abstract：:Serine palmitoyltransferase (SPT) catalyses the first step in the de novo biosynthesis of sphingolipids (SLs). It uses a decarboxylative Claisen-like condensation reaction to couple L-serine with palmitoyl-CoA to generate a long-chain base product, 3-ketodihydrosphingosine. SLs are produced by mammals, plants, yeast, ...

journal_title：Biopolymers

authors： Raman MC,Johnson KA,Clarke DJ,Naismith JH,Campopiano DJ

更新日期：2010-09-01 00:00:00

abstract：:The study of biologically active peptides is critical to the understanding of physiological pathways, especially those involved in the development of disease. Historically, the measurement of biologically active endogenous peptides has been undertaken by radioimmunoassay, a highly sensitive and robust technique that p...

journal_title：Biopolymers

authors： Xi L,Jin Y,Parker EA,Josh P,Jones A,Wijffels G,Colgrave ML

更新日期：2012-01-01 00:00:00

abstract：:This work advances bottom-up design of bioinspired materials built from peptide-amphiphiles, which are a class of bioconjugates in which a biofunctional peptide is covalently attached to a hydrophobic moiety that drives self-assembly in aqueous solution. Specifically, this work highlights the importance of peptide con...

journal_title：Biopolymers

authors： Marullo R,Kastantin M,Drews LB,Tirrell M

更新日期：2013-09-01 00:00:00

abstract：:Spray drying is a way to generate protein solids (powders), which is also true for lyophilization. Sugars are used to protect proteins from conformational changes and chemical degradations arising from drying processes and storage conditions such as the humidity. The influence of trehalose and humidity on the conforma...

journal_title：Biopolymers

authors： French DL,Arakawa T,Li T

更新日期：2004-03-01 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) in a silver sol assisted by density functional theory (DFT) calculations is shown to be a promising tool in the characterization of platinum complexes and their interaction with nucleic acid bases. This is demonstrated using cisplatin and guanine as a model. The energies and ...

journal_title：Biopolymers

authors： Giese B,McNaughton D

更新日期：2003-01-01 00:00:00

abstract：:N-ethylmaleimide sensitive factor (NSF) is a key protein of intracellular membrane traffic. NSF is a highly conserved protein belonging to the ATPases associated with other activities (AAA+ proteins). AAA+ share common domains and all transduce ATP hydrolysis into major conformational movements that are used to carry ...

journal_title：Biopolymers

authors： Ryu JK,Jahn R,Yoon TY

更新日期：2016-08-01 00:00:00

abstract：:Increasing attention is being paid to the role of selenium, both as an essential component required for the activity of many enzymes and in the context of selenium-based pharmaceutical agents. A wide range of therapeutics that include selenium are on the market and under development, such as antihypertensive, anticanc...

journal_title：Biopolymers

authors： Hartman I,Raia CA,Zauhar RJ

更新日期：2006-12-15 00:00:00

abstract：:The design, synthesis, and evaluation of a novel series of receptors for protein surface recognition are described. The design of these agents is based around the attachment of four constrained peptide loops onto a central calix[4]arene scaffold. This arrangement mimics the role of the hypervariable loops in antibody ...

journal_title：Biopolymers

authors： Lin Q,Park HS,Hamuro Y,Lee CS,Hamilton AD

更新日期：1998-01-01 00:00:00

abstract：:The rheological characteristics of gastric and duodenal mucin solutions, the building blocks of the mucus layer that covers the epithelia of the two organs, were investigated using particle tracking microrheology. We used biochemically well characterized purified porcine mucins (MUC5AC and MUC2) as models for human mu...

journal_title：Biopolymers

authors： Georgiades P,Pudney PD,Thornton DJ,Waigh TA

更新日期：2014-04-01 00:00:00

abstract：:The HPLC retention behavior of three complete single methionine and methionine sulfoxide replacement sets of two 18-mer model peptides and neuropeptide Y (NPY) were investigated. All peptides were prepared by multiple solid-phase peptide synthesis. Plotting the retention time differences between methionine and methion...

journal_title：Biopolymers

authors： Rothemund S,Krause E,Beyermann M,Bienert M,Sykes BD,Sönnichsen FD

更新日期：1996-08-01 00:00:00

abstract：:Hyaluronic acid (HA) is an important biomacromolecule, which fulfils a number of vital physiological functions (especially in the joint synovial fluid) and also has consumer and pharmaceutical applications. HA solution properties have already been quite thoroughly characterized in response to steady shear flows but ar...

journal_title：Biopolymers

authors： Haward SJ

更新日期：2014-03-01 00:00:00

abstract：:Peptides represent a rich natural source of potential medicines with one notable pharmaceutical limitation being their relatively short duration of action. A particularly good example of this phenomenon is glucagon-like peptide 1 (GLP), a hormone of appreciable interest for the treatment of type II diabetes. In the na...

journal_title：Biopolymers

authors： De A,DiMarchi RD

更新日期：2010-01-01 00:00:00

abstract：:Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen s...

journal_title：Biopolymers

authors： Guarracino DA,Bullock BN,Arora PS

更新日期：2011-01-01 00:00:00