Abstract:
:Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Guarracino DA,Bullock BN,Arora PSdoi
10.1002/bip.21546subject
Has Abstractpub_date
2011-01-01 00:00:00pages
1-7issue
1eissn
0006-3525issn
1097-0282journal_volume
95pub_type
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